... alleles with the program CRIMAP (Green et al., 1990) and the USERMl3 option of the MENDEL suite of linkage programs (Boehnke, 1991). Maximum likelihood estimates of marker allele frequencies were obtained for each data set separately by using the USERM13 program. Marker order and distance were estim ...
The universal reagent for genome tailoring
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
... control that the remaining loxP site does not create a disturbance in the gene function after the selectable marker is removed. Interestingly, this allele without the marker removal (Fig. 3B) can provide a useful tool for learning more about the function of the gene of interest. If the marker was de ...
Genetic factors affecting dental caries risk
... The calcium phosphate hydroxyapatite crystals forming the bulk of enamel are controlled through the interaction of a number of organic matrix molecules that include amelogenin, enamelin, ameloblastin, tuftelin and dentine sialophosphoprotein. The amelogenin (AMELX) gene resides on the p arm of the X ...
... The calcium phosphate hydroxyapatite crystals forming the bulk of enamel are controlled through the interaction of a number of organic matrix molecules that include amelogenin, enamelin, ameloblastin, tuftelin and dentine sialophosphoprotein. The amelogenin (AMELX) gene resides on the p arm of the X ...
MEF2 activity during embryogenesis - Development
... and are potent transactivators through that sequence (Gossett et al., 1989; Cserjesi and Olson, 1991). Whereas a single MEF2-binding site is transcriptionally inactive, when the ...
... and are potent transactivators through that sequence (Gossett et al., 1989; Cserjesi and Olson, 1991). Whereas a single MEF2-binding site is transcriptionally inactive, when the ...
Complex Heterozygosity Screening with Actin Alanine Scan Alleles
... genes has been shown to contribute to tumorigenesis (Santarosa and Ashworth 2004), and complex haploinsufficiency has been shown in mouse models to contribute to early aging (Baker et al. 2006) and tumorigenesis (Ma et al. 2005; Vives et al. 2006). Furthermore, recent genome-wide sequencing of 1092 ...
... genes has been shown to contribute to tumorigenesis (Santarosa and Ashworth 2004), and complex haploinsufficiency has been shown in mouse models to contribute to early aging (Baker et al. 2006) and tumorigenesis (Ma et al. 2005; Vives et al. 2006). Furthermore, recent genome-wide sequencing of 1092 ...
Genetics of host response in leprosy
... design has been largely employed in leprosy studies; generally SNPs are used as markers in candidate genes, like TNFa and IL-10, and comparisons are made with unrelated (independent) controls. The design of these studies are just like any classical epidemiological study, i.e. cases are identified in ...
... design has been largely employed in leprosy studies; generally SNPs are used as markers in candidate genes, like TNFa and IL-10, and comparisons are made with unrelated (independent) controls. The design of these studies are just like any classical epidemiological study, i.e. cases are identified in ...
Investigating the link between tRNA and mRNA - EMBL-EBI
... that the abundance of trna molecules is thus kept highly stable even across vastly different cellular conditions, in marked contrast with the abundance of protein-coding genes, which changes dynamically to drive cell function. The abundance of trna genes defines, to a large extent, the efficiency wi ...
... that the abundance of trna molecules is thus kept highly stable even across vastly different cellular conditions, in marked contrast with the abundance of protein-coding genes, which changes dynamically to drive cell function. The abundance of trna genes defines, to a large extent, the efficiency wi ...
Gene Section ALDOB (aldolase B, fructose-bisphosphate) Atlas of Genetics and Cytogenetics
... that caused catalytic deficiency of aldolase B, have been found in hereditary fructose intolerance (HFI). Many types of mutation in human ALDOB gene were reported, including missense mutations, nonsense mutations, deletions, insertions and mutation at the splicing regions (list in the diagram above) ...
... that caused catalytic deficiency of aldolase B, have been found in hereditary fructose intolerance (HFI). Many types of mutation in human ALDOB gene were reported, including missense mutations, nonsense mutations, deletions, insertions and mutation at the splicing regions (list in the diagram above) ...
Phylogenetic Relationships between the Western Aster Yellows
... The EcoRI fragments were ligated into the replicative form of EcoRI-digested, dephosphorylated M13mp18. The EcoRI-Hind111fragments were ligated into similarly digested M13mp19. Ligated molecules were transformed in competent Escherichia coli LL308 cells. Cells from each transformation reaction were ...
... The EcoRI fragments were ligated into the replicative form of EcoRI-digested, dephosphorylated M13mp18. The EcoRI-Hind111fragments were ligated into similarly digested M13mp19. Ligated molecules were transformed in competent Escherichia coli LL308 cells. Cells from each transformation reaction were ...
the hemophilia gene, click here
... Hemophilia is a disease that results from changes to the genetic code for a clotting factor. In many cases it is possible to trace a family history of hemophilia. However, in about one-third of new patients, hemophilia appears to occur in that family for the first time. There is now good evidence to ...
... Hemophilia is a disease that results from changes to the genetic code for a clotting factor. In many cases it is possible to trace a family history of hemophilia. However, in about one-third of new patients, hemophilia appears to occur in that family for the first time. There is now good evidence to ...
X-Chromosome dosage compensation
... 3. Dosage compensation proteins assemble onto hermaphrodite X chromosomes to regulate gene expression and also function separately in chromosome segregation ..................................................................... 3 4. Sex-specific targeting of the dosage compensation complex to hermaph ...
... 3. Dosage compensation proteins assemble onto hermaphrodite X chromosomes to regulate gene expression and also function separately in chromosome segregation ..................................................................... 3 4. Sex-specific targeting of the dosage compensation complex to hermaph ...
abnormalities of chromosome structure
... DNA can direct the synthesis of all the body’s proteins. Proteins are composed of one or more POLYPEPTIDES, which are in turn composed of sequences of AMINO ACIDS. The body contains 20 different types of amino acids, and the amino acid sequences that make up polypeptides must be specified by t ...
... DNA can direct the synthesis of all the body’s proteins. Proteins are composed of one or more POLYPEPTIDES, which are in turn composed of sequences of AMINO ACIDS. The body contains 20 different types of amino acids, and the amino acid sequences that make up polypeptides must be specified by t ...
chromosomal
... Any chromosome number that is not exact multiple of the haploid se [23]. Cells have extra chromosomes or chromosome missing Monosomy = condition where one chromosome is missing (mostly lethal in very early embryogenesis Trisomy = condition where one extra chromosome is abbreviated ...
... Any chromosome number that is not exact multiple of the haploid se [23]. Cells have extra chromosomes or chromosome missing Monosomy = condition where one chromosome is missing (mostly lethal in very early embryogenesis Trisomy = condition where one extra chromosome is abbreviated ...
Additional Table 1. Genotype and phenotype of the
... The SHANK3 change (SNP rs76224556) is supposed to affect the gene expression. Chr. 18p11.31 dup (position 6.1-6.5Mb, genome yes build hg 17). One gene involved (L3MBTL4 ). Patient's mother was normal by OGT array. The clinical significance of this variant is unclear. ...
... The SHANK3 change (SNP rs76224556) is supposed to affect the gene expression. Chr. 18p11.31 dup (position 6.1-6.5Mb, genome yes build hg 17). One gene involved (L3MBTL4 ). Patient's mother was normal by OGT array. The clinical significance of this variant is unclear. ...
Characterisation of the katA gene encoding a catalase and evidence
... TX350, was constructed by exchanging the 5P-end of katA for an erythromycin resistance gene, ermB (Fig. 1B). By this replacement, the ¢rst 60 codons of katA including the start codon and ribosome-binding site were removed resulting in a complete block of KatA production. Surprisingly, the KatA mutan ...
... TX350, was constructed by exchanging the 5P-end of katA for an erythromycin resistance gene, ermB (Fig. 1B). By this replacement, the ¢rst 60 codons of katA including the start codon and ribosome-binding site were removed resulting in a complete block of KatA production. Surprisingly, the KatA mutan ...
Implementation of molecular markers for quantitative traits in
... DNA fingerprinting techniques can be applied to plant breeding, mainly to rapidly transfer single genes between varieties, but conventional selection programs are still necessary. Key Words Selection, breeding, quantitative trait loci (QTL), linkage disequilibrium (LD) Introduction At present, DNA m ...
... DNA fingerprinting techniques can be applied to plant breeding, mainly to rapidly transfer single genes between varieties, but conventional selection programs are still necessary. Key Words Selection, breeding, quantitative trait loci (QTL), linkage disequilibrium (LD) Introduction At present, DNA m ...
Full Text
... Mishra et al. (2005) suggested that resistance was not invariably associated with PBC and Kota et al. (2006) reported that the two traits were inseparable by recombination. Besides, both monogenic (Sheen et al., 1968; Bariana et al., 2001) and digenic inheritance of PBC has been suggested (Kaur et a ...
... Mishra et al. (2005) suggested that resistance was not invariably associated with PBC and Kota et al. (2006) reported that the two traits were inseparable by recombination. Besides, both monogenic (Sheen et al., 1968; Bariana et al., 2001) and digenic inheritance of PBC has been suggested (Kaur et a ...
The splanchnic mesodermal plate directs spleen and
... left-right (LR) asymmetries appear throughout affecting the structure and location of internal organs (Capdevila et al., 2000; Hamada et al., 2002; Bisgrove et al., 2003). Such visceral asymmetries exist in all vertebrates, suggesting that many of the mechanisms that generate sidedness are conserved ...
... left-right (LR) asymmetries appear throughout affecting the structure and location of internal organs (Capdevila et al., 2000; Hamada et al., 2002; Bisgrove et al., 2003). Such visceral asymmetries exist in all vertebrates, suggesting that many of the mechanisms that generate sidedness are conserved ...
Basic Principles of Heredity
... minutes — but Mendel was under no pressure to publish quickly and was able to follow the inheritance of individual characteristics for several generations. Had he chosen to work on an organism with a longer generation time — horses, for example — he might never have discovered the basis of inheritan ...
... minutes — but Mendel was under no pressure to publish quickly and was able to follow the inheritance of individual characteristics for several generations. Had he chosen to work on an organism with a longer generation time — horses, for example — he might never have discovered the basis of inheritan ...
The splanchnic mesodermal plate directs spleen and
... left-right (LR) asymmetries appear throughout affecting the structure and location of internal organs (Capdevila et al., 2000; Hamada et al., 2002; Bisgrove et al., 2003). Such visceral asymmetries exist in all vertebrates, suggesting that many of the mechanisms that generate sidedness are conserved ...
... left-right (LR) asymmetries appear throughout affecting the structure and location of internal organs (Capdevila et al., 2000; Hamada et al., 2002; Bisgrove et al., 2003). Such visceral asymmetries exist in all vertebrates, suggesting that many of the mechanisms that generate sidedness are conserved ...
An Agony in Five Fits (R
... Fit the Second For population geneticists, fitness is an operational measure, exactly defined in terms of a measurement procedure. The word is applied not really to a whole individual organism but to a genotype, usually at a single locus. The fitness W of a genotype, say Aa, may be defined as 1–s, w ...
... Fit the Second For population geneticists, fitness is an operational measure, exactly defined in terms of a measurement procedure. The word is applied not really to a whole individual organism but to a genotype, usually at a single locus. The fitness W of a genotype, say Aa, may be defined as 1–s, w ...
Disintegrin, hemorrhagic, and proteolytic activities of Mohave
... lacked Mojave toxin. Two disintegrin genes, scutustatin and mojavestatin, were identified by PCR of genomic sequences. Scutustatin is a highly conserved disintegrin, while mojavestatin shows low conservation to other known disintegrins. Venoms with the highest LD50 measurements lacked both disintegr ...
... lacked Mojave toxin. Two disintegrin genes, scutustatin and mojavestatin, were identified by PCR of genomic sequences. Scutustatin is a highly conserved disintegrin, while mojavestatin shows low conservation to other known disintegrins. Venoms with the highest LD50 measurements lacked both disintegr ...