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Mendel and Meiosis
Mendel and Meiosis

... where each variation is called an allele.  Each offspring inherits only one allele from each parent.  The alleles are either dominant or ...
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Section 6.6: Meiosis and Genetic Variation

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X-Chromosome Inactivation: The Case of the Calico Cat1

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Heredity Inherited Traits - Saint Mary Catholic School

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Sem 1 Revision Chem and Biol File

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Lecture 1: Meiosis and Recombination

... e.g. cystic fibrosis – is caused by a mutation in the CFTR gene this encodes a chloride channel in the lungs, gut and many other tissues. (chromosome 7)- if you have a mutation in one copy, the other copy of the gene produces enough protein to give normal phenotype. However if you have 2 mutant copi ...
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Unit 7 Genetics Review

... A. Centromeres of replicated chromosomes line up along the cell’s equator B. Centromeres divide as sister chromatids move toward opposite poles of the cell C. Homologous chromosome pairs lineup along the cell’s equator D. Homologous chromosomes move toward opposite poles of the cell ...
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Sex Chromosomes
Sex Chromosomes

... – what percentage of male offspring will express? – what percentage of female offspring will express if, • mate is hemizygous for the recessive allele? • mate is hemizygous for the dominant allele? ...
Other Genetic Crosses
Other Genetic Crosses

... Since females have two X chromosomes, they could haveboth of those colors. If you see a cat with 3 colors: white, black, and orange, it’s almost certainly a female. Calico cats that are male are rare and infertile (XXY). Polygenic Traits ...
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Skewed X-inactivation

Skewed X chromosome inactivation occurs when the inactivation of one X chromosome is favored over the other, leading to an uneven number of cells with each chromosome inactivated. It is usually defined as one allele being found on the active X chromosome in over 75% of cells, and extreme skewing is when over 90% of cells have inactivated the same X chromosome. It can be caused by primary nonrandom inactivation, either by chance due to a small cell pool or directed by genes, or caused by secondary nonrandom inactivation, which occurs by selection. Most females will have some levels of skewing. It is relatively common in adult females; around 35% of women have skewed ratio over 70:30, and 7% of women have an extreme skewed ratio of over 90:10. This is of medical significance due to the potential for the expression of disease genes present on the X chromosome that are normally not expressed due to random X inactivation. X chromosome inactivation occurs in females to provide dosage compensation between the sexes. If females kept both X chromosomes active they would have twice the number of active X genes than males, who only have one copy of the X chromosome. At approximately the time of implantation (see Implantation (human embryo), one of the two X chromosomes is randomly selected for inactivation. The cell undergoes transcriptional and epigenetic changes to ensure this inactivation is permanent. All progeny from these initial cells will maintain the inactivation of the same chromosome, resulting in a mosaic pattern of cells in females.
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