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PPT: Genetics: From Mendel to Genome and Epigenome
PPT: Genetics: From Mendel to Genome and Epigenome

... The Greek prefix “epi” means “on top of” or “over”, so the term “Epigenetics” literally describes regulation at a level above, or in addition to, those of genetic mechanisms. Robin Holliday and John Pugh proposed that changes in gene expression during development depends on the methylation of specif ...
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... 3. LaD scores are used to assess the statistical significance oflinkage estimates made using information from human pedigrees. 4. Groups of linked alleles on a single chromosome are referred to as a haplotype. For example, Abe and aBc are two different haplotypes at the same genetic locus. 5. Within ...
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... chromosome has alleles for tall plants and red owers, and the other chromosome has genes for short plants and yellow owers, then when the gametes are formed, the tall and red alleles will tend to go together into a gamete and the short and yellow alleles will go into other gametes. These are calle ...
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... The search for a dominant female-suppressing mutation, which in the standard model becomes tightly linked to recessive malesterility mutations on the proto-sex chromosome (Charlesworth and Charlesworth, 1978), of course continues in other systems. So does the search for support for the gynodioecy pa ...
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... expected number of double crossovers equals 0.032 times 0.066, which is 0.002, or 0.2%. There were a total of 2,951 offspring produced. If we multiply 2,951 times 0.002, we get 5.9, which is the expected number of double crossovers. The observed number was 3. Therefore: C = 3/5.9 = 0.51 I = 1 – C = ...
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... Introduction: Background: Have you ever wondered why so many people can look different from each other, even when they are closely related? Our particular combination of features makes us unique. Just like in real life, the different combinations are created by the union of egg and sperm cells durin ...
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Polyploid



Polyploid cells and organisms are those containing more than two paired (homologous) sets of chromosomes. Most species whose cells have nuclei (Eukaryotes) are diploid, meaning they have two sets of chromosomes—one set inherited from each parent. However, polyploidy is found in some organisms and is especially common in plants. In addition, polyploidy occurs in some tissues of animals that are otherwise diploid, such as human muscle tissues. This is known as endopolyploidy. Species whose cells do not have nuclei, that is, Prokaryotes, may be polyploid organisms, as seen in the large bacterium Epulopicium fishelsoni [1]. Hence ploidy is defined with respect to a cell. Most eukaryotes have diploid somatic cells, but produce haploid gametes (eggs and sperm) by meiosis. A monoploid has only one set of chromosomes, and the term is usually only applied to cells or organisms that are normally diploid. Male bees and other Hymenoptera, for example, are monoploid. Unlike animals, plants and multicellular algae have life cycles with two alternating multicellular generations. The gametophyte generation is haploid, and produces gametes by mitosis, the sporophyte generation is diploid and produces spores by meiosis.Polyploidy refers to a numerical change in a whole set of chromosomes. Organisms in which a particular chromosome, or chromosome segment, is under- or overrepresented are said to be aneuploid (from the Greek words meaning ""not"", ""good"", and ""fold""). Therefore the distinction between aneuploidy and polyploidy is that aneuploidy refers to a numerical change in part of the chromosome set, whereas polyploidy refers to a numerical change in the whole set of chromosomes.Polyploidy may occur due to abnormal cell division, either during mitosis, or commonly during metaphase I in meiosis.Polyploidy occurs in some animals, such as goldfish, salmon, and salamanders, but is especially common among ferns and flowering plants (see Hibiscus rosa-sinensis), including both wild and cultivated species. Wheat, for example, after millennia of hybridization and modification by humans, has strains that are diploid (two sets of chromosomes), tetraploid (four sets of chromosomes) with the common name of durum or macaroni wheat, and hexaploid (six sets of chromosomes) with the common name of bread wheat. Many agriculturally important plants of the genus Brassica are also tetraploids.Polyploidy can be induced in plants and cell cultures by some chemicals: the best known is colchicine, which can result in chromosome doubling, though its use may have other less obvious consequences as well. Oryzalin will also double the existing chromosome content.
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