a complex voyage to the X chromosome
... an RNA/DNA helicase with multiple RNA-interaction domains, including its N-terminal double-stranded RNA-binding (RB) motifs and its C-terminal glycine-rich domain (Lee et al., 1997; Izzo et al., 2008). (F,G) The roX box elements (red) and inverse roX boxes (blue) are proposed to mediate the formatio ...
... an RNA/DNA helicase with multiple RNA-interaction domains, including its N-terminal double-stranded RNA-binding (RB) motifs and its C-terminal glycine-rich domain (Lee et al., 1997; Izzo et al., 2008). (F,G) The roX box elements (red) and inverse roX boxes (blue) are proposed to mediate the formatio ...
Alu
... The highest Alu and gene densities – Chromosome 19, 22 Alu density is correlated in the order GC content > gene density > intron density The abundance of Alu subfamilies – Alu S > Alu J > Alu Y ...
... The highest Alu and gene densities – Chromosome 19, 22 Alu density is correlated in the order GC content > gene density > intron density The abundance of Alu subfamilies – Alu S > Alu J > Alu Y ...
... A previous study reported linkage to chromosomes 1, 2, and 7 in a large data set that consisted of 105 families, each with at least three alcoholic members. Methods: AdditionaLgenotyping in the 105 families has been completed in the chromosomal regions identified in the initial analyses, and a repli ...
NIH Public Access
... RNA using standard biochemical approaches, identification of proteins that bind and localize XIST RNA has long frustrated researchers in this field. Evidence indicates that Xist RNA can recruit certain chromatin modifiers to Xi, as shown for EZH2/PRC2 (Schoeftner et al., 2006; Fang et al., 2004), bu ...
... RNA using standard biochemical approaches, identification of proteins that bind and localize XIST RNA has long frustrated researchers in this field. Evidence indicates that Xist RNA can recruit certain chromatin modifiers to Xi, as shown for EZH2/PRC2 (Schoeftner et al., 2006; Fang et al., 2004), bu ...
—1— User Guide © Copyright 2009 Robert C. Edgar, all rights
... (inter) once for the entire genome, then the intra-chromosome simulator (intra) once for each chromosome. This process is called a cycle. The output from one cycle can be used as input to another cycle. It is generally better to run many short cycles rather than one or a few long cycles as longer cy ...
... (inter) once for the entire genome, then the intra-chromosome simulator (intra) once for each chromosome. This process is called a cycle. The output from one cycle can be used as input to another cycle. It is generally better to run many short cycles rather than one or a few long cycles as longer cy ...
SEX-DETector: a probabilistic approach to uncover sex
... Although this RNA-seq cross-based strategy is very promising for studying sex chromosomes in nonmodel organisms, the existing approaches have a number of limitations due to the fact that inference of sex-linkage was done with empirical filters and without a statistical framework. Once RNA-seq reads ...
... Although this RNA-seq cross-based strategy is very promising for studying sex chromosomes in nonmodel organisms, the existing approaches have a number of limitations due to the fact that inference of sex-linkage was done with empirical filters and without a statistical framework. Once RNA-seq reads ...
A preanaphase role for a Cks/Suc1 in acentrosomal spindle
... Two Drosophila Cks homologues The Drosophila genome contains one more predicted cks homologue (CG9790), which we called cks85A. Although mammalian genomes also have two Cks genes, they are more similar in sequence to each other than to either of the two cks genes in Drosophila (Fig 4A). We next exam ...
... Two Drosophila Cks homologues The Drosophila genome contains one more predicted cks homologue (CG9790), which we called cks85A. Although mammalian genomes also have two Cks genes, they are more similar in sequence to each other than to either of the two cks genes in Drosophila (Fig 4A). We next exam ...
A selfish origin for recombination
... becomes 6 : 2), but on average, if there is no bias, still 5 : 3. A heterozygote for a locus with two alleles A and a, therefore, will produce gametes with a ratio A : a=5 : 3 instead of the Mendelian 1 : 1, if the initiation of crossing over occurs at this locus and if the displaced strand belongs ...
... becomes 6 : 2), but on average, if there is no bias, still 5 : 3. A heterozygote for a locus with two alleles A and a, therefore, will produce gametes with a ratio A : a=5 : 3 instead of the Mendelian 1 : 1, if the initiation of crossing over occurs at this locus and if the displaced strand belongs ...
Plant centromeres: structure and control Eric J Richards and R Kelly
... for the role of simple DNA repeats in specification of centromere function also comes from structural dissection of human and Drosophila centromeres. Analysis of structurally rearranged human Y chromosomes indicates that the alphoid repeat array is an important functional component of the centromere ...
... for the role of simple DNA repeats in specification of centromere function also comes from structural dissection of human and Drosophila centromeres. Analysis of structurally rearranged human Y chromosomes indicates that the alphoid repeat array is an important functional component of the centromere ...
Genome-Wide Scan of Obesity in the Old Order Amish*
... and leptin concentration were 0.41, 0.33, 0.36, and 0.40, respectively (all P ⬍ 0.0001), as we have previously reported (22). In addition, the heritability for BMI-adjusted leptin was 0.30 (P ⬍ 0.0001). These estimates indicate that a substantial portion of the variation in these traits can be attri ...
... and leptin concentration were 0.41, 0.33, 0.36, and 0.40, respectively (all P ⬍ 0.0001), as we have previously reported (22). In addition, the heritability for BMI-adjusted leptin was 0.30 (P ⬍ 0.0001). These estimates indicate that a substantial portion of the variation in these traits can be attri ...
Duchenne and Becker Types of Muscular Dystrophy
... Since all our chromosomes come in pairs, all our genes also come in pairs. Sometimes, a gene may have a variation in the instruction that causes the gene to no longer function properly. This variation is called a mutation or pathogenic variant, and means that the product produced by the gene, called ...
... Since all our chromosomes come in pairs, all our genes also come in pairs. Sometimes, a gene may have a variation in the instruction that causes the gene to no longer function properly. This variation is called a mutation or pathogenic variant, and means that the product produced by the gene, called ...
LIST OF CHECK-UP QUESTIONS for
... 7. What type of mutations has the greatest probability to be expressed in the next generation? a) recessive, linked with a sex, which arises in X-chromosome; b) recessive, which arises in autosomes; c) dominant autosomal mutation CORRECT d) all of these avove 8. A human has galactosemia — a disease ...
... 7. What type of mutations has the greatest probability to be expressed in the next generation? a) recessive, linked with a sex, which arises in X-chromosome; b) recessive, which arises in autosomes; c) dominant autosomal mutation CORRECT d) all of these avove 8. A human has galactosemia — a disease ...
heredity and variation
... The knowledge· of laws of inheritance is making possible a much more rational viewpoint concerning the heredity of human traits. It is even possible in some cases to predict the character of offspring from a knowledge of the parents, and vice versa. The mode of inheritance of many human characterist ...
... The knowledge· of laws of inheritance is making possible a much more rational viewpoint concerning the heredity of human traits. It is even possible in some cases to predict the character of offspring from a knowledge of the parents, and vice versa. The mode of inheritance of many human characterist ...
lecture5(GS351)
... • One round of DNA synthesis with one cell division • Two genetically identical daughters • Sister chromatids segregate • Homologs do not line up or separate • Homologs do not exchange corresponding segments (no crossing over) • Final products are diploid (2n) ...
... • One round of DNA synthesis with one cell division • Two genetically identical daughters • Sister chromatids segregate • Homologs do not line up or separate • Homologs do not exchange corresponding segments (no crossing over) • Final products are diploid (2n) ...
Load-balanced CDS construction in wireless sensor networks via
... they construct a CDS. If the workloads on each dominator in a CDS are not balanced, some heavy-duty dominators deplete their energy quickly. Then, the whole network might be disconnected. Hence, intuitively, we not only have to consider to construct an MCDS, but also need to consider to construct a ...
... they construct a CDS. If the workloads on each dominator in a CDS are not balanced, some heavy-duty dominators deplete their energy quickly. Then, the whole network might be disconnected. Hence, intuitively, we not only have to consider to construct an MCDS, but also need to consider to construct a ...
Abnormal anaphase resolution - Journal of Cell Science
... for 15 s after which they were placed in a drop of 60% acetic acid on a siliconized coverslip. The fixed brain was spread by picking the coverslip with a slide, excess liquid was blotted and the preparation squashed. The slide was quickly frozen in liquid nitrogen, the coverslip removed and the prep ...
... for 15 s after which they were placed in a drop of 60% acetic acid on a siliconized coverslip. The fixed brain was spread by picking the coverslip with a slide, excess liquid was blotted and the preparation squashed. The slide was quickly frozen in liquid nitrogen, the coverslip removed and the prep ...
sex-linked hybrid sterility in a butterfly - Ziheng Yang
... Primers for an approximately 470-bp fragment of the triose phosphate isomerase (Tpi) gene were developed by W. O. McMillan and D. Heckel for Heliconius erato from sequences of the noctuid moth Heliothis (Logsden et al. 1995). This locus is sex linked in Heliconius as in many other Lepidoptera (Turne ...
... Primers for an approximately 470-bp fragment of the triose phosphate isomerase (Tpi) gene were developed by W. O. McMillan and D. Heckel for Heliconius erato from sequences of the noctuid moth Heliothis (Logsden et al. 1995). This locus is sex linked in Heliconius as in many other Lepidoptera (Turne ...
dominant allele
... • Chromosomes in the same pair carry the same genes, but not necessarily the same alleles. ...
... • Chromosomes in the same pair carry the same genes, but not necessarily the same alleles. ...
Postzygotic isolation in Drosophila simulans and D. mauritiana
... The study of speciation is often focused on the mechanisms by which species become reproductively isolated. Species can be isolated due to barriers that occur before zygote formation (pre-zygotic isolation) or after zygote formation (post-zygotic isolation). In this chapter I review the types of spe ...
... The study of speciation is often focused on the mechanisms by which species become reproductively isolated. Species can be isolated due to barriers that occur before zygote formation (pre-zygotic isolation) or after zygote formation (post-zygotic isolation). In this chapter I review the types of spe ...
Patterns of Segmental Duplication in the Human Genome
... divided into 500-kb segments and Blasting was performed on all-against-all segments using the default parameters. In this study, we were interested in examining duplications with size 1 kb and sequence similarity 90%; we did not consider older duplications, because they are more difficult to def ...
... divided into 500-kb segments and Blasting was performed on all-against-all segments using the default parameters. In this study, we were interested in examining duplications with size 1 kb and sequence similarity 90%; we did not consider older duplications, because they are more difficult to def ...
Genetic Disorders Brochures
... differences in genotype. Each human has approximately 30,000 genes which control his/her characteristics. The autosomal traits mentioned in this lab are found on one of the first 22 chromosome pairs in the nuclei of each of your cells. PURPOSE: To investigate the inheritance of human characteristics ...
... differences in genotype. Each human has approximately 30,000 genes which control his/her characteristics. The autosomal traits mentioned in this lab are found on one of the first 22 chromosome pairs in the nuclei of each of your cells. PURPOSE: To investigate the inheritance of human characteristics ...
Comparative gene mapping in Arabidopsis lyrata chromosomes 6
... We have increased the density of genetic markers on the Arabidopsis lyrata chromosomes AL6 and AL7 corresponding to the A. thaliana chromosome IV, in order to determine chromosome rearrangements between these two species, and to compare recombination fractions across the same intervals. We confirm th ...
... We have increased the density of genetic markers on the Arabidopsis lyrata chromosomes AL6 and AL7 corresponding to the A. thaliana chromosome IV, in order to determine chromosome rearrangements between these two species, and to compare recombination fractions across the same intervals. We confirm th ...
thalassemia
... require medical or follow-up care after the initial diagnosis is made.People with β-thalassemia trait should be warned that their condition can be misdiagnosed as the more common iron deficiency anemia. They should avoid routine use of iron supplements; yet iron deficiency can develop during pregnan ...
... require medical or follow-up care after the initial diagnosis is made.People with β-thalassemia trait should be warned that their condition can be misdiagnosed as the more common iron deficiency anemia. They should avoid routine use of iron supplements; yet iron deficiency can develop during pregnan ...
Research in Biology
... Evolution of Nematode Dosage Compensation Mechanisms Organisms that utilize chromosome-based mechanisms to determine sex (e.g. XX, females and XY/XO, males) require the chromosome-wide regulatory mechanism of dosage compensation to balance sex-chromosome gene expression between sexes. Strategies to ...
... Evolution of Nematode Dosage Compensation Mechanisms Organisms that utilize chromosome-based mechanisms to determine sex (e.g. XX, females and XY/XO, males) require the chromosome-wide regulatory mechanism of dosage compensation to balance sex-chromosome gene expression between sexes. Strategies to ...
Chpt9_Transposition.doc
... Indeed, some viruses may be derived from natural transposable elements and vice versa. Since viruses move between individuals, at least some transposable elements can move between genomes (between individuals) as well as within an individual’s genome. Given their prevalence in genomes, the function ...
... Indeed, some viruses may be derived from natural transposable elements and vice versa. Since viruses move between individuals, at least some transposable elements can move between genomes (between individuals) as well as within an individual’s genome. Given their prevalence in genomes, the function ...
Y chromosome
The Y chromosome is one of two sex chromosomes (allosomes) in mammals, including humans, and many other animals. The other is the X chromosome. Y is the sex-determining chromosome in many species, since it is the presence or absence of Y that determines the male or female sex of offspring produced in sexual reproduction. In mammals, the Y chromosome contains the gene SRY, which triggers testis development. The DNA in the human Y chromosome is composed of about 59 million base pairs. The Y chromosome is passed only from father to son. With a 30% difference between humans and chimpanzees, the Y chromosome is one of the fastest evolving parts of the human genome. To date, over 200 Y-linked genes have been identified. All Y-linked genes are expressed and (apart from duplicated genes) hemizygous (present on only one chromosome) except in the cases of aneuploidy such as XYY syndrome or XXYY syndrome. (See Y linkage.)