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17 Human Genetics
17 Human Genetics

... Generation I, individual 1: Aa This individual has to be heterozygous because some of the children are affected. Generation II, individual 1: aa This individual has to be homozygous recessive because he is affected. Generation III, individual 8: Aa This has to be the case because the mother is homoz ...
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... Anopheles and other species investigated to date is that females only mate once during their lifetime (TRIPET et al., 2003); a key attribute affecting male testis size (HOSKEN and WARD, 2001). Whereas much of the sex-biased expression displayed by Drosophila and other polygonous species results dire ...
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Chapter 2 The Cell - Institute for Behavioral Genetics
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... cell wall is constructed down the middle of the cytoplasm. When this process is completed, there are now two cells. The second major type of cell division is meiosis (the adjectival form is meiotic) and it refers to the specialized cell division that produces sperm and eggs (see Figure 2.5). Obvious ...
Chapter 2 - SCHOOLinSITES
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... Chromosome Number Privet shrubs and humans each have a diploid number of 46 chromosomes per cell. Why are the two species so dissimilar? a) Privet chromosomes undergo only mitosis. b) Privet chromosomes are shaped differently. c) Human chromosomes have genes grouped together differently. d) The two ...
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Chromosome



A chromosome (chromo- + -some) is a packaged and organized structure containing most of the DNA of a living organism. It is not usually found on its own, but rather is complexed with many structural proteins called histones as well as associated transcription (copying of genetic sequences) factors and several other macromolecules. Two ""sister"" chromatids (half a chromosome) join together at a protein junction called a centromere. Chromosomes are normally visible under a light microscope only when the cell is undergoing mitosis. Even then, the full chromosome containing both joined sister chromatids becomes visible only during a sequence of mitosis known as metaphase (when chromosomes align together, attached to the mitotic spindle and prepare to divide). This DNA and its associated proteins and macromolecules is collectively known as chromatin, which is further packaged along with its associated molecules into a discrete structure called a nucleosome. Chromatin is present in most cells, with a few exceptions - erythrocytes for example. Occurring only in the nucleus of eukaryotic cells, chromatin composes the vast majority of all DNA, except for a small amount inherited maternally which is found in mitochondria. In prokaryotic cells, chromatin occurs free-floating in cytoplasm, as these cells lack organelles and a defined nucleus. The main information-carrying macromolecule is a single piece of coiled double-stranded DNA, containing many genes, regulatory elements and other noncoding DNA. The DNA-bound macromolecules are proteins, which serve to package the DNA and control its functions. Chromosomes vary widely between different organisms. Some species such as certain bacteria also contain plasmids or other extrachromosomal DNA. These are circular structures in the cytoplasm which contain cellular DNA and play a role in horizontal gene transfer.Compaction of the duplicated chromosomes during cell division (mitosis or meiosis) results either in a four-arm structure (pictured to the right) if the centromere is located in the middle of the chromosome or a two-arm structure if the centromere is located near one of the ends. Chromosomal recombination during meiosis and subsequent sexual reproduction plays a vital role in genetic diversity. If these structures are manipulated incorrectly, through processes known as chromosomal instability and translocation, the cell may undergo mitotic catastrophe and die, or it may unexpectedly evade apoptosis leading to the progression of cancer.In prokaryotes (see nucleoids) and viruses, the DNA is often densely packed and organized. In the case of archaea by homologs to eukaryotic histones, in the case of bacteria by histone-like proteins. Small circular genomes called plasmids are often found in bacteria and also in mitochondria and chloroplasts, reflecting their bacterial origins.
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