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AP Chapter 14-15 Study Guide: Chromosomes and Mendelian
AP Chapter 14-15 Study Guide: Chromosomes and Mendelian

... abstract concept of the gene, introduce chromosomes next and then proceed to a discussion of the DNA molecule. A superior pedagogical approach would be to introduce genetics with the concrete idea of the chromosome and then proceed to more abstract concepts. This is what I intend to do. Therefore, w ...
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X-inactivation



X-inactivation (also called lyonization) is a process by which one of the two copies of the X chromosome present in female mammals is inactivated. The inactive X chromosome is silenced by its being packaged in such a way that it has a transcriptionally inactive structure called heterochromatin. As nearly all female mammals have two X chromosomes, X-inactivation prevents them from having twice as many X chromosome gene products as males, who only possess a single copy of the X chromosome (see dosage compensation). The choice of which X chromosome will be inactivated is random in placental mammals such as humans, but once an X chromosome is inactivated it will remain inactive throughout the lifetime of the cell and its descendants in the organism. Unlike the random X-inactivation in placental mammals, inactivation in marsupials applies exclusively to the paternally derived X chromosome.
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