Immune Therapy Program - The Campbell Family Cancer Research
... has the ability to limit the strength or magnitude of T-cell responses. This can be useful in some The Princess Margaret Cancer Foundation | Page 4 ...
... has the ability to limit the strength or magnitude of T-cell responses. This can be useful in some The Princess Margaret Cancer Foundation | Page 4 ...
IgG2 subclass isotype antibody and intrauterine
... The foetus is dependent on its mother for passive immunity involving receptor-mediated specific transport of antibodies. IgG antibody is present in highest concentration in serum and is the only antibody type that can cross the placenta efficiently, except for its IgG2 subclass. Most of the pathogen ...
... The foetus is dependent on its mother for passive immunity involving receptor-mediated specific transport of antibodies. IgG antibody is present in highest concentration in serum and is the only antibody type that can cross the placenta efficiently, except for its IgG2 subclass. Most of the pathogen ...
Use of donor bone marrow mesenchymal stem cells for treatment of
... groups for histological and gene expression studies. Intravenous infusion with donor MSC in CsA-treated transplanted rats resulted in prolongation of skin allograft survival compared to control animals. Unexpectedly, donor MSC infusion in immunocompetent rats resulted in a faster rejection as compar ...
... groups for histological and gene expression studies. Intravenous infusion with donor MSC in CsA-treated transplanted rats resulted in prolongation of skin allograft survival compared to control animals. Unexpectedly, donor MSC infusion in immunocompetent rats resulted in a faster rejection as compar ...
neuropeptides activate t cells
... potently activate vital human T-cell functions needed for the T-cells to perform their specialized tasks, such as cytokine secretion, adhesion to extracellular matrix (ECM), chemotactic migration and homing into specific organs and eradication of infectious organisms and cancer cells ([1,2,3,4, ...
... potently activate vital human T-cell functions needed for the T-cells to perform their specialized tasks, such as cytokine secretion, adhesion to extracellular matrix (ECM), chemotactic migration and homing into specific organs and eradication of infectious organisms and cancer cells ([1,2,3,4, ...
Express Inducible NKG2D Ligands That Mouse NK Cell Activity
... of adoptively transferred CTL in vivo. However, in SCID mice that lack B and T lymphocytes, the growth of HSP70-overexpressing tumors was reduced compared with control tumors, even before any adoptive immunotherapy. More impressively, invasive growth and regional metastases were only observed in ani ...
... of adoptively transferred CTL in vivo. However, in SCID mice that lack B and T lymphocytes, the growth of HSP70-overexpressing tumors was reduced compared with control tumors, even before any adoptive immunotherapy. More impressively, invasive growth and regional metastases were only observed in ani ...
Great events in history of transplantation
... on HLA typing but on the severity of illness, ABO blood type (match or compatible), response to PRA, donor weight to recipient ratio (must be 75% to 125%), geographic location relative to donor, and length of time at current status. • The PRA is a rapid measurement of preformed reactive anti-HLA ant ...
... on HLA typing but on the severity of illness, ABO blood type (match or compatible), response to PRA, donor weight to recipient ratio (must be 75% to 125%), geographic location relative to donor, and length of time at current status. • The PRA is a rapid measurement of preformed reactive anti-HLA ant ...
Advances in siRNA delivery to T-cells: potential clinical applications
... allowing delivery of small molecules such as plasmids, siRNAs or antibodies into the cells [36]. A common problem with electroporation, however, is loss of cell viability, as the high voltages required for transfection and the longer resealing time of the pores can result in cell stress and/or cell ...
... allowing delivery of small molecules such as plasmids, siRNAs or antibodies into the cells [36]. A common problem with electroporation, however, is loss of cell viability, as the high voltages required for transfection and the longer resealing time of the pores can result in cell stress and/or cell ...
Human Leukocyte Antigen-Class II-Positive
... In the cornea, it is thought that Langerhans cells, which exist in limbal and peripheral cornea, can be potent APCs. It has been shown that rabbit corneal endothelium, expressing class II antigen after treatment with IFN-y, could stimulate fresh allogenic lymphocytes.25 On the other hand, human corn ...
... In the cornea, it is thought that Langerhans cells, which exist in limbal and peripheral cornea, can be potent APCs. It has been shown that rabbit corneal endothelium, expressing class II antigen after treatment with IFN-y, could stimulate fresh allogenic lymphocytes.25 On the other hand, human corn ...
PDF - Leukaemia Foundation
... of one type of cell in the body. For a cancer to become most dangerous, two things need to happen. Firstly, the cells need to grow excessively. Secondly, the cells need to not function normally and may invade and damage adjacent (normal) cells. Myeloproliferative neoplasms are cancers as the cells i ...
... of one type of cell in the body. For a cancer to become most dangerous, two things need to happen. Firstly, the cells need to grow excessively. Secondly, the cells need to not function normally and may invade and damage adjacent (normal) cells. Myeloproliferative neoplasms are cancers as the cells i ...
A crucial role for B cells in neuroinvasive scrapie
... the diseases kuru, iatrogenic Creutzfeldt–Jakob disease (CJD), bovine spongiform encephalopathy (BSE) and new-variant CJD1,2. The development of neurological disease after peripheral inocuNATURE | VOL 390 | 18/25 DECEMBER 1997 ...
... the diseases kuru, iatrogenic Creutzfeldt–Jakob disease (CJD), bovine spongiform encephalopathy (BSE) and new-variant CJD1,2. The development of neurological disease after peripheral inocuNATURE | VOL 390 | 18/25 DECEMBER 1997 ...
Oncology - Taconic Biosciences
... The super immunodeficient CIEA NOG mouse® is the ideal model for engraftment of human cells, and therefore the model of choice for combined immune system and tumor engraftment immunooncology experiments. When reconstituted with various human tissue sources, NOG mice are indispensable for basic resear ...
... The super immunodeficient CIEA NOG mouse® is the ideal model for engraftment of human cells, and therefore the model of choice for combined immune system and tumor engraftment immunooncology experiments. When reconstituted with various human tissue sources, NOG mice are indispensable for basic resear ...
Using Transfer Factor to Strengthen Cell
... Transfer factors might be able to convey protection against infections via Th1 immunity “Avian influenza…presents a threat of producing a pandemic. We present arguments for the use of cell mediated immunity for the prevention of the infection as well as for the treatment of infected patients. Trans ...
... Transfer factors might be able to convey protection against infections via Th1 immunity “Avian influenza…presents a threat of producing a pandemic. We present arguments for the use of cell mediated immunity for the prevention of the infection as well as for the treatment of infected patients. Trans ...
MINI-SERIES ‘‘T-CELL CO-STIMULATORY MOLECULES’’ Edited by M. Belvisi and K.F. Rabe
... ABSTRACT: T-cells play a central role in allergic airway diseases such as bronchial asthma. The imbalance between allergen-specific pro-inflammatory and pro-allergic T-cell responses on one hand and regulatory or suppressive T-cell responses on the other may best explain the development of unwanted ...
... ABSTRACT: T-cells play a central role in allergic airway diseases such as bronchial asthma. The imbalance between allergen-specific pro-inflammatory and pro-allergic T-cell responses on one hand and regulatory or suppressive T-cell responses on the other may best explain the development of unwanted ...
Immunology
... primary response to an antigen. It is the first immunoglobulin to be synthesized by the neonate, its presence fetal blood indicates intra-uterine infection. Due to its pentameric structure, serum IgM has a higher valency than the other isotypes in binding antigens with many repeating epitopes such a ...
... primary response to an antigen. It is the first immunoglobulin to be synthesized by the neonate, its presence fetal blood indicates intra-uterine infection. Due to its pentameric structure, serum IgM has a higher valency than the other isotypes in binding antigens with many repeating epitopes such a ...
Practical Hematology Leukocytosis
... • Eosinophilic granuloma Mast Cell Tumor Other neoplasia • Lymphoma • Mucinous carcinoma Canine estrus ...
... • Eosinophilic granuloma Mast Cell Tumor Other neoplasia • Lymphoma • Mucinous carcinoma Canine estrus ...
Leukocytosis - PowerPoint
... Organ infiltration with eosinophils • Bone marrow • Spleen • Liver • Lymph nodes (often mesenteric) • Gut • skin Clinical Signs • Diarrhea, vomiting • Anorexia, weight loss • Fever • Pruritus, lymphadenopathy ...
... Organ infiltration with eosinophils • Bone marrow • Spleen • Liver • Lymph nodes (often mesenteric) • Gut • skin Clinical Signs • Diarrhea, vomiting • Anorexia, weight loss • Fever • Pruritus, lymphadenopathy ...
THE MANY FACES OF MONOCLONAL GAMMOPATHIES
... Hepatitis or other longstanding chronic infections and skin diseases. • 2. Environmental Factors: Osserman had an inbred mouse highly susceptible to develop Plasmacytomas. If these mice were kept in a strictly sterile environment from birth, they did not develop the plasmacytoma. ...
... Hepatitis or other longstanding chronic infections and skin diseases. • 2. Environmental Factors: Osserman had an inbred mouse highly susceptible to develop Plasmacytomas. If these mice were kept in a strictly sterile environment from birth, they did not develop the plasmacytoma. ...
Human T-Cell Leukemia Virus Type I Induces Adult T
... type is characterized by prominent systemic lymphadenopathy, with few abnormal cells in the peripheral blood. These two subtypes have a poor prognosis since they are aggressive and the patients with these types are resistant to intensive chemotherapy. The median survival time (MST) of the patients w ...
... type is characterized by prominent systemic lymphadenopathy, with few abnormal cells in the peripheral blood. These two subtypes have a poor prognosis since they are aggressive and the patients with these types are resistant to intensive chemotherapy. The median survival time (MST) of the patients w ...
Aging, Persistent Viral Infections, and Immunosenescence: Can
... is an increased homeostatic proliferation and differentiation of resident memory cells that occupy the immune space and leave the older host at an increased risk of infection because of a severely restricted T-cell repertoire. The drastically lowered numbers of naı̈ve T cells in the elderly severely ...
... is an increased homeostatic proliferation and differentiation of resident memory cells that occupy the immune space and leave the older host at an increased risk of infection because of a severely restricted T-cell repertoire. The drastically lowered numbers of naı̈ve T cells in the elderly severely ...
The role of B cells in bone turnover in rheumatoid arthritis
... in RA has become more established and a number of treatments have been developed to specifically target B cells. TNF‑a-blocking agents were the first biological therapies to be approved for treating RA, however, it is estimated that between 20 and 40% of patients fail to achieve a 20% improvement in ...
... in RA has become more established and a number of treatments have been developed to specifically target B cells. TNF‑a-blocking agents were the first biological therapies to be approved for treating RA, however, it is estimated that between 20 and 40% of patients fail to achieve a 20% improvement in ...
Figures to be replicated
... i. Can the authors supply more precedural detail on their hydrodynamic injections? ii. What are the age and sex of the mice? iii. Are the CD4-/- and CD8-/- stock # correct? iv. Can you please provide information about housing conditions? 7) 5 days after injection of DNA, re-administer anti-mouse CD4 ...
... i. Can the authors supply more precedural detail on their hydrodynamic injections? ii. What are the age and sex of the mice? iii. Are the CD4-/- and CD8-/- stock # correct? iv. Can you please provide information about housing conditions? 7) 5 days after injection of DNA, re-administer anti-mouse CD4 ...
ASTRAGALUS AND IMMUNITY
... Our thymus gland, which sits on top of our heart and lungs, produces immune cells called T lymphocytes (the “T” comes from the word thymus), especially when we are young. It reaches maximum size just before puberty. Sex hormones created during puberty signal the thymus to shrink. It continues shrink ...
... Our thymus gland, which sits on top of our heart and lungs, produces immune cells called T lymphocytes (the “T” comes from the word thymus), especially when we are young. It reaches maximum size just before puberty. Sex hormones created during puberty signal the thymus to shrink. It continues shrink ...
The thymus in 2013: from a `vestigial` organ to immunological self
... receptors interferes with the early stages of T cell differentiation, while one mAb to proinsulin did not exert any significant effect (42). 3. The autoimmune regulator gene/protein (AIRE) controls the degree of intrathymic transcription of the genes encoding neuroendocrine self-peptides (43). 4. In ...
... receptors interferes with the early stages of T cell differentiation, while one mAb to proinsulin did not exert any significant effect (42). 3. The autoimmune regulator gene/protein (AIRE) controls the degree of intrathymic transcription of the genes encoding neuroendocrine self-peptides (43). 4. In ...