Slide 1
Slide 1

... • Genetically determined • Adaptive immunity defects -Humoral and cellular arms of immunity. Interaction between B &T cells –overlap of symptoms • Innate immunity- Non specific host defense mechanisms –complement, NK cells ,phagocytes ...
Severe combined immune deficiency syndrome
Severe combined immune deficiency syndrome

... 8. Infections that do not resolve with antibiotic treatment for two or more months 9. Failure to gain weight or grow normally 10. Infections that require intravenous antibiotic treatment 11. Deep-seated infections, such as pneumonia that affects an entire lung or an abscess in the liver 12. Persiste ...

X-linked severe combined immunodeficiency

X-linked severe combined immunodeficiency (X-SCID) is an immunodeficiency disorder in which the body produces very few T cells and NK cells. In the absence of T cell help, B cells become defective. It is an x-linked recessive trait, stemming from a mutated (abnormal) version of the IL2-RG gene located at xq13.1 on the X-chromosome, which is shared between receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.