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AACE/ACE Consensus Statement STATEmENT by
AACE/ACE Consensus Statement STATEmENT by

... and death is more common in patients with hypoglycemic episodes (and especially severe hypoglycemia) and that the benefit-to-risk ratio decreases progressively with the duration of diabetes, such that the use of intensive therapy may be at least relatively contraindicated in patients with a duration ...
Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach
Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach

... using a less intensive approach based on the sulfonylurea gliclazide. None of the trials demonstrated a statistically significant reduction in the primary combined cardiovascular end points. Indeed, in ACCORD, a 22% increase in total mortality with intensive therapy was observed, mainly driven by ca ...
Effect of Ghrelin Antagonist on Serum Testosterone and Luteinizing
Effect of Ghrelin Antagonist on Serum Testosterone and Luteinizing

... in the past twenty years, which may be due to altered eating habits and sedentary life style. 2 It not only affects the quality of life by decreasing the general body performance, but also leads to the development of many metabolic disorders including diabetes mellitus, insulin resistance, fatty liv ...
Premenopausal Advantages in Postprandial Lipid
Premenopausal Advantages in Postprandial Lipid

... OBJECTIVE — Women with type 2 diabetes appear to lose the protection against cardiovascular disease afforded by estrogens. We examined the effects of menopausal status on postprandial clearance of dietary fat in healthy and diabetic women. RESEARCH DESIGN AND METHODS — Fasting subjects (premenopausa ...
Management of type 1 and type 2 diabetes requiring insulin
Management of type 1 and type 2 diabetes requiring insulin

... long-acting insulin in addition to their mealtime doses of rapid-acting insulin analogues;6,12 the so-called basal part of the basal-bolus regimen. These insulins are administered in an attempt to mimic the background secretion of insulin from the pancreas in the interprandial or fasting period. In ...
Metabolic syndrome English (power point)
Metabolic syndrome English (power point)

... • Impaired glucose tolerance (IGT): 2 hour glucose levels 140 – 199 mg/dL (7.8 – 11.1 mmol/L) on the 75 g oral glucose tolerance test. Prevalence: 10 – 15% of adults in USA • People with IFG or IGT do not have DM, but are at substantial risk for developing type 2 DM and cardiovascular disease in the ...
Management of hyperglycaemia in type 2 diabetes
Management of hyperglycaemia in type 2 diabetes

... such as more weight gain, or simply the greater complexity of therapy, contributed. There were suggestions in these trials that patients without overt CVD, with shorter duration of disease, and lower baseline HbA1c, benefited from the more intensive strategies. Modest improvements in some microvascu ...
Lecture 12 Diabetes Mellitus
Lecture 12 Diabetes Mellitus

... 1. Why would a person with high glucose levels have polyphagia? 2. Explain why polyuria is a common symptom of diabetes Mellitus Type 1. 3. What is hyperglycemia? 4. Why does hyperglycemia happen in Type 1 diabetes mellitus? ...
Independent Nurse Management of prediabetes Prevalence The
Independent Nurse Management of prediabetes Prevalence The

... It is accepted that type 2 diabetes is a complex condition, which if not properly managed,  can  result  in  a  range  of  long‐term  complications,  including  micro‐  and  macrovascular  diseases  such  as  kidney  disease,  cardiovascular  disease,  eye  problems  and  foot  ulcers.  In  additio ...
Almost every one of us knows someone who has diabetes
Almost every one of us knows someone who has diabetes

... was originally suggested by seasonal variations in the onset of the disease and by what appeared to be more than a chance relationship between the appearance of diabetes and preceding episodes of mumps, hepatitis, infectious mononucleosis, congenital rubella, and coxsackievirus infections. Further s ...
Almost every one of us knows someone who has diabetes
Almost every one of us knows someone who has diabetes

... was originally suggested by seasonal variations in the onset of the disease and by what appeared to be more than a chance relationship between the appearance of diabetes and preceding episodes of mumps, hepatitis, infectious mononucleosis, congenital rubella, and coxsackievirus infections. Further s ...
Elevated Free Fatty Acids Impair Glucose Metabolism in
Elevated Free Fatty Acids Impair Glucose Metabolism in

... was infused into the femoral artery beginning at 1300. A glucose infusion also was begun at 1000, and the rate was adjusted to maintain plasma glucose concentrations at ⬃8.3 mmol/l over the next 4 h. To minimize the change in plasma glucose specific activity, all infused glucose contained [3-3H]gluc ...
Diabetes Update 2013 - Maine Pharmacy Association
Diabetes Update 2013 - Maine Pharmacy Association

... Native American Asian Amerian Pacific Islander Women with history of GDM or delivering a baby weighing > 9 lbs ...
Multimedia Appendix 5 The detailed information, taxonomic
Multimedia Appendix 5 The detailed information, taxonomic

... Identify: patients with T1DM who visit the diabetes outpatient clinic between Sept. until Oct. 2011. Inclusion criteria: over 18 years old, had T1DM, and were treated with insulin. Exclusion criteria: had used a diabetes application in the 3 months prior to their visit, did not have internet or emai ...
Inpatient Management of Surgical Patients with Diabetes
Inpatient Management of Surgical Patients with Diabetes

... This document may be reproduced for personal use only. It may not be distributed or sold. It may not be published in any other format without the prior, written permission of Joslin Diabetes Center, Publications Department, 617-226-5815. ...
1. INTRODUCTION The word diabetes derived from the Greek
1. INTRODUCTION The word diabetes derived from the Greek

... pounds for someone who weighs 200 pounds – by making modest changes in their diet and level of physical activity. People with pre-diabetes also have a higher risk of heart disease. Type 2 diabetes is sometimes defined as the form of diabetes that develops when the body does not respond properly to i ...
To know
To know

... A. Insulin needs are higher in the third trimester than in the first B. Insulin needs are based solely on the fetal weight C. Women with GDM requiring insulin should be educated on signs and symptoms of hypoglycemia D. Insulin therapy is recommended when the meal plan and activity alone are unable t ...
Hyperglycemic Crises in Adult Patients With Diabetes
Hyperglycemic Crises in Adult Patients With Diabetes

... The initial laboratory evaluation of patients with suspected DKA or HHS should include determination of plasma glucose, blood urea nitrogen, creatinine, serum ketones, electrolytes (with calculated anion gap), osmolality, urinalysis, urine ketones by dipstick, as well as initial arterial blood gases ...
Chapter 3 - Development of Type 1 diabetes
Chapter 3 - Development of Type 1 diabetes

... Glucose is a sugar that the body uses as an essential fuel. The extent to which blood glucose levels rise is dependent on the amount and type of food eaten as well as other factors, including the rate of digestion. After eating, glucose crosses the gut wall and enters the body’s bloodstream. Because ...
Advanced Delivery Devices Article
Advanced Delivery Devices Article

... administration. The shallow delivery of drugs with this novel device actually causes no pain or much less pain and enhances the uptake. This device (Figure 1) allows for the injection of drugs directly in between the epidermis and dermis (just under the stratum corneum), which avoids hitting nerves, ...
Guidline for managment of type 2 diabetes MellItus in
Guidline for managment of type 2 diabetes MellItus in

... Acronyms and abbreviations ...
Congenital hyperinsulinism
Congenital hyperinsulinism

... a signal transduction system whereby metabolic changes in the b-cell are linked to regulated insulin secretion.24 The metabolic changes are linked to regulated insulin secretion by potassium channels (KATP) located in the pancreatic b-cell membrane.25 Each KATP channel consists of a heteromultimeric ...
A randomized study of raisins versus alternative snacks on glycemic
A randomized study of raisins versus alternative snacks on glycemic

... those who consumed raisins had significantly reduced postprandial glucose levels by 23% (P = 0.024). Also compared to snacks, those who consumed raisins had reduced postprandial glucose levels by 36 mg/dL (P = 0.072), reduced fasting glucose levels by 32 mg/dL (P = 0.066), reduced fasting glucose le ...
Introducing and adjusting injectable insulin therapy for patients with
Introducing and adjusting injectable insulin therapy for patients with

... vs NPH)23 and if they are able to administer insulin using a pre-filled pen (compared to the use of a vial and syringe).24 Continuation of oral medications along with basal insulin is a common clinical practice. The use of metformin mitigates insulinassociated weight gain and provides another mechan ...
Guidelines for the Management of Diabetic Ketoacidosis (DKA) in Adults
Guidelines for the Management of Diabetic Ketoacidosis (DKA) in Adults

... There are some key changes recommended by the JBDS in the management of DKA and these have been incorporated into this guideline, the changes include: a) Use of venous rather than arterial blood sampling if possible b) Monitoring of blood ketone levels (using a near patient “finger prick” testing ki ...
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Gestational diabetes



Gestational diabetes (or gestational diabetes mellitus, GDM) is a condition in which women without previously diagnosed diabetes exhibit high blood glucose (blood sugar) levels during pregnancy (especially during their third trimester). Gestational diabetes is caused when insulin receptors do not function properly. This is likely due to pregnancy-related factors such as the presence of human placental lactogen that interferes with susceptible insulin receptors. This in turn causes inappropriately elevated blood sugar levels.Gestational diabetes generally has few symptoms and it is most commonly diagnosed by screening during pregnancy. Diagnostic tests detect inappropriately high levels of glucose in blood samples. Gestational diabetes affects 3-10% of pregnancies, depending on the population studied.As with diabetes mellitus in pregnancy in general, babies born to mothers with untreated gestational diabetes are typically at increased risk of problems such as being large for gestational age (which may lead to delivery complications), low blood sugar, and jaundice. If untreated, it can also cause seizures or stillbirth. Gestational diabetes is a treatable condition and women who have adequate control of glucose levels can effectively decrease these risks. The food plan is often the first recommended target for strategic management of GDM.Women with unmanaged gestational diabetes are at increased risk of developing type 2 diabetes mellitus (or, very rarely, latent autoimmune diabetes or Type 1) after pregnancy, as well as having a higher incidence of pre-eclampsia and Caesarean section; their offspring are prone to developing childhood obesity, with type 2 diabetes later in life. Most women are able to manage their blood glucose levels with a modified diet and the introduction of moderate exercise, but some require antidiabetic drugs, including insulin.
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