REVIEWS
... In the assembly of a complex machine, such as a car, every essential component must conform to carefully defined specifications, and is therefore subject to stringent quality control (QC). In the cell something similar occurs — there are QC systems for practically every step that leads to the synthe ...
... In the assembly of a complex machine, such as a car, every essential component must conform to carefully defined specifications, and is therefore subject to stringent quality control (QC). In the cell something similar occurs — there are QC systems for practically every step that leads to the synthe ...
Slides
... We have a large number of predominantly apo form structures being determined by structural genomics and functionally driven structure determination ...
... We have a large number of predominantly apo form structures being determined by structural genomics and functionally driven structure determination ...
The trans-Golgi network GRIP-domain proteins form α
... To determine whether the four mammalian GRIP proteins interact to form oligomers, a series of co-immunoprecipitation experiments was performed using epitope-tagged constructs. Mycand FLAG-tagged full-length constructs were generated for each of the four TGN golgins as described in the Experimental s ...
... To determine whether the four mammalian GRIP proteins interact to form oligomers, a series of co-immunoprecipitation experiments was performed using epitope-tagged constructs. Mycand FLAG-tagged full-length constructs were generated for each of the four TGN golgins as described in the Experimental s ...
Judge, P.J. and Watts, A.
... adaptable platform whose structure and composition may be tuned to provide specialised functionality. Although a number of biophysical techniques including X-ray crystallography have been used to determine membrane protein structures, these methods are unable to replicate and accommodate the complex ...
... adaptable platform whose structure and composition may be tuned to provide specialised functionality. Although a number of biophysical techniques including X-ray crystallography have been used to determine membrane protein structures, these methods are unable to replicate and accommodate the complex ...
ppt - Chair of Computational Biology
... properties of Class A Rhodopsin-like receptor but for which there are no defined ligands or functions. It is possible that many of these orphan receptors have ligand-independent properties, specifically the regulation of ligand-binding GPCRs on the cell surface. Davies et al. Bioinformatics 23, 3113 ...
... properties of Class A Rhodopsin-like receptor but for which there are no defined ligands or functions. It is possible that many of these orphan receptors have ligand-independent properties, specifically the regulation of ligand-binding GPCRs on the cell surface. Davies et al. Bioinformatics 23, 3113 ...
Theoretical studies of viral capsid proteins
... Recent results in structural biology and increases in computer power have prompted initial theoretical studies on capsids of nonenveloped icosahedral viruses. The macromolecular assembly of 60 to 180 protein copies into a protein shell results in a structure of considerable size for molecular dynami ...
... Recent results in structural biology and increases in computer power have prompted initial theoretical studies on capsids of nonenveloped icosahedral viruses. The macromolecular assembly of 60 to 180 protein copies into a protein shell results in a structure of considerable size for molecular dynami ...
Golgi Apparatus
... Figure 3.24 Microtubules and microfilaments function in cell motility by interacting with motor molecules powered by ATP. ...
... Figure 3.24 Microtubules and microfilaments function in cell motility by interacting with motor molecules powered by ATP. ...
Designed Ankyrin Repeat Proteins (DARPins)
... folding, allowing many new molecular formats. We summarize the DARPin properties and highlight some biomedical applications. Protocols are given for labeling with dyes and polyethylene glycol, for quantitatively measuring binding to cell surface receptors by kinetics and thermodynamics, and for expl ...
... folding, allowing many new molecular formats. We summarize the DARPin properties and highlight some biomedical applications. Protocols are given for labeling with dyes and polyethylene glycol, for quantitatively measuring binding to cell surface receptors by kinetics and thermodynamics, and for expl ...
Wilson`s disease and the copper ATPase transporters
... information on the Wilson’s disease protein and its homologues can be found in InterPro entries IPR001757 and its child entry IPR027256 (Table 1). From the description of IPR001757 , we know that ATP7B belongs to a broad family of membrane proteins that ...
... information on the Wilson’s disease protein and its homologues can be found in InterPro entries IPR001757 and its child entry IPR027256 (Table 1). From the description of IPR001757 , we know that ATP7B belongs to a broad family of membrane proteins that ...
Lab Dept: Coagulation Test Name: PROTEIN S, FREE
... adult levels by 80 – 180 days postnatal. There is evidence that functional deficiency of Protein S may occur in patients who have demonstrable Protein S antigen. Spurious low results may be obtained with plasma-based functional Protein S assay in patients who have activated Protein C resistance ...
... adult levels by 80 – 180 days postnatal. There is evidence that functional deficiency of Protein S may occur in patients who have demonstrable Protein S antigen. Spurious low results may be obtained with plasma-based functional Protein S assay in patients who have activated Protein C resistance ...
Tay Sachs: A Protein Targeting Disease
... In the lecture on lysosomes we saw that Tay Sachs was due to a lack of a single enzyme: hexosaminidase A. Tay Sachs disease is one of several classified as protein targeting diseases. Many are also classified in other ways as well. The following picture and points below provide more insight into thi ...
... In the lecture on lysosomes we saw that Tay Sachs was due to a lack of a single enzyme: hexosaminidase A. Tay Sachs disease is one of several classified as protein targeting diseases. Many are also classified in other ways as well. The following picture and points below provide more insight into thi ...
Relationships between amino acid sequence and backbone torsion
... Backbone configurations of a protein are fully determined by the specification of its and torsional angles. The native configuration is described by a unique set of the angles. Different levels of correlations among the angles are already identified and studied for native as well as denatured ...
... Backbone configurations of a protein are fully determined by the specification of its and torsional angles. The native configuration is described by a unique set of the angles. Different levels of correlations among the angles are already identified and studied for native as well as denatured ...
Impact of clostridial glucosylating toxins on the
... ICPL-reagent. Untreated control cells were labeled with the light ICPL version. Subsequently, proteins were combined and analyzed. Overall, 152 different proteins were identified that had been quantified by at least 2 labeled peptides. It was carefully checked whether for ICPL-labeled peptides corre ...
... ICPL-reagent. Untreated control cells were labeled with the light ICPL version. Subsequently, proteins were combined and analyzed. Overall, 152 different proteins were identified that had been quantified by at least 2 labeled peptides. It was carefully checked whether for ICPL-labeled peptides corre ...
Peptamide™ 6 - In
... tool for Research Biologists, and is becoming more popular in the Personal Care Industry to help identify the true potential of active ingredients and brings companies a step closer to understanding what specific body or cellular functions are being affected and the potential mechanism of actions be ...
... tool for Research Biologists, and is becoming more popular in the Personal Care Industry to help identify the true potential of active ingredients and brings companies a step closer to understanding what specific body or cellular functions are being affected and the potential mechanism of actions be ...
Critical Considerations for Analytical Similarity Assessment
... action are not entirely clear • Sufficient number of lots are required for meaningful statistical analysis • Small number of biosimilar batches reduce statistical power to detect ...
... action are not entirely clear • Sufficient number of lots are required for meaningful statistical analysis • Small number of biosimilar batches reduce statistical power to detect ...
Solubilization of Membrane Proteins into Functional Lipid‐Bilayer
... membrane proteins and associated lipids directly from natural or artificial membranes into “native nanodiscs” or SMA/lipid particles (SMALPs).[4–13] Hence, without requiring assistance from conventional detergents, SMA solubilizes and stabilizes a variety of membrane proteins, ranging from bacterior ...
... membrane proteins and associated lipids directly from natural or artificial membranes into “native nanodiscs” or SMA/lipid particles (SMALPs).[4–13] Hence, without requiring assistance from conventional detergents, SMA solubilizes and stabilizes a variety of membrane proteins, ranging from bacterior ...
msb201053-sup-0001 - Molecular Systems Biology
... periodicity of the corresponding gene (Periodic) and the cell cycle phase during which the transcript peaks (Phase). Furthermore, data is integrated about the presence of E2F or MSA motifs in the promoters of the corresponding gene, about the presence of CDK phosphorylation sites in the protein sequ ...
... periodicity of the corresponding gene (Periodic) and the cell cycle phase during which the transcript peaks (Phase). Furthermore, data is integrated about the presence of E2F or MSA motifs in the promoters of the corresponding gene, about the presence of CDK phosphorylation sites in the protein sequ ...
PSI - European Bioinformatics Institute
... • Given a set of uncharacterised sequences, we usually want to know: ...
... • Given a set of uncharacterised sequences, we usually want to know: ...
Identification of the factors that interact with NCBP, an 80 kDa
... RNA. Formation of the spliceosome was demonstrated to be cap ...
... RNA. Formation of the spliceosome was demonstrated to be cap ...
Materials by design: Merging proteins and music
... the silk case are amino acids, protein domains and the resulting network. These expressions are translated to music, where the domains of expression are tones, chords and melodies. The use of category theory helps us to ask the right questions, such as, what would be the critical conditions to achie ...
... the silk case are amino acids, protein domains and the resulting network. These expressions are translated to music, where the domains of expression are tones, chords and melodies. The use of category theory helps us to ask the right questions, such as, what would be the critical conditions to achie ...
University of Birmingham Armadillo repeat proteins: beyond the
... Arm repeat proteins can be subdivided on the basis of their homology with each other and with proteins from other organisms. Orange background, importin-a family; yellow background, proteins with a kinesin domain; light blue background, predicted U-box-containing proteins similar to PHOR1/ARC1; dark ...
... Arm repeat proteins can be subdivided on the basis of their homology with each other and with proteins from other organisms. Orange background, importin-a family; yellow background, proteins with a kinesin domain; light blue background, predicted U-box-containing proteins similar to PHOR1/ARC1; dark ...
Affinity Proteomics for Phosphatase Interactions in Atrial
... entirely male. Finally, the study was performed in ...
... entirely male. Finally, the study was performed in ...
Intrinsically disordered proteins
An intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure. IDPs cover a spectrum of states from fully unstructured to partially structured and include random coils, (pre-)molten globules, and large multi-domain proteins connected by flexible linkers. They constitute one of the main types of protein (alongside globular, fibrous and membrane proteins).The discovery of IDPs has challenged the traditional protein structure paradigm, that protein function depends on a fixed three-dimensional structure. This dogma has been challenged over the last decades by increasing evidence from various branches of structural biology, suggesting that protein dynamics may be highly relevant for such systems. Despite their lack of stable structure, IDPs are a very large and functionally important class of proteins. In some cases, IDPs can adopt a fixed three-dimensional structure after binding to other macromolecules.