FEBS Letters 541, 176-177
... period is consistent with that found experimentally, and also the time di¡erence between the peaks in Hes1 and mRNA is 18 min, similar to the experimental ¢ndings. For d 6 10 min, the system shows no oscillations. To check the robustness of the results, we have varied K, L and k over 5 orders of mag ...
... period is consistent with that found experimentally, and also the time di¡erence between the peaks in Hes1 and mRNA is 18 min, similar to the experimental ¢ndings. For d 6 10 min, the system shows no oscillations. To check the robustness of the results, we have varied K, L and k over 5 orders of mag ...
The Structure of Human Prions: From Biology to Structural Models
... and protein disulfide isomerases (PDI) [37]. Together, these findings suggest that PrPC organizes its molecular environment by binding adhesion molecules, which in turn recognize oligomannose-bearing membrane proteins. 4. Polymorphisms and Mutations in the PRNP Gene ORF More than 30 mutations in the ...
... and protein disulfide isomerases (PDI) [37]. Together, these findings suggest that PrPC organizes its molecular environment by binding adhesion molecules, which in turn recognize oligomannose-bearing membrane proteins. 4. Polymorphisms and Mutations in the PRNP Gene ORF More than 30 mutations in the ...
Poster
... and understanding how electrons are transported in photosynthesis. Many of the studies conducted with hole burning spectroscopy are not simply to find out more about myoglobin, but are also meant to test out the technique. Someday, hole burning spectroscopy might be used on more proteins, and electr ...
... and understanding how electrons are transported in photosynthesis. Many of the studies conducted with hole burning spectroscopy are not simply to find out more about myoglobin, but are also meant to test out the technique. Someday, hole burning spectroscopy might be used on more proteins, and electr ...
Definition of Protein Superfamily
... Margaret O. Dayhoff introduced the term protein superfamily in 1974 [1,2,3]. Since that time, the sequences in the PIR-International Protein Sequence Database have been classified into protein superfamilies. Prior to about 1990, the superfamily classification permitted a sequence to be assigned to a ...
... Margaret O. Dayhoff introduced the term protein superfamily in 1974 [1,2,3]. Since that time, the sequences in the PIR-International Protein Sequence Database have been classified into protein superfamilies. Prior to about 1990, the superfamily classification permitted a sequence to be assigned to a ...
Peptides
... of interest. These will then be used to make antibodies in a rabbit or mouse against the protein. -Another reason is that peptides have become instrumental in mass spectrometry, allowing the identification of proteins of interest based on peptide masses and sequence. In this case, the peptides are m ...
... of interest. These will then be used to make antibodies in a rabbit or mouse against the protein. -Another reason is that peptides have become instrumental in mass spectrometry, allowing the identification of proteins of interest based on peptide masses and sequence. In this case, the peptides are m ...
Protein Creation Pathway
... Remember, we are tracing the path of protein creation. 1st step: The nucleolus creates ribosomes 2nd step: The ribosomes exit the nucleus 3rd step: The ribosomes begin to make proteins as they travel along the rough ER. ...
... Remember, we are tracing the path of protein creation. 1st step: The nucleolus creates ribosomes 2nd step: The ribosomes exit the nucleus 3rd step: The ribosomes begin to make proteins as they travel along the rough ER. ...
Keyhole Limpet Hemocyanin ( KLH )
... immune response. The carrier-hapten conjugate carry many epitopes to which T lymphocytes can respond and subsequently provide the necessary help for antibody-producing B cells. Confering antigenicity, it is called antigen. KLH is one of the most commonly used carriers in the conjugation of haptens ( ...
... immune response. The carrier-hapten conjugate carry many epitopes to which T lymphocytes can respond and subsequently provide the necessary help for antibody-producing B cells. Confering antigenicity, it is called antigen. KLH is one of the most commonly used carriers in the conjugation of haptens ( ...
Hemoglobin
... Usually the rightward shift of the O2 saturation curve has an insignificant effect on the O2 saturation in the lungs ...
... Usually the rightward shift of the O2 saturation curve has an insignificant effect on the O2 saturation in the lungs ...
Epitope mapping of gliadin – a trigger of celiac disease
... Especially a deamidated peptide, which corresponds to amino acids 58-73 from the central domain induce celiac disease. This peptide contains the motif PQPELPY, which has been suggested to be an immunodominant epitope of gliadin ...
... Especially a deamidated peptide, which corresponds to amino acids 58-73 from the central domain induce celiac disease. This peptide contains the motif PQPELPY, which has been suggested to be an immunodominant epitope of gliadin ...
prions lecture notes
... - these mice were shown to have abnormalities in synaptic physiology and circadian rhythms and sleep - mice overexpressing PrPC have increased rates of PrPSc formation and shorter incubation times until the onset of disease ...
... - these mice were shown to have abnormalities in synaptic physiology and circadian rhythms and sleep - mice overexpressing PrPC have increased rates of PrPSc formation and shorter incubation times until the onset of disease ...
Reivew, Hemoglobin
... Allosteric proteins are typically multisubunit proteins Small molecules know as allosteric effectors bind to the protein at sites that are spatially distinct from the ligand binding site and exert either a positive or negative effect on ligand binding ...
... Allosteric proteins are typically multisubunit proteins Small molecules know as allosteric effectors bind to the protein at sites that are spatially distinct from the ligand binding site and exert either a positive or negative effect on ligand binding ...
Gene Section ABL (v-abl Abelson murine leukemia viral oncogene homolog 1)
... ABL/BCR may or may not be expressed; breakpoint in ABL is variable over a region of 200 kb, often between the two alternative exons 1b and 1a, sometimes 5’ of 1b or 3’ of 1a, but always 5’ of exon 2; breakpoint in BCR is either: 1- in a region called M-bcr (for major breakpoint cluster region), a cl ...
... ABL/BCR may or may not be expressed; breakpoint in ABL is variable over a region of 200 kb, often between the two alternative exons 1b and 1a, sometimes 5’ of 1b or 3’ of 1a, but always 5’ of exon 2; breakpoint in BCR is either: 1- in a region called M-bcr (for major breakpoint cluster region), a cl ...
Hedgehog signal transduction: recent findings Kent
... forms, which led to the idea that the cholesterol molecule acts as an anchor to cell membranes and limits the spread of Hh [4,5]. However, several recent papers examining the function of this cholesterol adjunct in vertebrate Sonic hedgehog (Shh) indicate that it may actually be required to spread S ...
... forms, which led to the idea that the cholesterol molecule acts as an anchor to cell membranes and limits the spread of Hh [4,5]. However, several recent papers examining the function of this cholesterol adjunct in vertebrate Sonic hedgehog (Shh) indicate that it may actually be required to spread S ...
Personal details Current position Name: Lilah Glazer, PhD E-mail:
... documented worldwide and are a cause for concern for both human health and wildlife conservation. Over the past several years there has been increased recognition that the earlylife environment can strongly influence the trajectory of developmental pathways, and that perturbations at critical stages ...
... documented worldwide and are a cause for concern for both human health and wildlife conservation. Over the past several years there has been increased recognition that the earlylife environment can strongly influence the trajectory of developmental pathways, and that perturbations at critical stages ...
BIOCHEMISTRY Medical biochemistry is an essential component of
... for all categories of health professionals. Contemporary. Biochemistry plays a crucial role in the Medical field, be it metabolic pathways, storage diseases, mechanism action of varied biomolecules or inter and intra cellular communications. Medical biochemistry integrates and summarizes the essenti ...
... for all categories of health professionals. Contemporary. Biochemistry plays a crucial role in the Medical field, be it metabolic pathways, storage diseases, mechanism action of varied biomolecules or inter and intra cellular communications. Medical biochemistry integrates and summarizes the essenti ...
Characterization of Phosphorylation Sites from the Activation Loop
... Reversible protein phosphorylation catalyzed by protein kinases is universally employed by eukaryotes to regulate enzyme activity, protein-protein interactions, subcelluar localization and protein turnover. The catalytic domains of most eukaryotic protein kinases are conserved in their primary seque ...
... Reversible protein phosphorylation catalyzed by protein kinases is universally employed by eukaryotes to regulate enzyme activity, protein-protein interactions, subcelluar localization and protein turnover. The catalytic domains of most eukaryotic protein kinases are conserved in their primary seque ...
Tissue Regeneration Factor
... which is necessary for bone health and joint integrity/regeneration (Bobacz K, et al, Arthritis Rheum, 2003). Research shows that BMPs are more effective when used in combination with growth factors such as insulin-like growth factor, which is present in TRF (Chubinskaya S, Osteoarthritis Cartilage, ...
... which is necessary for bone health and joint integrity/regeneration (Bobacz K, et al, Arthritis Rheum, 2003). Research shows that BMPs are more effective when used in combination with growth factors such as insulin-like growth factor, which is present in TRF (Chubinskaya S, Osteoarthritis Cartilage, ...
Chapter 1: Biological Introduction: RING domain proteins
... enzyme forms a thiol ester with the carboxyl terminal group of the small protein ubiquitin at position Gly76. The ubiquitin is then transferred to the ubiquitin conjugating enzyme (E2). Finally, ubiquitin ligase (E3) transfers the ubiquitin from E2 to the target protein promoting the ubiquitination ...
... enzyme forms a thiol ester with the carboxyl terminal group of the small protein ubiquitin at position Gly76. The ubiquitin is then transferred to the ubiquitin conjugating enzyme (E2). Finally, ubiquitin ligase (E3) transfers the ubiquitin from E2 to the target protein promoting the ubiquitination ...
12551_2008_5_MOESM1_ESM - Springer Static Content Server
... repeating sequences that are present. Amongst the quasi-repeats is the apolar-X sequence repeated four times consecutively in linker L12 Dalla Valle L, Nardi A, Gelmi C et al (2008) -keratins of the crocodilian epidermis: composition, structure, and phylogenetic relationships. J Exp Zool 310B: 1-16 ...
... repeating sequences that are present. Amongst the quasi-repeats is the apolar-X sequence repeated four times consecutively in linker L12 Dalla Valle L, Nardi A, Gelmi C et al (2008) -keratins of the crocodilian epidermis: composition, structure, and phylogenetic relationships. J Exp Zool 310B: 1-16 ...
The ATP-Cone: An Evolutionarily Mobile, ATP
... conserved sequence. This allowed precise mapping of the boundaries of this approximately 85-90 residue region, and a comparison with the available structure of NrdA (Eriksson et al., 1997) showed that this exactly corresponds to a compact, globular N-terminal ATP-binding domain which includes four α ...
... conserved sequence. This allowed precise mapping of the boundaries of this approximately 85-90 residue region, and a comparison with the available structure of NrdA (Eriksson et al., 1997) showed that this exactly corresponds to a compact, globular N-terminal ATP-binding domain which includes four α ...
Polyubiquitination in diseases: implications in skeletal muscle
... Polyubiquitination of lysine initiates proteasome-dependent degradation of target proteins, a process involved in both the pathogenic mechanisms of various diseases and in normal biological function. Recently we investigated polyubiquitination involves skeletal muscle atrophy by degradation of MyoD ...
... Polyubiquitination of lysine initiates proteasome-dependent degradation of target proteins, a process involved in both the pathogenic mechanisms of various diseases and in normal biological function. Recently we investigated polyubiquitination involves skeletal muscle atrophy by degradation of MyoD ...
Structure, function and evolution of armless mitochondrial tRNAs
... secondary structure composed of two helices with classical Watson-Crick base pairs. The helices are separated by a central bulge that does not contain any specific internal tertiary base pairings. Due to the designed 3D structure, we suppose an increased intrinsic flexibility of armless tRNAs which ...
... secondary structure composed of two helices with classical Watson-Crick base pairs. The helices are separated by a central bulge that does not contain any specific internal tertiary base pairings. Due to the designed 3D structure, we suppose an increased intrinsic flexibility of armless tRNAs which ...
Proteomics
Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term proteomics was first coined in 1997 to make an analogy with genomics, the study of the genome. The word proteome is a portmanteau of protein and genome, and was coined by Marc Wilkins in 1994 while working on the concept as a PhD student.The proteome is the entire set of proteins, produced or modified by an organism or system. This varies with time and distinct requirements, or stresses, that a cell or organism undergoes. Proteomics is an interdisciplinary domain formed on the basis of the research and development of the Human Genome Project; it is also emerging scientific research and exploration of proteomes from the overall level of intracellular protein composition, structure, and its own unique activity patterns. It is an important component of functional genomics.While proteomics generally refers to the large-scale experimental analysis of proteins, it is often specifically used for protein purification and mass spectrometry.