Second Strasbourg Summer School on Chemoinformatics
... PDB file. The binding site was defined around the co-crystal ligand E20. Noteworthy is the Phe330 conformation not compatible with tacrine binding. The enrichment factors obtained by ranking compounds using the total docking energy are reported in Table 4. 3.2. Load the 1acj receptor and define a 6. ...
... PDB file. The binding site was defined around the co-crystal ligand E20. Noteworthy is the Phe330 conformation not compatible with tacrine binding. The enrichment factors obtained by ranking compounds using the total docking energy are reported in Table 4. 3.2. Load the 1acj receptor and define a 6. ...
Interaction of the endothelial nitric oxide synthase with the CAT
... cells. We have raised and affinity-purified a polyclonal anti-CAT-1 antibody to test whether the antibody can co-immunoprecipitate the eNOS protein from endothelial cell lysates. Furthermore, it is known that the eNOS interaction with some proteins is indirect. For example, we have shown recently th ...
... cells. We have raised and affinity-purified a polyclonal anti-CAT-1 antibody to test whether the antibody can co-immunoprecipitate the eNOS protein from endothelial cell lysates. Furthermore, it is known that the eNOS interaction with some proteins is indirect. For example, we have shown recently th ...
Turnip yellow mosaic virus RNA can be separated into two distinct
... of the above three bands comigrates with coat protein and has been identified as the viral coat protein by tryptic peptide mapping. Coat protein has also been identified among the translation products of TYMV by Benicourt ...
... of the above three bands comigrates with coat protein and has been identified as the viral coat protein by tryptic peptide mapping. Coat protein has also been identified among the translation products of TYMV by Benicourt ...
(A6103) - Datasheet - Sigma
... Aprotinin is a protein consisting of 58 amino acids, arranged in a single polypeptide chain that is crosslinked by three disulfide bridges (See Appendix). Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzymes (See Table 1). The b ...
... Aprotinin is a protein consisting of 58 amino acids, arranged in a single polypeptide chain that is crosslinked by three disulfide bridges (See Appendix). Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzymes (See Table 1). The b ...
The monocarboxylate transporter family
... the C-terminal half of MCT1, and involves TM domains 7–10 (19). Subsequent studies on the inhibition of MCT2 by ARC155858 revealed that inhibition of this isoform only occurred when MCT2 is associated with the ancillary protein basigin and not when associated with embigin (see Some MCTs Require an A ...
... the C-terminal half of MCT1, and involves TM domains 7–10 (19). Subsequent studies on the inhibition of MCT2 by ARC155858 revealed that inhibition of this isoform only occurred when MCT2 is associated with the ancillary protein basigin and not when associated with embigin (see Some MCTs Require an A ...
Rhizobium
... 1993). It had been reported that some components of legume root exudates had positive effects on Rhizobium growth (Van Egeraat, 1975; Parke and Ornston, 1984; D’Arey-Lameta and Jay, 1987 and Streit et al., 1996). On the other hand, gamma radiation has been widely used to enhance the storability of g ...
... 1993). It had been reported that some components of legume root exudates had positive effects on Rhizobium growth (Van Egeraat, 1975; Parke and Ornston, 1984; D’Arey-Lameta and Jay, 1987 and Streit et al., 1996). On the other hand, gamma radiation has been widely used to enhance the storability of g ...
Structure, function and selective inhibition of bacterial acetyl
... pylori (Salama et al. 2004) and Pseudomonas aeruginosa (Jacobs et al. 2003) among others. Bacteria require regulated expression of the acc genes in order to maintain appropriate cellular concentrations of the enzyme's subunits. The importance of maintaining the correct stoichiometry in vivo has been ...
... pylori (Salama et al. 2004) and Pseudomonas aeruginosa (Jacobs et al. 2003) among others. Bacteria require regulated expression of the acc genes in order to maintain appropriate cellular concentrations of the enzyme's subunits. The importance of maintaining the correct stoichiometry in vivo has been ...
McKeown-Silica Stabilisers in filtration
... clarity. Its function is the same as a traditional filter but it is does not use DE. • The potential downside associated with CMF is loss in throughput due to membrane fouling. • Membrane fouling can be attributed to yeast cells, protein-tannin complexes, stabilisation products and hop resins. ...
... clarity. Its function is the same as a traditional filter but it is does not use DE. • The potential downside associated with CMF is loss in throughput due to membrane fouling. • Membrane fouling can be attributed to yeast cells, protein-tannin complexes, stabilisation products and hop resins. ...
Protein Sequences in the CAS Registry File on
... These codes are used for displaying or searching protein sequences with chain lengths of four or more. Dipeptides and tripeptides are also included in REGISTRY, but may be searched only by name or structure and not by sequence representation. For common amino acids, either one-letter or threeletter ...
... These codes are used for displaying or searching protein sequences with chain lengths of four or more. Dipeptides and tripeptides are also included in REGISTRY, but may be searched only by name or structure and not by sequence representation. For common amino acids, either one-letter or threeletter ...
The tumor suppressor Scrib interacts with the zyxin
... Correct processing of these signals allows appropriate cellular growth, differentiation, and tissue morphogenesis, but malfunctions often lie at the basis of pathologies such as tumor growth and metastasis. At sites of cell adhesion, more and more proteins are being identified that not only play a r ...
... Correct processing of these signals allows appropriate cellular growth, differentiation, and tissue morphogenesis, but malfunctions often lie at the basis of pathologies such as tumor growth and metastasis. At sites of cell adhesion, more and more proteins are being identified that not only play a r ...
Sequence Alignment - Mainlab Bioinformatics
... • Window size • A larger window size is used for DNA sequences than for proteins because the number of random matches is much larger due to the use of only 4 DNA characters compared to 20 amino acid characters • For DNA sequences comparisons use long windows and high stringencies, e.g. 15 and 10. ...
... • Window size • A larger window size is used for DNA sequences than for proteins because the number of random matches is much larger due to the use of only 4 DNA characters compared to 20 amino acid characters • For DNA sequences comparisons use long windows and high stringencies, e.g. 15 and 10. ...
... 8. (6 pts) What other significant interaction, besides the hydrophobic effect, conformational entropy, or van der Waals, plays an important role in the stability of double stranded DNA, but not protein stability. Why is this interaction more important for DNA? Electrostatic interactions (not H-bonds ...
A comparison of scoring functions for protein sequence
... with a reference alignment. SP is the number of correctly aligned pairs in the test alignment, tc, divided by the length of the reference alignment. This score has been used, for example, by Thompson et al. (1994), who call it SP, and by Sauder et al. (2000), who refer to it as fD, the developer's s ...
... with a reference alignment. SP is the number of correctly aligned pairs in the test alignment, tc, divided by the length of the reference alignment. This score has been used, for example, by Thompson et al. (1994), who call it SP, and by Sauder et al. (2000), who refer to it as fD, the developer's s ...
The Role of Amino Acids
... metabolism. The 20 amino acids that are found within proteins convey a vast array of chemical versatility. The precise amino acid content, and the sequence of those amino acids, of a specific protein, is determined by the sequence of the bases in the gene that encodes that protein. The chemical prop ...
... metabolism. The 20 amino acids that are found within proteins convey a vast array of chemical versatility. The precise amino acid content, and the sequence of those amino acids, of a specific protein, is determined by the sequence of the bases in the gene that encodes that protein. The chemical prop ...
University: Suez Canal University Faculty of Medicine Course
... structural similarities and differences between myoglobin and hemoglobin. 2. Contrast and explain the oxygen binding curves for myoglobin and hemoglobin. 3. List the major hemoglobins present in the adult and the fetus. 4. Identify the difference between normal Hb and methemoglobin. 5. Identify the ...
... structural similarities and differences between myoglobin and hemoglobin. 2. Contrast and explain the oxygen binding curves for myoglobin and hemoglobin. 3. List the major hemoglobins present in the adult and the fetus. 4. Identify the difference between normal Hb and methemoglobin. 5. Identify the ...
Improving muscle mass: response of muscle metabolism to exercise
... which is facilitated by an increased re-utilization of amino acids derived from MPB [20]. In other words, testosterone promotes MPS and turnover in part by increasing the efficiency of amino acid utilization in skeletal muscle [20]. An increase in protein turnover is inherent in the remodelling proc ...
... which is facilitated by an increased re-utilization of amino acids derived from MPB [20]. In other words, testosterone promotes MPS and turnover in part by increasing the efficiency of amino acid utilization in skeletal muscle [20]. An increase in protein turnover is inherent in the remodelling proc ...
Chapter 6: Metal induced selectivity in phosphate ion binding in
... mechanism have been identified E2, E7, E8 and E9. The intact ~60 kDa proteins consists of three domains: a translocation domain, a receptor binding domain and the aforementioned DNase domain. The DNase domain can be isolated as an active enzyme. A large number of biochemical and structural studies h ...
... mechanism have been identified E2, E7, E8 and E9. The intact ~60 kDa proteins consists of three domains: a translocation domain, a receptor binding domain and the aforementioned DNase domain. The DNase domain can be isolated as an active enzyme. A large number of biochemical and structural studies h ...
An Investigation into the Minimum Requirements for
... is similar in its goals to the minimialist approach to protein engineering9 in that it seeks to simplify the initial basis for catalyst design. Trypsin was chosen as a target for this analysis because it has already been optimized for highly specific peptidase activity. It contains an oxyanion hole ...
... is similar in its goals to the minimialist approach to protein engineering9 in that it seeks to simplify the initial basis for catalyst design. Trypsin was chosen as a target for this analysis because it has already been optimized for highly specific peptidase activity. It contains an oxyanion hole ...
Understanding nature`s catalytic toolkit
... their protonated forms through their proximity, enabling one of them to function as a nucleophile. Similarly, the well-known serine proteases use a triad of interacting residues to perform their chemistry [2]. But not all combinations of residues are useful: some might have no effect on or even redu ...
... their protonated forms through their proximity, enabling one of them to function as a nucleophile. Similarly, the well-known serine proteases use a triad of interacting residues to perform their chemistry [2]. But not all combinations of residues are useful: some might have no effect on or even redu ...
Selected reaction monitoring applied to proteomics
... of low-abundance proteins in clinical biological fluids such as serum, plasma or synovial fluid, which represent an even more challenging task due to the complexity and large dynamic range of proteins present in such media. The first application of this type was the quantification of C-reactive prot ...
... of low-abundance proteins in clinical biological fluids such as serum, plasma or synovial fluid, which represent an even more challenging task due to the complexity and large dynamic range of proteins present in such media. The first application of this type was the quantification of C-reactive prot ...
Knocking Down of Isoprene Emission Modiies the
... composition of thylakoid membranes and chloroplast ultrastructure in isoprene-emitting (IE) and nonisoprene-emitting (NE) poplar (Populus 3 canescens). We demonstrated that the total amount of monogalactosyldiacylglycerols, digalactosyldiacylglycerols, phospholipids, and fatty acids is reduced in ch ...
... composition of thylakoid membranes and chloroplast ultrastructure in isoprene-emitting (IE) and nonisoprene-emitting (NE) poplar (Populus 3 canescens). We demonstrated that the total amount of monogalactosyldiacylglycerols, digalactosyldiacylglycerols, phospholipids, and fatty acids is reduced in ch ...
ref. #28 of the TIBS article
... a model transmembrane helix in the endoplasmic reticulum membrane using the glycosylation mapping technique. Asp and Glu residues cause a re-positioning of the C-terminal end of the transmembrane helix when placed in the one to two C-terminal turns but not when placed more centrally. Arg and Lys res ...
... a model transmembrane helix in the endoplasmic reticulum membrane using the glycosylation mapping technique. Asp and Glu residues cause a re-positioning of the C-terminal end of the transmembrane helix when placed in the one to two C-terminal turns but not when placed more centrally. Arg and Lys res ...
The effecTs of benzoic acid and proTein level on urine ph and
... are in the spotlight. The main source of ammonia emissions is a mixture of urea and excreted in the urine. Urea is converted to ammonia and carbon dioxide by urease present in faeces. The most important factors that affect the process are the urea concentration in urine and the pH and temperature of ...
... are in the spotlight. The main source of ammonia emissions is a mixture of urea and excreted in the urine. Urea is converted to ammonia and carbon dioxide by urease present in faeces. The most important factors that affect the process are the urea concentration in urine and the pH and temperature of ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.