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Chapter 5: Structure and Function of Macromolecules
Chapter 5: Structure and Function of Macromolecules

...  A polypeptide is a polymer of amino acids connected in a specific sequence (pp. 71-74, FIGURES 5.15-5.16, TABLE 5.1) Polypeptides are constructed from 20 different amino acids, each with a characteristic side chain (R group). The carboxyl and amino groups of adjacent amino acids link together in p ...
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Subcellular targeting of proteins and pathways during evolution
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... targeting for proteins of the TIM/TOM and TIC/TOC translocons themselves, because if those components end up in the ‘wrong’ membranes, the consequences could be dramatic, albeit not sufficient to transform one organelle into another – the DNA retained in chloroplasts and mitochondria safeguards agai ...
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The Protein Truncation Test

... Detection and Primer Design The detection method for PTT products must be considered when designing primers for amplification (18). Typically, [35S]methionine is the label of choice but other labels such as [35S]cysteine and [3H]leucine could be used as well. Thus, the amplified segments should contai ...
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... • Roughly 20% of all peptidyl proline bonds in native proteins are in the cis configuration. • This is in part because the amide hydrogen is replaced by a methylene group, which can clash with the R group of the preceding amino acid. • Remember that there is still a kinetic effect on the rate of iso ...
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... these questions: http://www.wisc-online.com/objects/index_tj.asp?objid=AP13104 1. What elements are carbohydrates generally composed of? 2. What is the type of sugar found in fruit called? 3. What is the common name for sucrose? 4. Polysaccharides include starch, cellulose, and glycogen. These long, ...
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Structure and Function of Macromolecules

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... Only raw organic apple cider vinegar has the “mother of vinegar” that makes the vinegar so beneficial. The “mother” is made up living nutrients and bacteria. You can actually see it settled in the bottom of the bottle like sediment. Potassium – helps to prevent brittle teeth, hair loss and runny nos ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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