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Statistical analysis of DNA microarray data
Statistical analysis of DNA microarray data

... organism or system at a given time, i.e. the protein products of the genome. The term has been applied to several different types of biological systems. A cellular proteome is the collection of proteins found in a particular cell type under a particular set of environmental conditions such as exposu ...
Essential Knowledge
Essential Knowledge

... Once a chain of amino acids has been assembled by the ribosome, it tends to fold in on itself. Nitrogen and oxygen atoms are strongly electronegative, which means that they will attract hydrogen atoms bound to nearby atoms. The first hydrogen bonds to form tend to occur between the atoms which make ...
The Diversity of Lysine-Acetylated Proteins in Escherichia coli
The Diversity of Lysine-Acetylated Proteins in Escherichia coli

... Acetylation of lysine residues in proteins is a reversible and highly regulated posttranslational modification. However, it has not been systematically studied in prokaryotes. By affinity immunoseparation using an anti-acetyllysine antibody together with nano-HPLC/MS/MS, we identified 125 lysineacet ...
Powerpoint
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Ion Exchange Chromatography
Ion Exchange Chromatography

... molecules based on ionic interactions. The stationary phase surface displays ionic functional groups (R-X) that interact with analyte ions of opposite charge. This type of chromatography is further subdivided into: cation exchange chromatography anion exchange chromatography. Dr Gihan Gawish ...
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BIOL 201: Cell Biology and Metabolism
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MASCOT®
MASCOT®

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Parts Registry Scavenger Hunt
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The Identity of Proteins Associated with a Small Heat Shock Protein
The Identity of Proteins Associated with a Small Heat Shock Protein

... characteristics of cellular sHSP substrates remain poorly defined. Understanding the mechanism of sHSP chaperone action, as well as determining how these proteins may act to protect cells during stress, requires identification of proteins that interact with sHSPs in vivo, either as partners or subst ...
Catalog 1 Version: January, 2013 University of Illinois at Chicago
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hemp seed: the most nutritionally complete food source in the world
hemp seed: the most nutritionally complete food source in the world

... connected to the carbon atom shared by the amine and carboxyl groups. The amine group, ND, is slightly basic; the carboxyl group, COOH, is a mild acid. The amine group of one amino acid unites with the carboxyl group of another forming a peptide link. Proteins are made of amino acid peptide chains ...
Membrane-enclosed Crystals in Dictyostelium discoideum Cells
Membrane-enclosed Crystals in Dictyostelium discoideum Cells

... In confirmation of previous results, crystals enclosed into vesicles were found to be distributed throughout the cytoplasm of aggregating D. discoideum cells (Fig. 2). The membranes tightly surrounding the crystals were decorated on their cytoplasmic phase by ribosomes as described by George et al. ...
Cloning, Characterization, and Chromosomal Mapping of Human
Cloning, Characterization, and Chromosomal Mapping of Human

... profile predicts six membrane-spanning domains (8). The conserved amino acid sequence, named NPA box, and tandem repeat in the sequence, which are characteristics of MIP family (13, 14), were also conserved in hAQP-CD. One potential N-glycosilation site is present in the sequence of hAQP-CD (Asn 123 ...
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PHD domains and E3 ubiquitin ligases: viruses make the connection
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... can also downregulate two other molecules involved in immune recognition: B7.2 and ICAM-I [33,34]. B7.2 is a costimulatory signaling molecule involved in activating helper T cells; ICAM-1 is an intercellular adhesion molecule that functions at the immunological synapse. By making chimeras of MIR1 an ...
Macromolecules
Macromolecules

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Dynamics of Protein Metabolism in the Ruminant
Dynamics of Protein Metabolism in the Ruminant

... recycling of urea and other endogenous protein (sloughed epithelial cells, enzymes and glycoproteins of mucus). Energy substrates come from the residual fermentable fibre, the glycocalyx of rumen microorganisms, starch and other polysaccharides that have resisted rumen and enteric digestion. As the ...
Biochemistry
Biochemistry

... • R groups – Sequence of amino acids bound together • Varying combinations lead to distinct proteins • Changes in types or positions of amino acids • Sequence also affects levels of protein structure • Overall structure determines its biological function ...
Investigating the Dual Function of the Chloride Intracellular Ion
Investigating the Dual Function of the Chloride Intracellular Ion

... I certify that the work in this thesis has not previously been submitted for a degree nor has it been submitted as part of requirements for a degree except as fully acknowledged within the text. I also certify that the thesis has been written by me. Any help that I have received in my research work ...
Foldrec_2010 - Center for Biological Sequence Analysis
Foldrec_2010 - Center for Biological Sequence Analysis

... believed that only a very few people had the characteristics necessary to keep societies healthy. He had devoted much of his career to measuring those characteristics, in fact, in order to prove that the vast majority of people did not have them. … Galton came across a weight-judging competition…Eig ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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