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Foldrec_2010 - Center for Biological Sequence Analysis
Foldrec_2010 - Center for Biological Sequence Analysis

... believed that only a very few people had the characteristics necessary to keep societies healthy. He had devoted much of his career to measuring those characteristics, in fact, in order to prove that the vast majority of people did not have them. … Galton came across a weight-judging competition…Eig ...
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Carbon Compounds slideshow Carbon Compounds

... As parts of biological membranes To store energy To give plants rigidity As chemical messengers ...
Systems Biology Conceptual Modeling by Means of Discrete
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... Event-based modeling helps formalization, modeling and simulation of the production of proteins. The first conclusion is that dynamic processes of molecular and biological systems in general, the protein production process in particular can be modeled as a discrete dynamic system. Two areas can bene ...
Genetically encoded phenyl azide photochemistry drives
Genetically encoded phenyl azide photochemistry drives

... both the chromophore and residues at 143 occupying similar positions and planes (Fig. 2c). The packing around the chromophore was also very similar (Fig. S3‡). Thus, inserting a phenyl azide moiety into the core of the protein did not signicantly disrupt structure. However, the presence of the azid ...
lecture4
lecture4

... (molar mass ˜ 220,000). The Fe protein contains two identical subunits, each containing an Fe4S4 ...
Journal of Bacteriology
Journal of Bacteriology

... involved in production of antigen group III of R. leguminosarum bv. viciae strain 248, we made use of the strainspecific reactivity of one of the monoclonal antibodies that recognize the antigen group in this strain. MAb38 appears to recognize this group specifically in strain 248 and not in any of ...
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Slide 1

... Starchy foods contain carbohydrates, which are made of long chains of identical small sugar molecules. ...
05_lecture_presentation
05_lecture_presentation

... • Each cell has thousands of different macromolecules • Macromolecules vary among cells of an organism, vary more within a species, and vary even more between species • An immense variety of polymers can be built from a small set of monomers HO ...
Interaction interfaces of protein domains are not topologically
Interaction interfaces of protein domains are not topologically

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BioN03 Amino acids, peptides, proteins Summer 2015
BioN03 Amino acids, peptides, proteins Summer 2015

... acid residues that constitute the polypeptide chain. Secondary structure refers to the localized organization of parts of a polypeptide chain. Tertiary structure refers to the three-dimensional structure of a polypeptide chain, that is, the three-dimensional arrangement of all the amino acids residu ...
Development of a protein microarray using sequence
Development of a protein microarray using sequence

... micrograms per milliliter of antibody was labeled with the fluorescent dye Alexa Fluor 647 reactive dye, and was prepared in the binding buffer for the model experiment of protein–protein interaction. 400 lg/mL of GAL4 DBD/EGFP fusion protein was spotted on the slides. The protein-immobilized slides w ...
Biological Molecules
Biological Molecules

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Life and Cell
Life and Cell

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lecture4
lecture4

... Nitrogenase has been found to contain two components, a Mo-Fe-containing protein and an Fecontaining protein. The Mo-Fe protein contains two Mo and about 30 atoms each of Fe and sulfide (molar mass ˜ 220,000). The Fe protein contains two identical subunits, each containing an Fe4S4 cluster (molar ma ...
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S1 Methods.
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... sequences generated in step 1 A single degenerate position can be denoted by Χ, which represents all amino acids: Χ = { σp ϵ Σ } A single degenerate position or no element at that position can be denoted as Χε: Χε = { σp ϵ (Σ U empty set) } A sequence with at least one degenerate position whereby ...
MDM2 and Soft Tissue Sarcomas
MDM2 and Soft Tissue Sarcomas

... Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA ...
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... The high dietary protein requirements of salmonid fish are met with fishmeal-based feed in commercial aquaculture. The sustainability of this practice is questionable and, therefore, the feasibility of substituting fishmeal with plant-based products needs to be investigated. We investigated growth a ...
Secretion of Beta-Lactamase Requires the Carboxyl End of the Protein.
Secretion of Beta-Lactamase Requires the Carboxyl End of the Protein.

... were studied in Salmonella typhimurium infected with P22 phage carrying the structural gene for /3-lactamase (the b/a gene) in mutant or wild-type form. The wildtype gene was shown to specify two forms of /Ilactamase which differ in molecular weight by about 2500 daltons. This difference is consiste ...
Here
Here

... Orthologs: “deepest” bifurcation in molecular tree reflects speciation. These are the molecules people interested in the taxonomic classification of organisms want to study. Paralogs: “deepest” bifurcation in molecular tree reflects gene duplication. The study of paralogs and their distribution in g ...
Practice Exam - mvhs
Practice Exam - mvhs

... 26. Dr. E.N. Zyme is performing an experiment to test a new kind of cellulase using Cellazyme tablets. Cellazyme tablets act as a substrate for cellulase and release a blue dye upon digestion. Dr. Zyme incubates the cellulase and Cellazyme tablet at 40 degrees for 10 minutes at pH 9.0. After 10 minu ...
PROTEIN SUBCELLULAR LOCALIZATION - PolyU
PROTEIN SUBCELLULAR LOCALIZATION - PolyU

... [18], which was created by selecting all eukaryotic proteins with annotated subcellular locations from Swiss-Prot 41.0. The dataset comprises 3572 proteins with 11 classes (622 cytoplasm, 1188 nuclear, 424 mitochondria, 915 extracellular, 26 Golgi apparatus, 225 chloroplast, 45 endoplasmic reticulum ...
A steroid/thyroid hormone receptor superfamily member in
A steroid/thyroid hormone receptor superfamily member in

... been identified for either protein. The high degree of simllarity in the hormone-blnding domaln between the 2C protein and the H2RII binding protein outside regions II-IV suggests specific functional roles which are not shared by other members of the superfamily. Article: INTRODUCTION Steroid hormon ...
chapter 20 lo
chapter 20 lo

... structure, which acid is the N-terminal amino acid, and which amino acid is the C-terminal amino acid. You need to know the four different levels of protein structure…what they are and what they are caused by. You should be able to recognize a level of structure from a description of it. What is the ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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