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A Few Good Domains
A Few Good Domains

... Phosphotyrosine binding (PTB) domains are 100–150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More Nterminal sequences are also required for high affinity bi ...
Protein Structure III
Protein Structure III

... A repeating pattern of hydrophobic/-philic AAs that is conserved……significant ...
Rugby nutrition - Reading Crusade
Rugby nutrition - Reading Crusade

... To replace fluids lost through sweating and other body processes, we need to drink about 2.4 litres  of water per day, and more in hot weather, periods of high activity or illness.   ...
A candidate gene marker for bloat susceptibility in cattle?
A candidate gene marker for bloat susceptibility in cattle?

... Earlier physiological studies have shown differences in rumen volume, salivation rate, and salivary proteins between low and high susceptibility cattle (Carruthers et al., 1988; McIntosh and Cockrem, 1977; Morris et al., 1991). We have found that the abundance of a major salivary protein, which we h ...
The physiology of nutrition
The physiology of nutrition

... • Can be converted to other, biologically important molecules • Dietary fibres: – Water soluble (e.g. pektin) – Water insoluble (e.g. cellulose, hemicellulose, lignin) • Recommendation: 55-60% of the total energy uptake should be provided by carbohydrates. The energy uptake ensured by the ”added sug ...
Slide 1
Slide 1

... Computer-assisted ribbon model of the mitochondrial IDH protein depicting the “run” of the polypeptide chain ...
Youngs, Noah: Progress in the Side-Chain Prediction Problem
Youngs, Noah: Progress in the Side-Chain Prediction Problem

... steps: backbone modeling and side-chain modeling. Several techniques exist that provide relatively good structure prediction for the backbone of a protein. One such technique is homology modeling, whereby backbone structure of a protein is assumed to be similar to that of other proteins homologous t ...
Key To Problem Set 3R
Key To Problem Set 3R

... pass membranes unless there is RME or some other special process involved, so fluorescent protein X could not get inside the sealed vesicles and bind to receptors on the inside. B. You supply some cells with radioactive amino acids, etc. B-1. You are likely to find radioactivity first in (exocytotic ...
PowerPoint - 2014 Science Interns
PowerPoint - 2014 Science Interns

... acidocaldarius to make Lactic Acid Alicyclobacillus acidocaldarius is a gram-positive bacteria found in thermal features in Yellowstone National Park. It grows at 60 °C and a pH of 4.0. A. acidocaldarius has been found to aid in the production of lactic acid, a chemical that can be used to make biod ...
Detection of Cellular Response to an in vitro Challenge with
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... different peptide identification strategies were used. The simple search method (Figure 3) only searches for high-confidence, tryptic peptides and phosphopeptides. The more complex search strategy (Figure 4), breaks the PTM search strategy into multiple nodes, where small groups of PTMs, likely to o ...
Protein synthesis in the Liver and the Urea Cycle
Protein synthesis in the Liver and the Urea Cycle

... shows, ADP / GDP drive the reaction forward – because they represent the ‘low energy’ i.e. ATP or GTP have been ‘used’ by the cell so in order to reconstitute them substrate for the citric acid cycle is generated and ATP is replenished. When ATP concentration is high then glutamate is formed and bec ...
Q1. (a) An enzyme catalyses only one reaction. Explain why
Q1. (a) An enzyme catalyses only one reaction. Explain why

... Our knowledge of the relationship between protein structure and function has led to the development of the new technology of protein engineering. This involves changing the amino 10 acid sequence of a protein and altering its tertiary structure. Altering the tertiary structure changes the protein’s ...
F1000 - CBGP
F1000 - CBGP

... Identification of novel RNA-binding proteins in fungi is essential to unravel post-transcriptional networks and cellular processes that confer identity to the fungal kingdom. Here, we carried out the functional characterisation of the filamentous fungus-specific RNA-binding protein RBP35 required fo ...
Chapter 14 (Part 1)
Chapter 14 (Part 1)

... Electron Transport • Four protein complexes in the inner mitochondrial membrane • A lipid soluble coenzyme (UQ, CoQ) and a water soluble protein (cyt c) shuttle between protein complexes • Electrons generally fall in energy through the chain - from complexes I and II to complex IV ...
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... enough to meet their needs for several weeks. Vitamin C is easily secured through an orange juice supplement. • There are three kinds of proteins in milk: caseins, lactalbumins, and lactoglobulins. All are globular. ...
Advances in Natural and Applied Sciences Aedes aegypti  Aulanni’am
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... populations with 3 different kind of sera samples from endemic area. (A) SGE Lab. scale cultures, (B) SGE from landing population , (C) negative control, (M) Marker. The specific proteins of 56 and 31 kDa that were detected in this study (Fig. 3), were related to the immune response against SGE of A ...
Dataset S5.
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... XRA categories for each cell strain; this average intensity is used as a “virtual baseline” for the purpose of calculating fold-changes. The third group of columns contains the log2 results of each raw value normalized to its corresponding average baseline (e.g. log2 of “PrEC PRE 1” divided by PrEC ...
Biochemistry 2007
Biochemistry 2007

... (c) Has a subunit called λ (lambda), which acts as a proofreading ribonuclease. (d) Separates DNA strands throughout a long region of DNA (up to thousands of base pairs), then copies one of them. (e) Synthesizes RNA chains in the 3’→5’ direction ...
Macromolecule Expert Sheets
Macromolecule Expert Sheets

... Carbon, hydrogen, and oxygen (also phosphorous and sometimes nitrogen in phospholipids) 4. Explain why oils don’t dissolve in water. Their fatty acid components have long hydrocarbon tails that are hydrophobic. 5. What smaller molecules make up a fat molecule? 3 fatty acids and 1 glycerol 6. What fu ...
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Biomolecules

... Glucose is an essential ingredient for the organism to make energy –This happens in both PLANTS & ANIMALS and is known as ...
2015-2016 SMART Team Abstract Booklet.
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... plants do not posses. Therefore, plants have a sophisticated silencing mechanism which detects and destroys double stranded RNA (characteristically viral) in a process called RNA interference (RNAi). Small interfering RNAs (siRNA) are cleaved from double stranded introns by an enzyme called DICER. I ...
Unit 4 proteins
Unit 4 proteins

... 4.1 Proteins as Biotechnology Products • Proteins – large molecules that are required for the structure, function, and regulation of living cells • 2000 NIH launched Protein Structure Initiative – Effort to identify the structure of human proteins – 2010 began using high throughput structure determ ...
organic compounds
organic compounds

... Oxygen ( O ) elements (hydrocarbonsH-C) also can have N,P,S. •Can be produced by living organisms •They can give energy •Have complex and longer structure – Make up living structure ...
OVAX - Prodinra
OVAX - Prodinra

... ► The egg white is a nutritious reserve and a source of bioactive molecules for embryo ► Characterize the biological activities of egg white proteins ► Ovalbumin-related protein X (OVAX) belongs to the ovalbumin family which consists of 3 related genes : Ovalbumin, OVAX and OVAY which have evolved f ...
The effect of pH on the digestion of proteins in vitro by pepsin
The effect of pH on the digestion of proteins in vitro by pepsin

... It is evident from our results that all the proteins studied were most rapidly digested at pHs near z and that, although some proteolysis occurred at pH 4, there was no indication of a second peak of proteolytic activity at pH 3-5-4. There is general agreement that pepsin causes optimal proteolysis ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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