Cholesterol, steroids, and related molecules
... ates can leave the cells in which they are made and circulate as complexes either with serum albumin or with specific sterol-binding globulin proteins. These general principles can be used to rationalize two examples of normal tissuespecific hormone synthesis, and one pathological state, congenital ...
... ates can leave the cells in which they are made and circulate as complexes either with serum albumin or with specific sterol-binding globulin proteins. These general principles can be used to rationalize two examples of normal tissuespecific hormone synthesis, and one pathological state, congenital ...
Protein domains as units of genetic transfer
... We implemented a two-phase strategy [10] for the detection of recombination events among these data. To remove potential complication from paralogous history in the sequences and to ensure a confident inference of genetic transfer event rather subsequent evolution of duplicated genes, we selected 14 ...
... We implemented a two-phase strategy [10] for the detection of recombination events among these data. To remove potential complication from paralogous history in the sequences and to ensure a confident inference of genetic transfer event rather subsequent evolution of duplicated genes, we selected 14 ...
References - BioMed Central
... regulation of cytokines that signal through the JAK/STAT pathway: inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors: binding to JAK2 inhibits its kinase activity When phosphorylated by the insu ...
... regulation of cytokines that signal through the JAK/STAT pathway: inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors: binding to JAK2 inhibits its kinase activity When phosphorylated by the insu ...
Metabolic and physiological interdependencies in the
... Figure 2 Density gradient enrichment of symbiont cells and host components followed by CARD-FISH. (a) Step-wise workflow of the density gradient enrichment method for physical separation of B. azoricus host and symbiont cells. Sampling for tissue-based metaproteomic analysis of whole gill and foot t ...
... Figure 2 Density gradient enrichment of symbiont cells and host components followed by CARD-FISH. (a) Step-wise workflow of the density gradient enrichment method for physical separation of B. azoricus host and symbiont cells. Sampling for tissue-based metaproteomic analysis of whole gill and foot t ...
The complete nucleotide sequence of cucumber green mottle
... that of another CGMMV isolate (CGMMV-W) (Meshi et al., 1983b; Saito et al., 1988). The coat protein gene of our CGMMV isolate was also found to be composed of the same number of nucleotides as that found in CGMMV-W (Meshi et al., 1983b). In total, 27 nucleotide substitutions (six in the 186K protein ...
... that of another CGMMV isolate (CGMMV-W) (Meshi et al., 1983b; Saito et al., 1988). The coat protein gene of our CGMMV isolate was also found to be composed of the same number of nucleotides as that found in CGMMV-W (Meshi et al., 1983b). In total, 27 nucleotide substitutions (six in the 186K protein ...
Di-(2-ethylhexyl) phthalate mediates glycolysis and the TCA cycle
... bio-accumulated levels of DEHP in clam Venerupis philippinarum. After exposure to 0.4 mg L-1 and 4mg L-1 DEHP, the bio-accumulated DEHP in the clam foot was significantly increased in the first 24 h, and then sharply decreased from 0.203 ± 0.022 μg g-1 to 0.104 ± 0.011 μg g-1 , and from 1.689 ± 0.01 ...
... bio-accumulated levels of DEHP in clam Venerupis philippinarum. After exposure to 0.4 mg L-1 and 4mg L-1 DEHP, the bio-accumulated DEHP in the clam foot was significantly increased in the first 24 h, and then sharply decreased from 0.203 ± 0.022 μg g-1 to 0.104 ± 0.011 μg g-1 , and from 1.689 ± 0.01 ...
instructions on the annotation of pdf files
... and 0.016. This tendency is observed for all domain classes (a, b, a/b, and a+b) in both SCOP and CATH. The values of nACO(Nt) < ACO(Ct)/nACO(Ct) < ACO(Nt) are 1.7, 1.5, and 1.8 for the 19, 28, and 44 respective members of the a, b, a/b, and a+b classes in CATH, and 1.8, 1.3, and 1.4 for the 31, 46, ...
... and 0.016. This tendency is observed for all domain classes (a, b, a/b, and a+b) in both SCOP and CATH. The values of nACO(Nt) < ACO(Ct)/nACO(Ct) < ACO(Nt) are 1.7, 1.5, and 1.8 for the 19, 28, and 44 respective members of the a, b, a/b, and a+b classes in CATH, and 1.8, 1.3, and 1.4 for the 31, 46, ...
Mitochondrial protein acetylation regulates metabolism
... SIRT3 as a critical regulator of mitochondrial function, and suppression by high-fat diet feeding or reduction in enzymatic activity by a point-mutation both contribute to the metabolic syndrome [29]. LCAD hyperacetylation was induced by high-fat diet feeding and was sufficient to reduce enzymatic a ...
... SIRT3 as a critical regulator of mitochondrial function, and suppression by high-fat diet feeding or reduction in enzymatic activity by a point-mutation both contribute to the metabolic syndrome [29]. LCAD hyperacetylation was induced by high-fat diet feeding and was sufficient to reduce enzymatic a ...
Communication - Department of Molecular Physiology and Biophysics
... syntrophin triplet suggesting that all the syntrophins including α- as well as β-type may directly bind to dystrophin (Fig. 2). Previous work by Ozawa's group indicated that one of 43-DAGs was overlaid by dystrophin fusion protein containing cysteinerich and C-terminal domains (16). This interaction ...
... syntrophin triplet suggesting that all the syntrophins including α- as well as β-type may directly bind to dystrophin (Fig. 2). Previous work by Ozawa's group indicated that one of 43-DAGs was overlaid by dystrophin fusion protein containing cysteinerich and C-terminal domains (16). This interaction ...
chapter 23
... Fats and oils make up the most common group of lipids in your diet. These molecules are known as triglycerides. They are formed by condensation reactions in which three fatty acid molecules bond to one glycerol (a type of alcohol) molecule. Fats, such as butter and lard, come from animals, while oil ...
... Fats and oils make up the most common group of lipids in your diet. These molecules are known as triglycerides. They are formed by condensation reactions in which three fatty acid molecules bond to one glycerol (a type of alcohol) molecule. Fats, such as butter and lard, come from animals, while oil ...
Similarities between putative transport proteins of plant viruses
... sequence of proteins encoded by CMV strain O (Hayakawa et al., 1989) and the very similar strain Y (Nitta et al., 1988) were not separately analysed. Three ORF I product caulimoviral sequences were used: CaMV, Cabb S isolate (Franck et al., 1980), CERV (Hull et aL, 1986) and FMV (Richins et al., 198 ...
... sequence of proteins encoded by CMV strain O (Hayakawa et al., 1989) and the very similar strain Y (Nitta et al., 1988) were not separately analysed. Three ORF I product caulimoviral sequences were used: CaMV, Cabb S isolate (Franck et al., 1980), CERV (Hull et aL, 1986) and FMV (Richins et al., 198 ...
Does Sequence Dictate Structure Which Dictates Function?
... throughout (Figure 1A). Homology is all about functional relatedness; it is all or nothing, but not at all equivalent to either sequence similarity or even structural similarity. In fact, homology is the single most important requirement for the success of comparative sequence analysis, the most pow ...
... throughout (Figure 1A). Homology is all about functional relatedness; it is all or nothing, but not at all equivalent to either sequence similarity or even structural similarity. In fact, homology is the single most important requirement for the success of comparative sequence analysis, the most pow ...
V6-SecondaryStructur.. - Chair of Computational Biology
... However, Chen and Rost claim that most authors have significantly overestimated the accuracy of their methods. (1) there are not enough high-resolution structures to allow a statistically significant analysis. Training and test sets may share or have homologous members. Using low-resolution experime ...
... However, Chen and Rost claim that most authors have significantly overestimated the accuracy of their methods. (1) there are not enough high-resolution structures to allow a statistically significant analysis. Training and test sets may share or have homologous members. Using low-resolution experime ...
An Hypothetical Structure for an Intermolecular Electron Transfer
... contacts in both complexes revealed that a significant fraction of prohibitively close contacts between polypeptide backbone atoms, CD carbon atoms, or otherwise structurally constrained side chain atoms existed, along with some “holes” at the interface regions. Consequently, further checks of the s ...
... contacts in both complexes revealed that a significant fraction of prohibitively close contacts between polypeptide backbone atoms, CD carbon atoms, or otherwise structurally constrained side chain atoms existed, along with some “holes” at the interface regions. Consequently, further checks of the s ...
Matrix-assisted Laser Desorption/Ionization Mass Spectrometry in
... Amino acid sequence information can be obtained by one of several methods using MALDIMS. The first is called protein mass mapping which consists of the site-specific enzymatic or chemical degradation of a protein followed by mass spectrometric analysis of the released peptides. Owing to the complexi ...
... Amino acid sequence information can be obtained by one of several methods using MALDIMS. The first is called protein mass mapping which consists of the site-specific enzymatic or chemical degradation of a protein followed by mass spectrometric analysis of the released peptides. Owing to the complexi ...
... Strains. The C. neoformans isolates used in this study included strains H99 (serotype A, wild type), Cap 67 (derived from serotype D and lacking a GXM capsule), and 2E-TU and 2E-TUC (serotype D, LAC1 gene deletion and reconstituted laccase mutants) (46). Yeast cells were cultivated in a minimal medi ...
Biomolecules
... All biologically known protein are polymers of a set of twenty known amino acids. All biologically known amino acids are α L amino acids. They are composed of carboxylic end COOH and amino end NH2 and α carbon attached to both of them and special side chain (R) attached to this α carbon . This side ...
... All biologically known protein are polymers of a set of twenty known amino acids. All biologically known amino acids are α L amino acids. They are composed of carboxylic end COOH and amino end NH2 and α carbon attached to both of them and special side chain (R) attached to this α carbon . This side ...
Interactions of Virus Proteins Within the Host Cell
... Viruses are ancient parasites that predate all three domains of life: Eukarya, Bacteria and Archaea. Viruses usually specifically infect a determined cell type, largely defined by the receptors they recognise. Canine parvovirus is a small, non-enveloped animal virus that infects cells in dividing ce ...
... Viruses are ancient parasites that predate all three domains of life: Eukarya, Bacteria and Archaea. Viruses usually specifically infect a determined cell type, largely defined by the receptors they recognise. Canine parvovirus is a small, non-enveloped animal virus that infects cells in dividing ce ...
GPCR–G fusion proteins
... The b2AR coupled to GsaL, but not the b2AR coupled to GsaS possesses the properties of a constitutively active GPCR. These differences can be explained by the lower GDPaffinity of GsaL compared to the GDP-affinity of GsaS, i.e. GsaL is more often GDP-free than GsaS and, therefore, more often availab ...
... The b2AR coupled to GsaL, but not the b2AR coupled to GsaS possesses the properties of a constitutively active GPCR. These differences can be explained by the lower GDPaffinity of GsaL compared to the GDP-affinity of GsaS, i.e. GsaL is more often GDP-free than GsaS and, therefore, more often availab ...
Structural Basis of Biological Nitrogen Fixation
... MgADP. The original crystal structure of Av2 contained a low occupancy ADP molecule that apparently was carried from the protein purification.48 The ADP was positioned across the subunit-subunit interface, perpendicular to the 2-fold axis such that the purine ring was bound to one subunit and the ph ...
... MgADP. The original crystal structure of Av2 contained a low occupancy ADP molecule that apparently was carried from the protein purification.48 The ADP was positioned across the subunit-subunit interface, perpendicular to the 2-fold axis such that the purine ring was bound to one subunit and the ph ...
Exploring the Complement Interaction Network
... Obtaining biophysical profiles for individual interaction in the complement network has been the major aim for a large fraction of the published studies. While target immobilization is considered a major deviation from natural conditions for many biosensor experiments, the contrary is true in the ca ...
... Obtaining biophysical profiles for individual interaction in the complement network has been the major aim for a large fraction of the published studies. While target immobilization is considered a major deviation from natural conditions for many biosensor experiments, the contrary is true in the ca ...
Allosteric regulation and catalysis emerge via a common
... conformational change is not ligand induced. Rather, the role of ligand binding is to stabilize a pre-existing conformation, selecting this conformation in the population of protein conformers. This study highlights the unique suitability of NMR spectroscopy for studying protein dynamics: NMR relaxa ...
... conformational change is not ligand induced. Rather, the role of ligand binding is to stabilize a pre-existing conformation, selecting this conformation in the population of protein conformers. This study highlights the unique suitability of NMR spectroscopy for studying protein dynamics: NMR relaxa ...
as Powerpoint presentation
... potentials. The electrons flow from the more negative potential to the highest potential (oxygen). Three important features of the components are:Protein or non-protein; redox potential; whether a ‘2H’ carrier (2 protons plus 2 electrons, single electron carrier). ...
... potentials. The electrons flow from the more negative potential to the highest potential (oxygen). Three important features of the components are:Protein or non-protein; redox potential; whether a ‘2H’ carrier (2 protons plus 2 electrons, single electron carrier). ...
Protein–protein interaction
Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.