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Proteins
Proteins

... 2. Vitamin D3 – from cholesterol in your skin and ultraviolet rays from the sun. Vit D2 (ergocalciferol) from plants but studies show D3 (cholecalciferol) from animals, is much more effective. Cod fish liver oil best source (also fatty fish). Deficiency: linked to depression, impaired immune system, ...
Thinking big with small molecules
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... and the two techniques have complementary strengths and limitations. In comparison, this new proteomic mapping method combines the best of both worlds: proteome-wide detection and spatiotemporal resolution in live cells. By targeting an engineered form of ascorbate peroxidase (APEX) to the mitochond ...
pancreatic beta cells - Wiley Online Library
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... revealed an upregulation of machineries involved in proinsulin biogenesis, including the neuroendocrine convertases, protein disulfide isomerases as well as serveral proteins regulating unfolded protein response. In this study, we compared two different approaches to isolate rER from a pancreatic be ...
AP European History (Sem 1), Unit 03, Lesson 04
AP European History (Sem 1), Unit 03, Lesson 04

...  Proteins are unique macromolecules that are composed of several smaller monomers. These monomers, amino acids, are linked together through the process of dehydration synthesis. Peptide bonds join amino acids in the primary structure (as seen in Figure 1, while additional chemical interactions may ...
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91.510_ch8_part1
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FT-IR Protein Structure Analyzer

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Gene Section NONO non-POU domain containing, octamer- binding

... and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids ...
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Protein–protein interaction



Protein–protein interactions (PPIs) refer to physical contacts established between two or more proteins as a result of biochemical events and/or electrostatic forces.In fact, proteins are vital macromolecules, at both cellular and systemic levels, but they rarely act alone. Diverse essential molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. Indeed, these interactions are at the core of the entire interactomics system of any living cell and so, unsurprisingly, aberrant PPIs are on the basis of multiple diseases, such as Creutzfeld-Jacob, Alzheimer's disease, and cancer.PPIs have been studied from different perspectives: biochemistry, quantum chemistry, molecular dynamics, signal transduction, among others. All this information enables the creation of large protein interaction networks – similar to metabolic or genetic/epigenetic networks – that empower the current knowledge on biochemical cascades and disease pathogenesis, as well as provide putative new therapeutic targets.
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