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Incomplete penetrance of MHC susceptibility genes
Incomplete penetrance of MHC susceptibility genes

... such traits prospectively in persons presumed to be homozygous, heterozygous or non-carrying for susceptibility genes by determining trait expression in homozygotes, heterozygotes or non-carriers of trait-associated conserved extended MHC haplotypes. The method provides direct estimates of apparent ...
Supporting Information Legends
Supporting Information Legends

... antibody. (b) Changes in the proportions of the 2C (blue line) and 4C cells (pink line) in the synchronized rice cultured cells (line Oc) after release from G1 arrest. (c) Changes in the ENL1 protein levels in the synchronized cells that were examined in (b) were ...
Maternal-Effect Genes That Alter the Fate Map of the Drosophila
Maternal-Effect Genes That Alter the Fate Map of the Drosophila

... which pattern elements at the middle of the embryo appear “expanded” anteriorly and posteriorly with concomitant loss of pattern elements at the posterior- and anterior-most regions of the embryo. The eighth dentiexuperantia, A Member of the Anterior Class, Causes cle band is entirely absent or grea ...
The Gene Ontology
The Gene Ontology

... (EASE scores) for each annotation term associated with the gene members in the group. ...
The Optimal Discovery Procedure II: Applications to Comparative
The Optimal Discovery Procedure II: Applications to Comparative

... A microarray measures the abundance of mRNA transcripts of thousands of genes from a single biological sample (1, 2). Of much recent interest has been the problem of identifying genes that are differentially expressed across varying biological conditions based on microarray data (3). It is now possi ...
Natural Selection, Infectious Transfer and the Existence Conditions
Natural Selection, Infectious Transfer and the Existence Conditions

... positive selection at all times. Moreover, the simple presence of selectively advantageous genes on bacterial plasmids is not sufficient to explain plasmid maintenance. Genes originally carried on the plasmid presumably can be sequestered by the chromosome; the host bacterium could then continue to ...
Cleavage of Cohesin by the CD Clan Protease Separin
Cleavage of Cohesin by the CD Clan Protease Separin

... These observations have led to the notion that chromosome segregation during anaphase might be triggered not by any change in the force exerted by microtubules, but rather by the sudden loss of cohesion holding sister chromatids together. Evaluation of this hypothesis, however, has had to await disc ...
Gene Section ALK (anaplastic lymphoma kinase) Atlas of Genetics and Cytogenetics
Gene Section ALK (anaplastic lymphoma kinase) Atlas of Genetics and Cytogenetics

... Morris SW. Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis. Blood. 2000 Mar ...
Imprinted gene expression in hybrids: perturbed
Imprinted gene expression in hybrids: perturbed

... individual animals (Shi et al., 2004). The Mit1(Lb9)- and Copg2imprinted genes located close to Peg1 on chromosome 6, and the Nnat, Slc22a18 and Peg3 genes also showed evidence for loss of imprinting, again mostly in the (MU  S)F1 hybrids (Shi et al., 2005). A tissue-specific effect occurred at the ...
CIBI3031-091 Midterm Examination III November 2005
CIBI3031-091 Midterm Examination III November 2005

... ____ 26. The number of different alleles for ABO blood types in the total human population is a. 4. b. 3. c. 9. ____ 27. The chromosomes are moving to opposite poles during a. metaphase. b. anaphase. c. interphase. ____ 28. Which of the following does NOT produce variation? a. random alignment of ch ...
Identification and Analysis of Arabidopsis Expressed Sequence
Identification and Analysis of Arabidopsis Expressed Sequence

... they may play a role in regulatory processes, although their true functions are unknown. Another interesting family of ncRNAs present in plants is typified by Mt4 in Medicago truncatula (Burleigh and Harrison, 1998) and TPSI1 in tomato (Lycopersicon esculentum; Liu et al., 1997). As with the GUT15/C ...
CIBI3031-070 Midterm Examination III November 2005
CIBI3031-070 Midterm Examination III November 2005

... ____ 29. Mendel found that pea plants expressing a recessive trait a. were pure-breeding. b. appeared only in the first generation offspring of a cross between two pure-breeding plants expressing contrasting forms of a trait. c. both of these ____ 30. In mitosis, if a parent cell has 16 chromosomes, ...
Embryonic Development following Somatic Cell
Embryonic Development following Somatic Cell

... Figure 2. Reprogramming Resistant Regions Are Enriched for H3K9me3 in Somatic Cells (A) Heatmap illustration of the transcripts of IVF and SCNT embryos. Each tile represents an average of peaks within the region obtained by sliding-window analysis. Shown are the 811 regions that are activated from t ...
An Introduction to Genetic Analysis Chapter 18 Chromosome
An Introduction to Genetic Analysis Chapter 18 Chromosome

... arise naturally as spontaneous chromosomal mutations and, as such, they must be considered aberrations because they differ from the previous norm. However, many species of plants and animals have clearly arisen through polyploidy, so evidently evolution can take advantage of polyploidy when it arise ...
8. Principles of Genetics and Cytogenetics
8. Principles of Genetics and Cytogenetics

... modification of dihybrid F2 ratio due to gene interaction. 1855-Virchow showed that all cells arise from pre-existing cells by cell division 1879-W.Flemming, introduced the term chromatin. 1882-W.Flemming introduced the term mitosis. 1888-Waldeyar ...
TEV_v7_BY
TEV_v7_BY

... strains, an order of magnitude higher than previous studies 14,16. We employed two approaches to TEV discovery, SVMerge which combines the results of four methods of structural variation prediction 17, and RetroSeq (Methods). After filtering, SVMerge predicted 44,401 insertions within the lineage of ...
Chapter 1: Introduction: Themes in the Study of Life
Chapter 1: Introduction: Themes in the Study of Life

... Here is an idea that will recur throughout your study of the function of molecules: Change the structure, change the function. You see this in enantiomers, you will see it in proteins and enzymes, and now we are going to look at testosterone and estradiol. Notice how similar these two molecules are, ...
Promise – Spring 2009 - St. Jude Children`s Research Hospital
Promise – Spring 2009 - St. Jude Children`s Research Hospital

... (MRD), the small number of leukemic cells that survive after remission induction therapy. This measurement helps clinicians identify patients whose disease is highly responsive to chemotherapy and therefore might be cured with milder and less-toxic treatment, and which are more resistant and thus ne ...
Genetic code redundancy and its influence on the encoded
Genetic code redundancy and its influence on the encoded

... abundance tRNAs, although to a lesser extent. Genes with low expression in these organisms, such as those encoding regulatory proteins, were found to be encoded by less biased usage of optimal and non-optimal codons. These results have led to the generalized assumption that frequently used codons ar ...
Promise Vivian Laws: a model patient page 16
Promise Vivian Laws: a model patient page 16

... (MRD), the small number of leukemic cells that survive after remission induction therapy. This measurement helps clinicians identify patients whose disease is highly responsive to chemotherapy and therefore might be cured with milder and less-toxic treatment, and which are more resistant and thus ne ...
Protein Creation Pathway
Protein Creation Pathway

... nicknamed the “control center” of a cell. But why? The nucleus contains DNA in its active form and this DNA will ultimately be used as a blueprint to create proteins for use throughout the body. The process of creating a protein begins in the nucleus. Click the arrow to zoom inside and view a nucleu ...
PHANTASTICA Regulates Development of the Adaxial Mesophyll in
PHANTASTICA Regulates Development of the Adaxial Mesophyll in

... for alignment with the PHAN-like proteins of four eudicots, which is shown in Figure 1 with identical residues shaded. All have a highly conserved MYB DNA binding domain at the N terminus, consisting of two imperfect repeats (55 and 51 residues), both of which are essential for sequence-specific DNA ...
Protein Creation Pathway
Protein Creation Pathway

... nicknamed the “control center” of a cell. But why? The nucleus contains DNA in its active form and this DNA will ultimately be used as a blueprint to create proteins for use throughout the body. The process of creating a protein begins in the nucleus. Click the arrow to zoom inside and view a nucleu ...
Sager JJ, Bai Q, Burton EA
Sager JJ, Bai Q, Burton EA

... Disruption of E3 ubiquitin ligase activity in immature zebrafish mind bomb mutants leads to a failure in Notch signaling, excessive numbers of neurons, and depletion of neural progenitor cells. This neurogenic phenotype is associated with defects in neural patterning and brain development. Because d ...
Molecular pathogenesis of liver adenomas and FNH - HAL
Molecular pathogenesis of liver adenomas and FNH - HAL

... over-express SAA. These results suggested that the inflammatory pathway was intrinsically deregulated in tumor hepatocytes, and inflammatory infiltrates could be a secondary effect. According to this hypothesis, we identified a typical case of inflammatory HCA with clinical manifestation of an infla ...
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Polycomb Group Proteins and Cancer

The Polycomb-group proteins (PcGs) are a family of proteins that use epigenetic mechanisms to maintain or repress expression of their target genes. They were originally discovered in Drosophila (fruit flies), though they've been shown to be conserved in many species due to their vital roles in embryonic development. These proteins' ability to alter gene expression has made them targets of investigation for research groups seeking to understand disease pathology and oncology.
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