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49 What is the etiologic factor of the monogenic inherited pathology?
49 What is the etiologic factor of the monogenic inherited pathology?

... 48 The action of mutant gene at monogenic pathology shows up: A Only by clinical symptoms; B On clinical, biochemical and cellular levels C Only on the particular stages of metabolism; D Only by the loss of function of protein E Does not show up clinically. ANSWER: B 49 What is the etiologic factor ...
Hox patterning of the vertebrate axial skeleton
Hox patterning of the vertebrate axial skeleton

... INTRODUCTION Hox genes are homeodomain-containing transcription factors that were first described in Drosophila for their ability to cause segmental homeotic transformations of the body plan (Lewis, 1963, 1978). While flies have eight Hox, or HomC, genes located in a single cluster, mammals have 39 Ho ...
Molecular pathogenesis of liver adenomas and FNH - HAL
Molecular pathogenesis of liver adenomas and FNH - HAL

... over-express SAA. These results suggested that the inflammatory pathway was intrinsically deregulated in tumor hepatocytes, and inflammatory infiltrates could be a secondary effect. According to this hypothesis, we identified a typical case of inflammatory HCA with clinical manifestation of an infla ...
Oliver, B., Kim, Y.-J., and Baker, B. S.
Oliver, B., Kim, Y.-J., and Baker, B. S.

... determine the order of function of two genes is to inquire whether one gene regulates the expression of the other. To this end, our initial experiments address whether the sexspecific functioning of Sxl in the germ line is regulated by alternative pre-mRNA processing as it is in the soma. A finding ...
Testing the ABC floral-organ identity model: expression of
Testing the ABC floral-organ identity model: expression of

... Determine the time and place of expression for each ABC gene and consider whether the expression correlates with the functional domain defined by the loss-of-function phenotype. ...
unit 20 inheritance and cell division
unit 20 inheritance and cell division

... Experiments 1 and 2 each take about 30 minutes and relate to Sections 2.1 and 5.1, respectively. For these you will need the maize cobs, A and B, from your Experirnent Kit. The two AV sequences, one in Section 3.2 and the other in Section 6.1, should take 30 minutes and 20 minutes (respectively) to ...
pdf
pdf

... and the nucleotide sequence responsible for each terminal restriction fragment (T-RF) was determined by 16S rRNA gene cloning and sequencing [18]. Two major populations, one assigned to the genus Thauera, and another related to the genera Ralstonia and Limnobacter, were associated with 4-chlorobenzo ...
The Chromosome Theory of Inheritance
The Chromosome Theory of Inheritance

Temperature-dependent expression of virulence genes in fish
Temperature-dependent expression of virulence genes in fish

... 2010; Steinmann and Dersch, 2013). In addition, bacteria also have response mechanisms to drastic changes in temperature. The paradigms of this adaptation are the cold and heat shock response systems under which the bacteria induce a fast response to sudden and extreme temperature shift (Guisbert et ...
Medical genetics_1
Medical genetics_1

... 48 The action of mutant gene at monogenic pathology shows up: A Only by clinical symptoms; B On clinical, biochemical and cellular levels C Only on the particular stages of metabolism; D Only by the loss of function of protein E Does not show up clinically. ANSWER: B 49 What is the etiologic factor ...
Klf4 Organizes Long-Range Chromosomal
Klf4 Organizes Long-Range Chromosomal

... interactions and discovery of novel interactions locally and genome-wide (Dekker et al., 2002; Dixon et al., 2012; Fullwood et al., 2009; Lieberman-Aiden et al., 2009; Simonis et al., 2006; Zhao et al., 2006). Long-range interactions that recruit distant enhancers in cis and in trans have various bi ...
The Mutant of sll1961, Which Encodes a Putative
The Mutant of sll1961, Which Encodes a Putative

... PSII conducts a light-dependent oxidation of water and reduction of plastoquinone (for review, see Barber, 2002; Diner and Rappaport, 2002), while PSI is involved in a light-dependent electron transport from plastocyanin to NADP1 via ferredoxin (for review, see Fromme et al., 2001). The two light-de ...
Meiosis and Sexual Life Cycles
Meiosis and Sexual Life Cycles

... is equally important. A critical role of heredity is to maintain and obtain variation among members of a species. These variations are the result of the specific genes we inherit from our parents. We did not always know that genes were located on chromosomes. We didn't even know how genetic informat ...
anterior olfactory nucleus (aon) - Dashboard
anterior olfactory nucleus (aon) - Dashboard

... The anterior olfactory nucleus (AON) is a substructure of the olfactory areas, located within the rostral portion of the cerebral cortex. The AON is comprised of dorsal (AONd), external (AONe), lateral (AONl), medial (AONm) and posteroventral (AONpv) subdivisions. Rostrally, the AONe surrounds the r ...
P-Element Transformation with period Locus DNA Restores
P-Element Transformation with period Locus DNA Restores

... the array of behavioral phenotypes expressed by our transformants is not due merely to the fact that the various transformed flies carried only one dose of transduced per+ DNA (also, some of the flies we tested carried more than one dose, but were still long-period; see Experimental Procedures). We ...
Unit 30C Cell Division, Genetics, and Molecular
Unit 30C Cell Division, Genetics, and Molecular

... For most cells, the nuclear division that occurs during mitosis marks only a small part of their cycle. The stage between division phases, called interphase, is marked by a period of rapid growth (gap 1, or G1), the duplication of chromosomes (synthesis, or S), another period of growth (gap 2, or G2 ...
ACTIN-RELATED PROTEIN6 Regulates Female Meiosis By
ACTIN-RELATED PROTEIN6 Regulates Female Meiosis By

... events in megasporogenesis using a pSPL:GUS line (harboring the SPOROCYTELESS promoter fused to the b-glucuronidase reporter gene; Ito et al., 2004) as a marker for differentiation of the archesporial cell to a megasporocyte (Yang et al., 1999) at the distal end of each ovule primordium (Schneitz et ...
The E-Class PPR Protein MEF3 of Arabidopsis
The E-Class PPR Protein MEF3 of Arabidopsis

... The nuclear locus uniquely altered in Ler was mapped by following the phenotype of reduced editing through a genetic screen of about 200 individual F2 plants of a LerCol cross and its co-segregating linkage to ecotype-specific sequence variations to an interval of 0.5 Mb on chromosome 1 (Fig. 2A). ...
Analysis of Genetic Toggle Switch Systems Encoded on Plasmids
Analysis of Genetic Toggle Switch Systems Encoded on Plasmids

... Regulation processes in cells are performed by networks of interacting genes, which control each other’s expression [1,2]. In recent years these networks have been studied extensively in different organisms. It was proposed that the networks exhibit a modular structure [3–5]. In particular, they inc ...
PDF
PDF

... The continuous activity of meristems in which cells divide and produce new organs is a remarkable aspect of plant development. Primary meristems of angiosperm plants are laid down during embryogenesis. They contribute to post-embryonic development upon germination by producing organs and secondary m ...
Lesson Plan, GeneChip® Microarrays: Teacher`s Guide
Lesson Plan, GeneChip® Microarrays: Teacher`s Guide

... Before you do any planning for this activity, you should read the information about the structure and function of GeneChip microarrays found in the Activity #2 in the Student Manual. This reading has all the information you will need. If you are looking for further information and more background kn ...
the contribution of gene movement to the two rules of speciation
the contribution of gene movement to the two rules of speciation

... contribute to hybrid dysfunction and the Large X-effect depends upon the specific mechanism of gene movement and on details of developmental and reproductive biology of the X. We briefly introduce these mechanisms below, returning to the evidence for each in the next section. There are three mechani ...
ATP-dependent Clp Proteases in Photosynthetic Organisms~ A Cut
ATP-dependent Clp Proteases in Photosynthetic Organisms~ A Cut

... (Wang et al., 1997). Although compelling, several aspects of this proteolytic model still require experimental verification, in particular how the Clp\Hsp100 partners interact with ClpP at its apical surface, and how they recognize, bind and translocate the protein substrate into the proteolytic cha ...
Natural variation in nucleolar dominance reveals
Natural variation in nucleolar dominance reveals

... n genetic hybrids or allopolyploids, nucleoli often assemble at specific chromosomal loci of one parent but not the other. This phenomenon, known as nucleolar dominance (1–4), was initially discovered as a change in chromosome structure (5). At nucleolus organizer regions (NORs), the loci where nucl ...
FTZFactor1 and Fushi tarazu interact via conserved nuclear receptor
FTZFactor1 and Fushi tarazu interact via conserved nuclear receptor

... et al., 1988). Homeodomain-containing proteins are found in all metazoans and are key regulators of embryonic patterning (reviewed in Veraksa et al., 2000). Interestingly, FTZ can perform some of its regulatory functions in the absence of its homeodomain (Fitzpatrick et al., 1992; Copeland et al., 1 ...
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Polycomb Group Proteins and Cancer

The Polycomb-group proteins (PcGs) are a family of proteins that use epigenetic mechanisms to maintain or repress expression of their target genes. They were originally discovered in Drosophila (fruit flies), though they've been shown to be conserved in many species due to their vital roles in embryonic development. These proteins' ability to alter gene expression has made them targets of investigation for research groups seeking to understand disease pathology and oncology.
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