Genetics of Hemophilia
... Chromosomes are best seen in the nucleus when they are in the process of dividing and are somewhat spread out. At that time, the two copies, chromatids, are still attached at the center, the centromere. The tips of the chromosomes are called telomeres. The two chromatids and centromere look like the ...
... Chromosomes are best seen in the nucleus when they are in the process of dividing and are somewhat spread out. At that time, the two copies, chromatids, are still attached at the center, the centromere. The tips of the chromosomes are called telomeres. The two chromatids and centromere look like the ...
Computational Definition of
... the control, such that the central exon was now skipped 50% to 80% of the time instead of 10%. Interestingly, whereas PESS PS9 had almost no effect on splicing, insertion of 2 tandem 8-mers of this sequence was effective and 3 virtually abolished central exon splicing (Fig. 4C, columns 1 to 3). Sinc ...
... the control, such that the central exon was now skipped 50% to 80% of the time instead of 10%. Interestingly, whereas PESS PS9 had almost no effect on splicing, insertion of 2 tandem 8-mers of this sequence was effective and 3 virtually abolished central exon splicing (Fig. 4C, columns 1 to 3). Sinc ...
Selective Disruption of Aurora C Kinase Reveals Distinct Functions
... In germ cells, sperm and egg, an abnormal chromosome number leads to infertility, miscarriage, or, in the case of a live birth, developmental disorders such as Down Syndrome. For reasons not entirely clear, eggs are more prone to chromosome segregation mistakes than sperm. In this study, we study th ...
... In germ cells, sperm and egg, an abnormal chromosome number leads to infertility, miscarriage, or, in the case of a live birth, developmental disorders such as Down Syndrome. For reasons not entirely clear, eggs are more prone to chromosome segregation mistakes than sperm. In this study, we study th ...
Parallel Evolution of Copy-Number Variation across Continents in
... similar ecological gradients (e.g., Jones et al. 2012). Therefore, for each differentiated CNV detected on one continent, we asked whether it was also significantly differentiated on the other continent and in the same direction with respect to distance from the equator; that is, if allele A is at h ...
... similar ecological gradients (e.g., Jones et al. 2012). Therefore, for each differentiated CNV detected on one continent, we asked whether it was also significantly differentiated on the other continent and in the same direction with respect to distance from the equator; that is, if allele A is at h ...
Intellectual property rights and innovation: Evidence from
... on the upstream technologies could deter R&D on downstream products. For example, Bessen (2004) extends the Green and Scotchmer framework to show that if the downstream firm’s research costs are private information, the optimal licenses may not be offered, and socially desirable R&D investments may ...
... on the upstream technologies could deter R&D on downstream products. For example, Bessen (2004) extends the Green and Scotchmer framework to show that if the downstream firm’s research costs are private information, the optimal licenses may not be offered, and socially desirable R&D investments may ...
The amelogenin gene
... skipping exon 4 is a protein of 19.8 kDa with 175 amino acid residues and which trom Y is a 20 kDa protein with 176 amino acids. The methionine at residue 29 of the Y -chromosome amelogenin is absent from the X amelogenin, due to a 3-base deletion in the human X amelogenin gene. The overall sequence ...
... skipping exon 4 is a protein of 19.8 kDa with 175 amino acid residues and which trom Y is a 20 kDa protein with 176 amino acids. The methionine at residue 29 of the Y -chromosome amelogenin is absent from the X amelogenin, due to a 3-base deletion in the human X amelogenin gene. The overall sequence ...
Gene Section PML (promyelocytic leukemia) Atlas of Genetics and Cytogenetics
... Viguié F. PML (Promyelocytic leukemia). Atlas Genet Cytogenet Oncol Haematol 2000;4(4):193-194. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2015 Atlas of Genetics and Cytogenetics in Oncology and Haematology ...
... Viguié F. PML (Promyelocytic leukemia). Atlas Genet Cytogenet Oncol Haematol 2000;4(4):193-194. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence. © 2015 Atlas of Genetics and Cytogenetics in Oncology and Haematology ...
Huntingtin function during zebrafish (Danio rerio) development
... neurodegenerative diseases: expansion of an existing polyglutamine tract. In each case, this repeat tract occurs within otherwise unrelated proteins. These proteins show widespread and overlapping patterns of expression in the brain and yet the diseases are distinguished by neurodegeneration in a sp ...
... neurodegenerative diseases: expansion of an existing polyglutamine tract. In each case, this repeat tract occurs within otherwise unrelated proteins. These proteins show widespread and overlapping patterns of expression in the brain and yet the diseases are distinguished by neurodegeneration in a sp ...
Phylogenetic analysis of three complete gap
... from the zebrafish genome, some are found as single relatives, and others are found in multiple copies. In addition, the zebrafish has 14 apparently novel connexins, several of which arose by recent tandem duplication events. This analysis provides evidence that the connexin gene family is increasin ...
... from the zebrafish genome, some are found as single relatives, and others are found in multiple copies. In addition, the zebrafish has 14 apparently novel connexins, several of which arose by recent tandem duplication events. This analysis provides evidence that the connexin gene family is increasin ...
p68/DDX5 DEAD-box RNA helicase gene encodes a novel miRNA
... that while p68 RNA helicase activity appears to be important for some functions (e.g., RNA processing), it does not appear to be required for its role as a transcriptional coactivator. The p68 gene contains a large intron (intron 11, 1.2 kb in the human gene), which has been conserved through evolut ...
... that while p68 RNA helicase activity appears to be important for some functions (e.g., RNA processing), it does not appear to be required for its role as a transcriptional coactivator. The p68 gene contains a large intron (intron 11, 1.2 kb in the human gene), which has been conserved through evolut ...
Induced Adrenocortical Tumorigenesis in Mice
... Helsinki (A.K., M.P., H.P., M.H.) and Helsinki University Central Hospital, 00290 Helsinki, Finland ...
... Helsinki (A.K., M.P., H.P., M.H.) and Helsinki University Central Hospital, 00290 Helsinki, Finland ...
Auxin metabolism and homeostasis during plant development
... pathways were missing and the regulation of auxin metabolism was poorly understood, but genetic and biochemical evidence in combination with sensitive methods for auxin metabolite identification and quantification have greatly improved our knowledge in this respect. This Primer describes the recent ...
... pathways were missing and the regulation of auxin metabolism was poorly understood, but genetic and biochemical evidence in combination with sensitive methods for auxin metabolite identification and quantification have greatly improved our knowledge in this respect. This Primer describes the recent ...
Charles K. Wairuri , Jacquie E. van der Waals
... different pili (Fronzes et al. 2008), the type IV pili (T4P) are the most abundant pili described ...
... different pili (Fronzes et al. 2008), the type IV pili (T4P) are the most abundant pili described ...
Introduction to Genetics
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
BT314 Virology
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
... regulation — the processes that control the expression of genetic information. The focus in molecular genetics is the gene — its structure, organization, and function. Population genetics explores the genetic composition of groups of individual members of the same species (populations) and how that ...
Modified uridine at wobble position in tRNA of
... facilitated the identification of genes required for tRNA modification. So far, in S. cerevisiae 60 genes have been identified. These gene products include tRNA modifying enzymes as well as the proteins that in other ways are required for synthesis of the modified nucleosides (Table 1; Paper II). ...
... facilitated the identification of genes required for tRNA modification. So far, in S. cerevisiae 60 genes have been identified. These gene products include tRNA modifying enzymes as well as the proteins that in other ways are required for synthesis of the modified nucleosides (Table 1; Paper II). ...
Establishing neuroblast-specific gene expression in the Drosophila
... also activates hkb expression in a small cluster of row 7 neuroectodermal cells that produces the Hkb+ NB 7-3 (data not shown); NB 7-3 occasionally lacks Hkb protein in hh embryos (data not shown). In addition, we find that the post-S1 row 2 neuroblasts fail to form in hh embryos (data not shown). T ...
... also activates hkb expression in a small cluster of row 7 neuroectodermal cells that produces the Hkb+ NB 7-3 (data not shown); NB 7-3 occasionally lacks Hkb protein in hh embryos (data not shown). In addition, we find that the post-S1 row 2 neuroblasts fail to form in hh embryos (data not shown). T ...
Leukaemia Section 3q rearrangements in myeloid malignancies Atlas of Genetics and Cytogenetics
... Recently we demonstrated EVI1 involvement in other recurrent rearrangements such as: - t(2;3)(p13-p23;q26) - t(3;6)(q26;q25) - t(3;13)(q26;q14) - t(3;17)(q26;q22) In addition, EVI1 is involved in more rare rearrangements such as inv(3)(p12q26) inv(3)(q23q26) - t(3;3)(p24;q26) - t(3;5)(q26;q34) - t(3 ...
... Recently we demonstrated EVI1 involvement in other recurrent rearrangements such as: - t(2;3)(p13-p23;q26) - t(3;6)(q26;q25) - t(3;13)(q26;q14) - t(3;17)(q26;q22) In addition, EVI1 is involved in more rare rearrangements such as inv(3)(p12q26) inv(3)(q23q26) - t(3;3)(p24;q26) - t(3;5)(q26;q34) - t(3 ...
Identification of genes that interact with glp-1, a gene
... meiosis; therefore the glp-1 product must function throughout development for continued mitoses. A second glp-1 mutant phenotype is seen in conditional or leaky glp-1 mutants which can make enough germ cells to produce some embryos. Progeny of a homozygous glp-1 mutant mother inevitably die during e ...
... meiosis; therefore the glp-1 product must function throughout development for continued mitoses. A second glp-1 mutant phenotype is seen in conditional or leaky glp-1 mutants which can make enough germ cells to produce some embryos. Progeny of a homozygous glp-1 mutant mother inevitably die during e ...
How to recognize and diagnose chromosome rearrangements. David D. Perkins Background
... In most eukaryotes, chromosome rearrangements are recognized cytologically by visibly altered chromosome structure, or genetically by altered linkage relations. The first translocations in Neurospora were detected and verified using these methods (McClintock 1945, Houlahan et al. 1949). However, cha ...
... In most eukaryotes, chromosome rearrangements are recognized cytologically by visibly altered chromosome structure, or genetically by altered linkage relations. The first translocations in Neurospora were detected and verified using these methods (McClintock 1945, Houlahan et al. 1949). However, cha ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
... (AF15q14) • t(11;15)(q23;q14) → MLL - MPFYVE • t(11;15)(q23;q15) → MLL - AF15 • t(11;16)(q23;p13)/MDS, ANLL, t-ANLL, ALL → MLL - CREBBP (CBP) • t(11;17)(q23;p13)/t-ANLL → MLL - GAS7 • t(11;17)(q23;q21)/ANLL → MLL - ACACA • t(11;17)(q23;q21)/ANLL → MLL - LASP1 • t(11;17)(q23;q21)/ANLL → MLL - MLLT6 ( ...
... (AF15q14) • t(11;15)(q23;q14) → MLL - MPFYVE • t(11;15)(q23;q15) → MLL - AF15 • t(11;16)(q23;p13)/MDS, ANLL, t-ANLL, ALL → MLL - CREBBP (CBP) • t(11;17)(q23;p13)/t-ANLL → MLL - GAS7 • t(11;17)(q23;q21)/ANLL → MLL - ACACA • t(11;17)(q23;q21)/ANLL → MLL - LASP1 • t(11;17)(q23;q21)/ANLL → MLL - MLLT6 ( ...