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with notes for guidance
with notes for guidance

... It is inadmissible to dispense an antibiotic for an indication that has not yet been established at the time of dispensing. This is because the decision on the timing of administration and the animals to be treated must not be left to the animal keeper. The use of antibiotics always requires a diagn ...
Short term outcomes of topiramate monotherapy as a first
Short term outcomes of topiramate monotherapy as a first

... of TPM in patients with West syndrome who were refractory to conventional drugs. With high doses (up to 24 mg/kg/day, with a mean dose of 15.0±5.7 mg/kg/day) and rapid titration rates (raising doses every 2 to 3 days), 9 of 11 subjects, including 5 spasms-free patients, achieved a ≥50% reduction of ...
jakavi - GuildLink
jakavi - GuildLink

... Jakavi or matching placebo. The primary efficacy endpoint was proportion of subjects achieving ≥35% reduction from baseline in spleen volume at Week 24 as measured by MRI or CT. Secondary endpoints included duration of maintenance of a ≥35% reduction from baseline in spleen volume, proportion of pat ...
New Steps Aimed at Cutting Risks from Acetaminophen
New Steps Aimed at Cutting Risks from Acetaminophen

... • took more than the prescribed dose of an acetaminophen-containing product in a 24-hour period • took more than one acetaminophen-containing product at the same time • drank alcohol while taking the drug “There is no immediate danger to patients who take these combination pain medications and th ...
highlights of prescribing information
highlights of prescribing information

... in the clinical trials of another drug and may not reflect the rates observed in practice. Patients With Irritable Bowel Syndrome: Table 1 summarizes adverse reactions from 22 repeat-dose studies in patients with IBS who were treated with 1 mg of LOTRONEX twice daily for 8 to 24 weeks. The adverse r ...
Fuzeon® Prescribing Information
Fuzeon® Prescribing Information

... refrigerated in the original vial until use. Reconstituted FUZEON must be used within 24 hours. The subsequent dose of FUZEON can be reconstituted in advance and must be stored in the refrigerator in the original vial and used within 24 hours. Refrigerated reconstituted solution should be brought to ...
contents - Health Sciences Authority
contents - Health Sciences Authority

... drugs, outpatient setting investigation where it is likely that few patients were treated for severe or life-threatening infections, and the method of determination of cardiovascular deaths through death certificates instead of full medical records. Despite these, the study was noted to be methodolo ...
FDA Approval: Ibrutinib for Patients with Previously Treated Mantle
FDA Approval: Ibrutinib for Patients with Previously Treated Mantle

... present with generalized lymphadenopathy, and extranodal involvement is common. The median overall survival (OS) in patients with newly diagnosed MCL historically has been 3 to 4 years (4). First-line treatment regimens include multiagent chemotherapies; however, almost all patients eventually exper ...
Proscar - Merck.com
Proscar - Merck.com

... with PROSCAR. New reports of drug-related sexual adverse experiences decreased with duration of therapy. 6.2 Postmarketing Experience The following additional adverse events have been reported in postmarketing experience with PROSCAR. Because these events are reported voluntarily from a population o ...
Gilenya - Novartis Pharmaceuticals Corporation
Gilenya - Novartis Pharmaceuticals Corporation

... should be available. Consider suspending treatment with GILENYA if a patient develops a serious infection, and reassess the benefits and risks prior to reinitiation of therapy. Because the elimination of fingolimod after discontinuation may take up to 2 months, continue monitoring for infections thr ...
Product Information - Therapeutic Goods Administration
Product Information - Therapeutic Goods Administration

... mg/day, NUVIGIL® 250 mg/day or matching placebo. Patients treated with NUVIGIL ® showed a statistically significant improvement in the ability to remain awake compared to placebo-treated patients as measured by the MWT at final visit. A statistically significant greater number of patients treated wi ...
erlotinib - Cancer Care Ontario
erlotinib - Cancer Care Ontario

... sulfadiazine, (Adjei, 2001) or tetracycline may reduce the severity, but not the incidence of skin rashes. ...
Document
Document

...  Community prevalence of drug resistance If drug resistance is suspected based on any of the above factors, culture and susceptibility testing should be performed for at least INH and ...
Stroke and AF - West Suffolk Clinical Commissioning Group
Stroke and AF - West Suffolk Clinical Commissioning Group

... 1:4 individuals aged 40 years have a life time risk for developing AF In 2007, 6.3 million people in US, Japan and Europe were living with diagnosed AF. With an aging population now likely to double in 30 years. Prevalence of AF increases with age: 0.5% at 50-59 years Almost 9% at 80-89 years ...
correlations between ophthalmology and orthopedics
correlations between ophthalmology and orthopedics

... Eye diseases such as cataract, glaucoma and macular degeneration are common among the elderly [1-6]. These ocular pathologies, among many others, which produce significant vision problems, have been associated with an increased risk of falling by mechanism of tripping or lack of spotting the causati ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... randomized to receive inhaled budesonide. inhaled beclomethasonedipropionate, or non-corticosteroid treatment for two years, and the authors reported that there was no difference in the change of BMD Between the three groups. In our study, it had been significantly found that incidence of adverse ef ...
Glaucoma Handout 2016
Glaucoma Handout 2016

... administered bid. (acetazolamide) SR cap 500 mg bid has been better tolerated than tablets; Tab 125 mg q 4 hr to 250 mg qid. Dosages >1 g/day are not more effective. (Methazolamide) 50–100 mg bidtid. ...
Glaucoma Mikael Jones, Pharm.D., BCPS PHR 946 Spring 2015
Glaucoma Mikael Jones, Pharm.D., BCPS PHR 946 Spring 2015

... administered bid. (acetazolamide) SR cap 500 mg bid has been better tolerated than tablets; Tab 125 mg q 4 hr to 250 mg qid. Dosages >1 g/day are not more effective. (Methazolamide) 50–100 mg bidtid. ...
BESIVANCE  Potency and Broad-spectrum Activity for the Treatment of Bacterial Conjunctivitis
BESIVANCE Potency and Broad-spectrum Activity for the Treatment of Bacterial Conjunctivitis

... potency necessary to neutralize even resistant organisms. BESIVANCE® (besifloxacin ophthalmic suspension) 0.6% was developed specifically for ophthalmic use and approved for the treatment of bacterial conjunctivitis in 2009.7 Like other fluoroquinolones, its bactericidal activity is a result of inhi ...
Advanced Toxicology Lecture 3: Excretion
Advanced Toxicology Lecture 3: Excretion

... Transporters on hepatic parenchymal cells Many active transporters aid in excretion of acids, bases, neutrals and peptides Substances with molecular weight of 350-740 are preferentially excreted in bile versus urine, as well as thiol (glutathione) conjugates of mercury, lead, copper. ...
Take up one idea
Take up one idea

... • Cold compresses and saline irrigation to lower the elevated tear pH • In more severe cases, there is potential for damage to the eye caused by scratching and rubbing. Wear cotton gloves at night to prevent unintentional damage to the ocular surface. • Astringent drops, e.g. zinc sulphate, to re ...
I. 	 . Chemical Physical  Information A. 	 Synonyms:
I. . Chemical Physical Information A. Synonyms:

... thranbocytopenia on the ninth postoperative day. ...
SPIRIVA® 18 microgram, inhalation powder, hard capsule
SPIRIVA® 18 microgram, inhalation powder, hard capsule

... Description of selected adverse reactions In controlled clinical studies, the commonly observed undesirable effects were anti­cholinergic undesirable effects such as dry mouth which occurred in approximately 4% of patients. In 28 clinical trials, dry mouth led to discontinuation in 18 of 9,647 tiotr ...
Chapter 9 Drugs for Treating Asthma Case Study This is your first
Chapter 9 Drugs for Treating Asthma Case Study This is your first

... growth from inhaled corticosteroids; however, no effect on adult height has been demonstrated. The inhaled corticosteroids have significantly fewer adverse effects than systemic corticosteroids; therefore, systemic corticosteroids should only be used as chronic treatment in severe persistent asthma ...
Antibacterials - Harper College
Antibacterials - Harper College

... A beta-lactum structure (beta-lactum ring) interferes w/ bacterial cell wall synthesis by inhibiting the bacterial enzyme necessary for cell division & synthesis Bacteria die of cell lysis (breakdown) Both ‘static’ & ‘cidal’ in nature Mainly referred to as beta-lactum antibiotics (enzymes produced b ...
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Ofloxacin



Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.
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