Product Monograph Template - Standard
... In pre-marketing clinical trials, two (one with Sjögren’s Syndrome) out of 2,796 patients treated with REMERON® Tablets and one patient treated with imipramine developed agranulocytosis. In all three cases, the patients recovered after the drug with which they were being treated was stopped. In the ...
... In pre-marketing clinical trials, two (one with Sjögren’s Syndrome) out of 2,796 patients treated with REMERON® Tablets and one patient treated with imipramine developed agranulocytosis. In all three cases, the patients recovered after the drug with which they were being treated was stopped. In the ...
Item 90 : Nose and sinus infections in children and adults
... 2.3. Acute maxillary sinusitis This is the most common type of acute sinusitis. Typically, symptoms are worse in the evening and include throbbing pain under one eye aggravated by effort or lying down, nasal obstruction, and thick or even mucopurulent discharge sometimes streaked with blood, all on ...
... 2.3. Acute maxillary sinusitis This is the most common type of acute sinusitis. Typically, symptoms are worse in the evening and include throbbing pain under one eye aggravated by effort or lying down, nasal obstruction, and thick or even mucopurulent discharge sometimes streaked with blood, all on ...
adverse reactions were defined by any of the
... clinically significant arrhythmias, or who have a history of arrhythmia or angina. [See regardless of severity, were reported more frequently (≥5%) in patients age ≥60 years Adverse Reactions.] Renal Severe, including fatal, renal toxicity can occur after Rituxan receiving R-CHOP as compared to CHOP ...
... clinically significant arrhythmias, or who have a history of arrhythmia or angina. [See regardless of severity, were reported more frequently (≥5%) in patients age ≥60 years Adverse Reactions.] Renal Severe, including fatal, renal toxicity can occur after Rituxan receiving R-CHOP as compared to CHOP ...
Macrolide Antibiotics - Christchurch Drug Information Service
... similar efficacy. Dilution in 250mL of either normal saline or 5% dextrose, administered over 60 minutes into a large proximal vein is required to reduce phlebitis. In severe renal dysfunction (CrCl<0.5mL/s) the dose should be halved. Azithromycin’s oral availability is independent of food. A very l ...
... similar efficacy. Dilution in 250mL of either normal saline or 5% dextrose, administered over 60 minutes into a large proximal vein is required to reduce phlebitis. In severe renal dysfunction (CrCl<0.5mL/s) the dose should be halved. Azithromycin’s oral availability is independent of food. A very l ...
Antifungal agents for the treatment of systemic fungal infections in
... nal pain, vomiting, diarrhea and elevated liver en zymes. Given that itraconazole inhibits the cytochrome P450 3A4 enzyme, drug interactions are common. Clinical use in paediatrics: Itraconazole may be ad vantageous for prophylaxis in situations in which pre vention of Candida and Aspergillus inf ...
... nal pain, vomiting, diarrhea and elevated liver en zymes. Given that itraconazole inhibits the cytochrome P450 3A4 enzyme, drug interactions are common. Clinical use in paediatrics: Itraconazole may be ad vantageous for prophylaxis in situations in which pre vention of Candida and Aspergillus inf ...
PRODUCT MONOGRAPH ANAFRANIL - Sunovion Pharmaceuticals
... rodents after chronic administration of neuroleptic drugs. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusi ...
... rodents after chronic administration of neuroleptic drugs. Neither clinical studies nor epidemiologic studies conducted to date, however, have shown an association between chronic administration of these drugs and mammary tumorigenesis; the available evidence is considered too limited to be conclusi ...
Nasalox Insert
... Patients sensitive to other nasal decongestants may be sensitive to this medication also. Drug Interactions Oxymetazoline causes hypertensive crisis if used simultaneously with MAO inhibitor or Tricyclic antidepressant. Use in Pregnancy and Lactation Pregnancy: Pregnancy Category C. Avoid during pre ...
... Patients sensitive to other nasal decongestants may be sensitive to this medication also. Drug Interactions Oxymetazoline causes hypertensive crisis if used simultaneously with MAO inhibitor or Tricyclic antidepressant. Use in Pregnancy and Lactation Pregnancy: Pregnancy Category C. Avoid during pre ...
Pharmacology of Antidysrhythmic and Vasoactive Medications
... Cardioselectivity lost at high doses ...
... Cardioselectivity lost at high doses ...
08_opoids
... users who strain suspended drug through cotton balls or cigarette filters to remove particulates. Filters are boiled to extract residual drug when supply is low. Cotton is a known pyrogen and can cause a benign fever in patients who subsequently “shoot the cottons” or inject the extracted residue fr ...
... users who strain suspended drug through cotton balls or cigarette filters to remove particulates. Filters are boiled to extract residual drug when supply is low. Cotton is a known pyrogen and can cause a benign fever in patients who subsequently “shoot the cottons” or inject the extracted residue fr ...
Long-term Maintenance of Normal Sinus Rhythm in Patients With
... In patients receiving propafenone, the risk for AF relapse or side effects appeared to be highest during the first few months and greatly diminished afterwards. In patients receiving amiodarone, this risk appeared to remain constant throughout the period of observation, although after 18 months the ...
... In patients receiving propafenone, the risk for AF relapse or side effects appeared to be highest during the first few months and greatly diminished afterwards. In patients receiving amiodarone, this risk appeared to remain constant throughout the period of observation, although after 18 months the ...
Long-term Maintenance of Normal Sinus Rhythm
... In patients receiving propafenone, the risk for AF relapse or side effects appeared to be highest during the first few months and greatly diminished afterwards. In patients receiving amiodarone, this risk appeared to remain constant throughout the period of observation, although after 18 months the ...
... In patients receiving propafenone, the risk for AF relapse or side effects appeared to be highest during the first few months and greatly diminished afterwards. In patients receiving amiodarone, this risk appeared to remain constant throughout the period of observation, although after 18 months the ...
product information
... the α4β2 receptor subtype than to other common nicotinic receptors (>500-fold α3β4, >3,500fold α7, >20,000-fold α1βγδ), or to non-nicotinic receptors and transporters (>2,000-fold). Pharmacokinetics Absorption Maximum plasma concentrations of varenicline tartrate occur typically within 3-4 hours aft ...
... the α4β2 receptor subtype than to other common nicotinic receptors (>500-fold α3β4, >3,500fold α7, >20,000-fold α1βγδ), or to non-nicotinic receptors and transporters (>2,000-fold). Pharmacokinetics Absorption Maximum plasma concentrations of varenicline tartrate occur typically within 3-4 hours aft ...
Pharmacologic Control of Vomiting
... of nothing per os may be all that is required), fluid support, and antiemetics. Initial feeding includes small portions of a low fat, single source protein diet starting 6-12 hours after vomiting has ceased. Drugs used to control vomiting will be discussed here. The most effective antiemetics are th ...
... of nothing per os may be all that is required), fluid support, and antiemetics. Initial feeding includes small portions of a low fat, single source protein diet starting 6-12 hours after vomiting has ceased. Drugs used to control vomiting will be discussed here. The most effective antiemetics are th ...
Glucocorticoids
... prednisone/prednisolone q 24 hours in dog/cats. Injectable dexamethasone formulations are often confusing in their use in veterinary medicine. Dexamethasone solution is a 2 mg/mL solution of dexamethasone (free base) dissolved in polyethylene glycol due to the poor water solubility dexamethasone (fr ...
... prednisone/prednisolone q 24 hours in dog/cats. Injectable dexamethasone formulations are often confusing in their use in veterinary medicine. Dexamethasone solution is a 2 mg/mL solution of dexamethasone (free base) dissolved in polyethylene glycol due to the poor water solubility dexamethasone (fr ...
dbl™ adrenaline injection 1:10000
... Syncope has occurred following administration to asthmatic children. In patients with Parkinsonian syndrome the drug increases rigidity and tremor. Intra-arterial administration should be avoided since marked vasoconstriction may result in gangrene. Intramuscular injection into the buttocks should b ...
... Syncope has occurred following administration to asthmatic children. In patients with Parkinsonian syndrome the drug increases rigidity and tremor. Intra-arterial administration should be avoided since marked vasoconstriction may result in gangrene. Intramuscular injection into the buttocks should b ...
Product Monograph - AstraZeneca Canada
... 2-4 hours after dosing and are subject to a 4-fold variability. The plasma levels are proportional to dose over the range 50-400 mg and 6 to 16% of atenolol is bound to plasma proteins. The mean peak plasma concentrations of atenolol were approximately 300 and 700 nanogram/mL following 50 and 100 mg ...
... 2-4 hours after dosing and are subject to a 4-fold variability. The plasma levels are proportional to dose over the range 50-400 mg and 6 to 16% of atenolol is bound to plasma proteins. The mean peak plasma concentrations of atenolol were approximately 300 and 700 nanogram/mL following 50 and 100 mg ...
Headache - Well Care Pharmacy
... define a multiple-dose regimen. Howev¬ er, rescue medications were taken at the patient's discretion. It was not un¬ common for patients to self-medicate with rescue medication in anticipation of the return of headache or associated symptoms, in spite of being pain free. Significantly more adverse e ...
... define a multiple-dose regimen. Howev¬ er, rescue medications were taken at the patient's discretion. It was not un¬ common for patients to self-medicate with rescue medication in anticipation of the return of headache or associated symptoms, in spite of being pain free. Significantly more adverse e ...
Side Effects of Long-Term Oral Antiviral Therapy for
... doses of 30 mg/day was followed by development of milder degrees of nephrotoxicity in up to one-third of patients treated for more than 6 months.18 The frequency of nephrotoxicity led to the evaluation and ultimate approval of lower doses of adefovir (10 mg daily). At this dose, adefovir has only ra ...
... doses of 30 mg/day was followed by development of milder degrees of nephrotoxicity in up to one-third of patients treated for more than 6 months.18 The frequency of nephrotoxicity led to the evaluation and ultimate approval of lower doses of adefovir (10 mg daily). At this dose, adefovir has only ra ...
Long-term Maintenance of Normal Sinus Rhythm in Patients With
... In patients receiving propafenone, the risk for AF relapse or side effects appeared to be highest during the first few months and greatly diminished afterwards. In patients receiving amiodarone, this risk appeared to remain constant throughout the period of observation, although after 18 months the ...
... In patients receiving propafenone, the risk for AF relapse or side effects appeared to be highest during the first few months and greatly diminished afterwards. In patients receiving amiodarone, this risk appeared to remain constant throughout the period of observation, although after 18 months the ...
REMERON PRODUCT MONOGRAPH
... In pre-marketing clinical trials, two (one with Sjögren’s Syndrome) out of 2,796 patients treated with REMERON® Tablets and one patient treated with imipramine developed agranulocytosis. In all three cases, the patients recovered after the drug with which they were being treated was stopped. In the ...
... In pre-marketing clinical trials, two (one with Sjögren’s Syndrome) out of 2,796 patients treated with REMERON® Tablets and one patient treated with imipramine developed agranulocytosis. In all three cases, the patients recovered after the drug with which they were being treated was stopped. In the ...
Product Monograph - Paladin Labs Inc.
... drug is protein bound. Studies based on an in vitro model system using porcine brain endothelial cells have shown that ergot alkaloids such as ergotamine are able to cross the blood-brain barrier reaching the central nervous system (CNS) in a high concentration. Ergotamine is extensively metabolized ...
... drug is protein bound. Studies based on an in vitro model system using porcine brain endothelial cells have shown that ergot alkaloids such as ergotamine are able to cross the blood-brain barrier reaching the central nervous system (CNS) in a high concentration. Ergotamine is extensively metabolized ...
Pumpinox Esomeprazole Tablets 20mg and 40mg
... respect to embryonal/fetal development. Animal studies with the racemic mixture do not indicate direct or indirect harmful effects with respect to pregnancy, parturition or postnatal development. Caution should be exercised when prescribing to pregnant women. It is not known whether esomeprazole is ...
... respect to embryonal/fetal development. Animal studies with the racemic mixture do not indicate direct or indirect harmful effects with respect to pregnancy, parturition or postnatal development. Caution should be exercised when prescribing to pregnant women. It is not known whether esomeprazole is ...
Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas original article
... (ALCLs), embryonal carcinomas, and select subtypes of B-cell derived, non-Hodgkin’s lymphomas and mature T-cell lymphomas.10-12 Because normal expression of CD30 is highly restricted to a relatively small population of activated B cells and T cells and a small portion of eosinophils,10-12 the deleti ...
... (ALCLs), embryonal carcinomas, and select subtypes of B-cell derived, non-Hodgkin’s lymphomas and mature T-cell lymphomas.10-12 Because normal expression of CD30 is highly restricted to a relatively small population of activated B cells and T cells and a small portion of eosinophils,10-12 the deleti ...
lung transplant manual - UCSF | Department of Medicine
... Lung transplantation has become accepted therapy for the treatment of carefully chosen patients with end stage lung disease who have not benefited from available therapies. The treatment is highly successful, with more than 80 percent of patients surviving the first year and greater than 50% of pati ...
... Lung transplantation has become accepted therapy for the treatment of carefully chosen patients with end stage lung disease who have not benefited from available therapies. The treatment is highly successful, with more than 80 percent of patients surviving the first year and greater than 50% of pati ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.