Dextromethorphan (DXM)
... commence. DMX is subject to significant first-pass metabolism, thereby reducing its bioavailability. Its half-life is 2 to 4 hours. The duration of the effect is approximately 3 to 8 hours, depending on the dose. The rate of metabolism varies between individuals and some may be more susceptible to t ...
... commence. DMX is subject to significant first-pass metabolism, thereby reducing its bioavailability. Its half-life is 2 to 4 hours. The duration of the effect is approximately 3 to 8 hours, depending on the dose. The rate of metabolism varies between individuals and some may be more susceptible to t ...
Product Monograph
... Animal studies have shown that RBV causes birth defects and/or fetal deaths (see CONTRAINDICATIONS and RBV prescribing information). Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to RBV; therefore, RBV is contraindicated in women who are preg ...
... Animal studies have shown that RBV causes birth defects and/or fetal deaths (see CONTRAINDICATIONS and RBV prescribing information). Significant teratogenic and/or embryocidal effects have been demonstrated in all animal species exposed to RBV; therefore, RBV is contraindicated in women who are preg ...
Sodium Nitroprusside
... Toxicity may occur, particularly with prolonged infusion (>48 hours) or higher than recommended maximum dose, due to accumulation of cyanide or thiocyanate. In normal renal function cyanide accumulates with infusion rate of >2 microgram/kg/minute. Risk of toxicity is greater in renal impairment beca ...
... Toxicity may occur, particularly with prolonged infusion (>48 hours) or higher than recommended maximum dose, due to accumulation of cyanide or thiocyanate. In normal renal function cyanide accumulates with infusion rate of >2 microgram/kg/minute. Risk of toxicity is greater in renal impairment beca ...
Controlled Substance Prior Authorization
... agonist-antagonists, or partial agonists by their activity at opioid receptors. There are three major classes of opioid receptors in the central nervous system (CNS): mu, kappa, and delta. Mu-receptor activation causes analgesia, respiratory depression, miosis, reduced GI motility, and euphoria. Kap ...
... agonist-antagonists, or partial agonists by their activity at opioid receptors. There are three major classes of opioid receptors in the central nervous system (CNS): mu, kappa, and delta. Mu-receptor activation causes analgesia, respiratory depression, miosis, reduced GI motility, and euphoria. Kap ...
Long-acting Beta-Agonists with and without Inhaled Corticosteroids and Catastrophic Asthma Events
... this meta-analysis are based on a relatively small number of events, so they should be interpreted with caution. However, these findings provide evidence that long-acting -agonists are associated with significant risk, even when used with concomitant inhaled corticosteroids. This is the first meta- ...
... this meta-analysis are based on a relatively small number of events, so they should be interpreted with caution. However, these findings provide evidence that long-acting -agonists are associated with significant risk, even when used with concomitant inhaled corticosteroids. This is the first meta- ...
Treatment of interface keratitis with oral corticosteroids
... medical history and surgical records. During this period, all eyes that developed grade 3 or higher interface keratitis (Linebarger classification)18 were treated with a high-dose oral corticosteroid (prednisone). Patients were questioned about past medical conditions to exclude a history of tubercu ...
... medical history and surgical records. During this period, all eyes that developed grade 3 or higher interface keratitis (Linebarger classification)18 were treated with a high-dose oral corticosteroid (prednisone). Patients were questioned about past medical conditions to exclude a history of tubercu ...
Ritalin LA
... Alcohol may exacerbate the adverse CNS effects of psychoactive drugs, including Ritalin. It is therefore advisable for patients to abstain from alcohol during treatment. An in vitro study was conducted to explore the effect of alcohol on the release characteristics of methylphenidate from the Ritali ...
... Alcohol may exacerbate the adverse CNS effects of psychoactive drugs, including Ritalin. It is therefore advisable for patients to abstain from alcohol during treatment. An in vitro study was conducted to explore the effect of alcohol on the release characteristics of methylphenidate from the Ritali ...
Ritalin LA - Novartis Pharmaceuticals Corporation
... Alcohol may exacerbate the adverse CNS effects of psychoactive drugs, including Ritalin. It is therefore advisable for patients to abstain from alcohol during treatment. An in vitro study was conducted to explore the effect of alcohol on the release characteristics of methylphenidate from the Ritali ...
... Alcohol may exacerbate the adverse CNS effects of psychoactive drugs, including Ritalin. It is therefore advisable for patients to abstain from alcohol during treatment. An in vitro study was conducted to explore the effect of alcohol on the release characteristics of methylphenidate from the Ritali ...
Intramuscular aripiprazole for the treatment of agitation in
... propensity for several adverse effects that sometime limit the clinical use of other drugs 19. The efficacy of oral aripiprazole on the positive and negative symptoms of schizophrenia and its tolerability have been extensively reviewed elsewhere 11 20. As reported for oral aripiprazole 11, the pharm ...
... propensity for several adverse effects that sometime limit the clinical use of other drugs 19. The efficacy of oral aripiprazole on the positive and negative symptoms of schizophrenia and its tolerability have been extensively reviewed elsewhere 11 20. As reported for oral aripiprazole 11, the pharm ...
ASMANEX™ TWISTHALER™ PRODUCT MONOGRAPH
... Hepatic/Biliary/Pancreatic There is an enhanced effect of corticosteroids on patients with cirrhosis. Immune Corticosteroids may mask some signs of infections and new infections may appear. Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy indi ...
... Hepatic/Biliary/Pancreatic There is an enhanced effect of corticosteroids on patients with cirrhosis. Immune Corticosteroids may mask some signs of infections and new infections may appear. Persons who are on drugs which suppress the immune system are more susceptible to infections than healthy indi ...
tenofovir disoproxil fumarate
... HBV coinfected patients as part of an appropriate antiretroviral combination therapy. HIV antibody testing should be offered to all HBV-infected patients before initiating therapy with VIREAD. It is also recommended that all patients with HIV be tested for the presence of chronic hepatitis B before ...
... HBV coinfected patients as part of an appropriate antiretroviral combination therapy. HIV antibody testing should be offered to all HBV-infected patients before initiating therapy with VIREAD. It is also recommended that all patients with HIV be tested for the presence of chronic hepatitis B before ...
5 Hypertension PREP
... apnea syndrome (OSAS) need to be considered. In the United States, more that 9 million children or youth older than 6 years of age are obese, (3) defined as having a BMI ⱖ95th percentile according to the age- and sexspecific Centers for Disease Control and Prevention BMI charts. Compared with nonobe ...
... apnea syndrome (OSAS) need to be considered. In the United States, more that 9 million children or youth older than 6 years of age are obese, (3) defined as having a BMI ⱖ95th percentile according to the age- and sexspecific Centers for Disease Control and Prevention BMI charts. Compared with nonobe ...
ASPIRIN 75 mg, WHICH FORMULATION?
... mucosa from local irritation although duodenal damage can still occur.4 Results from several endoscopic studies in healthy volunteers support this hypothesis, gastric erosion6-10 and micro-bleeding6-8 being less in those who used the enteric-coated preparation. It is known that these lesions are not ...
... mucosa from local irritation although duodenal damage can still occur.4 Results from several endoscopic studies in healthy volunteers support this hypothesis, gastric erosion6-10 and micro-bleeding6-8 being less in those who used the enteric-coated preparation. It is known that these lesions are not ...
Risperdal Label
... The safety and effectiveness of RISPERDAL® in pediatric patients with autistic disorder less than 5 years of age have not been established. The dosage of RISPERDAL® should be individualized according to the response and tolerability of the patient. The total daily dose of RISPERDAL® can be administe ...
... The safety and effectiveness of RISPERDAL® in pediatric patients with autistic disorder less than 5 years of age have not been established. The dosage of RISPERDAL® should be individualized according to the response and tolerability of the patient. The total daily dose of RISPERDAL® can be administe ...
Scleral inflammations: An update - All India Ophthalmological Society
... subsequently “Hot eyes” by Hutchinson. The name “episcleritis” was first used by Fuchs, who described the condition as “episcleritis periodica fugax” in 1895. Episcleritis is seen more frequently in young to middle-aged women. The chief complaint of patients with episcleritis is usually ocular redne ...
... subsequently “Hot eyes” by Hutchinson. The name “episcleritis” was first used by Fuchs, who described the condition as “episcleritis periodica fugax” in 1895. Episcleritis is seen more frequently in young to middle-aged women. The chief complaint of patients with episcleritis is usually ocular redne ...
Product Information: Taladafil
... is no clinically relevant effect of food on the rate and extent of absorption of tadalafil, thus tadalafil may be taken with or without food. The time of dosing (morning versus evening) has no clinically relevant effects on the rate and extent of absorption. The absolute bioavailability of oral tada ...
... is no clinically relevant effect of food on the rate and extent of absorption of tadalafil, thus tadalafil may be taken with or without food. The time of dosing (morning versus evening) has no clinically relevant effects on the rate and extent of absorption. The absolute bioavailability of oral tada ...
Ilotycin - Perrigo
... Pregnancy: Teratogenic effects —Pregnancy category B. Reproduction studies have been performed in rats, mice, and rabbits using erythromycin and its various salts and esters, at doses that were several multiples of the usual human dose. No evidence of harm to the fetus that appeared related to eryth ...
... Pregnancy: Teratogenic effects —Pregnancy category B. Reproduction studies have been performed in rats, mice, and rabbits using erythromycin and its various salts and esters, at doses that were several multiples of the usual human dose. No evidence of harm to the fetus that appeared related to eryth ...
Xenazine® 25 mg
... dihydrotetrabenazine. The majority of the observed metabolites appear to be formed from these dihydrotetrabenazines as a result of O-dealkylation, hydroxylation and conjugation. No significant build-up has been observed after daily administration. The elimination half-life of dihydrotetrabenazine is ...
... dihydrotetrabenazine. The majority of the observed metabolites appear to be formed from these dihydrotetrabenazines as a result of O-dealkylation, hydroxylation and conjugation. No significant build-up has been observed after daily administration. The elimination half-life of dihydrotetrabenazine is ...
quality evidence - American Pain Society
... cases of cardiac arrhythmias (including 80 deaths) from 1993 to 1999 85% of cisapride-associated arrhythmias occurred with known risk factors ECG monitoring recommended for a number of drugs associated with prolonged ...
... cases of cardiac arrhythmias (including 80 deaths) from 1993 to 1999 85% of cisapride-associated arrhythmias occurred with known risk factors ECG monitoring recommended for a number of drugs associated with prolonged ...
(Dihydroergotamine mesylate) Nasal Spray 4 mg/mL
... In subjects (n=10) with suspected coronary artery disease undergoing angiography, a 5-HT1 agonist at a subcutaneous dose of 1.5 mg produced an 8% increase in aortic blood pressure, an 18% increase in pulmonary artery blood pressure, and an 8% increase in systemic vascular resistance. In addition, mi ...
... In subjects (n=10) with suspected coronary artery disease undergoing angiography, a 5-HT1 agonist at a subcutaneous dose of 1.5 mg produced an 8% increase in aortic blood pressure, an 18% increase in pulmonary artery blood pressure, and an 8% increase in systemic vascular resistance. In addition, mi ...
Use of Thromboelastography (TEG) for Detection of New Oral
... available tests, including thrombin time, ecarin clotting time, Heptest (American Diagnostica, Stamford, Connecticut), prothrombinase-induced clotting time, and chromogenic factor IIa, either do not correlate well with drug levels or are cumbersome and lengthy to perform. The difficulty of managing ...
... available tests, including thrombin time, ecarin clotting time, Heptest (American Diagnostica, Stamford, Connecticut), prothrombinase-induced clotting time, and chromogenic factor IIa, either do not correlate well with drug levels or are cumbersome and lengthy to perform. The difficulty of managing ...
Revealing the secrets - Canadian Healthcare Network
... and/or gastrointestinal (GI) adverse events, other management strategies that do NOT include the use of NSAIDs should be considered first. Use of VIMOVO should be limited to the lowest effective dose for the shortest possible duration of treatment in order to minimize the potential risk for cardiovas ...
... and/or gastrointestinal (GI) adverse events, other management strategies that do NOT include the use of NSAIDs should be considered first. Use of VIMOVO should be limited to the lowest effective dose for the shortest possible duration of treatment in order to minimize the potential risk for cardiovas ...
Consumption of antibacterial agents
... agents, the number of patient’s days on an estimated clinical dose, or as a defined daily dose (DDD). The DDD for an active pharmaceutical substance is the average maintenance dose used for its major indication in adults (9). All units except the proportion of prescription with antibacterial agents ...
... agents, the number of patient’s days on an estimated clinical dose, or as a defined daily dose (DDD). The DDD for an active pharmaceutical substance is the average maintenance dose used for its major indication in adults (9). All units except the proportion of prescription with antibacterial agents ...
CYANOKIT® Administration Guide
... Substantial increases in blood pressure may occur following CYANOKIT therapy. Elevations in blood pressure (≥180 mmHg systolic or ≥110 mmHg diastolic) were observed in approximately 18% of healthy subjects receiving hydroxocobalamin 5 g and 28% of subjects receiving 10 g. Usage may interfere with so ...
... Substantial increases in blood pressure may occur following CYANOKIT therapy. Elevations in blood pressure (≥180 mmHg systolic or ≥110 mmHg diastolic) were observed in approximately 18% of healthy subjects receiving hydroxocobalamin 5 g and 28% of subjects receiving 10 g. Usage may interfere with so ...
Ibuprofen and paracetamol for patent ductus arteriosus
... in premature infants during treatment for PDA [7]. Desfrere et al. demonstrated, in double blind randomized study in a cohort of infants of ≤ 29 weeks of gestational age, that the currently recommended dose regimen of ibuprofen (10-5-5 mg/kg/day) is associated with a low estimated probability (30.6% ...
... in premature infants during treatment for PDA [7]. Desfrere et al. demonstrated, in double blind randomized study in a cohort of infants of ≤ 29 weeks of gestational age, that the currently recommended dose regimen of ibuprofen (10-5-5 mg/kg/day) is associated with a low estimated probability (30.6% ...
Ofloxacin
Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.