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Antifungal Agents
Antifungal Agents

... - Cyclosporin and phenytoin inhibit its metabolism and hence increase ketokonazole toxicity - Warfarin and rifampin increase its metabolism and hence decrease concentration (shorten its DOA) - H2 blockers, antacids, proton pump inhibitors and sucralfate decrease its absorption ...
Express Scripts Drug Information & Wellness Center Pharmacy in the News:
Express Scripts Drug Information & Wellness Center Pharmacy in the News:

... Drug Information Question of the Month: Question: Does a negative hepatitis B antibody (HbsAb) titer warrant revaccination with the HepB vaccine? HBsAB or anti-HBs test for a successful response to the hepatitis B vaccine (HBV). (1) A positive or reactive result means the patient is immune to future ...
Antifungal Agents
Antifungal Agents

... - Cyclosporin and phenytoin inhibit its metabolism and hence increase Ketokonazole toxicity - Warfarin and Rifampin increase its metabolism and hence decrease concentration (shorten its DOA) - H2 blockers, Antacids, proton pump inhibitors and Sucralfate decrease its absorption ...
Attachment: Product Information: Vismodegib
Attachment: Product Information: Vismodegib

... staging, or morphology were observed. A decrease in the number of corpora lutea was observed in female rats treated for 26 weeks at 100 mg/kg/day (corresponding to 1.1-fold of the estimated AUC0-24h steady-state exposure at the recommended human dose), and was not reversed by the end of an 8-week re ...
Methylprednisolone
Methylprednisolone

... The more drugs that are taken, the more likely that DI will occur Often under-reported as they mimic exaggerated action of drug ...
MGB-BP-3 - MGB Biopharma
MGB-BP-3 - MGB Biopharma

... 2 & 3. www.hps.scot.nhs.uk & www.gov.uk/government/organisations/public-health-england ...
FDA Advisory Panel Recommends Approval of Tysabri
FDA Advisory Panel Recommends Approval of Tysabri

... either the active drug at a dose of 300 mg (n = 627) or placebo (n = 315) every 4 weeks. Both groups were treated for more than 2 years. Among patients treated with the active drug, the rate of clinical relapse was diminished by 68% and the number of new or enhancing MRI lesions was reduced by 83%. ...
the treatment of parkinson`s disease
the treatment of parkinson`s disease

... Levodopa (L-dopa)& Dopa Decarboxylase Inhibitors (DDCI) L-dopa remains the most effective symptomatic treatment for PD.1,6,9,10 It is converted to dopamine within the central nervous system, and when combined with a DDCI reduces unwanted peripheral effects. This allows a lower dose of L-dopa to be u ...
Drugs used for Alzheimer disease
Drugs used for Alzheimer disease

... extension of CNS depressant action ,tolerance, dependence liability> ...
ramadan and cardiovascular drug use
ramadan and cardiovascular drug use

... Aldouni A, Ghamil N, Sail R, et al: Beneficial effect on serum APO B and LPAT levels of Ramadan fasting. Clin ...
P-RMS
P-RMS

... For those patients receiving cardiovascular drug therapy including diuretics and/or digoxin and/or ACE inhibitors and/or angiotensin II antagonists, dosing of these drugs should be stabilised during the past two weeks prior to initiation of treatment. ...
tresaderm
tresaderm

... Caution(s): Federal law restricts this drug to use by or on the order of a licensed veterinarian. On rare occasions dogs may be sensitive to neomycin. In these animals, application of the drug will result in erythema of the treated area, which may last for 24 to 48 hours. Also, evidence of transient ...
No significant differences were found between the two groups in
No significant differences were found between the two groups in

... Limited duration of use No information on safety/interactions with other medications ...
(lurasidone HCl) Treatment Resulted in Higher
(lurasidone HCl) Treatment Resulted in Higher

... movements that can develop in patients with antipsychotic drugs. There is no known treatment for established cases of TD, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. The risk of developing TD and the likelihood that it will become irreversible a ...
Equianalgesic Chart (Page 1)
Equianalgesic Chart (Page 1)

... Longer acting than morphine when given repeatedly. Long half-life can lead to accumulation within 2-3 days of repeated dosing. No longer preferred as a first-line opioid for the management of acute or chronic pain due to potential toxicity from accumulation of metabolite, normeperidine. Normeperidin ...
PowerPoint File
PowerPoint File

... tachycardia were randomized 1:1 to either intravenous procainamide (single dose 10 mg/kg) or intravenous amiodarone (single dose 5 mg/kg). They were followed for 1 day. ...
Durogesic Article-30 referral
Durogesic Article-30 referral

... fever or external heat application, and cautionary statements on interchangeability have been deleted as local guidance is required to be followed on the distribution of fentanyl patches, which may differ between Member States. Other warnings included in section 4.4 are: chronic pulmonary disease, d ...
Treating Psoriasis - Society of Nurses in Advanced Practice
Treating Psoriasis - Society of Nurses in Advanced Practice

... upper respiratory tract infections being the most common – Serious infections are uncommon, with patients with underlying predisposing medical conditions being more at risk – In the event of an infection requiring an antibiotic the TNF Inhibitor should be withheld, and more serious infections or opp ...
Prior Authorization Protocol ENTRESTO™ (sacubitril
Prior Authorization Protocol ENTRESTO™ (sacubitril

... in patients with chronic heart failure NYHA (New York Heart Association) Class II-IV and reduced ejection fraction Usually administered in conjunction with other heart failure therapies, in place of an angiotensin converting enzyme (ACE) inhibitor or other angiotensin II receptor blockers (ARB) ...
TB lecture - Mayo Clinic Center for Tuberculosis
TB lecture - Mayo Clinic Center for Tuberculosis

... Were only 4 manufactures of isoniazid tablets = Versapharm, West-Ward, Sandoz, Teva ...
Chemotherapeutic agents are used to treat a variety of disease
Chemotherapeutic agents are used to treat a variety of disease

... The American College of Chest Physicians recently released an updated clinical practice guideline for antithrombotic therapy for venous thromboembolism (VTE) disease (January 2016).1 There is much discussion regarding the update and questions about the practical implications of the recommended chang ...
Antiprotozoal Drugs
Antiprotozoal Drugs

... • Adverse Effects and Cautions – Nausea, headache, dry mouth, a metallic taste in the mouth. – Infrequent: vomiting, diarrhea, rash, insomnia, neutropenia, …… – Rare: severe central nervous system toxicity ( ataxia, encephalopathy(脑病), seizures)——drug withdrawal – Has a disulfiram(双硫仑,乙醛脱氢酶抑制药)-lik ...
7-Antiparasitic Chemotherapy
7-Antiparasitic Chemotherapy

... redical injury) • Disulfiram effect ...
Geriatric Medicine Update for General Practitioners
Geriatric Medicine Update for General Practitioners

... • Selection of antidepressant usually based on previous response to the drug: – trazodone (50mg at bedtime) – sedating and useful with agitated depression and insomnia – also consider nortriptyline 10mg at bedtime – Sertraline 25-50mg per day (proven effective in clinical trials, may especially be u ...
28 life - Dr. Mel Borins
28 life - Dr. Mel Borins

... Drugs that act directly on the renin-angiotensin system can cause fetal and neonatal morbidity and mortality when administered to pregnant women. If pregnancy is detected, MICARDIS® (telmisartan) should be discontinued as soon as possible. The use of drugs that act directly on the renin-angiotensin ...
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Ofloxacin



Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.Ofloxacin was first patented in 1982 (European Patent Daiichi) and received approval from the U.S. Food and Drug Administration (FDA) on December 28, 1990. Ofloxacin is sold under a wide variety of brand names as well as generic drug equivalents, for oral and intravenous administration. Ofloxacin is also available for topical use, as eye drops and ear drops (marketed as Ocuflox and Floxin Otic respectively in the United States and marketed as Optiflox, eylox respectively in Jordan and Saudi Arabia).Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin.Ofloxacin has been associated with adverse drug reactions, such as tendon damage (including spontaneous tendon ruptures) and peripheral neuropathy (which may be irreversible); tendon damage may manifest long after therapy had been completed, and, in severe cases, may result in lifelong disabilities.
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