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Drugs used for Alzheimer disease Generic name Manufacturer Distributer CLINICAL USES 1.Galantamine Trade name Reminyl Janssen Mina drug store Used to treat mild to moderate Alzheimer disease 2.Rivastigmine Exelon Novartis 3.Donepezil Aricept 4.Memantine Ebixa SIDE EFFECTS Nausea vomiting, diarrhea, dizziness, loss of appetite, weight loss CONTRAINDICATIONS Exelon should not be given to : Patients with hypersensitivity to rivastigmine or any excipient. Pregnant women & breast feeding mothers. Donepezil (Aricept) should be used with caution in patient with cardiac disease, cardiac conduction disturbances, chronic obstructive pulmonary disease, asthma. مستودع األدوية األردني Used to treat mild to moderate Alzheimer disease Nausea Vomiting Weight loss Diarrhea Loss of apetite Eisai (japan) Nairoukh drug store Used to treat mild to moderate Alzheimer disease Dizziness Insomnia Generalized pain Nausea vomitting Lundbeck Ltd مستودع أبو شريف It prevents the rate of memory loss in Alzheimer disease Headache Sleepiness Constipation Dizziness High blood pressure Reminyl is contraindicated in patients with hypersensitivity to galantamine or other excipients and also in patients with severe hepatic impairement. Ebixa should not be given to: Patients with hypersensitivity to donepezil or any excipients. Pregnant women & breast feeding mothers.. Drugs for psychiatric disorders Generic Trade Name name `1.Haloperido Serenace l Haldol Manufacturer Distributers Clinical uses Side effects Pfizer Al sabbagh drug store Mina drug store Acute psychosis & acute manic phases. 2.Clozapine Leponex Novartis Clozapin e Remidica The Jordan drug store Al salem drug store Management of psychotic disorders including schizophrenia. Extrapyramidal dysfunction, blurred vision, insomnia, and hair loss,Constipati on; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea;stomac h upset. Agranulocytosi s Diabetes Weight gain Prexal Joswe Zyprexa Lilly Schizophrenia Bipolar disorders Pranza Hikma Trust drug store مستودع أمين شقير Hikma drug store Diabetes,Weig ht gain,gynecoma stia, galactorrhea,in creased blood pressure Risperdal Janssen-cilag Respal Joswe Rispharm Pharma international Mina drug store Trust drug store Jerusalem drug store Acute and chronic schizophrenic psychoses& psychotic conditions.use Hyperprolacten emia Insomnia Agitation Headache anxiety 3.Olanzapine 4.Risperidon e Janseen pharmaceutica contraindicatio ns Contraindicate d in patients with CNS depression, parkinsonism, in coma individuals with uncontrolled epilepsy, myeloproliferat ive disease, or agranulocytosis with prior clozapine treatment should not be given clozapine products. Should not be given to patients with hypersensitivit y to olanzapine or other ingredients, also it should not be given to pregnant females & lactating mothers. Pregnant females and breast feeding mothers as well as patients with d also for manic episodes in bipolar disordes. 5.Quetiapine Seroquel Astrazeneca Omnia drug store Treatment of schizophrenia, manic and depressive episodes in bipolar disorders. Somnolence Dizziness Dry mouth Mild asthenia Constipation Tachycardia Orthostatic hypotension dyspepsia 6.Ziprasidone Zeldox Pfizer Al sabbagh drug store Treatment of schizophrenia. Asthenia Headache Constipation Dry mouth Dyspepsia Nausea Vomiting somnolence 7. Lithium carbonate Camcolit Norgine Khory drug store Bipolar affective disorders Tremor Edema Hypothyroidis m Renal dysfunction hypersensitivit y to risperidone or other excipients should not use any of resperidone products. Patients with hypersensitivit y to Quetiapine or any other ingredient as well as pregnant females & breast feeding mothers should not use seroquel. Patients with hypersensitivit y to ziprasidone or any of the excipients ,patients with known QT prolongation or recent MI, as well as pregnant and breast feeding females should not use zeldox. Lithium clearance is reduced by diuretics,NSAID 's. Drugs used for Epilepsy Generic Name Phenytoin Trade name Epanutin Carbatol Manufacturer Park-Davis Dar AL Dawa Distributers Clinical uses Side effects contraindications Sabbagh generalized tonic-clonic and partial seizure. ataxia , diplopia, gingival hyperplasia, hirsutism , neuropathy if you are allergic (hypersensitive) to Phenytoin, or any of the other ingredients Dar AL Dawa Carbamazepine Tegretol Clonazepam Rivotril Novartis Jerdana F.Hoffmann La- Roche Shawi & Rushedat Drug Store generalized tonic-clonic and partial seizure. ataxia , diplopia, headache, nausia absence and myoclonic seizures , infantile spasm sedation * allergic to carbamazepine or to any ingredients of the tablets or suspension * allergic to tricyclic compounds such as amitriptyline, trimipramine, or imipramine *has liver disease *has a history of acute intermittent porphyria *has a history of hyponatremia *has a serious blood disorder *has a history of bone marrow depression *has taken an MAO inhibitor within the past 14 days or will take one within the next 14 days *has certain kinds of heart rhythm disturbances (AV block) Clonazepam should not be used in patients with a history of sensitivity to benzodiazepines or in patients with significant liver dysfunctioin. It is also contraindicated in patients with acute narrow angle glaucoma Neurotin Pfizer Pregabalin Lyrica Lamictal Al-Hikma Pfizer gsk Sabbagh Tannos loxol Al-Hikma Al-Hikma Epitam Al-Hikma Al-Hikma Leveliracetam Topiramate Topamax UCB Pharmaceutica ls Inc. Janssen Cilag partial seizure ataxia ,dizzeness, somnolence You should not use Lyrica if you are allergic to pregabalin. Al-Hikma Lamotrigine Keppra ataxia ,dizzeness, somnolence Sabbagh Gababentin Gabatrex generalized tonic-clonic and partial seizure. Patients who are allergic to gabapentin or other ingredients should not take gabapentin. Gabapentin may worsen absence and myoclonic seizures, so caution should be observed if the patient might have these seizure types. Tannos Ninos generalized tonicclonic,partial, myoclonic,and absence seizure. dizzenes,diplopia , headache , rash Generalized tonic clonic and partial seizures dizzenes, nervousness , depression , seizures. generalized tonicclonic,partial, and absence seizure sleepness , cognitive slowing ,confusion , paresthesia. lamotrigine is contraindicated in patients who have demonstrated hypersensitivity to the drug or its ingredients This product should not be administered to patients who have previously exhibited hypersensitivity to levetiracetam or any of the inactive ingredients Patients who are allergic to topiramate should not take Topamax. Patients with a history of kidney stones or those taking high-dose vitamin C or calcium supplementation should not take Topamax because of the increased risk of kidney stones. Sedatives and Hypnotics Generic Name Zolpidem Tartarat diazepam Trade name stilnox Stedon Manufacturer sanofisynthellabo Adelco Distributers Clinical uses Side effects Nabulsi drug store Initiate and maintain sleep in insomnia patients. • drowsiness • dizziness • headache • diarrhoea, nausea and vomiting • muscle weakness Jarzeem drug store Anxiety disorders and symptomatic treatment of organic anxiety Insomnia associated with anxiety. It is also used in status epilepticus, alcohol withdrawal syndrome as adjunctive therapy, as muscle relaxant and in anesthesia. drowsiness, fatigue, and ataxia (loss of balance) contraindications Do not take STILNOX if you have: • been drinking alcohol or you believe that you may have alcohol in your bloodstream • sleep apnoea • myasthenia gravis • severe liver problems • acute and/or severe lung problems • Do not take STILNOX if you are allergic to it or any of the ingredients *Serious Myasthenia *Hypersensitivity to benzodiazepines or to any of the excipients *Severe respiratory insufficiency *The syndrome of sleeping apnea *Serious liver insufficiency *Acute pulmonary insufficiency *Injections containing benzyl alcohol should be avoided in neonates *Caution is required when diazepam is administered in patients with narrow angle glaucoma DIAZEPAM + CLIDINIUM BROMIDE Lorazepam DISTEDON Adelco Jarzeem drug store Lorans-1 Medochemie/ Cyprus alHilal drug store xanax Pfizer khouri drug store Alprazolam Prazin Hikma Hikma Zolam Ram Pharmaceutica l Industries Co. Ltd Ram Pharmaceutica l Industries Co. Ltd For the symptomatic treatment of gastric and duodenal ulcer, gastritis, duodenitis, stomach spasms, motility disorders of bile duct, spastic colitis, mild ulcerative colitis, functional constipation and diarrhea, urethral and bladder spasm, dysmenorrhea .it can restore disturbed autonomic functions to normal. extension of CNS depressant action ,tolerance, dependence liability Sedativehypnotic, antianxiety, anticonvulsant , antipanic extension of CNS depressant action ,tolerance, dependence liability Xanax is used to treat anxiety. Xanax is also used to treat panic attacks. extension of CNS depressant action ,tolerance, dependence liability It is contraindicated to patients with myasthenia, glaucoma, prostate hypertrophy as well as for subjects with known hypersensitivity to diazepam and or clidinium bromide DISTEDON should not be used in the first trimester of pregnancy and from nursing mothers. *Allergy or hypersensitivity to contents *Severe respiratory failure *Acute intoxication *Ataxia *Acute narrow-angle glaucoma *Sleep apnea *Myasthenia gravis *Pregnancy and breast feeding Do not take Xanax if you have an allergy to: • any medicine containing alprazolam • any of the ingredients • any other medicine in the benzodiazepine group •myasthenia gravis which • severe and chronic lung disease. •Do not take this medicine if you are pregnant. Chlordiazep oxide Proxidium Hikma Librax ICN Pharmaceutica ls Switz Ltd ORINT DRUG STORE CO Medospas MEDOCHEMIE Al Hilal Drug Store Lexotanil F.Hoffmann La- Roche Shawi & Rushedat Drug Store Bromazepa m thiopental Hikma Novepam Ram Pharmaceutica l Industries Co. Ltd Ram Pharmaceutica l Industries Co. Ltd Lexopam United Pharmaceutica l Manufacturing Co. Ltd United Pharmaceutica l Manufacturing Co. Ltd Thiopenta l Vial Sandoz GmbH Nabulsi Drug Store Chlordiazepoxi de is indicated for the short term (2–4 weeks) treatment of anxiety which is severe and disabling or subjecting the person to unacceptable distress. It is also indicated as a treatment for the management of acute alcohol withdrawal syndrome Short-term treatment of anxiety or panic attacks, if a benzodiazepin e is required. Premedication to alleviate anxiety before surgery anesthesia •Drowsiness •Coordination problems •Confusion. Myasthenia gravis Acute intoxication with alcohol, narcotics, or other psychoactive substances Ataxia Severe hypoventilation Acute narrowangle glaucoma Severe liver deficiencies (hepatitis and liver cirrhosis decrease elimination by a factor of 2) Severe sleep apnea Hypersensitivity or allergy to any drug in the benzodiazepine class extension of CNS depressant action ,tolerance, dependence liability Benzodiazepines require special precaution if used in the elderly, pregnancy, children, alcohol- or drugdependent individuals and individuals with comorbid psychiatric disorders extension of CNS depressant action ,tolerance, dependence liability> benzodiazepines Thiopental should not be given in case of liver disease, Addison's disease, myxedema, severe heart disease, severe hypotension, a severe breathing disorder, or a history of porphyria Zolpidem Tartarate Stilnox SanofiSynthelabo Nabulsi Drug Store used to initiate and maintain sleep in insomnia patinents extension of CNS depressent effect , dependence liability (• drowsiness • dizziness • headache • diarrhoea, nausea and vomiting • muscle weakness) Do not take STILNOX if you have: • been drinking alcohol or you believe that you may have alcohol in your bloodstream • sleep apnoea (a condition where you temporarily stop breathing while you sleep) • myasthenia gravis (a condition in which the muscles become weak and tire easily) • severe liver problems • acute and/or severe lung problems Do not take STILNOX if you are allergic to it or any of the ingredients