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Cell Mediated Immunity in Virus Infections
Cell Mediated Immunity in Virus Infections

Interferon- acts directly on CD8 T cells to increase their abundance
Interferon- acts directly on CD8 T cells to increase their abundance

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Chapter 19 Notes
Chapter 19 Notes

... Every time the host divides, it copies the phage DNA and passes the copies to daughter cells. ○ The viruses thus propagate without killing the host cells on which they depend. ○ A single infected cell can quickly give rise to a large population of bacteria carrying the virus in prophage form. ...
Chapter 19 lecture outline
Chapter 19 lecture outline

... Every time the host divides, it copies the phage DNA and passes the copies to daughter cells. ○ The viruses thus propagate without killing the host cells on which they depend. ○ A single infected cell can quickly give rise to a large population of bacteria carrying the virus in prophage form. ...
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Interferon



Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.IFNs belong to the large class of proteins known as cytokines, molecules used for communication between cells to trigger the protective defenses of the immune system that help eradicate pathogens. Interferons are named for their ability to ""interfere"" with viral replication by protecting cells from virus infections. IFNs also have various other functions: they activate immune cells, such as natural killer cells and macrophages; they increase host defenses by up-regulating antigen presentation by virtue of increasing the expression of major histocompatibility complex (MHC) antigens. Certain symptoms of infections, such as fever, muscle pain and ""flu-like symptoms"", are also caused by the production of IFNs and other cytokines.More than twenty distinct IFN genes and proteins have been identified in animals, including humans. They are typically divided among three classes: Type I IFN, Type II IFN, and Type III IFN. IFNs belonging to all three classes are important for fighting viral infections and for the regulation of the immune system.
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