Acute Renal Failure (ARF)
... • fluid restriction (insensible losses) • attempt furosemide 1-2 mg/kg • Renal replacement therapy If patient is dehydrated: • restore intravascular volume first • then treat as euvolemic (below) If patient is euvolemic: • restrict to insensible losses (30-35 ml/100kcal/24 hours) + other losses (uri ...
... • fluid restriction (insensible losses) • attempt furosemide 1-2 mg/kg • Renal replacement therapy If patient is dehydrated: • restore intravascular volume first • then treat as euvolemic (below) If patient is euvolemic: • restrict to insensible losses (30-35 ml/100kcal/24 hours) + other losses (uri ...
Glomerular Filtration
... • The cortex receives more than 90% of the blood that perfused into the kidney, which is perfused at a rate of about 500 ml/min per 100 gm tissue. (100 times greater than resting muscle blood flow) The remainder of the renal blood supply goes to the capsule and the renal adipose tissue. Some of the ...
... • The cortex receives more than 90% of the blood that perfused into the kidney, which is perfused at a rate of about 500 ml/min per 100 gm tissue. (100 times greater than resting muscle blood flow) The remainder of the renal blood supply goes to the capsule and the renal adipose tissue. Some of the ...
(Renal haemodynamic and GFR).
... • Resistance in efferent arterioles: – Reinforces high glomerular pressure – Reduces hydrostatic pressure in peritubular capillaries ...
... • Resistance in efferent arterioles: – Reinforces high glomerular pressure – Reduces hydrostatic pressure in peritubular capillaries ...
NVCC Bio 212 - gserianne.com
... Net Filtration Pressure = force favoring filtration – forces opposing filtration (*glomerular capillary ( capsular hydrostatic pressure hydrostatic pressure) + glomerular capillary osmotic pressure ) ...
... Net Filtration Pressure = force favoring filtration – forces opposing filtration (*glomerular capillary ( capsular hydrostatic pressure hydrostatic pressure) + glomerular capillary osmotic pressure ) ...
Unit One: Introduction to Physiology: The Cell and General Physiology
... A. The substance is freely filtered but not reabsorbed B. The substance is freely filtered but part is reabsorbed C. The substance is freely filtered but not excreted because all is reabsorbed. D. The substance is freely filtered but is not reabsorbed but secreted from the peritubular capillaries i ...
... A. The substance is freely filtered but not reabsorbed B. The substance is freely filtered but part is reabsorbed C. The substance is freely filtered but not excreted because all is reabsorbed. D. The substance is freely filtered but is not reabsorbed but secreted from the peritubular capillaries i ...
Respiratory Physiology
... If the GFR is too high, needed substances cannot be reabsorbed quickly enough and are lost in the urine If the GFR is too low - everything is reabsorbed, including lipid-soluble wastes that are normally disposed of GFR normally controlled by adjustment of glomerular BP Three mechanisms control the G ...
... If the GFR is too high, needed substances cannot be reabsorbed quickly enough and are lost in the urine If the GFR is too low - everything is reabsorbed, including lipid-soluble wastes that are normally disposed of GFR normally controlled by adjustment of glomerular BP Three mechanisms control the G ...
BP - PracSavvy
... Please Note – this document is a guide only, and your Nephrologist/Renal Clinic may have a different preferred format ...
... Please Note – this document is a guide only, and your Nephrologist/Renal Clinic may have a different preferred format ...
AKI
... Serum creatinine rises by ≥ 26µmol/L within 48 hours or Serum creatinine rises ≥ 1.5X the reference value which is known or presumed to have occurred within one week or Urine output is < 0.5ml/kg/hr for >6 consecutive hours ...
... Serum creatinine rises by ≥ 26µmol/L within 48 hours or Serum creatinine rises ≥ 1.5X the reference value which is known or presumed to have occurred within one week or Urine output is < 0.5ml/kg/hr for >6 consecutive hours ...
GFR - ISpatula
... of both kidneys per minute. • The volume of fluid filtered daily through all the corpuscles of both kidneys per day = 180 L • Hence, GFR= 180 L/24hours * (1000 ml/ L)*(1hour/60 min)= 125 ml/min (Males) • For 125ml/min; renal plasma flow = 625ml/min FF * PF=GFR, PF= 125/(20%)=625 ml/min • 55% of bloo ...
... of both kidneys per minute. • The volume of fluid filtered daily through all the corpuscles of both kidneys per day = 180 L • Hence, GFR= 180 L/24hours * (1000 ml/ L)*(1hour/60 min)= 125 ml/min (Males) • For 125ml/min; renal plasma flow = 625ml/min FF * PF=GFR, PF= 125/(20%)=625 ml/min • 55% of bloo ...
SECTION 9 - RENAL FUNCTION AND HOMEOSTASIS
... urine, the efficiency of the kidneys in performing this function can be evaluated. GFR is commonly measured by the clearance of exogenous inulin or by the renal plasma clearance of endogenous creatinine. Inulin (a large polysaccharide) is neither reabsorbed nor secreted by the nephron so its clearan ...
... urine, the efficiency of the kidneys in performing this function can be evaluated. GFR is commonly measured by the clearance of exogenous inulin or by the renal plasma clearance of endogenous creatinine. Inulin (a large polysaccharide) is neither reabsorbed nor secreted by the nephron so its clearan ...
SECTION 9 - RENAL FUNCTION AND HOMEOSTASIS
... urine, the efficiency of the kidneys in performing this function can be evaluated. GFR is commonly measured by the clearance of exogenous inulin or by the renal plasma clearance of endogenous creatinine. Inulin (a large polysaccharide) is neither reabsorbed nor secreted by the nephron so its clearan ...
... urine, the efficiency of the kidneys in performing this function can be evaluated. GFR is commonly measured by the clearance of exogenous inulin or by the renal plasma clearance of endogenous creatinine. Inulin (a large polysaccharide) is neither reabsorbed nor secreted by the nephron so its clearan ...
The Urinary Physiology Chapter 17
... Macula Densa are a patch of cells in thick ascending loop of Henle passing between afferent and efferent arterioles. At the same point, secretory Juxtaglomerular cells, lie in afferent arteriole Macula Densa + Juxtaglomerular cells = Juxtaglomerular Apparatus = JGA. JGA secretes Renin an enzyme. • G ...
... Macula Densa are a patch of cells in thick ascending loop of Henle passing between afferent and efferent arterioles. At the same point, secretory Juxtaglomerular cells, lie in afferent arteriole Macula Densa + Juxtaglomerular cells = Juxtaglomerular Apparatus = JGA. JGA secretes Renin an enzyme. • G ...
Regulation of Glomerular Filtration
... of both kidneys per minute. • The volume of fluid filtered daily through all the corpuscles of both kidneys per day = 180 L • Hence, GFR= 180 L/24hours * (1000 ml/ L)*(1hour/60 min)= 125 ml/min (Males) • For 125ml/min; renal plasma flow = 625ml/min FF * PF=GFR, PF= 125/(20%)=625 ml/min • 55% of bloo ...
... of both kidneys per minute. • The volume of fluid filtered daily through all the corpuscles of both kidneys per day = 180 L • Hence, GFR= 180 L/24hours * (1000 ml/ L)*(1hour/60 min)= 125 ml/min (Males) • For 125ml/min; renal plasma flow = 625ml/min FF * PF=GFR, PF= 125/(20%)=625 ml/min • 55% of bloo ...
Renal Physiology 1
... • Can be absorbed by GI tract, products of protein catabolism, or de novo synthesis of nonessential amino acids. • TM values lower than that of glucose, so can excrete excess in urine. • Amino acid transporters rely upon Na+ gradient at apical membrane, but a couple of exceptions don’t. • Exit acros ...
... • Can be absorbed by GI tract, products of protein catabolism, or de novo synthesis of nonessential amino acids. • TM values lower than that of glucose, so can excrete excess in urine. • Amino acid transporters rely upon Na+ gradient at apical membrane, but a couple of exceptions don’t. • Exit acros ...
evaluation of renal function and renal risk
... 12:00 “Can we really evaluate the evolution of chronic nephropathies with formulas” (Norberto Perico, Italy) 13:00 Lunch break ...
... 12:00 “Can we really evaluate the evolution of chronic nephropathies with formulas” (Norberto Perico, Italy) 13:00 Lunch break ...
lec#30 by salsabeel khreem
... all what's filtered (they loss there substances) & those who is filtered they are also reabsorbed ...
... all what's filtered (they loss there substances) & those who is filtered they are also reabsorbed ...
Renal Physiology
... • In a number of glomerular diseases, the negative charge on various barriers for filtration is lost due to immunologic damage and inflammation, resulting in proteinuria (i.e. increased filtration of serum proteins that are mostly negatively charged). • Filtration is driven by Starling forces across ...
... • In a number of glomerular diseases, the negative charge on various barriers for filtration is lost due to immunologic damage and inflammation, resulting in proteinuria (i.e. increased filtration of serum proteins that are mostly negatively charged). • Filtration is driven by Starling forces across ...
renal physiology tutorial discussion
... Q23. After filtration, how much percentage of the following substances is reabsorbed in the tubule Water ___ % Sodium ___ % Glucose ___ % ...
... Q23. After filtration, how much percentage of the following substances is reabsorbed in the tubule Water ___ % Sodium ___ % Glucose ___ % ...
Integrative Sciences: Biological Systems B
... calculate the filtered load, tubular transport, and excretion rate of a given compound. Given the appropriate plasma and urine concentrations and the urine flow, calculate the clearance of inulin, creatinine, para-amino hippuric acid (PAH), and glucose. Predict how changes in filtration, reabsorptio ...
... calculate the filtered load, tubular transport, and excretion rate of a given compound. Given the appropriate plasma and urine concentrations and the urine flow, calculate the clearance of inulin, creatinine, para-amino hippuric acid (PAH), and glucose. Predict how changes in filtration, reabsorptio ...
1. The term "renal autoregulation" refers in part to the fact that A. the
... 10. D. Remember that creatinine is filtered but neither reabsorbed nor secreted (approximately), so creatinine concentration depends on the amount of water remaining. The volume of urine is less that the volume of fluid at any of the other sites listed. 11. C. Less urea would be cleared because less ...
... 10. D. Remember that creatinine is filtered but neither reabsorbed nor secreted (approximately), so creatinine concentration depends on the amount of water remaining. The volume of urine is less that the volume of fluid at any of the other sites listed. 11. C. Less urea would be cleared because less ...
Kidney 1
... liters/day. • Of total renal plasma flow RPF, 20-25% gets filtered – this is the filtered fraction FF. • So, FF=GFR/RPF • Therefore, if cardiac output is about 7,200 liters/day, RPF is about 900 liters/day, and total renal blood flow is about 1,800 liters/day. ...
... liters/day. • Of total renal plasma flow RPF, 20-25% gets filtered – this is the filtered fraction FF. • So, FF=GFR/RPF • Therefore, if cardiac output is about 7,200 liters/day, RPF is about 900 liters/day, and total renal blood flow is about 1,800 liters/day. ...
Renal Physiology Basics 2 kidneys 10
... Leads to production of substances (endothelin, TXA2, AT2) from granular cells of juxtaglomerular apparatus, leading to constriction of afferent arteriole NB. Granular cells of JGA secrete renin in predominantly in response to low tubular chloride rather than sodium. Sodium follows chloride, leading ...
... Leads to production of substances (endothelin, TXA2, AT2) from granular cells of juxtaglomerular apparatus, leading to constriction of afferent arteriole NB. Granular cells of JGA secrete renin in predominantly in response to low tubular chloride rather than sodium. Sodium follows chloride, leading ...
Chemical Composition of Blood Plasma
... • High- and low- MW compounds of bl.pl. • Interpretation of investigations in clinical practice: – “Basic set” – Disorders of the kidneys and internal environment – Inflammation – Liver disorders ...
... • High- and low- MW compounds of bl.pl. • Interpretation of investigations in clinical practice: – “Basic set” – Disorders of the kidneys and internal environment – Inflammation – Liver disorders ...
Renal function
Renal function, in nephrology, is an indication of the state of the kidney and its role in renal physiology. Glomerular filtration rate (GFR) describes the flow rate of filtered fluid through the kidney. Creatinine clearance rate (CCr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit time and is a useful measure for approximating the GFR. Creatinine clearance exceeds GFR due to creatinine secretion, which can be blocked by cimetidine. In alternative fashion, overestimation by older serum creatinine methods resulted in an underestimation of creatinine clearance, which provided a less biased estimate of GFR. Both GFR and CCr may be accurately calculated by comparative measurements of substances in the blood and urine, or estimated by formulas using just a blood test result (eGFR and eCCr). The results of these tests are used to assess the excretory function of the kidneys. Staging of chronic kidney disease is based on categories of GFR as well as albuminuria and cause of kidney disease.Dosage of drugs that are excreted primarily via urine may need to be modified based on either GFR or creatinine clearance.