PHARMACOLOGY – Simplified, not Mystified
... • Most important—take at the same time of day • Adjust doses as the patient ages—why? • Levothyroxine RX can also cause atrial fib if the dose is too high; levothyroxine doses DECREASE with aging; some patients only need 0.5 mcg/kg/day vs. younger adults with 1.7 mcg/kg/day (Prescriber’s Letter July ...
... • Most important—take at the same time of day • Adjust doses as the patient ages—why? • Levothyroxine RX can also cause atrial fib if the dose is too high; levothyroxine doses DECREASE with aging; some patients only need 0.5 mcg/kg/day vs. younger adults with 1.7 mcg/kg/day (Prescriber’s Letter July ...
Drug chirality: Stereoselectivity in the action and disposition
... Neurotoxic at high doses Effects of Gantacurium, a chlorofumarate muscle relaxant, can be rapidly reveresed by L-cysteine. Not been introduced in clinical practice. ...
... Neurotoxic at high doses Effects of Gantacurium, a chlorofumarate muscle relaxant, can be rapidly reveresed by L-cysteine. Not been introduced in clinical practice. ...
The Power of One: a Highly Detailed, Log
... “off-label” experience. That is the purpose of reporting the case herein. Ranolazine is an already marketed antianginal compound which in its development program has been found to be free from organ toxicity; ventricular proarrhythmia; the provocation of bradyarrhythmias, conduction defects, or hypo ...
... “off-label” experience. That is the purpose of reporting the case herein. Ranolazine is an already marketed antianginal compound which in its development program has been found to be free from organ toxicity; ventricular proarrhythmia; the provocation of bradyarrhythmias, conduction defects, or hypo ...
L6- Teratogens and drugs of abuse
... • However, CNS is sensitive to toxic effects throughout pregnancy. ...
... • However, CNS is sensitive to toxic effects throughout pregnancy. ...
Medication Assisted Treatment for Opioid Addiction
... Decrease in high risk behaviors such as IVDU = ...
... Decrease in high risk behaviors such as IVDU = ...
Prototype drug - Nursing Pharmacology
... of the fight-or-flight response. Nausea, vomiting, nervousness, bronchial dilation, and hypertension are potential adverse reactions related to the use of adrenergic agonists. Hypotension is a potential adverse reaction related to the use of adrenergic antagonists. ...
... of the fight-or-flight response. Nausea, vomiting, nervousness, bronchial dilation, and hypertension are potential adverse reactions related to the use of adrenergic agonists. Hypotension is a potential adverse reaction related to the use of adrenergic antagonists. ...
Final Internal Assessment: PHARMACOLOGY
... 1. A 10 year old school girl suffering from mild exercise induced bronchial asthma has been treated with a metered does inhaler containing 500 g of Terbutaline per inhalation as and when required, which effectively controls the individual attack. However, she has attacks of wheezing every 3 to 4 ...
... 1. A 10 year old school girl suffering from mild exercise induced bronchial asthma has been treated with a metered does inhaler containing 500 g of Terbutaline per inhalation as and when required, which effectively controls the individual attack. However, she has attacks of wheezing every 3 to 4 ...
Digitalis
... • Action: Taken up by LDL particles and endothelial cells, inhibits oxidation of LDL and prevents ingestion by macrophage foam cells, decreases HDL production. • Effects: 1) decreases atherosclerotic plaque formation; 2) small reduction in serum LDL; 3) greater reduction of serum HDL. • Clinical use ...
... • Action: Taken up by LDL particles and endothelial cells, inhibits oxidation of LDL and prevents ingestion by macrophage foam cells, decreases HDL production. • Effects: 1) decreases atherosclerotic plaque formation; 2) small reduction in serum LDL; 3) greater reduction of serum HDL. • Clinical use ...
Suggestion from clinicians
... reassuringly shows that overall, the tolerability, as indicated by discontinuation rates in different randomized trials, of β blockers as a class of drugs is generally good and comparable to a range of pharmacologically active and inactive comparators. Our analysis shows that among the different β b ...
... reassuringly shows that overall, the tolerability, as indicated by discontinuation rates in different randomized trials, of β blockers as a class of drugs is generally good and comparable to a range of pharmacologically active and inactive comparators. Our analysis shows that among the different β b ...
Treatment of HFPEF
... • no evidence-based recommendations for “pure” HFPEF • Diuretics in case of fluid retention • In clinical practice, most patients receive RASinhibitor: many studies, conflicting evidence • Differential effects of drugs in HFREF and HFPEF indicate two different disease entities ...
... • no evidence-based recommendations for “pure” HFPEF • Diuretics in case of fluid retention • In clinical practice, most patients receive RASinhibitor: many studies, conflicting evidence • Differential effects of drugs in HFREF and HFPEF indicate two different disease entities ...
1-Antipsychotic drug..
... divided into two groups: The typical = 1st generation and the atypical = 2nd generation antipsychotics Atypical drugs are preferred as a first line treatment because they: 1- have fewer side effects 2- have additional benefits for the ...
... divided into two groups: The typical = 1st generation and the atypical = 2nd generation antipsychotics Atypical drugs are preferred as a first line treatment because they: 1- have fewer side effects 2- have additional benefits for the ...
Selected module tests in Pharmacology
... 2. Atropinе-like adverse reactions are observed in the treatment with: A. M-cholinomimetics. B. Mcholinolytics. C. Tricyclic antidepressants. D. Phenothiazine neuroleptics. 3. In connection with biorhythms, the therapeutic efficacy of cholinolytics is higher during: A. The day. B. The night. C. Wint ...
... 2. Atropinе-like adverse reactions are observed in the treatment with: A. M-cholinomimetics. B. Mcholinolytics. C. Tricyclic antidepressants. D. Phenothiazine neuroleptics. 3. In connection with biorhythms, the therapeutic efficacy of cholinolytics is higher during: A. The day. B. The night. C. Wint ...
Slides - Clinical Trial Results
... and parents as well ● Parents often have therapeutic bias Will hesitate to enroll their children in RCT with placebo ...
... and parents as well ● Parents often have therapeutic bias Will hesitate to enroll their children in RCT with placebo ...
Side Effects of Calcium Channel Blockers
... may differ. However, the majority of adverse reactions are predictable from their pharmacological actions and may be conveniently grouped in the following categories: 1) vasodilatation, 2) negative inotropic effects, 3) conduction disturbances, 4) gastrointestinal effects, 5) metabolic effects, and ...
... may differ. However, the majority of adverse reactions are predictable from their pharmacological actions and may be conveniently grouped in the following categories: 1) vasodilatation, 2) negative inotropic effects, 3) conduction disturbances, 4) gastrointestinal effects, 5) metabolic effects, and ...
Mechanisms of Therapeutic Actions and Adverse Side Effects
... All antipsychotics (both conventional and atypical) bind to some degree at dopamine D2 receptors. It is believed that D2 antagonism mediates antipsychotics’ ability to reduce positive symptoms of schizophrenia, including hallucinations and delusions. What sets the atypical antipsychotics apart from ...
... All antipsychotics (both conventional and atypical) bind to some degree at dopamine D2 receptors. It is believed that D2 antagonism mediates antipsychotics’ ability to reduce positive symptoms of schizophrenia, including hallucinations and delusions. What sets the atypical antipsychotics apart from ...
• • • • •
... • Aldosterone is a very powerful mineralocorticoid, but it has a week glucocorticoid activity. • Its release from the adrenal cortex is controlled by the renin-angiotensin system. • It acts on collecting tubules causing reabsorption of sodium, bicarbonate & water. Potassium & H + are lost in the uri ...
... • Aldosterone is a very powerful mineralocorticoid, but it has a week glucocorticoid activity. • Its release from the adrenal cortex is controlled by the renin-angiotensin system. • It acts on collecting tubules causing reabsorption of sodium, bicarbonate & water. Potassium & H + are lost in the uri ...
Introduction to neuropharmacology
... In the brain the main excitatory (depolarizing) transmitter is glutamate. Glutamate binds to several metabotropic and several ionotropic receptors. The main ionotropic receptor is the AMPA receptor. AMPA is an abbreviation of (±)alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, obviously ...
... In the brain the main excitatory (depolarizing) transmitter is glutamate. Glutamate binds to several metabotropic and several ionotropic receptors. The main ionotropic receptor is the AMPA receptor. AMPA is an abbreviation of (±)alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, obviously ...
Drugs used in the treatment of cardiac failure
... Amrinone, Enoximone, Milrinone These agents are indicated in severe congestive AHF, resistant to other drugs; usually for short i.v. treatment. They have positive inotropic effect, but they increase oxygen consumption. ARs: ventricular and SV arrhythmias, angina, hypotension, headache, hypokalemia. ...
... Amrinone, Enoximone, Milrinone These agents are indicated in severe congestive AHF, resistant to other drugs; usually for short i.v. treatment. They have positive inotropic effect, but they increase oxygen consumption. ARs: ventricular and SV arrhythmias, angina, hypotension, headache, hypokalemia. ...
Beta-Adrenoceptor Antagonists (Beta
... catecholamines at beta-adrenoceptors which are widely distributed throughout body systems. Beta1-receptors are predominant in the heart (and kidney) while beta2-receptors are predominant in other organs such as the lung, peripheral blood vessels and skeletal muscle. Kidney: Blockade of beta1-recepto ...
... catecholamines at beta-adrenoceptors which are widely distributed throughout body systems. Beta1-receptors are predominant in the heart (and kidney) while beta2-receptors are predominant in other organs such as the lung, peripheral blood vessels and skeletal muscle. Kidney: Blockade of beta1-recepto ...
Cardiovascular System Drugs – Summary
... o Drugs include: atenolol, propranolol, pindolol, nebivolol, labetelol o Mechanism of action: Their main mechanism of action is to competitively bind to beta1adrenoceptors before catecholamines can bind to them This causes the blockade of receptors Effects: Decreases heart rate Decreases f ...
... o Drugs include: atenolol, propranolol, pindolol, nebivolol, labetelol o Mechanism of action: Their main mechanism of action is to competitively bind to beta1adrenoceptors before catecholamines can bind to them This causes the blockade of receptors Effects: Decreases heart rate Decreases f ...
4._Bipolar_disorder_def
... intoxiction with substances depressing CNS, neuroleptic malignant syndrome history, Parkinson´s syndrome, be carefull at patients with kidney and liver problems ...
... intoxiction with substances depressing CNS, neuroleptic malignant syndrome history, Parkinson´s syndrome, be carefull at patients with kidney and liver problems ...
4._Bipolar_disorder_def
... intoxiction with substances depressing CNS, neuroleptic malignant syndrome history, Parkinson´s syndrome, be carefull at patients with kidney and liver problems ...
... intoxiction with substances depressing CNS, neuroleptic malignant syndrome history, Parkinson´s syndrome, be carefull at patients with kidney and liver problems ...
Dia 1 - pace
... • If a diuretic is required, choose a thiazide-like diuretic, such as chlortalidone (12.5 mg–25.0mg once daily) or indapamide (1.5mg SR, or 2.5 mg once daily) in preference to a conventional thiazide diuretic such as bendroflumethiazide or hydrochlorthiazide. [new 2011] ...
... • If a diuretic is required, choose a thiazide-like diuretic, such as chlortalidone (12.5 mg–25.0mg once daily) or indapamide (1.5mg SR, or 2.5 mg once daily) in preference to a conventional thiazide diuretic such as bendroflumethiazide or hydrochlorthiazide. [new 2011] ...
1. ------IND- 2016 0643 HU- EN- ------ 20161215 --- --
... According to literature, smaller doses have a stimulating effect, whereas higher doses make the consumer perceive bizarre phenomena as if they were having an out-of-body experience while even losing control of their behaviour. Doses of over 100 mg inevitably cause dissociative effects; due to these ...
... According to literature, smaller doses have a stimulating effect, whereas higher doses make the consumer perceive bizarre phenomena as if they were having an out-of-body experience while even losing control of their behaviour. Doses of over 100 mg inevitably cause dissociative effects; due to these ...