The biology of ageing e-Science integration and simulation system
... models/simulations • Once a model is made public it cannot be ...
... models/simulations • Once a model is made public it cannot be ...
The Quantification of Multiple Signalling Pathway Proteins in Intact
... AKT has recently been found to play a paradoxical role: on the one hand it increases cancer cells’ survival capability, while on the other it blocks their motility and invasion abilities, thereby preventing cancer from spreading (4). Previously, it had been presumed that one could promote cancer cel ...
... AKT has recently been found to play a paradoxical role: on the one hand it increases cancer cells’ survival capability, while on the other it blocks their motility and invasion abilities, thereby preventing cancer from spreading (4). Previously, it had been presumed that one could promote cancer cel ...
ATP-driven Pumps
... binding site orientation: ATP hydrolysis drives alternation in binding site orientation ...
... binding site orientation: ATP hydrolysis drives alternation in binding site orientation ...
MAPTrix TM Biomimetic Library
... Fibronectin naturally exists as a dimer, consisting of two nearly identical monomers. Two regions in each fibronectin subunit possess cell binding activity: III9-10 and III14-V (refer to the modular structure of fibronectin below). The primary receptor for adhesion to fibronectin commonly involves t ...
... Fibronectin naturally exists as a dimer, consisting of two nearly identical monomers. Two regions in each fibronectin subunit possess cell binding activity: III9-10 and III14-V (refer to the modular structure of fibronectin below). The primary receptor for adhesion to fibronectin commonly involves t ...
Gene Section USP15 (ubiquitin specific peptidase 15) Atlas of Genetics and Cytogenetics
... may underpin recent reports that USP15 levels can influence the taxol sensitivity of cancer cells (Xu et al., 2009; Xie et al., 2010). VCP/p97 is a large AAA+-type ATPase that acts as a chaperone in many cellular processes. Its basic function is to segregate ubiquitinated proteins from macromolecula ...
... may underpin recent reports that USP15 levels can influence the taxol sensitivity of cancer cells (Xu et al., 2009; Xie et al., 2010). VCP/p97 is a large AAA+-type ATPase that acts as a chaperone in many cellular processes. Its basic function is to segregate ubiquitinated proteins from macromolecula ...
Motor Proteins and The Cytoskeleton
... Formation of Leading Edge of a Lamellipodia Nucleation of Actin at the Plasma Membrane ...
... Formation of Leading Edge of a Lamellipodia Nucleation of Actin at the Plasma Membrane ...
Complexity and diversity in c-type cytochrome biogenesis systems
... Until recently it had been assumed that no cells had more than one c-type cytochrome biogenesis system potentially functioning in the same location. Intriguingly, however, the genomes of some β-proteobacteria, including Bordetella bronchiseptica, contain all the components of both systems I and II [ ...
... Until recently it had been assumed that no cells had more than one c-type cytochrome biogenesis system potentially functioning in the same location. Intriguingly, however, the genomes of some β-proteobacteria, including Bordetella bronchiseptica, contain all the components of both systems I and II [ ...
Chapter 11. Review Notes [10-2
... A quick note: Never focus on the wording of things as with Biochem its always A to D (i.e. If A, then also B and C but most important the last effect D), not what does this what does that. Most medical questions will be cause and effect, so knowing how things are accomplished (the cell produces more ...
... A quick note: Never focus on the wording of things as with Biochem its always A to D (i.e. If A, then also B and C but most important the last effect D), not what does this what does that. Most medical questions will be cause and effect, so knowing how things are accomplished (the cell produces more ...
Hurdles for clinical validation
... Bile duct ligation, liver will be back to when bile duct ligation is released. • Human Spontaneous regression of liver fibrosis when causative agent of disease is eliminated ...
... Bile duct ligation, liver will be back to when bile duct ligation is released. • Human Spontaneous regression of liver fibrosis when causative agent of disease is eliminated ...
AMP-activated protein kinase induces apoptosis in LX2 cell
... Hepatic stellate cells (HSCs) are a major fibrogenic cell type which contributes to extracellular matrix accumulation during chronic liver diseases. HSCs also play a critical role in the resolution of hepatic fibrosis, where activated HSCs take place apoptosis. So inducing apotosis of HSCs is ...
... Hepatic stellate cells (HSCs) are a major fibrogenic cell type which contributes to extracellular matrix accumulation during chronic liver diseases. HSCs also play a critical role in the resolution of hepatic fibrosis, where activated HSCs take place apoptosis. So inducing apotosis of HSCs is ...
MitoToxTM Mitochondrial toxicity application guide
... Drug-induced mitochondrial dysfunction Mitochondria are known as the ‘powerhouses of the cell’ that control energy production. Following cellular insult, mitochondria also regulate the intrinsic cell death pathway, known as apoptosis. Evaluating compounds for mitochondrial toxicity is an important ...
... Drug-induced mitochondrial dysfunction Mitochondria are known as the ‘powerhouses of the cell’ that control energy production. Following cellular insult, mitochondria also regulate the intrinsic cell death pathway, known as apoptosis. Evaluating compounds for mitochondrial toxicity is an important ...
The Ubiquitin Proteosome pathway
... Enzymologically Ubiquitination is more complex pathway compared to other post translational modification. Mechanism of catalysis by E3 ligase still remains unclear. Elucidation of complete catalytic mechanism of ubiquitylation will provide considerable insight on cellular functions. ...
... Enzymologically Ubiquitination is more complex pathway compared to other post translational modification. Mechanism of catalysis by E3 ligase still remains unclear. Elucidation of complete catalytic mechanism of ubiquitylation will provide considerable insight on cellular functions. ...
New Insights in Molecular Mechanisms of Male
... failure following assisted reproduction may be related, at least in part, to increased DNA damage in spermatozoa. Apoptosis and Spermatozoa Apoptosis (programmed cell death) is a regulated physiological process that leads to cell shrinkage, membrane blebbing, and DNA fragmentation. In somatic cells, ...
... failure following assisted reproduction may be related, at least in part, to increased DNA damage in spermatozoa. Apoptosis and Spermatozoa Apoptosis (programmed cell death) is a regulated physiological process that leads to cell shrinkage, membrane blebbing, and DNA fragmentation. In somatic cells, ...
Poster
... perception of pain. With this discovery, scientists can find out more about the structure of P2X4 and learn other ways to inhibit the proteinperhaps solving the issue of chronic pain. ...
... perception of pain. With this discovery, scientists can find out more about the structure of P2X4 and learn other ways to inhibit the proteinperhaps solving the issue of chronic pain. ...
The Role of Patched in Basal Cell Carcinoma
... Basal cell carcinoma is the most common type of cancer Patch can still be present and cause BCC Other mutations in the SHH pathway along with decreased expression of Patch can cause BCC ...
... Basal cell carcinoma is the most common type of cancer Patch can still be present and cause BCC Other mutations in the SHH pathway along with decreased expression of Patch can cause BCC ...
ab109719 Cell Fractionation Kit - Standard
... material can be prepared for subsequent Western blot analysis, or for analysis by microplate ELISA or dipstick assay. ab109719 is designed to allow the measurement of any proteins which are differentially represented in the cytosol, mitochondria and nuclei, and is particularly applicable to studies ...
... material can be prepared for subsequent Western blot analysis, or for analysis by microplate ELISA or dipstick assay. ab109719 is designed to allow the measurement of any proteins which are differentially represented in the cytosol, mitochondria and nuclei, and is particularly applicable to studies ...
Research in the Rizk Lab Dynamic Control of protein structure and
... adopt very precise 3D structures that enable them to carry out their functions. Mutations that disrupt protein structure in most cases result in proteins that are unable to perform their natural function, leading to disease. Our goal in the Rizk lab is to understand the structural basis of protein f ...
... adopt very precise 3D structures that enable them to carry out their functions. Mutations that disrupt protein structure in most cases result in proteins that are unable to perform their natural function, leading to disease. Our goal in the Rizk lab is to understand the structural basis of protein f ...
Regulator of tumour suppression found Research Highlights
... complex; degradation by the ubiquitin-proteasome pathway; and sequestration by the transcription factor c-Myc. In 1999, Junya Kato and co-workers at Japan’s Nara Institute of Science and Technology (NAIST) identified another important mechanism for p27 regulation – they found a protein called p38 th ...
... complex; degradation by the ubiquitin-proteasome pathway; and sequestration by the transcription factor c-Myc. In 1999, Junya Kato and co-workers at Japan’s Nara Institute of Science and Technology (NAIST) identified another important mechanism for p27 regulation – they found a protein called p38 th ...
Case Study Template 1
... the channel, then no mechanism exists to open the channel on the outside so the block has been ‘ratcheted’ through SecY. ...
... the channel, then no mechanism exists to open the channel on the outside so the block has been ‘ratcheted’ through SecY. ...
Study Sheet: Endomembrane System and Endosymbiosis
... of a protein from its site of manufacture in the RER to the outside of the cell with a red arrow. Finally, trace the path of ...
... of a protein from its site of manufacture in the RER to the outside of the cell with a red arrow. Finally, trace the path of ...
Nociceptin mediated microvascular inflammation during sepsis
... the main source of oxidative stress; mitochondria determine excitotoxicity because they are the key calcium-buffering organelles in motor neurons; mitochondria regulate protein homeostasis, and mitochondrial dysfunction causes ER stress; last but not least mitochondria produce most energy (ATP) requ ...
... the main source of oxidative stress; mitochondria determine excitotoxicity because they are the key calcium-buffering organelles in motor neurons; mitochondria regulate protein homeostasis, and mitochondrial dysfunction causes ER stress; last but not least mitochondria produce most energy (ATP) requ ...
TESI DOCTORAL
... Greenblatt MS, Bennett WP, Hollstein M and Harris CC. (1994). Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis, Cancer Res. 54, 4855-4878. ...
... Greenblatt MS, Bennett WP, Hollstein M and Harris CC. (1994). Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis, Cancer Res. 54, 4855-4878. ...
Immunology: 2nd lecture/ 3rd Class /Microbio.Deprt.Vet.Med.2015
... The Complement System:The complement system consists of several plasma proteins that interact with one another and with other molecules of the immune system in a highly regulated manner to generate products that function to eliminate microbes. The name of complement system is derived from experiment ...
... The Complement System:The complement system consists of several plasma proteins that interact with one another and with other molecules of the immune system in a highly regulated manner to generate products that function to eliminate microbes. The name of complement system is derived from experiment ...
Apoptosome
The apoptosome is a large quaternary protein structure formed in the process of apoptosis. Its formation is triggered by the release of cytochrome c from the mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental cues such as those leading to the degradation of a tadpole's tail.In mammalian cells, once cytochrome c is released, it binds to the cytosolic protein Apaf-1 to facilitate the formation of apoptosome. An early biochemical study suggests a two-to-one ratio of cytochrome c to apaf-1 for apoptosome formation. However, recent structural studies suggest the cytochrome c to apaf-1 ratio is one-to-one. It has also been shown that the nucleotide dATP as third component binds to apaf-1, however its exact role is still debated. The mammalian apoptosome had never been crystallized, but a human APAF-1/cytochrome-c apoptosome has been imaged at lower (2 nm) resolution by cryogenic transmission electron microscopy 10 years ago, revealing a wheel-like particle with 7-fold symmetry. Recently, a medium resolution (9.5 Ångström) structure of human apoptosome was also solved by cryo-electron microscopy, which allows unambiguous inference for positions of all the APAF-1 domains (CARD, NBARC and WD40) and cytochrome c. There is also now a crystal structure of the monomeric, inactive Apaf-1 subunit (PDB 3SFZ). Once formed, the apoptosome can then recruit and activate the inactive pro-caspase-9. Once activated, this initiator caspase can then activate effector caspases and trigger a cascade of events leading to apoptosis.