INSILICO MODELING OF CAPSULAR POLYSACCHARIDE BIOSYNTHESIS PROTEIN STREPTOCOCCUS PNEUMONIAE LIGAND IDENTIFICATION
... module of Discovery Studio under CHARMm force field and the energy function is based on pairwise structural analysis between the nonbonding interactions of protein-ligand complex [14,15]. Finally, ADMET properties of ligands were studied through DISCOVERY STUDIO[16,17]. RESULTS AND DISCUSSION Homolo ...
... module of Discovery Studio under CHARMm force field and the energy function is based on pairwise structural analysis between the nonbonding interactions of protein-ligand complex [14,15]. Finally, ADMET properties of ligands were studied through DISCOVERY STUDIO[16,17]. RESULTS AND DISCUSSION Homolo ...
Biochemistry Objectives 38 and 39
... Cholera toxin: ADP-ribosylation of the s subunit inhibiting ATP hydrolysis and constitutively activating s and thus, adenylyl cyclase (cAMP overproduction). b. Pertussis toxin: ADP-ribosylation of the i subunit inhibiting interaction with the receptor and thus, rendering the i subunit inactive a ...
... Cholera toxin: ADP-ribosylation of the s subunit inhibiting ATP hydrolysis and constitutively activating s and thus, adenylyl cyclase (cAMP overproduction). b. Pertussis toxin: ADP-ribosylation of the i subunit inhibiting interaction with the receptor and thus, rendering the i subunit inactive a ...
Betulinic Acid-induced Programmed Cell Death in
... this response. As reported previously, betulinic acid is capable of modulating apoptosis (1, 4), and mitochondria have been a focus of attention (9). Whereas it is clear that mitochondria are integrally involved in the process of programmed cell death, our objective was to identify more specific cel ...
... this response. As reported previously, betulinic acid is capable of modulating apoptosis (1, 4), and mitochondria have been a focus of attention (9). Whereas it is clear that mitochondria are integrally involved in the process of programmed cell death, our objective was to identify more specific cel ...
FCH 532 Lecture 27
... glycolytic intermediate 3phosphoglycerate to serine. 1. Conversion of 3phosphoglycerate’s 2-OH group to a ketone 2. Transamination of 3phosphohydroxypyruvate to 3-phosphoserine 3. Hydrolysis of phosphoserine to make ...
... glycolytic intermediate 3phosphoglycerate to serine. 1. Conversion of 3phosphoglycerate’s 2-OH group to a ketone 2. Transamination of 3phosphohydroxypyruvate to 3-phosphoserine 3. Hydrolysis of phosphoserine to make ...
In vitro phosphorylation of the movement protein of tomato mosaic
... tabacum and tobacco suspension culture cells (BY-2) in the presence of [γ-32P]ATP. Phosphorylation occurred even after washing the beads with a detergent-containing buffer, indicating that the recombinant MP formed a stable complex with some protein kinase(s) during incubation with the cell extract. ...
... tabacum and tobacco suspension culture cells (BY-2) in the presence of [γ-32P]ATP. Phosphorylation occurred even after washing the beads with a detergent-containing buffer, indicating that the recombinant MP formed a stable complex with some protein kinase(s) during incubation with the cell extract. ...
Slide 1
... FIGURE 23-1: Stereo chemistry of the quantitatively major inositol lipids. Inositol lipids characteristically contain stearic acid (18:0) and arachidonic acid (20:4 ω6) esterified to the 1 and 2 position of sn-glycerolphosphate, respectively. The phosphate (colored circle) is diesterified to the 1 ...
... FIGURE 23-1: Stereo chemistry of the quantitatively major inositol lipids. Inositol lipids characteristically contain stearic acid (18:0) and arachidonic acid (20:4 ω6) esterified to the 1 and 2 position of sn-glycerolphosphate, respectively. The phosphate (colored circle) is diesterified to the 1 ...
Lesson 2 - The George S. Wise Faculty of Life Sciences
... sequence - the sequence with which we are searching Hit – a sequence found in the database, suspected as homologous ...
... sequence - the sequence with which we are searching Hit – a sequence found in the database, suspected as homologous ...
Identification of the Tuberous Sclerosis Complex
... 4P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns3,4,5P3; reviewed by Katso et al., 2001; Rameh and Cantley, 1999). Downstream targets containing specialized domains, such as pleckstrin-homology (PH) domains, that specifically bind to these lipid products of PI3K are then activated. These ac ...
... 4P2) and phosphatidylinositol-3,4,5-trisphosphate (PtdIns3,4,5P3; reviewed by Katso et al., 2001; Rameh and Cantley, 1999). Downstream targets containing specialized domains, such as pleckstrin-homology (PH) domains, that specifically bind to these lipid products of PI3K are then activated. These ac ...
IL-5 Receptor-mediated Tyrosine Phosphorylation of SH2
... which activates Sos protein, a Ras nucleotide-exchange protein (22). Ras has been shown to work downstream of tyrosine kinases in the growth signaling pathway (23-25). p95 ray (26) and p75 Hsl (27), which are expressed specifically in hematopoietic cells and have SH2 and/or SH3 domains, were recentl ...
... which activates Sos protein, a Ras nucleotide-exchange protein (22). Ras has been shown to work downstream of tyrosine kinases in the growth signaling pathway (23-25). p95 ray (26) and p75 Hsl (27), which are expressed specifically in hematopoietic cells and have SH2 and/or SH3 domains, were recentl ...
Amino acid metabolism III. Brake down of amino acids
... • much of the catabolism of amino acids takes place in the liver • branched-chain amino acids are oxidized as fuels primarily in the muscles, adipose, kidney, and brain tissue ...
... • much of the catabolism of amino acids takes place in the liver • branched-chain amino acids are oxidized as fuels primarily in the muscles, adipose, kidney, and brain tissue ...
Multiple Choice
... 6. Though the presence of self-replicating molecules was essential for the origin of life, what could be considered as the essential requirement for the construction of a cell? A. The presence of proteins, nucleic acids and polysaccharides. B. None of the above are essential. C. Membranes D. Enzymes ...
... 6. Though the presence of self-replicating molecules was essential for the origin of life, what could be considered as the essential requirement for the construction of a cell? A. The presence of proteins, nucleic acids and polysaccharides. B. None of the above are essential. C. Membranes D. Enzymes ...
Reactive Oxygen Intermediates Activate NF-KB in a
... radicals, hydrated electrons, and H202. Additional H,Oz is generated in irradiated cells by the dismutation of superoxide anions that are produced by the action of hydrated electrons on oxygen molecule^.^ H202 can be converted into highly active ROI.’ Compelling evidence indicates that a cascade of ...
... radicals, hydrated electrons, and H202. Additional H,Oz is generated in irradiated cells by the dismutation of superoxide anions that are produced by the action of hydrated electrons on oxygen molecule^.^ H202 can be converted into highly active ROI.’ Compelling evidence indicates that a cascade of ...
Reactive Oxygen Intermediates Activate NF-KB in a
... radicals, hydrated electrons, and H202. Additional H,Oz is generated in irradiated cells by the dismutation of superoxide anions that are produced by the action of hydrated electrons on oxygen molecule^.^ H202 can be converted into highly active ROI.’ Compelling evidence indicates that a cascade of ...
... radicals, hydrated electrons, and H202. Additional H,Oz is generated in irradiated cells by the dismutation of superoxide anions that are produced by the action of hydrated electrons on oxygen molecule^.^ H202 can be converted into highly active ROI.’ Compelling evidence indicates that a cascade of ...
Metabolic Pathways
... A cell has to control enzyme activity. It does this by: • Controlling number of enzyme molecules in cell • Keeping reactions (and enzymes) in compartments eg. Mitochondria or lysosome. • Changing enzyme shape (most effective) ...
... A cell has to control enzyme activity. It does this by: • Controlling number of enzyme molecules in cell • Keeping reactions (and enzymes) in compartments eg. Mitochondria or lysosome. • Changing enzyme shape (most effective) ...
CHAPTER 10 REVIEW SHEET Briefly describe metabolism. What
... 12. For what does compartmentation of metabolism allow? Where does it occur? ...
... 12. For what does compartmentation of metabolism allow? Where does it occur? ...
Slide 1
... Regions containing phospho-Tyr may serve as specific docking sites for SH2 domain-containing signaling proteins (SH = Src Homology domain) ...
... Regions containing phospho-Tyr may serve as specific docking sites for SH2 domain-containing signaling proteins (SH = Src Homology domain) ...
Section 6 – Catalysis
... metabolic pathways with enzymes controlling each chemical reaction The end-product can act as a negative modulator, binding to the first enzyme preventing the metabolic pathway from proceeding because intermediary substrates are not produced This is a process of negative feedback ...
... metabolic pathways with enzymes controlling each chemical reaction The end-product can act as a negative modulator, binding to the first enzyme preventing the metabolic pathway from proceeding because intermediary substrates are not produced This is a process of negative feedback ...
AnSc 5311 Ruminant Nutrition Microbial Fermentation of
... Ruminal cellulolytic organisms – cellulase activity is cellassociated, not found in cell-free ruminal fluid ...
... Ruminal cellulolytic organisms – cellulase activity is cellassociated, not found in cell-free ruminal fluid ...
Midterm Exam Advanced Biochemistry II (Answer) 1. At equilibrium
... 18. Role of Lactate Dehydrogenase During strenuous activity, the demand for ATP in muscle tissue is vastly increased. In rabbit leg muscle or turkey flight muscle, the ATP is produced almost exclusively by lactic acid fermentation. ATP is formed in the payoff phase of glycolysis by two reactions, pr ...
... 18. Role of Lactate Dehydrogenase During strenuous activity, the demand for ATP in muscle tissue is vastly increased. In rabbit leg muscle or turkey flight muscle, the ATP is produced almost exclusively by lactic acid fermentation. ATP is formed in the payoff phase of glycolysis by two reactions, pr ...
cAMP-Dependent Protein Kinase, Catalytic Subunit Product
... cAMP-Dependent Protein Kinase (PKA) is an ubiquitous serine/threonine protein kinase present in a variety of tissues, including brain, skeletal muscle and heart tissues. Changes in intracellular cAMP levels regulate cellular responses by influencing interaction between the Regulatory (R) and Catalyt ...
... cAMP-Dependent Protein Kinase (PKA) is an ubiquitous serine/threonine protein kinase present in a variety of tissues, including brain, skeletal muscle and heart tissues. Changes in intracellular cAMP levels regulate cellular responses by influencing interaction between the Regulatory (R) and Catalyt ...
Datasheet: AHP1261 Product Details
... alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localisation, stability, and possibly even the substrate specificity of AurB. Two CPCs ...
... alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localisation, stability, and possibly even the substrate specificity of AurB. Two CPCs ...
Technical Approach to Generate Polyclonal Antibodies Against
... injecting rabbits with GST-fusion proteins constructed by cloning the C-terminal of pyk-2 into pGEX-3X expression vector in frame. Protein engineering taking advantage of computer aided structural design based on available X-ray crystallographic coordinates has become a widely used tool for antigen ...
... injecting rabbits with GST-fusion proteins constructed by cloning the C-terminal of pyk-2 into pGEX-3X expression vector in frame. Protein engineering taking advantage of computer aided structural design based on available X-ray crystallographic coordinates has become a widely used tool for antigen ...
IIIb
... Do not use acronyms unless instructed to do so. Use structures whenever they are asked for, or appropriate. Your explanations should be brief. Overly lengthy answers with irrelevant or erroneous material will receive deductions. Use the back of the page if you ...
... Do not use acronyms unless instructed to do so. Use structures whenever they are asked for, or appropriate. Your explanations should be brief. Overly lengthy answers with irrelevant or erroneous material will receive deductions. Use the back of the page if you ...