Slide 1
... • Sample amount may be limiting for small tumors – RNA can be degraded – FFPE samples ...
... • Sample amount may be limiting for small tumors – RNA can be degraded – FFPE samples ...
West of England Genomic Medicine Centre Progress and plans
... – per sequence: GL/tumour mapped reads, insert size, chimeric reads, median coverage, ‘eveness’ of coverage – per variant: VRF ...
... – per sequence: GL/tumour mapped reads, insert size, chimeric reads, median coverage, ‘eveness’ of coverage – per variant: VRF ...
Clinical and genomic analysis of a randomised phase II study
... before and after treatment. The software finds the peaks corresponding to the major ploidy values (the blue dots in Sup Fig. 4B). When the amount of normal tissue differs before and after treatment the spacing of the peaks is different in the two plots. The linear model adjusts the scale to ensure ...
... before and after treatment. The software finds the peaks corresponding to the major ploidy values (the blue dots in Sup Fig. 4B). When the amount of normal tissue differs before and after treatment the spacing of the peaks is different in the two plots. The linear model adjusts the scale to ensure ...
2015_Abstract_ATLAS_seq résumé complet
... in humans. Several redundant cellular pathways limit L1 expression and mobility in normal tissues. In spite of these defense mechanisms, L1s are reactivated in 50% of all tumors, resulting in extensive genome remodeling. Yet, the cellular mechanisms leading to L1 reactivation in cancer are poorly un ...
... in humans. Several redundant cellular pathways limit L1 expression and mobility in normal tissues. In spite of these defense mechanisms, L1s are reactivated in 50% of all tumors, resulting in extensive genome remodeling. Yet, the cellular mechanisms leading to L1 reactivation in cancer are poorly un ...
Deciphering the links between Cancer and Aging via an integrOmics Network-based Meta-analysis approach (ACMON)
... in cancer cases and fatalities. Understanding the links between cancer and aging is therefore more important than ever. Moreover, the reported existence of cross- and tissue-specific tumor markers hampers even more the identification of bridges between the underlying processes. From the drug design ...
... in cancer cases and fatalities. Understanding the links between cancer and aging is therefore more important than ever. Moreover, the reported existence of cross- and tissue-specific tumor markers hampers even more the identification of bridges between the underlying processes. From the drug design ...
May 2014 Ben Ho Park, M.D., Ph.D. Presentation
... cancer cell that is different from normal cells, i.e. good target for therapy Also because mutations leading to cancer are somatic, it can in theory be a marker of cancer and used for detection and possible prognosis Sequencing involves amplifying via polymerase chain reaction (PCR) a “coding” r ...
... cancer cell that is different from normal cells, i.e. good target for therapy Also because mutations leading to cancer are somatic, it can in theory be a marker of cancer and used for detection and possible prognosis Sequencing involves amplifying via polymerase chain reaction (PCR) a “coding” r ...
BIOGRAPHICAL SKETCH NAME: Stuart, Joshua M eRA COMMONS
... perspective paper (Weinstein, Nat Genetics 2013) that described the overall project. I also led a group to collect all of the datasets produced by the six different data platforms in order to identify patient subtypes suggested by each of the data modalities (Hoadley, Cell 2014). The surprising find ...
... perspective paper (Weinstein, Nat Genetics 2013) that described the overall project. I also led a group to collect all of the datasets produced by the six different data platforms in order to identify patient subtypes suggested by each of the data modalities (Hoadley, Cell 2014). The surprising find ...
Pathology and the Lung Cancer Patient
... Today lung cancer remains the most frequent cause of cancer death in the United States. Tobacco smoking is the major cause of lung cancer. In male smokers, the risk of developing lung cancer is 8-15 times higher than in nonsmokers. In female smokers, the risk is 3-10 times higher versus non-smokers. ...
... Today lung cancer remains the most frequent cause of cancer death in the United States. Tobacco smoking is the major cause of lung cancer. In male smokers, the risk of developing lung cancer is 8-15 times higher than in nonsmokers. In female smokers, the risk is 3-10 times higher versus non-smokers. ...
Integrative analysis of genomic variants in carcinogenesis
... maximize efficacy and minimize toxicity. A key approach to conquer cancer is to identify cancer biomarkers that can be used for early diagnosis, accurate cancer type classification, and accurately predicting therapeutic outcome. Therefore, cancer biomarker discovery has been at the centre cancer res ...
... maximize efficacy and minimize toxicity. A key approach to conquer cancer is to identify cancer biomarkers that can be used for early diagnosis, accurate cancer type classification, and accurately predicting therapeutic outcome. Therefore, cancer biomarker discovery has been at the centre cancer res ...
DNA Based Diagnostics and Treatment
... • Scalability allows for it to be useful for viral/bacterial genomes along with large human genomes • Allows for better understanding of genetic mutations ...
... • Scalability allows for it to be useful for viral/bacterial genomes along with large human genomes • Allows for better understanding of genetic mutations ...
Material and Methods S1.
... in never smokers as part of a larger program (Programme National d’Excellence Spécialisée Poumon, or PNES Poumon) that was initiated by the Institut National du Cancer (INCa, France). The present collaborative work involved 13 centers in France (a list of participants is shown at the end of the manu ...
... in never smokers as part of a larger program (Programme National d’Excellence Spécialisée Poumon, or PNES Poumon) that was initiated by the Institut National du Cancer (INCa, France). The present collaborative work involved 13 centers in France (a list of participants is shown at the end of the manu ...
His group is trying different cell systems to look at
... and neck data represent the latest addition, which already includes similar data for breast, colorectal, ovarian, adenocarcinoma and squamous cell carcinoma of the lung, glioblastoma, and endometrial cancers. An analysis on the TCGA website shows that from January 2011 to December 2012, the number o ...
... and neck data represent the latest addition, which already includes similar data for breast, colorectal, ovarian, adenocarcinoma and squamous cell carcinoma of the lung, glioblastoma, and endometrial cancers. An analysis on the TCGA website shows that from January 2011 to December 2012, the number o ...
Unique cancer discovery opens path to early diagnosis and
... scientists in the divisions of pathology and human genetics at UCT’s medical campus and the Centre for Proteomics and Genomics Research to analyse the blood samples of South African patients. They hope to develop a low-cost gene expression tool for breast cancer that will form the basis of a routine ...
... scientists in the divisions of pathology and human genetics at UCT’s medical campus and the Centre for Proteomics and Genomics Research to analyse the blood samples of South African patients. They hope to develop a low-cost gene expression tool for breast cancer that will form the basis of a routine ...
Analysis and Integration of Large-scale Molecular and Clinical Data in
... in bio-databases and analysis tools. The main design principles are: ...
... in bio-databases and analysis tools. The main design principles are: ...
Genomics
... To date 228,000 human genomes have been sequenced worldwide (80% research) Sequencing dropped from $3 billion to near ...
... To date 228,000 human genomes have been sequenced worldwide (80% research) Sequencing dropped from $3 billion to near ...
bears 10 - EECS Berkeley
... BC Cancer Research Center Fred Hutchinson Cancer Research Center Complete Genomics Inc. Pacific NW National Laboratory University of Southern California Oregon Health & Science University Institute for Systems Biology University of California, Santa Cruz ...
... BC Cancer Research Center Fred Hutchinson Cancer Research Center Complete Genomics Inc. Pacific NW National Laboratory University of Southern California Oregon Health & Science University Institute for Systems Biology University of California, Santa Cruz ...
- HTG Molecular Diagnostics
... samples far too small for reliable RNA extraction • Reproducibility was robust, with technical replicates correlating >0.98, and small areas of the tumor correlating very well with each other, and reasonably well with NanoString and TaqMan data from extracted RNA • The lower limit for tissue input f ...
... samples far too small for reliable RNA extraction • Reproducibility was robust, with technical replicates correlating >0.98, and small areas of the tumor correlating very well with each other, and reasonably well with NanoString and TaqMan data from extracted RNA • The lower limit for tissue input f ...
Can high-throughput genomics data identify new therapeutic targets
... October 11: Wie Chen, University of Texas Medical School at Houston October 18: Gordana Vunjak-Novakovic, Columbia University ...
... October 11: Wie Chen, University of Texas Medical School at Houston October 18: Gordana Vunjak-Novakovic, Columbia University ...
For Immediate Release June 6, 2016 9:15 am EDT (8:15 CDT
... WHAT: The Genomic Data Commons (GDC), a unified data system that promotes sharing of genomic and clinical data between researchers, launched today with a visit from Vice President Joe Biden to the operations center at the University of Chicago. An initiative of the National Cancer Institute (NCI), t ...
... WHAT: The Genomic Data Commons (GDC), a unified data system that promotes sharing of genomic and clinical data between researchers, launched today with a visit from Vice President Joe Biden to the operations center at the University of Chicago. An initiative of the National Cancer Institute (NCI), t ...
Abstract - Cancer Imaging Archive Wiki
... ImageJ software. Mean, median, standard deviation, skew, and kurtosis of the normalized ADC and FA histograms were computed from voxels within tumor. Tumor volume also was computed. The diffusion histogram analysis has been performed on 39 of the TCGA glioblastomas at the time current time. Eighteen ...
... ImageJ software. Mean, median, standard deviation, skew, and kurtosis of the normalized ADC and FA histograms were computed from voxels within tumor. Tumor volume also was computed. The diffusion histogram analysis has been performed on 39 of the TCGA glioblastomas at the time current time. Eighteen ...
TCGA Data is
... https://lbg.unc.edu/~hoadley/BRCA.817.rsemg.uqnorm.counts.txt (all 20,000 gene expression values) https://lbg.unc.edu/~hoadley/BRCA.817.rsemg.uqnorm.counts.intrinsic.txt (~2000 gene “classification list”) ...
... https://lbg.unc.edu/~hoadley/BRCA.817.rsemg.uqnorm.counts.txt (all 20,000 gene expression values) https://lbg.unc.edu/~hoadley/BRCA.817.rsemg.uqnorm.counts.intrinsic.txt (~2000 gene “classification list”) ...
Workshop Contents - Khyber Medical University
... Organisers: Dr Asif Ali, Dr Yasar Mehmood Yousafzai & Dr Asif Naseer Date: 15 October Thursday, 2015 Time: 9:00am to 1:00pm Venue: Seminar Room, Institute of Basic Medical Sciences, Khyber Medical University Cost: Free event but prior registration is required. Kindly email your interest to the follo ...
... Organisers: Dr Asif Ali, Dr Yasar Mehmood Yousafzai & Dr Asif Naseer Date: 15 October Thursday, 2015 Time: 9:00am to 1:00pm Venue: Seminar Room, Institute of Basic Medical Sciences, Khyber Medical University Cost: Free event but prior registration is required. Kindly email your interest to the follo ...
Hartmaier et al., Supplementary Methods Novel insights into
... gene fusions, as previously described (1). Since tumor samples were sequenced without a corresponding matching normal sample, additional custom filtering was applied to highlight cancer-relevant alterations and reduce noise from benign germline events (Supplementary Fig S2). In brief, frequent germl ...
... gene fusions, as previously described (1). Since tumor samples were sequenced without a corresponding matching normal sample, additional custom filtering was applied to highlight cancer-relevant alterations and reduce noise from benign germline events (Supplementary Fig S2). In brief, frequent germl ...