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- Sapien Biosciences

... Fresh tumor and adjacent non-tumor samples Hematological tumors Blood, Plasma, Serum Saliva, Urine, BAL, Pleural fluid, synovial fluid etc. Non-diseased specimens ...
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... cancer has metastasized to other parts of the body, only about 12% of patients will live longer than five years following their diagnosis7. Therefore, it is important to identify and diagnose RCC at early stages5,7. If RCC is diagnosed in the early stages before it has spread to other parts of the b ...
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... origin of several cancers affecting both human and dog. Analysis of our data has revealed that we are well on the way towards development of more sophisticated molecular sub-classification of canine, and possibly human, cancers. This approach should facilitate the emergence of improved and tailored ...
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Personal Genome Diagnostics Announces AACR Annual Meeting
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... identify tumor neoantigens and support development of cancer immunotherapies. The service combines the high accuracy of PGDx’s CancerXomeTM analysis with its proprietary bioinformatics neoantigen prediction pipeline. The study data demonstrate that the company’s combined tissue processing, macrodiss ...
GlOSSARY OF COMMON FORMS OF CANCER
GlOSSARY OF COMMON FORMS OF CANCER

... blood cells. There are two main groups, acute myeloid leukemia and chronic myelogenous leukemia; there are eight subtypes of acute myeloid leukemia. Nonmyeloid cancers: All cancers other than myeloid leukemias. These nonmyeloid cancers include all types of carcinoma, sarcoma, melanoma, lymphomas, ly ...
Understanding progressive disease
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... The study assesses the quality of routine national datasets for analysing progressive cancer, and determines how these data can be used to develop a methodology to identify cancer progression. The project is in the early stages, but initial analysis will be complete later this year. There are a numb ...
The Role of Alternative Polyadenylation in Glioblastoma
The Role of Alternative Polyadenylation in Glioblastoma

... The University of Texas Medical Branch at Galveston Lay Summary: Glioblastoma (GBM) is the most prevalent and malignant primary brain tumor. The unfortunate combination of its infiltrative growth and aggressive phenotype prevents virtually any positive clinical outcome. The Cancer Genome Atlas proje ...
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Hydrogels for bladder cancer

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Merkel*s Cell Carcinoma
Merkel*s Cell Carcinoma

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Identification of Lung Cancer Biomarkers in the Clinical Molecular

... for mutation analysis from a panel of 50 genes. The results of this test indicate that tumor cells comprising 25.0% of the tissue specimen analyzed were normal for BRAF, KRAS and hotspots in 46 other genes. A p.L858R activating mutation was detected in exon 21 of the EGFR gene suggesting that this p ...
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Big Data–Led Cancer Research, Application, and Insights

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The Cancer Genome Atlas

The Cancer Genome Atlas (TCGA) is a project, begun in 2005, to catalogue genetic mutations responsible for cancer, using genome sequencing and bioinformatics. TCGA represents an effort in the War on Cancer that is applying high-throughput genome analysis techniques to improve our ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of this disease.TCGA is supervised by the National Cancer Institute and the National Human Genome Research Institute funded by the US government. A three-year pilot project, begun in 2006, focused on characterization of three types of human cancers: glioblastoma multiforme, lung, and ovarian cancer. In 2009, it expanded into phase II, which plans to complete the genomic characterization and sequence analysis of 20-25 different tumor types by 2014. Funding is split between genome characterization centers (GCCs), which perform the sequencing, and genome data analysis centers (GDACs), which perform the bioinformatic analyses.The project scheduled 500 patient samples, more than most genomics studies, and used different techniques to analyze the patient samples. Techniques gene expression profiling, copy number variation profiling, SNP genotyping, genome wide DNA methylation profiling, microRNA profiling, and exon sequencing of at least 1,200 genes. The TCGA is sequencing the entire genomes of some tumors, including at least 6,000 candidate genes and microRNA sequences. This targeted sequencing is being performed by all three sequencing centers using hybrid-capture technology. In phase II, TCGA is performing whole exon sequencing on 80% of the cases and whole genome sequencing on 80% of the cases used in the project.
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