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Surveillance, Epidemiology and End Results (SEER) Program
Surveillance, Epidemiology and End Results (SEER) Program

... 9. Percent Complete as of February 2009 10. 1 year reporting delay 11. Follow-up age < 20 12. Follow-up age 20-64 13. Follow-up age 65+ 14. Follow-up all in situs ...
Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab
Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab

... to no trastuzumab. Overall, 202 of 232 HER2-positive tumors had sufficient good quality RNA for gene expression analysis. The clinical pathological characteristics of the patients with HER2-positive tumors who also had available gene expression data (n = 202) were compared with the general series (n ...
Lung Tumors
Lung Tumors

... cells, which accumulate and eventually lead to the neoplastic phenotype. It has been estimated that 10 to 20 genetic mutations have occurred by the time the tumor is clinically apparent.[121] As will be discussed below, for all practical purposes, lung cancers can be divided into two clinical subgro ...
cervical squamous cell carcinoma metastases to the brain
cervical squamous cell carcinoma metastases to the brain

Key factors in the acquisition of contrast kinetic data for oncology
Key factors in the acquisition of contrast kinetic data for oncology

... the desire to sample the entire tumor with the highest spatial resolution possible (see Spatial and Temporal Resolution, below). Moreover, the temporal requirements for accurately characterizing the more rapidly changing arterial time-concentration curve are greater than for the tissue if a rapid bo ...
risk Prediction for late-Stage Ovarian cancer by Meta
risk Prediction for late-Stage Ovarian cancer by Meta

... Criteria for inclusion of studies in this database, the corresponding literature reviews, and the data-processing protocols have been described previously (5). We restricted our meta-analysis to primary, late-stage, high-grade, serous tumors with available overall survival time-to-event data (Table  ...
1 Retrospective Study of Canine Cutaneous Neoplasia RESUMO O
1 Retrospective Study of Canine Cutaneous Neoplasia RESUMO O

... (29/8,36%), Adanal Gland Adenoma (25/7,20%), Cutaneous Transmissible Venereal ...
Metastatic squamous cell carcinoma of colon from esophageal cancer
Metastatic squamous cell carcinoma of colon from esophageal cancer

... The predominant histology type of primary colorectal cancer is adenocarcinoma; less common ones include neuroendocrine tumor, lymphoma, sarcoma and SCC [14]. The incidence of primary colorectal SCC is about 0.4% of colorectal cancers, and more than 90% of cases are at the rectum which may be associa ...
Classification of DCE-MRI Data for Breast Cancer Diagnosis
Classification of DCE-MRI Data for Breast Cancer Diagnosis

... In this section, we study the performance of the 3TP segmentation methods, the impact of the ROI selection and the performance of different classifiers. Our implementation is done in Matlab 2015a on a Windows 7 platform with an Intel Core i5 CPU at 3.3GHz and 8GB memory. Fig. 3 shows two example tum ...
Genome‑wide analysis of gynecologic cancer: The Cancer Genome
Genome‑wide analysis of gynecologic cancer: The Cancer Genome

... Data from the tumor genomes of several hundred patients with ovarian cancer, brain tumors or squamous cell lung cancer, and comparative data from normal genomes, have been analyzed in the CGA (14‑16). These results were published in 2009, and formed the basis for the Pan‑Cancer Analysis Project, whi ...
- NetGestalt
- NetGestalt

... button below the “Search System Tracks” button (see red box in Figure 7). In the “Upload Track” dialog, the user can click the “Choose File” button to select a local file (see blue box in Figure 7), then select the type of gene identifier from the “ID type” drop down box (see orange box in Figure 7) ...
Primary Neuroendocrine Carcinoma of the Breast
Primary Neuroendocrine Carcinoma of the Breast

... mammary carcinoid tumor is a neuroendocrine neoplasm derived from argyrophilic cells of neural-crest origin. In most of the early studies, primary breast NE carcinoma was diagnosed using Grimeliu’s stain and electron microscopy6. However, according to some reports, only 5-10% of ordinary breast carc ...
Era of molecular targeted therapy for lung cancer: The
Era of molecular targeted therapy for lung cancer: The

... •May help maintain pluripotency, may allow for squamous differentiation. These discoveries have ushered in a new era of targeted therapeutic agents for patients with Squamous Cell Carcinoma. Lung cancer genomics –Gene expression profiling and lung cancer classificationAlain Borczuk, MDColumbia Unive ...
From Bytes to Bedside: Data Integration and Computational Biology for Translational Perspective
From Bytes to Bedside: Data Integration and Computational Biology for Translational Perspective

... use, distribution, and reproduction in any medium, provided the original author and source are credited. Abbreviations: caBIG, Cancer Biomedical Informatics Grid; CGH, comparative genomic hybridization; FISH, fluorescent in situ hybridization; mRNA, messenger RNA; miRNA, microRNA; MITF, micropthalmi ...
Overview of the Stage Capture and Pathology Reporting Project The
Overview of the Stage Capture and Pathology Reporting Project The

... hospitals that are electronically submitting pathology reports to CCO. All reports will be standardized according to the College of American Pathologists cancer reporting checklist standard, for all cancer sites. CCO is working in collaboration with hospitals, laboratories and pathologists across On ...
Cancer of the Esophagus and Esophagogastric Junction
Cancer of the Esophagus and Esophagogastric Junction

... T1 subcategorized as T1a and T1b, producing stage subgroups IA and IB for squamous cell carcinoma and IA and IC for adenocarcinoma T2 squamous cell carcinoma: location removed as staging category T4a includes direct invasion of peritoneum G4 was eliminated, and additional testing is required to unco ...
Additional file 2
Additional file 2

... Where Jij is the Jaccard index (the ratio between size of the intersection and the size of the union of the representative probe sets of component i and j); Cij is the cosine correlation coefficient between the weights of the common representative probe sets of component i and j. In the DNBC study, ...
Comprehensive Genomic Profiling Of 295 Cases of Clinically
Comprehensive Genomic Profiling Of 295 Cases of Clinically

... events. Comprehensive genomic profiling was performed and revealed an FGFR1-NTM rearrangement as well as amplifications of CCND3 ,CDK4, MCL1, MDM2 and MYC genes. Images to the right demonstrate response of a lung metastasis to treatment with the FGFR inhibitor, pazopanib and the MTOR inhibitor, ever ...
Full Text Article - European Journal of Pharmaceutical and Medical
Full Text Article - European Journal of Pharmaceutical and Medical

... survival rate of patients. In recent years, the growing interest of researchers to investigate the role of microRNAs (miRNAs) in various biological processes as well as many disease including carcinomas. With the advent of next generation sequencing technique, it has been determined that about 1400 ...
How Wide Is the Spectrum of Neuroendocrine Carcinoma of the
How Wide Is the Spectrum of Neuroendocrine Carcinoma of the

... We suspect that this large cell variant of NE bladder carcinoma is quite rare, but we are not certain about the extent of NE differentiation in urothelial carcinomas until a large series of cases is immunostained with NE markers. ...
Document
Document

... 3. Lymphatic invasion: data conflicting; overlaps with other indications. This is also a very subjective determination ...
Tubal Hypothesis of Ovarian Cancer
Tubal Hypothesis of Ovarian Cancer

... important to understand at what age this occurs to inform ideal timing for salpingectomy. • The border between the tubal and ovarian surface epithelium could be a site of malignant transformation, making it a high-risk zone that salpingectomy alone may not effectively address. In Summary: Ovarian ca ...
Identification of novel target proteins in sebaceous gland carcinoma
Identification of novel target proteins in sebaceous gland carcinoma

... malignancies arising most commonly from the meibomian or Zeis glands.1 There is a high tendency for metastatic disease particularly to regional lymph nodes.2 Unfortunately, despite early and aggressive surgical treatment, patients with sebaceous gland carcinomas have a high incidence rate of locoreg ...
CCOP Agreement Letter - Southeast Clinical Oncology
CCOP Agreement Letter - Southeast Clinical Oncology

... Consortium, Inc. (SCCC), of Winston-Salem, North Carolina. The agreement is intended to assure compliance with all requirements of the National Institute of Health (NIH), the National Cancer Institute (NCI), Office for Human Research Protections (OHRP), the Food and Drug Administration (FDA), and th ...
Analysis of Copy Number Loss of the ErbB4 Receptor
Analysis of Copy Number Loss of the ErbB4 Receptor

... in TCGA and the general, healthy population in DECIPHER disproved our initial hypothesis that ERBB4 may be acting as a tumor suppressor in GBM. We attribute this artefactual initial finding from glioma cell lines in CCLE to a number of possible factors including the known limitations associated with ...
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The Cancer Genome Atlas

The Cancer Genome Atlas (TCGA) is a project, begun in 2005, to catalogue genetic mutations responsible for cancer, using genome sequencing and bioinformatics. TCGA represents an effort in the War on Cancer that is applying high-throughput genome analysis techniques to improve our ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of this disease.TCGA is supervised by the National Cancer Institute and the National Human Genome Research Institute funded by the US government. A three-year pilot project, begun in 2006, focused on characterization of three types of human cancers: glioblastoma multiforme, lung, and ovarian cancer. In 2009, it expanded into phase II, which plans to complete the genomic characterization and sequence analysis of 20-25 different tumor types by 2014. Funding is split between genome characterization centers (GCCs), which perform the sequencing, and genome data analysis centers (GDACs), which perform the bioinformatic analyses.The project scheduled 500 patient samples, more than most genomics studies, and used different techniques to analyze the patient samples. Techniques gene expression profiling, copy number variation profiling, SNP genotyping, genome wide DNA methylation profiling, microRNA profiling, and exon sequencing of at least 1,200 genes. The TCGA is sequencing the entire genomes of some tumors, including at least 6,000 candidate genes and microRNA sequences. This targeted sequencing is being performed by all three sequencing centers using hybrid-capture technology. In phase II, TCGA is performing whole exon sequencing on 80% of the cases and whole genome sequencing on 80% of the cases used in the project.
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