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How Much Tissue Sampling Is Required When Unsuspected
How Much Tissue Sampling Is Required When Unsuspected

... in any of our patients. Therefore, additional examination of the remaining tissue in this study was not contributory when T1a tumor was detected in the initial 6 cassettes. We have not included the initial Gleason scores in stratifying stage T1 disease. However, of 26 cases only 1 showed Gleason sco ...
Supervised Risk Predictor of Breast Cancer Based
Supervised Risk Predictor of Breast Cancer Based

... Total RNA isolation, labeling, and hybridizations on Agilent human 1Av2 microarrays or custom-designed Agilent human 22k arrays were performed using the protocol described in Hu et al.6 All microarray data have been deposited into the Gene Expression Omnibus18 under the accession number of GSE10886. ...
Profiling Tumor-Associated Antibodies for Early Detection of Non
Profiling Tumor-Associated Antibodies for Early Detection of Non

... model showed great homology to paxillin, SEC15L2, BAC clone RP11-499F19, XRCC5, and MALAT1. The first three were identified in previous work as immunoreactive with plasma from patients with advanced-stage lung cancers.8 XRCC5 is a DNA repair gene overexpressed in some lung cancers.12 Anomalous activ ...
Intra-procedural Transcatheter Intraarterial Perfusion MRI as
Intra-procedural Transcatheter Intraarterial Perfusion MRI as

... acceleration factor 2. Dynamic images were acquired for 35 sec after IA injection of 5 or 10 mL 20% Gd-DTPA contrast (Magnevist, Berlex). Imaging parameters were chosen to provide a relatively linear relationship between signal intensity and tissue contrast agent concentration. Tumor regions-of-inte ...
studies in the incidence tumors
studies in the incidence tumors

... case mentioned by Creighton (15) as having been reported by Twort, in which a cancer of the pylorus of a mouse apparently resulted from the injury produced by a piece of swallowed glass. In our earlier report mention was made of an adenocarcinoma developing under a hair ball in the stomach. Similar ...
Solid Tumour Section Head and neck: Laryngeal squamous cell carcinoma
Solid Tumour Section Head and neck: Laryngeal squamous cell carcinoma

... abnormalities in short-term cultured primary squamous cell carcinomas of the head and neck. Cancer Res 1995;55:32043210. ...
Bilateral Primary Adenocarcinoma of Fallopian Tube: A Case Report
Bilateral Primary Adenocarcinoma of Fallopian Tube: A Case Report

... The carcinoma of the fallopian tube is the least common of all gynecological malignancies and accounts for approximately 0.14-1.8% of all female genital tract malignancies. The annual incidence is about 3.6 per million women per year.4 The primary carcinoma of the fallopian tube is rarer, accounting ...
Cancer Registry is a Dynamic Profession
Cancer Registry is a Dynamic Profession

... cancer free ...
Learn More about Cancer Registry Services
Learn More about Cancer Registry Services

... cancer free ...
Cancer Review
Cancer Review

... In cancer research each cancer sample presents the researcher with an altered genome that contains a unique and unpredictable number of point mutations, indels, translocations, fusions, and other aberrations. Since many of these alterations might never have been observed before and might not necessa ...
Ovarian Cancer
Ovarian Cancer

... called  serous  intraepithelial  tubal  CA   (STIC)  ,    is  very  similar  to  high-­‐grade   ovarian  serous  carcinoma.       •  The  current  theory  is  that  most  of  these   tumors  arise  from  a  STIC  in  the  Uimbriated ...
Identification of tissue of origin in carcinoma of unknown primary
Identification of tissue of origin in carcinoma of unknown primary

... immunohistochemistry (IHC) panels can help identify the tissue of origin, the primary site is identified in * Correspondence: [email protected] ...
DNA Copy Number Aberrations in Breast Cancer by Array
DNA Copy Number Aberrations in Breast Cancer by Array

... parameters (20 ). Markers from gene expression micorarray analyses have also shown some promise as a prognostic tool in breast cancer (21 , 22 ). Thus, novel molecular profiling and classification of breast cancers should eventually give stronger correlation with clinical outcome and patient surviva ...
Breast Cancer: Ductal Carcinoma In-Situ
Breast Cancer: Ductal Carcinoma In-Situ

... It is suggested by the findings of this report that the USC/Van Nuys Prognostic Index may be a useful aid in the decision making process for those patients diagnosed with DCIS. ‘With advancing technology, there will come a time when patients with DCIS can be better defined as to whether or not their ...
Esophageal Cancer - Prof. Dr. Koray TOPGÜL
Esophageal Cancer - Prof. Dr. Koray TOPGÜL

... than 50% of people with esophageal carcinoma. • Pain can be felt in the epigastric or retrosternal area. It can also be felt over bony structures, representing a sign of metastatic disease. • Hoarseness caused by invasion of the recurrent laryngeal nerve is a sign of unresectability. • Respiratory s ...
1995-2010 SAMC Ductal Carcinoma In-situ
1995-2010 SAMC Ductal Carcinoma In-situ

... It is suggested by the findings of this report that the USC/Van Nuys Prognostic Index may be a useful aid in the decision making process for those patients diagnosed with DCIS. ‘With advancing technology, there will come a time when patients with DCIS can be better defined as to whether or not their ...
Head and Neck - Florida Cancer Data System
Head and Neck - Florida Cancer Data System

... Dental Director, AIDS Resource Ctr of Wisconsin http://www.hivdent.org/_picturegallery_/HPV1.htm ...
Greater Than the Sum of Its Parts: Single
Greater Than the Sum of Its Parts: Single

... may be an emergent property arising from the interplay of competition and cooperation between tumor cells differing in genetic and functional properties. This emergent balance can potentially be shaped by nutrient limitations, regional influences, and the capability of tumor cells to signal to each o ...
Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma
Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma

... occur in approximately 50% of patients of all histological types and the positivity correlated with disease stage. This biomarker could be used either alone, or in combination with other biomarkers, for diagnosis and prognosis of lung carcinoma. ...
1 Genomic analysis of metastatic cutaneous squamous cell
1 Genomic analysis of metastatic cutaneous squamous cell

... are 65-times more likely to develop cSCC (10). Human papillomavirus (HPV) infection has also been associated with increased risk in developing cSCC (11) and patients on chemotherapy targeting BRAF frequently develop cSCCs with RAS mutations (12). The risk factors for developing metastases are less c ...
Profiles and Cancer Stem Cell Organization Single
Profiles and Cancer Stem Cell Organization Single

... difficulty in measuring tumor dynamics directly in patients, various parameters such as the CSC organization, the rate of mutation and apoptosis, and the tumor age, have not been quantified. These features play a fundamental role in tumor progression and therapy response and are likely variable among ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... diagnosis of cholecystitis. The risk of GBC increases with increasing size of the gall stones—patients with larger stones (>3 cm) have about a ten times higher risk of having GBC as compared to those with smaller (<1cm) stones (10,11). Other risk factors are female sex, obesity, increasing age, typh ...
Gallium-67 accumulation to the tumor thrombus in anaplastic thyroid
Gallium-67 accumulation to the tumor thrombus in anaplastic thyroid

... Although there are many cases of thyroid cancer accompanied by infiltration to lymphatic and blood vessels, cases of thyroid cancer with tumor thrombus seem to be rare.2 Onaran et al. reported only 3 such cases (1.5%) out of 204 cases of thyroid cancer that received surgery.3 Thompson et al. reporte ...
Association of Directors of Anatomic and Surgical Pathology
Association of Directors of Anatomic and Surgical Pathology

... term for the presence of tumor beyond the confines of the prostate gland.11 Tumor abutting or admixed with fat constitutes EPE and, in general, is the only method to reliably diagnose EPE on needle biopsy. However, if one relies on the identification of tumor in fat to diagnose EPE in radical prosta ...
PDF
PDF

... not peer-reviewed) is the author/funder. It is made available under a CC-BY-ND 4.0 International license. ...
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The Cancer Genome Atlas

The Cancer Genome Atlas (TCGA) is a project, begun in 2005, to catalogue genetic mutations responsible for cancer, using genome sequencing and bioinformatics. TCGA represents an effort in the War on Cancer that is applying high-throughput genome analysis techniques to improve our ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of this disease.TCGA is supervised by the National Cancer Institute and the National Human Genome Research Institute funded by the US government. A three-year pilot project, begun in 2006, focused on characterization of three types of human cancers: glioblastoma multiforme, lung, and ovarian cancer. In 2009, it expanded into phase II, which plans to complete the genomic characterization and sequence analysis of 20-25 different tumor types by 2014. Funding is split between genome characterization centers (GCCs), which perform the sequencing, and genome data analysis centers (GDACs), which perform the bioinformatic analyses.The project scheduled 500 patient samples, more than most genomics studies, and used different techniques to analyze the patient samples. Techniques gene expression profiling, copy number variation profiling, SNP genotyping, genome wide DNA methylation profiling, microRNA profiling, and exon sequencing of at least 1,200 genes. The TCGA is sequencing the entire genomes of some tumors, including at least 6,000 candidate genes and microRNA sequences. This targeted sequencing is being performed by all three sequencing centers using hybrid-capture technology. In phase II, TCGA is performing whole exon sequencing on 80% of the cases and whole genome sequencing on 80% of the cases used in the project.
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