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Fasciolosis
Fasciolosis

... Fasciolosis Fasciolosis is a worldwide zoonotic disease caused by trematode parasite of the genus Fasciola. WHO (2011) estimates that at least 2.4 million people are infected in more than 70 countries world wide, with several million people at risk. Recently, Fasciola sp. was added to the WHO list ...
Innate immunity
Innate immunity

... mechanism of the phagocytes. It involves both the consumption of oxygen and specific aminoacids to produce toxic compounds. • Reactive oxygen species (ROS) include H2O2, O2.-, O. and are generated by the NADPH oxidase. Those compounds are able to destroy/destabilize all major classes of biomolecules ...
Why Is It So Difficult To Develop A Malaria Vaccine?
Why Is It So Difficult To Develop A Malaria Vaccine?

... Asn-Ala-Asn-Pro (NANP) interspersed with four copies of Asn-Val-Asp-Pro (NVDP). The function of the CS repeats is unknown, but they may fulfill a structural role, with repeats from neighbouring CS molecules interlocked to form a sheath surrounding the parasite. CSP antibody responses to the CS prote ...
The Future of Smallpox Vaccination - Medical Immunology
The Future of Smallpox Vaccination - Medical Immunology

... outcome of clinical trials that directly compare the immunogenicity of MVA to either Dryvax or ACAM1000, two vaccines that are likely to provide the required high levels of protective immunity that will be necessary in the event of an accidental or deliberate smallpox outbreak. Quantitative analysis ...
Immune System and Parkinson`s Disease
Immune System and Parkinson`s Disease

... active disease state and is believed to actually cause an effect leading to further neurodegeneration by inducing cell death in dopaminergic neurons [30]. Once microglia become activated by a stimulus such as α-synuclein, they may remain activated and respond atypically to subsequent stimuli thereby ...
Document
Document

... to fungi are elicited. These primary barriers to fungal infection include intact skin, naturally occurring long-chain unsaturated fatty acids※, and competition with normal bacterial flora. In addition the mucous membranes are covered with fluids containing antifungal substances. Furthermore, many ep ...
Experts and glutathione
Experts and glutathione

... Diabetics are prone to infections and circulatory problems leading to heart disease, kidney failure and blindness. Glutathione protects against the complications of diabetes. Clinical Science 91: 575-582, 1996 ...
Inbred decorated crickets exhibit higher immunity than outbred
Inbred decorated crickets exhibit higher immunity than outbred

... and hemocytes. In this study, we examined both cellmediated and humoral responses. First, we estimated the amount of the inactive hemolymph-bound enzyme, phenoloxidase (PO). PO catalyzes the reaction of dopamine into melanin, a key step in the encapsulation response pathway (Söderhäll and Cerenius ...
Novel vaccines from biotechnology
Novel vaccines from biotechnology

... immunosuppressive components associated with the pathogen, there is a significant risk during production, especially with Level III organisms, due to the potential of accidental release or escape to the external environment and subsequent transmission. It is for these reasons that native-organism pu ...
Canine Vaccines:
Canine Vaccines:

... recommends that the product literature indicates that: The regime for booster vaccinations is based on a minimum duration of immunity rather than a maximum A risk/benefit assessment should be made for each individual animal by the veterinarian in consultation with the owner with respect to each vacc ...
LESSON 2: THE ADAPTIVE IMMUNITY Today we will get to know
LESSON 2: THE ADAPTIVE IMMUNITY Today we will get to know

... differentiate into either plasma cells (antibody-producing cells) or memory cells (cells which are “stored” to ensure a fast antibody response against the same pathogen). They are involved in humoral immunity. • T lymphocytes (or T-cells) are involved in cellular immunity because they do not produce ...
Destiny Johnson Assignment #1 Professor Gallo 15 September
Destiny Johnson Assignment #1 Professor Gallo 15 September

... Pertussis is very contagious with an 80% secondary attack rate (CDC, 2005). The transmission of pertussis occurs via respiratory droplets. However, direct contact with respiratory secretions from infected individuals may lead to the disease (CDC, 2005). Additionally, freshly contaminated articles, s ...
The influence of sex and gender on immunity, infection and
The influence of sex and gender on immunity, infection and

... the up-regulation of TLR–associated genes, that activate IFN production only in women [61]. In the case of Hepatitis B vaccination in children and adults, antiHBV antibody titers are higher in females than males [62, 63]. Similarly, the antibody responses to seasonal trivalent inactivated influenza ...
Single-trial conditioning in a human taste-endotoxin
Single-trial conditioning in a human taste-endotoxin

... the behaviorally conditioned immune response was accompanied by a pronounced taste aversion against the CS. Human studies in which experimental immune activation was induced reported inconsistent results regarding a behaviorally conditioned immune activation. One study failed to behaviorally conditi ...
Policy Forum
Policy Forum

... unclear whether the induction of neutralizing antibodies is the only response contributing to robust protection, or whether other functional characteristics of non-neutralizing antibodies have equal or additional importance [30–32]. This question may be key in focusing vaccine development efforts. N ...
Vaccination in autoimmune diseases
Vaccination in autoimmune diseases

... Infections and vaccinations are often associated with the development of autoimmune diseases (AID). Infections may trigger AID via antigen-specific (molecular mimicry) or antigen-nonspecific mechanisms (bystander activation). By contrast, a protective role of infections has also been proposed. The h ...
Upswing in Local Influenza activity
Upswing in Local Influenza activity

... Offer influenza vaccine to your patients, especially those who are at high risk. Annual influenza vaccine is recommended for all people ages six months and older who do not have contraindications. Review the categories considered to be high risk for influenza complications: o Children younger than 5 ...
Diphtheria, Tetanus and Acellular Pertussis
Diphtheria, Tetanus and Acellular Pertussis

... coughing and sneezing. It causes sore throat, fever and chills. It can be complicated by breathing problems, heart failure and nerve damage. Treatment for diphtheria includes an antitoxin, followed by antibiotics. However, it is becoming more difficult to treat the diphtheria bacteria due to antibio ...
and t-lymphocyte immune deficiencies
and t-lymphocyte immune deficiencies

...  The most common causative organisms are bacteria such as S. pneumoniae and H. influenza  Severe inherited disorders of antibody production are rare  usually present at 5-6 months of age, when the protective benefit of transferred maternal immunoglobulin has waned  Three major primary antibody d ...
Deserves a Shot at Fighting Flu Immunization Programs
Deserves a Shot at Fighting Flu Immunization Programs

... (HCP), vaccine coverage rates continue to fall below the 2010 national health objective goal of 60%. According to the Centers for Disease Control and Prevention (CDC), estimated vaccination coverage of HCP remains less than 50%. Nevertheless, vaccination of HCP is an important component of influenza ...
FA13 BIOS 40427 Topics in Epidemiology—Modern Infectious
FA13 BIOS 40427 Topics in Epidemiology—Modern Infectious

... Please note that there will be a number of different instructors who will provide students with training in specific skill areas. This course is to introduce students to the field and methodology for researching modern infectious disease epidemiology. The emphasis will be on the important need to ta ...
A New Hypothesis: correlation between Phlogosis Allergic Minimum
A New Hypothesis: correlation between Phlogosis Allergic Minimum

... The criteria are the absence of any pathological underlying condition (primary or secondary immunodeficiency, cystic fibrosis, malformations of airways, immotile-cilia syndrome) justifying the recurrence of infections and the presence of at least one of the following conditions: a) six or more annua ...
Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2
Role of Innate Immunity in the Pathogenesis of Type 1 and Type 2

... diabetes after transfer of specific autoreactive T cells, etc. However, recent investigations by many investigators showed essential role of innate immunity also which has not been appreciated for a long time. Indeed, the field of innate immunity itself has been neglected since the discovery of inna ...
Chapter_021
Chapter_021

... Active immunity—when the immune system responds to a harmful agent regardless of whether it was natural or artificial; lasts longer than passive  Passive immunity—developed when immunity from another individual is transferred to an individual who was not previously immune; it is temporary but provi ...
Immunomodulatory Activity of Septilin, a Polyherbal
Immunomodulatory Activity of Septilin, a Polyherbal

... Drug therapy was continued and 7 days later (i.e. on day 28 of drug therapy), 0.01 mL of 3% oxazolone sensitizing agent was applied to the inner and outer aspect of the left ear after measuring the initial ear thickness with a micrometer screw gauge. Twenty four hours after the challenge, the thickn ...
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Herd immunity



Herd immunity (also called herd effect, community immunity, population immunity, or social immunity) is a form of indirect protection from infectious disease that occurs when a large percentage of a population has become immune to an infection, thereby providing a measure of protection for individuals who are not immune. In a population in which a large number of individuals are immune, chains of infection are likely to be disrupted, which stops or slows the spread of disease. The greater the proportion of individuals in a community who are immune, the smaller the probability that those who are not immune will come into contact with an infectious individual.Individual immunity can be gained through recovering from a natural infection or through artificial means such as vaccination. Some individuals cannot become immune due to medical reasons and in this group herd immunity is an important method of protection. Once a certain threshold has been reached, herd immunity will gradually eliminate a disease from a population. This elimination, if achieved worldwide, may result in the permanent reduction in the number of infections to zero, called eradication. This method was used for the eradication of smallpox in 1977 and for the regional elimination of other diseases. Herd immunity does not apply to all diseases, just those that are contagious, meaning that they can be transmitted from one individual to another. Tetanus, for example, is infectious but not contagious, so herd immunity does not apply.The term herd immunity was first used in 1923. It was recognized as a naturally occurring phenomenon in the 1930s when it was observed that after a significant number of children had become immune to measles, the number of new infections temporarily decreased, including among susceptible children. Mass vaccination to induce herd immunity has since become common and proved successful in preventing the spread of many infectious diseases. Opposition to vaccination has posed a challenge to herd immunity, allowing preventable diseases to persist in or return to communities that have inadequate vaccination rates.
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