Chapter 9 Population genetics Heritability
... Heritability = Vg/Vp Heritability = Vg/Vg+Ve This is broad-sense heritability (H2). It defines the ...
... Heritability = Vg/Vp Heritability = Vg/Vg+Ve This is broad-sense heritability (H2). It defines the ...
Exome Sequencing Project release
... population and often were only observed in a single individual, explained Dr. Leal, who presented the findings today at the American Society of Human Genetics 2012 meeting. Dr. Leal added that most of the observed coding variants are population specific, occurring in either European or African Ameri ...
... population and often were only observed in a single individual, explained Dr. Leal, who presented the findings today at the American Society of Human Genetics 2012 meeting. Dr. Leal added that most of the observed coding variants are population specific, occurring in either European or African Ameri ...
breeding salmon for resistance to infectious pancreatic necrosis
... those receiving the susceptible variant from both parents have mortality levels higher than 50% during epidemics. The disease resistance effect does not appear to show any negative correlations with other economically important production traits. Dr Ross Houston has continued the research using high ...
... those receiving the susceptible variant from both parents have mortality levels higher than 50% during epidemics. The disease resistance effect does not appear to show any negative correlations with other economically important production traits. Dr Ross Houston has continued the research using high ...
breeding salmon for resistance to infectious pancreatic necrosis
... those receiving the susceptible variant from both parents have mortality levels higher than 50% during epidemics. The disease resistance effect does not appear to show any negative correlations with other economically important production traits. Dr Ross Houston has continued the research using high ...
... those receiving the susceptible variant from both parents have mortality levels higher than 50% during epidemics. The disease resistance effect does not appear to show any negative correlations with other economically important production traits. Dr Ross Houston has continued the research using high ...
GENESIS: genome evolution scenarios
... in score per weight is 2/wt, this yields a 1.5 approximation. We combined the algorithm with a greedy strategy that generates different starting sequences, out of which the one with the best gain in score per weight is applied. A further improvement of the output can be obtained if the greedy strate ...
... in score per weight is 2/wt, this yields a 1.5 approximation. We combined the algorithm with a greedy strategy that generates different starting sequences, out of which the one with the best gain in score per weight is applied. A further improvement of the output can be obtained if the greedy strate ...
幻灯片 1 - SERSC
... each parameter and feature chromosome from its genotype into a phenotype. (4) Feature subset. After the genetic operation and converting each feature subset chromosome from the genotype into the phenotype, a feature subset can be determined. ...
... each parameter and feature chromosome from its genotype into a phenotype. (4) Feature subset. After the genetic operation and converting each feature subset chromosome from the genotype into the phenotype, a feature subset can be determined. ...
Abundant Genetic Overlap between Blood Lipids and Immune
... approach to identify shared genetic risk loci between psychiatric, cardiovascular, immunerelated diseases and cancer[15–20]. Conjunction FDR, denoted by FDRtrait1& trait2 is defined as the posterior probability that a SNP is null for either phenotype or both simultaneously, given the p-values for bo ...
... approach to identify shared genetic risk loci between psychiatric, cardiovascular, immunerelated diseases and cancer[15–20]. Conjunction FDR, denoted by FDRtrait1& trait2 is defined as the posterior probability that a SNP is null for either phenotype or both simultaneously, given the p-values for bo ...
statgen7
... "LIPED" written by Ott in 1974 was the pioneering software in linkage analysis. It is able to carry out this calculation, in an extensive pedigree for any values of q, f1, f2, f3 and for penetration as a function of age. The "Linkage" program of Lathrop et al, 1984 is the one most often used for gen ...
... "LIPED" written by Ott in 1974 was the pioneering software in linkage analysis. It is able to carry out this calculation, in an extensive pedigree for any values of q, f1, f2, f3 and for penetration as a function of age. The "Linkage" program of Lathrop et al, 1984 is the one most often used for gen ...
GLYPHOSATE RESISTANCE Background / Problem
... catapulted sequencing into realm of population genetics Human genome took 10 years to sequence originally, and hundreds of millions of dollars Now we can do it in a week for <$2,000 ...
... catapulted sequencing into realm of population genetics Human genome took 10 years to sequence originally, and hundreds of millions of dollars Now we can do it in a week for <$2,000 ...
slides
... What is local adaptation? Evolution, through divergent natural selection, of traits that have high fitness in the environmental conditions specific to a population. e.g. populations of sunflowers around the Great Salt Lake are highly salt tolerant there, but not elsewhere. These adaptations are loca ...
... What is local adaptation? Evolution, through divergent natural selection, of traits that have high fitness in the environmental conditions specific to a population. e.g. populations of sunflowers around the Great Salt Lake are highly salt tolerant there, but not elsewhere. These adaptations are loca ...
Genetic Algorithms - Iust personal webpages
... correspond to biological traits The x-y-plane holds all possible trait combinations Therefore, each different individual (phenotype) represents a single point on the landscape Population is therefore a “cloud” of points, moving on the landscape over time as it ...
... correspond to biological traits The x-y-plane holds all possible trait combinations Therefore, each different individual (phenotype) represents a single point on the landscape Population is therefore a “cloud” of points, moving on the landscape over time as it ...
the selective value of alleles underlying polygenic traits
... Moreover, uncertainty as to the value of a does not greatly obscure the message of Figure 1. For example, even when a >> 0.001, members of the class of alleles underlying characters for which the selective mortality is
... Moreover, uncertainty as to the value of a does not greatly obscure the message of Figure 1. For example, even when a >> 0.001, members of the class of alleles underlying characters for which the selective mortality is
Genotype to Phenotype v2 - Avida-ED
... Similarly, in Avida-ED, phenotypic variation depends upon genotypic variations. As in nature, different sequences of instructions in an Avidian’s genome produce whatever different traits it can exhibit, from the performance (or non-performance) of the possible functions of its virtual metabolism to ...
... Similarly, in Avida-ED, phenotypic variation depends upon genotypic variations. As in nature, different sequences of instructions in an Avidian’s genome produce whatever different traits it can exhibit, from the performance (or non-performance) of the possible functions of its virtual metabolism to ...
In silico Analysis of Single Nucleotide Polymorphisms (Snps) in
... obesity has taken in concern. An estimation of 40 to 70% of the variation in obesity susceptibility observed in the population is due to inter-individual genetic variants [3, 5-7]. Understanding the molecular roots of obesity is an important prerequisite to improve both prevention and management of ...
... obesity has taken in concern. An estimation of 40 to 70% of the variation in obesity susceptibility observed in the population is due to inter-individual genetic variants [3, 5-7]. Understanding the molecular roots of obesity is an important prerequisite to improve both prevention and management of ...
MetaXcan: Summary Statistics Based Gene-Level
... showed that 80% of phenotype variability (in 12 diseases) can be attributed to DNAase I hypersensitivity sites, further highlighting the importance of transcript regulation in determining phenotypes [3]. Many transcriptome studies have been conducted where genotype and expression levels are assayed ...
... showed that 80% of phenotype variability (in 12 diseases) can be attributed to DNAase I hypersensitivity sites, further highlighting the importance of transcript regulation in determining phenotypes [3]. Many transcriptome studies have been conducted where genotype and expression levels are assayed ...
Package `trio`
... a numeric value between 0 and 1 (excluding 0). If alpha1 = 1, all SNPs will be tested with a genotypic TDT. Otherwise, the two-step procedure of Gauderman et al. (2010) will be used to select all SNPs showing a p-value smaller than or equal to alpha1 in a logistic regression in which the environment ...
... a numeric value between 0 and 1 (excluding 0). If alpha1 = 1, all SNPs will be tested with a genotypic TDT. Otherwise, the two-step procedure of Gauderman et al. (2010) will be used to select all SNPs showing a p-value smaller than or equal to alpha1 in a logistic regression in which the environment ...
Effects of the Pattern of Energy Supply on the Efficiency of Nitrogen
... Haplotypes were reconstructed according to the genotyping data obtained from all 360 individuals with the PHASE program (Stephens et al., 2001). Polymorphism evaluation Genotype and allelic frequencies at each SNP site were calculated, with each polymorphism evaluated for HardyWeinberg equilibrium u ...
... Haplotypes were reconstructed according to the genotyping data obtained from all 360 individuals with the PHASE program (Stephens et al., 2001). Polymorphism evaluation Genotype and allelic frequencies at each SNP site were calculated, with each polymorphism evaluated for HardyWeinberg equilibrium u ...
Genetic survey of polymorphic populations of Podarcis mu
... wall lizard occur in sympatry by using highly polymorphic microsatellite loci. When alternative color morph coexist in a population, correlational selection favouring certain trait value combinations at the expense of others may result in modification of genomic architecture and may lead to divergen ...
... wall lizard occur in sympatry by using highly polymorphic microsatellite loci. When alternative color morph coexist in a population, correlational selection favouring certain trait value combinations at the expense of others may result in modification of genomic architecture and may lead to divergen ...
rational selection of pcr-based platforms for pharmacogenomic testing
... ABSTRACT: Background: Genotyping is crucial to the identification of genetic markers underlying development of neoplastic diseases and individual variations in responses to specific drugs. Costand time-effective technologies able to accurately identify genetic polymorphisms will dramatically affect ...
... ABSTRACT: Background: Genotyping is crucial to the identification of genetic markers underlying development of neoplastic diseases and individual variations in responses to specific drugs. Costand time-effective technologies able to accurately identify genetic polymorphisms will dramatically affect ...
use of genomic tools to discover the cause of
... Three sire families were identified as segregating for this trait. Genome wide linkage analysis using 104 microsatellite DNA markers was used to map the gene to ECA14 (LOD > 11.0). Four genes, namely SPARC, SLC36A1, SLC36A2 and SLC36A3, were selected from the region implicated by linkage and their e ...
... Three sire families were identified as segregating for this trait. Genome wide linkage analysis using 104 microsatellite DNA markers was used to map the gene to ECA14 (LOD > 11.0). Four genes, namely SPARC, SLC36A1, SLC36A2 and SLC36A3, were selected from the region implicated by linkage and their e ...
Natural selection mapping of the warfarin
... We used an assignment test (42–44) to identify the chromosomal regions and individual loci that are most informative to discriminate among resistant and susceptible rats. For this, rats were grouped into three categories based on BCR test results without respect to their population affiliation as fo ...
... We used an assignment test (42–44) to identify the chromosomal regions and individual loci that are most informative to discriminate among resistant and susceptible rats. For this, rats were grouped into three categories based on BCR test results without respect to their population affiliation as fo ...
Error Checking in Pedigrees
... • CSGA (1997) A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 15:389-92 • ~15 families with wrong relationships • No significant evidence for linkage • Error checking is essential! ...
... • CSGA (1997) A genome-wide search for asthma susceptibility loci in ethnically diverse populations. Nat Genet 15:389-92 • ~15 families with wrong relationships • No significant evidence for linkage • Error checking is essential! ...
POPSIM: a general population simulation program.
... Cox et al., 1992; Orholm et al., 1993; Risch and Botstein, 1996). Possible approaches for the ultimate mapping of susceptibility genes responsible for these conditions include non-parametric linkage analysis (using recombination events within the families under investigation) and linkage disequilibr ...
... Cox et al., 1992; Orholm et al., 1993; Risch and Botstein, 1996). Possible approaches for the ultimate mapping of susceptibility genes responsible for these conditions include non-parametric linkage analysis (using recombination events within the families under investigation) and linkage disequilibr ...
Evolutionary Analysis 4/e
... The general case for random mating in the gene pool of our model mouse population (a) We can predict the genotype frequencies among the zygotes by multiplying the allele frequencies. ...
... The general case for random mating in the gene pool of our model mouse population (a) We can predict the genotype frequencies among the zygotes by multiplying the allele frequencies. ...
Tag SNP
A tag SNP is a representative single nucleotide polymorphism (SNP) in a region of the genome with high linkage disequilibrium that represents a group of SNPs called a haplotype. It is possible to identify genetic variation and association to phenotypes without genotyping every SNP in a chromosomal region. This reduces the expense and time of mapping genome areas associated with disease, since it eliminates the need to study every individual SNP. Tag SNPs are useful in whole-genome SNP association studies in which hundreds of thousands of SNPs across the entire genome are genotyped.