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The Role of Autoantibodies in Diagnosis of Multiple Sclerosis
The Role of Autoantibodies in Diagnosis of Multiple Sclerosis

... of MS. Indeed, it permits obtaining molecular characteristics of disease in each patient in term of an antibody response against certain myelin and non-myelin antigens. It has been shown that in RRMS patients the increased level of serum antibodies against PLP is important, so that it might be consi ...
Bioanalytical chemistry
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... There are 3 types of "particles" commonly used in agglutination tests: 1) erythrocytes (RBCs), 2) bacterial cells (often stained to make the clumps visible), 3) latex particles (the antigens are chemically attached prior to running the test). The agglutination or precipitation reaction is affected by ...
High mortality among young Wetterhoun dogs due to an
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... pups it is imperative to find the origin of this immune-mediated problem and more important to find out if it is possible to diagnose the disorder in an early stadium. This way it might be possible to prevent part of the traumatizing experience for the new owner, because the pup is kept with the bre ...
Slide 1
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... called gamma-globulin (now immunoglobulin) was shown to be responsible for all these activities. The active molecules in the immunoglobulin fraction are called antibodies. Because immunity was mediated by antibodies contained in body fluids (known at the time as humors), it was called humoral immuni ...
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Your Immune System -Why It Fails & How To Fix It

... subsequently passed on from parents to offspring. Such things as species immunity protect us from invasion by microbes that do not specifically attack humans. For example, most infections found in animals cannot affect humans, yet many microbes that do not harm animals affect us. Racial Immunity is ...
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... The clinical presentation is limited to one or two organs only Immune complex deposition is rather sparse Autoantibodies are restricted to antibodies against dsDNA SLE is associated with deficiencies of complement component C2 and C4 Damage in various organs is predominantly mediated by natural kill ...
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... Input: NF-κB can be constitutively activated in myeloid and lymphoid cells in response to growth factors and cytokines or the expression of certain viral oncoproteins. Gene errors: Persistent NF-κB activation can also be brought about by chromosomal rearrangements that affect genes that encode NF-κB ...
Toll-like receptors in innate immunity
Toll-like receptors in innate immunity

... major mechanisms, such as diversity, clonality and memory, have been well characterized. However, these receptors are present only in vertebrates, and accordingly we do not fully understand the mechanism for non-self recognition in less evolved organisms. In addition, the innate immune system in mam ...
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Complement system



The complement system is a part of the immune system that helps or complements the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the innate immune system, which is not adaptable and does not change over the course of an individual's lifetime. However, it can be recruited and brought into action by the adaptive immune system.The complement system consists of a number of small proteins found in the blood, in general synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 30 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum and can serve as opsonins.Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway, and the lectin pathway.
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