Crystal structure and association behavior of the GluR2 amino
... correctly described for full-length receptors. Whereas one might be tempted to argue that the dimer interface as defined by crystallography is almost certainly correct, one need only revisit 2003 when this same group reported the dimer interface between two NR1 glycine binding domains. Some months l ...
... correctly described for full-length receptors. Whereas one might be tempted to argue that the dimer interface as defined by crystallography is almost certainly correct, one need only revisit 2003 when this same group reported the dimer interface between two NR1 glycine binding domains. Some months l ...
Lipid bylayers and Membranes
... regulate the passage of solutes such as ions and small molecules through biological membranes namely lipid bilayers that contain proteins embedded in them. • The regulation of passage through the membrane is due to selective membrane permeability. • The movements of most solutes through the membrane ...
... regulate the passage of solutes such as ions and small molecules through biological membranes namely lipid bilayers that contain proteins embedded in them. • The regulation of passage through the membrane is due to selective membrane permeability. • The movements of most solutes through the membrane ...
STRUCTURE AND FUNCTION OF THE CHLOROPLAST Ndh
... encoding components of the multi-polypeptidic Ndh complex of thylakoid, homologous to the complex I (EC 1.6.5.3) of the respiratory electron transport chain, which catalyses the reduction of plastoquinone (PQ) with NADH: ...
... encoding components of the multi-polypeptidic Ndh complex of thylakoid, homologous to the complex I (EC 1.6.5.3) of the respiratory electron transport chain, which catalyses the reduction of plastoquinone (PQ) with NADH: ...
Poster
... accessibility determine structural changes that researchers can see using gel electrophoresis. In the experiment, thermolysin, was used to break down the protein into its domains. The results of the gel electrophoresis showed that several domains of Ago-2 were separated when miRNA was not present. W ...
... accessibility determine structural changes that researchers can see using gel electrophoresis. In the experiment, thermolysin, was used to break down the protein into its domains. The results of the gel electrophoresis showed that several domains of Ago-2 were separated when miRNA was not present. W ...
How ATP Packs Energy
... by compressing a spring. The tightly coiled spring has potential energy. When the compressed spring relaxes, its potential energy is released. The spring's kinetic energy can be used to perform work such as pushing a block attached to one end of the spring. The phosphate bonds are symbolized by spri ...
... by compressing a spring. The tightly coiled spring has potential energy. When the compressed spring relaxes, its potential energy is released. The spring's kinetic energy can be used to perform work such as pushing a block attached to one end of the spring. The phosphate bonds are symbolized by spri ...
UBIQUITIN AT FOX CHASE
... pivotal question asked of Urban was: Do you know any examples of two proteins that are linked covalently. This recalled the small protein of unknown function, ubiquitin, a covalent ligand of histone H2A. The size and amino acid composition of APF-l reported by Hershko and known for ubiquitin were in ...
... pivotal question asked of Urban was: Do you know any examples of two proteins that are linked covalently. This recalled the small protein of unknown function, ubiquitin, a covalent ligand of histone H2A. The size and amino acid composition of APF-l reported by Hershko and known for ubiquitin were in ...
Basic Principle in Plant Physiology
... • Biological catalysts produced by cells • Nearly all are proteins • Enormous catalytic power – Reactions occur at lower temperatures and at higher rates ...
... • Biological catalysts produced by cells • Nearly all are proteins • Enormous catalytic power – Reactions occur at lower temperatures and at higher rates ...
A Few Good Domains
... Phosphotyrosine binding (PTB) domains are 100–150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More Nterminal sequences are also required for high affinity bi ...
... Phosphotyrosine binding (PTB) domains are 100–150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More Nterminal sequences are also required for high affinity bi ...
Cellular Respiration
... • Examples: plants, algae, some bacteria – Heterotrophs or Consumers • Cannot make their own food • Take in food by eating • Examples: animals, protists, fungi, most bacteria ...
... • Examples: plants, algae, some bacteria – Heterotrophs or Consumers • Cannot make their own food • Take in food by eating • Examples: animals, protists, fungi, most bacteria ...
Deep Insight Section Understanding the structure and function of ASH2L
... when these components are incubated with the MLL1 SET domain containing methyltransferase (Patel et al., 2009; Patel et al., 2011). This indicates the subcomplex has poor catalytic activity when the main catalytic SET domain-containing subunit is not present in the reaction. However, Cao et al. show ...
... when these components are incubated with the MLL1 SET domain containing methyltransferase (Patel et al., 2009; Patel et al., 2011). This indicates the subcomplex has poor catalytic activity when the main catalytic SET domain-containing subunit is not present in the reaction. However, Cao et al. show ...
The Use of the Energy in ATP for Muscle Contractions
... causing muscles to shorten. •This process is driven by the release of energy from an ATP (adenosine triphosphate) molecule. •As such, ATP is the major energy currency in the human body. ...
... causing muscles to shorten. •This process is driven by the release of energy from an ATP (adenosine triphosphate) molecule. •As such, ATP is the major energy currency in the human body. ...
Purine Riboswitch
... The hypoxanthine hydrogen bonds with four nucleotides U22 C74 U51 U47 to stabilize the binding pocket. It is these hydrogen bonds which form a base quadruple which stacks directly on top of the P1 helix. In the pocket all of hypoxanthine's functional groups are bound and there is space for guanine's ...
... The hypoxanthine hydrogen bonds with four nucleotides U22 C74 U51 U47 to stabilize the binding pocket. It is these hydrogen bonds which form a base quadruple which stacks directly on top of the P1 helix. In the pocket all of hypoxanthine's functional groups are bound and there is space for guanine's ...
Slide 1
... the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates sufficient for life . ...
... the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates sufficient for life . ...
Exam 1
... Know the structure of a phospholipid. Which side is hydrophilic, which is hydrophobic? Which molecules pass freely through the membrane? Which molecules do not pass freely through the membrane and require membrane proteins? What is the function of membrane cholesterol? Know the different types of me ...
... Know the structure of a phospholipid. Which side is hydrophilic, which is hydrophobic? Which molecules pass freely through the membrane? Which molecules do not pass freely through the membrane and require membrane proteins? What is the function of membrane cholesterol? Know the different types of me ...
Electrodeposition of CdTe in Aqueous Medium and Aluminum metal
... Department of Chemistry and Biochemistry Duquesne University, Pittsburgh, PA 15282 Inroduction: Cadmium telluride (CdTe) has been well recognized as a candidate for low cost thin film solar cell application because of its near ideal bandgap and high absorption coefficient of light. For the low cost ...
... Department of Chemistry and Biochemistry Duquesne University, Pittsburgh, PA 15282 Inroduction: Cadmium telluride (CdTe) has been well recognized as a candidate for low cost thin film solar cell application because of its near ideal bandgap and high absorption coefficient of light. For the low cost ...
lecture 11
... TIFFs Triton insoluble membranes Raft is more generic as the microdomain can be “caused” by protein association, not just physical properties of the lipids themselves Rafts may or may not contain caveolin ...
... TIFFs Triton insoluble membranes Raft is more generic as the microdomain can be “caused” by protein association, not just physical properties of the lipids themselves Rafts may or may not contain caveolin ...
Chapter 3B Notes
... • Maintains electrochemical gradients essential for functions of muscle and nerve tissues • Allows all cells to maintain fluid volume ...
... • Maintains electrochemical gradients essential for functions of muscle and nerve tissues • Allows all cells to maintain fluid volume ...
Issues in predicting protein function from sequence
... secondary structures Disulphide bridges are invariant among homologues Although the same function or the same fold may have evolved more than once due to convergence, convergent evolution of sequences does not occur Domains possess single conformations ...
... secondary structures Disulphide bridges are invariant among homologues Although the same function or the same fold may have evolved more than once due to convergence, convergent evolution of sequences does not occur Domains possess single conformations ...
Exposure to the metalloid arsenic is a daily occurrence as a result of
... 2. Crystallization and structural studies of human Cdc25B-cd with glutaredoxin. We have shown that Cdc25-cd requires human glutaredoxin (Grx1) for arsenate reduction (6). The human genome encodes for two dicysteinic glutaredoxin. Grx1 is a cytosolic protein (8), whereas Grx2 is found in mitochondria ...
... 2. Crystallization and structural studies of human Cdc25B-cd with glutaredoxin. We have shown that Cdc25-cd requires human glutaredoxin (Grx1) for arsenate reduction (6). The human genome encodes for two dicysteinic glutaredoxin. Grx1 is a cytosolic protein (8), whereas Grx2 is found in mitochondria ...
Enzyme Structure and Function
... active site. They DO change the 3-D shape of an enzyme, thereby changing its active site. – “Lock and Key” no longer match; enzyme can’t bind to substrate when they collide. ...
... active site. They DO change the 3-D shape of an enzyme, thereby changing its active site. – “Lock and Key” no longer match; enzyme can’t bind to substrate when they collide. ...
Evaluating Surface Cleanliness
... Visual assessment is among the most common, and the most inaccurate as microbes are invisible to the human eye. Lab tests of cultures is the most accurate and specific (microbes can be identified by type), but can take up to a week for results to be published. What are the benefits of ATP testing? ...
... Visual assessment is among the most common, and the most inaccurate as microbes are invisible to the human eye. Lab tests of cultures is the most accurate and specific (microbes can be identified by type), but can take up to a week for results to be published. What are the benefits of ATP testing? ...
A TUrBO SWITCH SpEEdS Up A CRUCIAL CALCIUM PUMP
... The SERCA calcium pump is related to the PMCA calcium pump and it is present in all higher cells, where it pumps calcium from the cytoplasm into internal stores, e.g. when muscles are relaxed. This calcium pump has been extensively studied in our lab with structure determination of several high-reso ...
... The SERCA calcium pump is related to the PMCA calcium pump and it is present in all higher cells, where it pumps calcium from the cytoplasm into internal stores, e.g. when muscles are relaxed. This calcium pump has been extensively studied in our lab with structure determination of several high-reso ...
Dermatomyositis
... Vacuoles are difficult to identify in paraffin sections, but they may be highlighted by immunohistochemistry against the heat shock protein Ubiquitin. ...
... Vacuoles are difficult to identify in paraffin sections, but they may be highlighted by immunohistochemistry against the heat shock protein Ubiquitin. ...
P-type ATPase
The P-type ATPases, also known as E1-E2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. They are α-helical bundle primary transporters referred to as P-type ATPases because they catalyze auto- (or self-) phosphorylation of a key conserved aspartate residue within the pump. In addition, they all appear to interconvert between at least two different conformations, denoted by E1 and E2.Most members of this transporter family are specific for the pumping of a large array of cations, however one subfamily is involved in flipping phospholipids to maintain the asymmetric nature of the biomembrane.Prominent examples of P-type ATPases are the sodium-potassium pump (Na+,K+-ATPase), the plasma membrane proton pump (H+-ATPase), the proton-potassium pump (H+,K+-ATPase), and the calcium pump (Ca2+-ATPase).