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Therapeutic approaches in arterial thrombosis
... also been observed (Fig. 2) [23,24]. While these results may have a simple explanation, resulting from the inhibition of fibrin formation by the anticoagulant, where fibrin contributes to thrombus stability under arterial shear rate [25], the emerging data indicate that the anti-thrombotic synergisms ...
... also been observed (Fig. 2) [23,24]. While these results may have a simple explanation, resulting from the inhibition of fibrin formation by the anticoagulant, where fibrin contributes to thrombus stability under arterial shear rate [25], the emerging data indicate that the anti-thrombotic synergisms ...
Functional Characterization of GABAA Receptors in Neonatal
... molecular architecture of native GABAA receptors is extremely heterogeneous (Bonnert et al. 1999; Hevers and Lüddens 1998). Pharmacological studies of recombinant receptors have shown that individual subunits and their subtypes confer different sensitivities to GABAA receptor modulators (Hevers and ...
... molecular architecture of native GABAA receptors is extremely heterogeneous (Bonnert et al. 1999; Hevers and Lüddens 1998). Pharmacological studies of recombinant receptors have shown that individual subunits and their subtypes confer different sensitivities to GABAA receptor modulators (Hevers and ...
Drugs That Grow Hair
... FDA for treating enlarged prostate glands, it has been extensively researched and tested. Based on studies of hormone breakdown products found in the urine, it seems to affect only the 5-alpha-reductase enzyme, and not other hormones in the blood such as testosterone. Propecia is not an antiandrogen ...
... FDA for treating enlarged prostate glands, it has been extensively researched and tested. Based on studies of hormone breakdown products found in the urine, it seems to affect only the 5-alpha-reductase enzyme, and not other hormones in the blood such as testosterone. Propecia is not an antiandrogen ...
melanoma Aspirin and other NSAIDs as chemoprevention agents in
... While early reports indicated that the anti-cancer effects of NSAIDs were related to COX inhibition, there is a growing body of evidence suggesting that NSAIDs also mediate anti-cancer activities independent of COX inhibition (31). For instance, some NSAIDs have been shown to inhibit activation of n ...
... While early reports indicated that the anti-cancer effects of NSAIDs were related to COX inhibition, there is a growing body of evidence suggesting that NSAIDs also mediate anti-cancer activities independent of COX inhibition (31). For instance, some NSAIDs have been shown to inhibit activation of n ...
REVIEWS - Lindquist Lab
... membranous structures such as the endoplasmic reticulum (ER) (b). For many clients involved in signal transduction pathways, association with the chaperone machinery maintains the protein in a meta-stable state that allows it to be activated by specific stimuli such as ligand binding, phosphorylatio ...
... membranous structures such as the endoplasmic reticulum (ER) (b). For many clients involved in signal transduction pathways, association with the chaperone machinery maintains the protein in a meta-stable state that allows it to be activated by specific stimuli such as ligand binding, phosphorylatio ...
Antipsychotic Drugs - Pharmacological Reviews
... some of the earlier studies used ligands related to spiperone (e.g., [11C]N-methylspiperone). The binding properties of these ligands are such that they do not reach equilibrium at the receptors during the scan, and this leads to problems in the interpretation of experiments that will be considered ...
... some of the earlier studies used ligands related to spiperone (e.g., [11C]N-methylspiperone). The binding properties of these ligands are such that they do not reach equilibrium at the receptors during the scan, and this leads to problems in the interpretation of experiments that will be considered ...
Advances in Aromatase Inhibition
... It has long been established that estrogen is the major hormone involved in the biology of breast cancer (1). Endocrine agents have therefore been designed to affect the supply of estrogens to the breast tumor, principally by blockade of estrogen activity at the receptor level or by inhibition of es ...
... It has long been established that estrogen is the major hormone involved in the biology of breast cancer (1). Endocrine agents have therefore been designed to affect the supply of estrogens to the breast tumor, principally by blockade of estrogen activity at the receptor level or by inhibition of es ...
Volume 48 Number 4
... Our membership is also growing; this year we’ve recruited almost 500 new members, 350 of which are new student members. Next year, we hope to continue this growth and encourage more interest in pharmacology and the Society. Centennial Celebration: This year we have also begun preparations for ASPET’ ...
... Our membership is also growing; this year we’ve recruited almost 500 new members, 350 of which are new student members. Next year, we hope to continue this growth and encourage more interest in pharmacology and the Society. Centennial Celebration: This year we have also begun preparations for ASPET’ ...
4-aminoquinolines as Antimalarial Drugs
... Koh only accounted for the protonation of the terminal amino group and not the quinoline nitrogen, and so while the original binding model is reasonably accurate otherwise, it fails to account for any interactions the protonated heterocyclic nitrogen may have. This was highlighted in a publication b ...
... Koh only accounted for the protonation of the terminal amino group and not the quinoline nitrogen, and so while the original binding model is reasonably accurate otherwise, it fails to account for any interactions the protonated heterocyclic nitrogen may have. This was highlighted in a publication b ...
Anticancer potential of curcumin
... their tumors. If a non-toxic, natural substance can help prevent this damage and enhance the effectiveness of our radiation, that’s a winning situation,” said Paul Okunieff , M.D., chief of radiation oncology at the Wilmot Cancer Center. Scientists presented results of the pilot study at the 44th an ...
... their tumors. If a non-toxic, natural substance can help prevent this damage and enhance the effectiveness of our radiation, that’s a winning situation,” said Paul Okunieff , M.D., chief of radiation oncology at the Wilmot Cancer Center. Scientists presented results of the pilot study at the 44th an ...
An Introduction to Medicinal Chemistry
... different. In this case you crave sedation or a calming influence, and it is the nicotine in the cigarette smoke which induces that effect. There can be little doubt that alcohol is a drug and as such causes society more problems than all other drugs put together. One only has to study road accident ...
... different. In this case you crave sedation or a calming influence, and it is the nicotine in the cigarette smoke which induces that effect. There can be little doubt that alcohol is a drug and as such causes society more problems than all other drugs put together. One only has to study road accident ...
Hallucinogens - Multidisciplinary Association for Psychedelic Studies
... Hallucinogens (psychedelics) are psychoactive substances that powerfully alter perception, mood, and a host of cognitive processes. They are considered physiologically safe and do not produce dependence or addiction. Their origin predates written history, and they were employed by early cultures in ...
... Hallucinogens (psychedelics) are psychoactive substances that powerfully alter perception, mood, and a host of cognitive processes. They are considered physiologically safe and do not produce dependence or addiction. Their origin predates written history, and they were employed by early cultures in ...
Hypolipidemic effect of aqueous leaf extract of carmona microphylla
... mg/kg) in decreasing serum TC and LDL-c was slightly weaker than sivastatin (5 mg/kg) but more potent in decreasing TG. These results indicate a discrepancy between CAE and statins in lipid-lowering action. The non-ionic detergent Triton WR-1339 can block the uptake of TG-rich lipoproteins from plas ...
... mg/kg) in decreasing serum TC and LDL-c was slightly weaker than sivastatin (5 mg/kg) but more potent in decreasing TG. These results indicate a discrepancy between CAE and statins in lipid-lowering action. The non-ionic detergent Triton WR-1339 can block the uptake of TG-rich lipoproteins from plas ...
carbapenam and monobactam - Home
... Meropenem is not hydrolyzed by DHP-I and is resistant to most β-lactamases, including a few carbapenemases that hydrolyze ...
... Meropenem is not hydrolyzed by DHP-I and is resistant to most β-lactamases, including a few carbapenemases that hydrolyze ...
ABSTRACT Title of Dissertation: ENERGETICS OF DRUG INTERACTIONS
... functions the effects of experimental factors, such as water, mutagenesis, or the presence of a second substrate on the energetics of drug-inhibitor binding interactions. The binding of non-steroidal anti-inflammatory drugs within the rigid cavities of cyclodextrins was investigated by titration cal ...
... functions the effects of experimental factors, such as water, mutagenesis, or the presence of a second substrate on the energetics of drug-inhibitor binding interactions. The binding of non-steroidal anti-inflammatory drugs within the rigid cavities of cyclodextrins was investigated by titration cal ...
biochemical pharmacology - WatCut
... (1) Some drugs are legal, others are not. This difference will not matter for the purpose of this book—we will look at examples of either group. (2) One might argue that drugs, at least the legal ones, should be distinguished from poisons by the beneficial nature of their effect. Yet most drugs turn ...
... (1) Some drugs are legal, others are not. This difference will not matter for the purpose of this book—we will look at examples of either group. (2) One might argue that drugs, at least the legal ones, should be distinguished from poisons by the beneficial nature of their effect. Yet most drugs turn ...
LA`s - Notes For ANZCA Primary Exam
... A. Is predominantly by albumin B. Is predominantly by alpha-1 acid glycoprotein C. Is greater for tetracaine than for bupivacaine D. Neonates have a greater number of binding sites E. Plasma binding is directly proportional to local anaesthetic concentration. (Comment: wording in option E was 'plasm ...
... A. Is predominantly by albumin B. Is predominantly by alpha-1 acid glycoprotein C. Is greater for tetracaine than for bupivacaine D. Neonates have a greater number of binding sites E. Plasma binding is directly proportional to local anaesthetic concentration. (Comment: wording in option E was 'plasm ...
Macrolids
... The major metabolite is 14-hydroxyclarithromycin, which also has antibacterial activity. A portion of active drug and this major metabolite is eliminated in the urine, and dosage reduction (eg, a 500-mg loading dose, then 250 mg once or twice daily) is recommended for patients with creatinine cleara ...
... The major metabolite is 14-hydroxyclarithromycin, which also has antibacterial activity. A portion of active drug and this major metabolite is eliminated in the urine, and dosage reduction (eg, a 500-mg loading dose, then 250 mg once or twice daily) is recommended for patients with creatinine cleara ...
Inhibition of Bladder Activity by 5 - Duke Statistical
... In a recent cystometric study of the 5-HT1A receptor agonist (R)-(⫹)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (Thor et al., 2002), normal cat bladders were filled either with saline to innocuously initiate micturition via activation of myelinated A␦ fibers or with dilute acetic acid to noc ...
... In a recent cystometric study of the 5-HT1A receptor agonist (R)-(⫹)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (Thor et al., 2002), normal cat bladders were filled either with saline to innocuously initiate micturition via activation of myelinated A␦ fibers or with dilute acetic acid to noc ...
Pharmacokinetics of Vindesine Given as an
... Nelson ef a/. (12, 13) and Owellen ef al. (16) reported pharmacokinetic parameters of VDS in humans obtained by similar radioimmunoassay. They have shown that the central compart ment was compatible with the total blood volume. In contrast, the central compartment obtained in this report is approxim ...
... Nelson ef a/. (12, 13) and Owellen ef al. (16) reported pharmacokinetic parameters of VDS in humans obtained by similar radioimmunoassay. They have shown that the central compart ment was compatible with the total blood volume. In contrast, the central compartment obtained in this report is approxim ...
ABC Clinical Guide 2003 - American Botanical Council
... Vogel, 1970). Indigenous Americans prepared an aqueous infusion of the berries to treat stomachache and dysentery (Duke, 1985). They also used the fruit as a diuretic and sexual tonic (Duke, 1985). Since the mid-1990s, saw palmetto has been one of the ten top-selling herbs in the U.S. (Blumenthal et ...
... Vogel, 1970). Indigenous Americans prepared an aqueous infusion of the berries to treat stomachache and dysentery (Duke, 1985). They also used the fruit as a diuretic and sexual tonic (Duke, 1985). Since the mid-1990s, saw palmetto has been one of the ten top-selling herbs in the U.S. (Blumenthal et ...
DOCEtaxel - Cancer Care Ontario
... Cystoid macular edema (CME) has been reported in docetaxel-treated patients, as well as with other taxanes. Patients who present with impaired vision during docetaxel treatment should undergo a prompt ophthalmologic examination. Docetaxel associated CME may not be associated with vascular leakage. C ...
... Cystoid macular edema (CME) has been reported in docetaxel-treated patients, as well as with other taxanes. Patients who present with impaired vision during docetaxel treatment should undergo a prompt ophthalmologic examination. Docetaxel associated CME may not be associated with vascular leakage. C ...
AACE/ACE Position Statement - American Association of Clinical
... testosterone is likely associated with higher risk of allcause and cardiovascular mortality. However, substantial between-study heterogeneity limited the ability to provide valid summary estimates (17). These authors caution that low testosterone levels could be markers of illness and not causal fac ...
... testosterone is likely associated with higher risk of allcause and cardiovascular mortality. However, substantial between-study heterogeneity limited the ability to provide valid summary estimates (17). These authors caution that low testosterone levels could be markers of illness and not causal fac ...
JA Jeevendra Martyn
... drugs. One example of this is the role of qualitative or quantitative changes in acetylcholine receptors modifying neurotransmission and response to drugs.[1][2] In myasthenia gravis, for example, the decrease in acetylcholine receptors results in decreased efficiency of neurotransmission (and there ...
... drugs. One example of this is the role of qualitative or quantitative changes in acetylcholine receptors modifying neurotransmission and response to drugs.[1][2] In myasthenia gravis, for example, the decrease in acetylcholine receptors results in decreased efficiency of neurotransmission (and there ...
Regulation of Brain Reward by the Endocannabinoid System: A
... early 1990s and are named so because they were first found to activate the same receptors as natural cannabinoids. The two most widely studied endocannabinoids are N-arachidonoylethanolamide (AEA), also called anandamide [36], and 2-arachidonoylglycerol (2-AG) [37, 38]. It should be noted that AEA c ...
... early 1990s and are named so because they were first found to activate the same receptors as natural cannabinoids. The two most widely studied endocannabinoids are N-arachidonoylethanolamide (AEA), also called anandamide [36], and 2-arachidonoylglycerol (2-AG) [37, 38]. It should be noted that AEA c ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.