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http://www.utdallas.edu/~tres/papers/thompson&disterhoft.97a.pdf
... The subjects used were 75 young (3.4 ± 0.2 months) and 75 aging (37.4 ± 0.3 months) female New Zealand White rabbits (Oryctolagus cuniculus) obtained from Hazelton Research Products (Denver, PA) and Kuiper Rabbitry (Gary, IN). All rabbits were experimentally naive before training. The rabbits were b ...
... The subjects used were 75 young (3.4 ± 0.2 months) and 75 aging (37.4 ± 0.3 months) female New Zealand White rabbits (Oryctolagus cuniculus) obtained from Hazelton Research Products (Denver, PA) and Kuiper Rabbitry (Gary, IN). All rabbits were experimentally naive before training. The rabbits were b ...
Hypoglossal Nerve Response to 5-HT3 Drugs Injected into the XII
... Adult male Sprague-Dawley rats (Charles River) weighing 320-390g were used. All procedures were approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania. ...
... Adult male Sprague-Dawley rats (Charles River) weighing 320-390g were used. All procedures were approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania. ...
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ
... Users, particularly teenagers, claim the drug is not addictive, but its potential abuse is not known. Salvinorin A is a potent and highly selective κ-agonist, with greater efficacy than that of the synthetic κ-agonist U-50488 and U-69593, as revealed by binding studies (Roth et al. 2002; Sheffler an ...
... Users, particularly teenagers, claim the drug is not addictive, but its potential abuse is not known. Salvinorin A is a potent and highly selective κ-agonist, with greater efficacy than that of the synthetic κ-agonist U-50488 and U-69593, as revealed by binding studies (Roth et al. 2002; Sheffler an ...
Chemotherapy Counteracts Metastatic Dissemination Induced by
... data on the effect of antiangiogenesis in general, or antiVEGF therapy, on malignant progression are lacking and widely debated. With certain tumors, such as glioblastoma, there was an increase in the volume of infiltrative tumor after bevacizumab, or a switch to more infiltrating growth after cedir ...
... data on the effect of antiangiogenesis in general, or antiVEGF therapy, on malignant progression are lacking and widely debated. With certain tumors, such as glioblastoma, there was an increase in the volume of infiltrative tumor after bevacizumab, or a switch to more infiltrating growth after cedir ...
APTAMERS ROLE IN BASIC DRUG RESEARCH AND DEVELOPMENT - AN... Review Article STALIN.C*, DINESHKUMAR.P.
... oligonucleotides or peptides that assume a specific and stable three-dimensional shape in vivo, thereby providing specific tight binding to protein targets. In some cases and as opposed to antisense oligonucleotides, effects can be mediated against extracellular targets, thereby preventing a need fo ...
... oligonucleotides or peptides that assume a specific and stable three-dimensional shape in vivo, thereby providing specific tight binding to protein targets. In some cases and as opposed to antisense oligonucleotides, effects can be mediated against extracellular targets, thereby preventing a need fo ...
Affinity Chromatography in Environmental Analysis and Drug
... contaminants in various settings. These contaminants have been found in plants and animals, including human tissue.8 These contaminants have also been detected in waters throughout the world,6, 9 including sources of public drinking water.8 It is difficult to set drinking water standards because inf ...
... contaminants in various settings. These contaminants have been found in plants and animals, including human tissue.8 These contaminants have also been detected in waters throughout the world,6, 9 including sources of public drinking water.8 It is difficult to set drinking water standards because inf ...
Diminished Cocaine-Like Effects in Dopamine Transporter Ligands
... Receptor Screen. Three of the compounds, AHN 2-005, GA-I103, and JHW 007, were screened for their activity at various receptor sites by examining their competition with the appropriate radioligands (ProfilingScreen procured from MDS Panlabs Pharmacology Services, Bothell, WA). The screen consisted o ...
... Receptor Screen. Three of the compounds, AHN 2-005, GA-I103, and JHW 007, were screened for their activity at various receptor sites by examining their competition with the appropriate radioligands (ProfilingScreen procured from MDS Panlabs Pharmacology Services, Bothell, WA). The screen consisted o ...
The Magic Mint - Stephanie Nichole Halbleib
... • Activated endogenous by peptides (like endorphins), or exogenously by alkaloid opiates (such as morphine) • Signal transduction is theorized as follows: – Activation is coupled to the G protein which increases phosphodiesterase activity – Breaks down cAMP, producing an inhibitory effect in neurons ...
... • Activated endogenous by peptides (like endorphins), or exogenously by alkaloid opiates (such as morphine) • Signal transduction is theorized as follows: – Activation is coupled to the G protein which increases phosphodiesterase activity – Breaks down cAMP, producing an inhibitory effect in neurons ...
ii. immunosuppressive drugs - The University of Tennessee, Knoxville
... As a result of calcineurin inhibition, FK506 alters multiple biochemical processes in a variety of cells besides lymphocytes. This may be the cause for its adverse side effects including neurotoxicity, nephrotoxicity, diabetogenicity and gastrointestinal disturbances (Dumont 2000). One of the most c ...
... As a result of calcineurin inhibition, FK506 alters multiple biochemical processes in a variety of cells besides lymphocytes. This may be the cause for its adverse side effects including neurotoxicity, nephrotoxicity, diabetogenicity and gastrointestinal disturbances (Dumont 2000). One of the most c ...
List of Figures - The University of Tennessee, Knoxville
... As a result of calcineurin inhibition, FK506 alters multiple biochemical processes in a variety of cells besides lymphocytes. This may be the cause for its adverse side effects including neurotoxicity, nephrotoxicity, diabetogenicity and gastrointestinal disturbances (Dumont 2000). One of the most c ...
... As a result of calcineurin inhibition, FK506 alters multiple biochemical processes in a variety of cells besides lymphocytes. This may be the cause for its adverse side effects including neurotoxicity, nephrotoxicity, diabetogenicity and gastrointestinal disturbances (Dumont 2000). One of the most c ...
Blum et al. 2011 - Boston University
... and buprenorphine/naloxone (Subutex, Suboxone) in a traditional office setting when treating patients with opioid dependence. Clinical studies indicate that buprenorphine maintenance is as effective as methadone maintenance in retaining patients in substance abuse treatment and reducing illicit opio ...
... and buprenorphine/naloxone (Subutex, Suboxone) in a traditional office setting when treating patients with opioid dependence. Clinical studies indicate that buprenorphine maintenance is as effective as methadone maintenance in retaining patients in substance abuse treatment and reducing illicit opio ...
Mona Sayed Ahmed Mohammed Ellithey S12000541
... Compound 7 demonstrated strong cytotoxicity against HeLa cells (CC50 4.3±0.8 µM), with a selectivity index of SI 8.1 which was confirmed by real time cell electronic sensing (RT-CES). Compounds 2, 7 and 8 showed strong inhibitory activity against HIV-1 PR at IC50‘s of 7.2 ±0.7, 4.85±0.2 and 4.80 ±0. ...
... Compound 7 demonstrated strong cytotoxicity against HeLa cells (CC50 4.3±0.8 µM), with a selectivity index of SI 8.1 which was confirmed by real time cell electronic sensing (RT-CES). Compounds 2, 7 and 8 showed strong inhibitory activity against HIV-1 PR at IC50‘s of 7.2 ±0.7, 4.85±0.2 and 4.80 ±0. ...
Heart Glucocorticoids Activate Cardiac Mineralocorticoid Receptors
... To explore whether GR activation might also aggravate infarct size in response to ischemia and reperfusion, we used 10 and 100 nM dexamethasone in the perfusate, with or without spironolactone. The results were unanticipated; although dexamethasone increased infarct size at both concentrations, the ...
... To explore whether GR activation might also aggravate infarct size in response to ischemia and reperfusion, we used 10 and 100 nM dexamethasone in the perfusate, with or without spironolactone. The results were unanticipated; although dexamethasone increased infarct size at both concentrations, the ...
Structure-based design of hyaluronidase inhibitors
... As major constituent of the extracellular matrix, hyaluronan is present in the skin (about 50 % of the total HA in the body) but also in the vitreous humour of the eye (0.1-0.4 mg/g wet weight), in the synovial joint fluid (3-4 mg/ml), in the matrix produced by the cumulus cells around the oocyte pr ...
... As major constituent of the extracellular matrix, hyaluronan is present in the skin (about 50 % of the total HA in the body) but also in the vitreous humour of the eye (0.1-0.4 mg/g wet weight), in the synovial joint fluid (3-4 mg/ml), in the matrix produced by the cumulus cells around the oocyte pr ...
Testosterone Therapy in Men with Androgen Practice Guideline
... clinical syndrome that results from failure of the testis to produce physiological levels of testosterone (androgen deficiency) and a normal number of spermatozoa due to disruption of one or more levels of the hypothalamic-pituitary-testicular axis. Classification of hypogonadism: Abnormalities of t ...
... clinical syndrome that results from failure of the testis to produce physiological levels of testosterone (androgen deficiency) and a normal number of spermatozoa due to disruption of one or more levels of the hypothalamic-pituitary-testicular axis. Classification of hypogonadism: Abnormalities of t ...
Overview of pleiotropic effects of platelet P2Y12receptor inhibitors
... the development of antithrombotic drugs (1). Since 1991, when ticlopidine became the first P2Y12 antagonist ever approved by the Food and Drug Administration (FDA), several subsequent P2Y12 blockers have been introduced to clinical use. P2Y12 receptor inhibitors can be classified based on their chem ...
... the development of antithrombotic drugs (1). Since 1991, when ticlopidine became the first P2Y12 antagonist ever approved by the Food and Drug Administration (FDA), several subsequent P2Y12 blockers have been introduced to clinical use. P2Y12 receptor inhibitors can be classified based on their chem ...
Octreotide Acetate Injection in a prefilled syringe
... L-Lactic acid and sodium hydroxide are added to provide a buffered solution, pH range 3.9 to 4.5. The molecular weight of octreotide acetate is 1019.3 (free peptide, C49H66N10O10S2) and its amino acid sequence is: ...
... L-Lactic acid and sodium hydroxide are added to provide a buffered solution, pH range 3.9 to 4.5. The molecular weight of octreotide acetate is 1019.3 (free peptide, C49H66N10O10S2) and its amino acid sequence is: ...
Lipid mediators of tumor necrosis factor-alpha-induced uveitis.
... nonocular tissues, TNFa is a pluripotent inflammatory mediator because of its ability to enhance neutrophil and monocyte chemotaxis,3'4 neutrophil-endothelial cell adherence,5'6 endothelial cell permeability,7 endothelial cell procoagulant properties,8 and neutrophil and monocyte/macrophage degranul ...
... nonocular tissues, TNFa is a pluripotent inflammatory mediator because of its ability to enhance neutrophil and monocyte chemotaxis,3'4 neutrophil-endothelial cell adherence,5'6 endothelial cell permeability,7 endothelial cell procoagulant properties,8 and neutrophil and monocyte/macrophage degranul ...
The risk of male breast cancer with finasteride
... Risk factors associated with male breast cancer include genetic and epidemiological factors. Major genetic factors include mutations in the BRCA gene family; in women, mutations of the BRCA1 and BRCA2 tumour suppressor genes are associated with a breast cancer risk of 50–80% a . BRCA2 gene mutations ...
... Risk factors associated with male breast cancer include genetic and epidemiological factors. Major genetic factors include mutations in the BRCA gene family; in women, mutations of the BRCA1 and BRCA2 tumour suppressor genes are associated with a breast cancer risk of 50–80% a . BRCA2 gene mutations ...
Does Oral Trenbolone Really Have the Best Steroid
... Oral Trenbolone PCT The drugs you will take during PCT include aromatase inhibitors and Selective Estrogen Receptor Modulators (SERM). Aromatase inhibitors stop androgens from binding with estrogen receptors and SERMs are supposed to prevent their effects. However, with oral Trenbolone, users are sp ...
... Oral Trenbolone PCT The drugs you will take during PCT include aromatase inhibitors and Selective Estrogen Receptor Modulators (SERM). Aromatase inhibitors stop androgens from binding with estrogen receptors and SERMs are supposed to prevent their effects. However, with oral Trenbolone, users are sp ...
Slide 1
... Figure 2. Mean number of episodes of vomiting ({+/-} standard deviation) experienced 5-24 hours after chemotherapy as a function of the number of active cytochrome P450 CYP2D6 enzyme genes in patients receiving tropisetron, 5 mg once a day (A), and ondansetron, 8 mg twice a day (B) Adapted from: Kai ...
... Figure 2. Mean number of episodes of vomiting ({+/-} standard deviation) experienced 5-24 hours after chemotherapy as a function of the number of active cytochrome P450 CYP2D6 enzyme genes in patients receiving tropisetron, 5 mg once a day (A), and ondansetron, 8 mg twice a day (B) Adapted from: Kai ...
Scotopic vision in the monkey is modulated by the G protein
... (Bouskila et al., 2013b). A variety of anatomical and functional visual effects of cannabinoids have also been reported for every retinal cell type in both rodents and fish (Yazulla, 2008; Cécyre et al., 2013). However, these studies did not investigate GPR55 because of its recent and controversial ...
... (Bouskila et al., 2013b). A variety of anatomical and functional visual effects of cannabinoids have also been reported for every retinal cell type in both rodents and fish (Yazulla, 2008; Cécyre et al., 2013). However, these studies did not investigate GPR55 because of its recent and controversial ...
Hepatotoxicity associated with illicit use of anabolic androgenic
... (anabolic) and masculinizing (androgenic) effects, while, as above reported, most of the synthetic AAS have been developed with the aim to separate the anabolic from the androgenic properties, preferring synthetic androgens that have preferential anabolic activity and no androgenic one. Testosterone ...
... (anabolic) and masculinizing (androgenic) effects, while, as above reported, most of the synthetic AAS have been developed with the aim to separate the anabolic from the androgenic properties, preferring synthetic androgens that have preferential anabolic activity and no androgenic one. Testosterone ...
Section II. Autonomic Drugs Chapter 6. Introduction to Autonomic
... (independent) in that its activities are not under direct conscious control. It is concerned primarily with visceral functions—cardiac output, blood flow to various organs, digestion, etc—that are necessary for life. The somatic division is largely concerned with consciously controlled functions suc ...
... (independent) in that its activities are not under direct conscious control. It is concerned primarily with visceral functions—cardiac output, blood flow to various organs, digestion, etc—that are necessary for life. The somatic division is largely concerned with consciously controlled functions suc ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.