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Comprehensive Management Of Prostate Cancer
... was diagnosed with this disease in February 1999. At that time, I had a palpable nodule, a PSA of 20.4 ng/ml and a Gleason 3+4 = 7 cancer. I decided that my only chance at survival was to pull out all stops and treat this cancer very aggressively. I received hormonal therapy with Lupron, Casodex, an ...
... was diagnosed with this disease in February 1999. At that time, I had a palpable nodule, a PSA of 20.4 ng/ml and a Gleason 3+4 = 7 cancer. I decided that my only chance at survival was to pull out all stops and treat this cancer very aggressively. I received hormonal therapy with Lupron, Casodex, an ...
Document
... The 2(1H)-pyrazinone scaffold can allow the easy introduction of a wide range of pharmacologically active groups with the ability to address the diverse set of biological targets. Besides their broad physiological activities, 2(1H)-pyrazinones can be used as important building blocks in the synthesi ...
... The 2(1H)-pyrazinone scaffold can allow the easy introduction of a wide range of pharmacologically active groups with the ability to address the diverse set of biological targets. Besides their broad physiological activities, 2(1H)-pyrazinones can be used as important building blocks in the synthesi ...
Alternative Therapy in Cancer Miracle or Myth?
... Why is an oncologist talking about alternative therapy? •Cancer remains a serious illness in Malaysia •2nd leading cause of death after MVA ...
... Why is an oncologist talking about alternative therapy? •Cancer remains a serious illness in Malaysia •2nd leading cause of death after MVA ...
(3)
... -When labor occurs prematurely (before 37 weeks), it is a risk to the fetus. - b2 AR agonists relax the smooth muscle of the uterus and help prevent premature delivery. The goal is to reach at least 37 weeks when the fetal lungs have matured. ...
... -When labor occurs prematurely (before 37 weeks), it is a risk to the fetus. - b2 AR agonists relax the smooth muscle of the uterus and help prevent premature delivery. The goal is to reach at least 37 weeks when the fetal lungs have matured. ...
Cancer Chemotherapy-2
... asparagine to aspartic acid and ammonia. L-Asparaginase is used in combination therapy to treat childhood acute lymphocytic leukemia Its mechanism of action is based on the fact that some neoplastic cells require an external source of asparagine because of their limited capacity to synthesize su ...
... asparagine to aspartic acid and ammonia. L-Asparaginase is used in combination therapy to treat childhood acute lymphocytic leukemia Its mechanism of action is based on the fact that some neoplastic cells require an external source of asparagine because of their limited capacity to synthesize su ...
DOSE *RESPONSE CURVES
... Researchers must first show that three things are true in an experiment. 1. If the drug isn’t there, you don’t get any effect. 2. Adding more of the drug (up to a certain point) causes an incremental change in effect 3. Taking the drug away (or masking its action with a molecule that blocks the drug ...
... Researchers must first show that three things are true in an experiment. 1. If the drug isn’t there, you don’t get any effect. 2. Adding more of the drug (up to a certain point) causes an incremental change in effect 3. Taking the drug away (or masking its action with a molecule that blocks the drug ...
Focal Cryotherapy in the Treatment of Localized Prostate Cancer
... prostate cancer are radically treated with either surgery or radiation therapy. With better patient selection by defining the biological potential of the cancer and with improvements in technology to follow these men, active surveillance will become more widely used. For low-risk and some intermedia ...
... prostate cancer are radically treated with either surgery or radiation therapy. With better patient selection by defining the biological potential of the cancer and with improvements in technology to follow these men, active surveillance will become more widely used. For low-risk and some intermedia ...
Why is Pharma So Scared of Psychiatric Drug Discovery?
... Finally, the potential for High Throughput Screening (HTS) as a drug discovery tool is becoming more apparent as a powerful route towards greater functional selectivity and clinical efficacy. The sorry tale of cortico-releasing factor (CRF) receptor antagonists is a prime example of how HTS may be n ...
... Finally, the potential for High Throughput Screening (HTS) as a drug discovery tool is becoming more apparent as a powerful route towards greater functional selectivity and clinical efficacy. The sorry tale of cortico-releasing factor (CRF) receptor antagonists is a prime example of how HTS may be n ...
Timothy Goodson, M.D.
... for clinically localized disease stated that1: – Adjuvant ADT given after completion of primary treatment is not a standard treatment at this time with the exception of high-risk patients treated with radiation therapy. – Low volume, high grade prostate cancer may warrant adjuvant ADT for 4-6 month ...
... for clinically localized disease stated that1: – Adjuvant ADT given after completion of primary treatment is not a standard treatment at this time with the exception of high-risk patients treated with radiation therapy. – Low volume, high grade prostate cancer may warrant adjuvant ADT for 4-6 month ...
Week 6 lecture slides
... GABAA: Ethanol site antagonists Most benzodiazepine ligands do not interfere with ethanol binding, but Ro 154513 does interfere with ethanol binding because of this bulky azido group that displaces ethanol. In vitro, Ro 15-4513 competitively inhibits ethanol binding to the GABAA receptor complex. I ...
... GABAA: Ethanol site antagonists Most benzodiazepine ligands do not interfere with ethanol binding, but Ro 154513 does interfere with ethanol binding because of this bulky azido group that displaces ethanol. In vitro, Ro 15-4513 competitively inhibits ethanol binding to the GABAA receptor complex. I ...
Understanding Cancer Section 1: Factors reported to be associated
... Review your notes from Section 1 then write a sentence that describes how our current understanding of cancer explains the rule that each factor plays in causing cancer. Cancer and Chemical Poisons: ...
... Review your notes from Section 1 then write a sentence that describes how our current understanding of cancer explains the rule that each factor plays in causing cancer. Cancer and Chemical Poisons: ...
Prostate Cancer Statistics
... for palliative care in patients with very advanced or recurrent prostate cancer. When hormone therapy is used testosterone levels decrease (like castration), the tumor shrinks and PSA levels generally drop, often to undetectable (< 0.1 ng/ml). In patients with metastases, the disease can be stabiliz ...
... for palliative care in patients with very advanced or recurrent prostate cancer. When hormone therapy is used testosterone levels decrease (like castration), the tumor shrinks and PSA levels generally drop, often to undetectable (< 0.1 ng/ml). In patients with metastases, the disease can be stabiliz ...
- PMAS-Arid Agriculture University Rawalpindi
... Tumor-activated prodrug therapy uses the approach that a drug conjugated to a tumorspecific molecule will remain inactive until it reaches the tumor [8] ...
... Tumor-activated prodrug therapy uses the approach that a drug conjugated to a tumorspecific molecule will remain inactive until it reaches the tumor [8] ...
tetrahydrogestrinone (THG)
... periods up to 12 days in direct comparison to testosterone propionate (o.1mg/animal/day s. c.): THG induced (a dose dependent) androgenic effect on prostate and vesicular seminales parameters and LH serum levels in doses of 1,3,10mg/animal. This androgenic stimulation could be antagonized by the sim ...
... periods up to 12 days in direct comparison to testosterone propionate (o.1mg/animal/day s. c.): THG induced (a dose dependent) androgenic effect on prostate and vesicular seminales parameters and LH serum levels in doses of 1,3,10mg/animal. This androgenic stimulation could be antagonized by the sim ...
Direct cholinergic agonists
... allergic reactions and shock. The control of localized bleeding and the prolongation of the action of local anesthetics. Norepinephrine has a relatively low affinity for b2 receptors. The main effect of al stimulation (with an agonist such as phenylephrine) is vasoconstriction. Local application of ...
... allergic reactions and shock. The control of localized bleeding and the prolongation of the action of local anesthetics. Norepinephrine has a relatively low affinity for b2 receptors. The main effect of al stimulation (with an agonist such as phenylephrine) is vasoconstriction. Local application of ...
5th Lecture 1433
... The two-state model of receptor activation The receptor is in two conformational states, ‘resting’ (R) and ‘active’ (R*), which exist in equilibrium Normally, when no ligand is present, the equilibrium lies far to the left, and a few receptors are found in the R* state For constitutively activ ...
... The two-state model of receptor activation The receptor is in two conformational states, ‘resting’ (R) and ‘active’ (R*), which exist in equilibrium Normally, when no ligand is present, the equilibrium lies far to the left, and a few receptors are found in the R* state For constitutively activ ...
Digital rectal examination in prostate cancer screening
... and conversely as a “crucial part of the examination [of a patient]”.1, 2 Despite its many diagnostic applications, the test is also uncomfortable for some patients, doctors, and medical students. This article will focus on the characteristics of the test in prostate cancer screening, and how the ch ...
... and conversely as a “crucial part of the examination [of a patient]”.1, 2 Despite its many diagnostic applications, the test is also uncomfortable for some patients, doctors, and medical students. This article will focus on the characteristics of the test in prostate cancer screening, and how the ch ...
**** 1 - unist
... adipose tissue biology to this staggering array of pathologies is scientifically and clinically crucial. The nuclear receptor PPARg is a master regulator of adipose cell differentiation and development. It is also the functioning receptor for the thiozolidinedione (TZD) class of antidiabetic drugs s ...
... adipose tissue biology to this staggering array of pathologies is scientifically and clinically crucial. The nuclear receptor PPARg is a master regulator of adipose cell differentiation and development. It is also the functioning receptor for the thiozolidinedione (TZD) class of antidiabetic drugs s ...
oxybowel label
... been used for many years to support the male system. Standardized to contain between 85%-95% fatty acids and biologically active sterol compounds. This product CONTAINS NO: corn, milk egg, gluten, soy, wheat, yeast, sugar, salt, starch, shellfish or preservatives. Caution: Do Not Eat Freshness Packe ...
... been used for many years to support the male system. Standardized to contain between 85%-95% fatty acids and biologically active sterol compounds. This product CONTAINS NO: corn, milk egg, gluten, soy, wheat, yeast, sugar, salt, starch, shellfish or preservatives. Caution: Do Not Eat Freshness Packe ...
Plasma Protein Binding
... Validation of the TRANSILXL PPB Binding Kit Human serum albumin (HSA) and human 1-acid glycoprotein (AGP) are the most important plasma binding proteins. TRANSIL binding assays are available for both proteins. Binding measurements with TRANSIL HSA and AGP beads are equivalent to dialysis with thes ...
... Validation of the TRANSILXL PPB Binding Kit Human serum albumin (HSA) and human 1-acid glycoprotein (AGP) are the most important plasma binding proteins. TRANSIL binding assays are available for both proteins. Binding measurements with TRANSIL HSA and AGP beads are equivalent to dialysis with thes ...
Medicinal Lecture
... cyclic structure instead of the three methylsacceptable. Substitute N(CH3) with this ring ...
... cyclic structure instead of the three methylsacceptable. Substitute N(CH3) with this ring ...
Drug Receptors
... bind to alpha receptors on blood vessels to increase blood pressure. The binding of the agonist often triggers a series of biochemical events that ultimately leads to the alteration in function. The biochemicals that initiate these changes are referred to as second messe or antagonists. ...
... bind to alpha receptors on blood vessels to increase blood pressure. The binding of the agonist often triggers a series of biochemical events that ultimately leads to the alteration in function. The biochemicals that initiate these changes are referred to as second messe or antagonists. ...
Protein Data Bank Advisory Committee
... • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to market is huge ~$800M – drug reuse is a big business • The cost of failure is even higher e.g. Vioxx ...
... • We know even less about what side effects they might have - receptors are unknown • Drug discovery seems to be approached in a very consistent and conventional way • The cost of bringing a drug to market is huge ~$800M – drug reuse is a big business • The cost of failure is even higher e.g. Vioxx ...
Sympatholytics
... - It is less active than NA on α1 receptors and thus it is less effective in causing vasoconstriction - It is more active on presynaptic α2 receptors and so stimulates autoinhibitory feedback mechanism It is used in treatment of hypertension ...
... - It is less active than NA on α1 receptors and thus it is less effective in causing vasoconstriction - It is more active on presynaptic α2 receptors and so stimulates autoinhibitory feedback mechanism It is used in treatment of hypertension ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.