Bez nadpisu - Univerzita Karlova
... mast cells). These conditions include hay fever and urticardia. The drugs have a broad spectrum of adverse effects that limit their usefulness but can sometimes be used to good effect (eg, the sedative effect is used in over-the-counter-sleep aids). H1-blocking drugs have sedative and antimotion sic ...
... mast cells). These conditions include hay fever and urticardia. The drugs have a broad spectrum of adverse effects that limit their usefulness but can sometimes be used to good effect (eg, the sedative effect is used in over-the-counter-sleep aids). H1-blocking drugs have sedative and antimotion sic ...
Living With Metastatic Prostate Cancer
... Hot flashes In most men treated with hormonal therapy for their metastatic prostate cancer, hot flashes are fairly limited. If you are especially troubled by hot flashes, ask your doctor about medications such as low doses of female hormones (estrogen or progesterone) that can help. Osteoporosis (i ...
... Hot flashes In most men treated with hormonal therapy for their metastatic prostate cancer, hot flashes are fairly limited. If you are especially troubled by hot flashes, ask your doctor about medications such as low doses of female hormones (estrogen or progesterone) that can help. Osteoporosis (i ...
Does Androgen Deficiency Exist in Women
... Failure to maintain the aforementioned pattern and quantity of bioavailable androgen secretion as a result of surgical menopause or a more rapid reduction in androgen production from either ovarian or adrenal sources results in a state of androgen insufficiency. This ageindependent decrease can be l ...
... Failure to maintain the aforementioned pattern and quantity of bioavailable androgen secretion as a result of surgical menopause or a more rapid reduction in androgen production from either ovarian or adrenal sources results in a state of androgen insufficiency. This ageindependent decrease can be l ...
What is P-MAPA?
... 2- P-MAPA immunotherapy increased wild-type p53 protein levels. The increased wild-type p53 protein levels were fundamental to NO-induced apoptosis and the up-regulation of BAX. 3- Interferon signaling pathway induction and increased p53 protein levels by P-MAPA led to important antitumor effects, n ...
... 2- P-MAPA immunotherapy increased wild-type p53 protein levels. The increased wild-type p53 protein levels were fundamental to NO-induced apoptosis and the up-regulation of BAX. 3- Interferon signaling pathway induction and increased p53 protein levels by P-MAPA led to important antitumor effects, n ...
Marine Halophyte: An Inviolated and Promising Source of Novel
... and on final stage hydrogen atoms were added to receptor molecule before docking. Totally 3 important phytocompounds available in the plant extract of Salicornia europaea were selected based on Lipinski rule of 5 described by Ref. [6]. Lipinski's rule of five also known as the Pfizer's rule of five ...
... and on final stage hydrogen atoms were added to receptor molecule before docking. Totally 3 important phytocompounds available in the plant extract of Salicornia europaea were selected based on Lipinski rule of 5 described by Ref. [6]. Lipinski's rule of five also known as the Pfizer's rule of five ...
Saw Palmetto 320 - Pure Encapsulations
... Austria, this herb has been the gold standard for prostate support for many years. Its primary mode of action involves supporting healthy testosterone metabolism, in part by maintaining healthy 5-alpha-reductase enzyme activity and receptor binding. In a JAMA meta-analysis involving 18 randomized co ...
... Austria, this herb has been the gold standard for prostate support for many years. Its primary mode of action involves supporting healthy testosterone metabolism, in part by maintaining healthy 5-alpha-reductase enzyme activity and receptor binding. In a JAMA meta-analysis involving 18 randomized co ...
PROTEIN BINDING
... ALBUMIN Is the most important protein that binds to drug molecule due to its high concentration compared with other proteins It binds both acidic and basic Constitute 5% of the total plasma ...
... ALBUMIN Is the most important protein that binds to drug molecule due to its high concentration compared with other proteins It binds both acidic and basic Constitute 5% of the total plasma ...
capslide - Urology Information
... A large variety of MITs exist for BPH who fail drug therapy, but for most patients the gold standard surgical procedure remains TURP The next few years will see many more techniques available to challenge the position of TURP ...
... A large variety of MITs exist for BPH who fail drug therapy, but for most patients the gold standard surgical procedure remains TURP The next few years will see many more techniques available to challenge the position of TURP ...
OS002 EP4 Receptor Agonists in the Inhibition of Airway
... muscle cells (hBSMc; Promocell) and primary human lung fibroblasts (HLF; Lonza) after treatment with a range of EP receptor agonists. cAMP accumulation: all incubations performed in HBSS (5 mM HEPES, 0.1 % (w/v) HSA, 5 µM rolipram), for 2 hours at room temperature. ERK phosphorylation and proliferat ...
... muscle cells (hBSMc; Promocell) and primary human lung fibroblasts (HLF; Lonza) after treatment with a range of EP receptor agonists. cAMP accumulation: all incubations performed in HBSS (5 mM HEPES, 0.1 % (w/v) HSA, 5 µM rolipram), for 2 hours at room temperature. ERK phosphorylation and proliferat ...
d) Bronchodilator Response
... Antagonists. A drug that has affinity for a receptor but is not able to induce an effect is known as an antagonist. Antagonists can be either competitive or non-competitive. Competitive antagonism exists when an agonist and an antagonist compete for a common receptor. Competitive antagonism is surmo ...
... Antagonists. A drug that has affinity for a receptor but is not able to induce an effect is known as an antagonist. Antagonists can be either competitive or non-competitive. Competitive antagonism exists when an agonist and an antagonist compete for a common receptor. Competitive antagonism is surmo ...
State-of-the-art Treatment for Prostate Cancer
... did not find that men who are screened lived any longer than those who were not screened. There were a lot of flaws with that study. People were actually prescreened. A good fraction of people were prescreened before they went into that study, and then a good number of people in the control arm, mea ...
... did not find that men who are screened lived any longer than those who were not screened. There were a lot of flaws with that study. People were actually prescreened. A good fraction of people were prescreened before they went into that study, and then a good number of people in the control arm, mea ...
Prostate Cancer Fact Sheet
... cancer recurrence. Although severe or life-threatening complications associated with this surgery are rare, it is shown that up to two thirds of men may have impaired erectile function or impotence as a result of radical prostatectomy and as many as 50% of operated men have urinary incontinence one ...
... cancer recurrence. Although severe or life-threatening complications associated with this surgery are rare, it is shown that up to two thirds of men may have impaired erectile function or impotence as a result of radical prostatectomy and as many as 50% of operated men have urinary incontinence one ...
Anticoagulants, Thrombolytics Agents and Antiplatelet Drugs
... ANAGRELEIDE is indicated for the treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. Therapeutic doses do not produce significant changes in white or red cell counts and has not been shown to be leukemogenic. The drug's labeling provides guidelines f ...
... ANAGRELEIDE is indicated for the treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. Therapeutic doses do not produce significant changes in white or red cell counts and has not been shown to be leukemogenic. The drug's labeling provides guidelines f ...
receptor
... B, Potency is an index of how much drug must be administered to elicit a desired response. In this example, achieving pain relief with meperidine requires higher doses than with morphine. We would say that morphine is more potent than meperidine. Note that, if administered in sufficiently high doses ...
... B, Potency is an index of how much drug must be administered to elicit a desired response. In this example, achieving pain relief with meperidine requires higher doses than with morphine. We would say that morphine is more potent than meperidine. Note that, if administered in sufficiently high doses ...
Document
... Drugs that bind to enzymes interfere with the normal activity of the enzyme in one of 2 ways CompetitiveNon-competitiveDrugs can also bind to membrane transport proteins (competitively and non-competitively) and inhibit their function. Some drugs can also bind to membrane lipids and DNA in order to ...
... Drugs that bind to enzymes interfere with the normal activity of the enzyme in one of 2 ways CompetitiveNon-competitiveDrugs can also bind to membrane transport proteins (competitively and non-competitively) and inhibit their function. Some drugs can also bind to membrane lipids and DNA in order to ...
1B Ulcer Medicines
... in the stomach wall, but an enzyme (15-hydroxyprostaglandin dehydrogenase) stops the prostaglandins from working. Licorice blocks this enzyme, and so the prostaglandins stick around longer, make ulcers heal. HOWEVER chemistry always has a price, licorice causes cortisol to bind to a protein causing ...
... in the stomach wall, but an enzyme (15-hydroxyprostaglandin dehydrogenase) stops the prostaglandins from working. Licorice blocks this enzyme, and so the prostaglandins stick around longer, make ulcers heal. HOWEVER chemistry always has a price, licorice causes cortisol to bind to a protein causing ...
Beta blockers
... Glucagon provides us with a bypass opportunity to increase intracellular cAMP concentration. B blockers can bind to the receptors strongly making hard to break through the blockade. Activation of myocardial glucagon receptors has positive inotropic and chronotropic effects, thereby providing us with ...
... Glucagon provides us with a bypass opportunity to increase intracellular cAMP concentration. B blockers can bind to the receptors strongly making hard to break through the blockade. Activation of myocardial glucagon receptors has positive inotropic and chronotropic effects, thereby providing us with ...
Men`s Health 2016
... decision with their doctor about whether to be tested for prostate cancer. Research has not yet proven that the potential benefits of testing outweigh the harms of testing and treatment. • The American Cancer Society believes that men should not be tested without learning about what we know and don’ ...
... decision with their doctor about whether to be tested for prostate cancer. Research has not yet proven that the potential benefits of testing outweigh the harms of testing and treatment. • The American Cancer Society believes that men should not be tested without learning about what we know and don’ ...
Steroid Hormones
... - Tablet of 0.18 mg of norgestimate and 35 mg of ethinyl estradiol for 7 days - Tablet of 0.215 mg of norgestrimate and 35 mg of ethinyl estradiol for 7 days - Tablet of 0.25 mg of norgestrimate and 35 mg of ethinyl estradiol for 7 days ...
... - Tablet of 0.18 mg of norgestimate and 35 mg of ethinyl estradiol for 7 days - Tablet of 0.215 mg of norgestrimate and 35 mg of ethinyl estradiol for 7 days - Tablet of 0.25 mg of norgestrimate and 35 mg of ethinyl estradiol for 7 days ...
Nutt - pharmacodynamics
... Once aripirazole has been taken it will occupy brain receptors, and in brain regions where dopamine is high it will partially block the effects of dopamine, so leading to an antipsychotic effect. However, in brain regions where dopamine levels are lower, then aripirazole will act as an agonist to in ...
... Once aripirazole has been taken it will occupy brain receptors, and in brain regions where dopamine is high it will partially block the effects of dopamine, so leading to an antipsychotic effect. However, in brain regions where dopamine levels are lower, then aripirazole will act as an agonist to in ...
New anticancer compounds could boost effectiveness of standard
... cancer and other diseases. These compounds prevent the removal of acetyl groups from many proteins, including histones, which regulate gene expression. They also interfere by a different mechanism with the degradation of mutant but functional proteins. Because abnormal gene regulation is a hallmark ...
... cancer and other diseases. These compounds prevent the removal of acetyl groups from many proteins, including histones, which regulate gene expression. They also interfere by a different mechanism with the degradation of mutant but functional proteins. Because abnormal gene regulation is a hallmark ...
Medtronic TUNA Therapy for Benign Prostatic Hyperplasia (BPH)
... symptoms due to urinary outflow obstruction secondary to benign prostatic hyperplasia (BPH) in men over the age of 50 with prostate sizes between 20 cc and 50 cc. § In January 2003, the United States Food and Drug Administration (FDA) cleared the TUNA Therapy Precision Plus System. § TUNA Therapy is ...
... symptoms due to urinary outflow obstruction secondary to benign prostatic hyperplasia (BPH) in men over the age of 50 with prostate sizes between 20 cc and 50 cc. § In January 2003, the United States Food and Drug Administration (FDA) cleared the TUNA Therapy Precision Plus System. § TUNA Therapy is ...
A rare presentation of prostate cancer with diffuse osteolytic
... vertebroplasty and kyphoplasty [4]. Zoledronic acid, an aminobisphosphonate, exerts potent inhibition of osteoclast adherence or activity and enhances osteoclast apoptosis; and it is currently used to prevent skeletal complications from bone metastases [3, 4, 9]. The NCCN (National Comprehensive Can ...
... vertebroplasty and kyphoplasty [4]. Zoledronic acid, an aminobisphosphonate, exerts potent inhibition of osteoclast adherence or activity and enhances osteoclast apoptosis; and it is currently used to prevent skeletal complications from bone metastases [3, 4, 9]. The NCCN (National Comprehensive Can ...
Discovery and development of antiandrogens
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.