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Low dose rate brachytherapy for the treatment of prostate cancer
... Imodium. Blood from the rectum is noticed by a few patients and although it can be alarming it is usually for a short period and stops on its own. Severe cases may need additional medication such as steroid suppositories which can be prescribed from your GP. Erectile dysfunction As with most of the ...
... Imodium. Blood from the rectum is noticed by a few patients and although it can be alarming it is usually for a short period and stops on its own. Severe cases may need additional medication such as steroid suppositories which can be prescribed from your GP. Erectile dysfunction As with most of the ...
Practical guide to immunotherapy in castration resistant prostate cancer:
... of prostate cancer patients present with metastatic disease, and up to one-third of patients who present at an earlier stage will have disease recurrence despite surgical or radiotherapeutic treatment.2 In over 80% of men with metastatic disease, primary androgen ablation leads to initial clinical i ...
... of prostate cancer patients present with metastatic disease, and up to one-third of patients who present at an earlier stage will have disease recurrence despite surgical or radiotherapeutic treatment.2 In over 80% of men with metastatic disease, primary androgen ablation leads to initial clinical i ...
Combining Kinetic Ligand Binding and 3D Tumor Invasion
... vivo, neutralizing the interaction of CXCR4 and its known ligand, SDF1-α (CXCL12), significantly impaired the metastasis of breast cancer cells and cell migration2. Traditionally, the discovery of novel agents has been guided by the affinity of the ligand for the receptor under equilibrium condition ...
... vivo, neutralizing the interaction of CXCR4 and its known ligand, SDF1-α (CXCL12), significantly impaired the metastasis of breast cancer cells and cell migration2. Traditionally, the discovery of novel agents has been guided by the affinity of the ligand for the receptor under equilibrium condition ...
What lessons can we learn from 20 years of chemokine receptor drug discovery?
... Glu283 essential for almost all compound interactions (except TAK-779) Partially overlaps with endogenous ligand binding site 2 ...
... Glu283 essential for almost all compound interactions (except TAK-779) Partially overlaps with endogenous ligand binding site 2 ...
PharmacoTheraputics
... Expensive Lack of clinical rationale for use Bioequivalence of Thyroxine Products: o Basics: FDA approved generics may differ from brands by up to 33% o Issue: narrow therapeutic index drug; slight dose alterations can lead to sub/supratherapeutic effects o Recommendations: ...
... Expensive Lack of clinical rationale for use Bioequivalence of Thyroxine Products: o Basics: FDA approved generics may differ from brands by up to 33% o Issue: narrow therapeutic index drug; slight dose alterations can lead to sub/supratherapeutic effects o Recommendations: ...
The Drugs - chem4520
... • Synthesis was tedious and expensive but could be scaled up to give the large quantities of the microbial agent required to make several different 2-nitroimidazole based compounds • Very good yield • The best yields and shorter reaction times were obtain when DMSO was used as a solvent ...
... • Synthesis was tedious and expensive but could be scaled up to give the large quantities of the microbial agent required to make several different 2-nitroimidazole based compounds • Very good yield • The best yields and shorter reaction times were obtain when DMSO was used as a solvent ...
Introduction
... Represent the final step of the natural course for virus induced liver disease ...
... Represent the final step of the natural course for virus induced liver disease ...
Introduction to neuropharmacology
... Pharmacology is the science that study the interaction of drugs with biological systems either in vivo, ex vivo or in vitro. Pharmacology comes from pharmakon, poison or drug in Greek. In Spanish there is a handy word farmaco that is lacking in English. Drug is defined as any natural or synthetic mo ...
... Pharmacology is the science that study the interaction of drugs with biological systems either in vivo, ex vivo or in vitro. Pharmacology comes from pharmakon, poison or drug in Greek. In Spanish there is a handy word farmaco that is lacking in English. Drug is defined as any natural or synthetic mo ...
Document
... also increased. it enhances salivary and lacrimal gland secretion (minimal unless large doses are given) ...
... also increased. it enhances salivary and lacrimal gland secretion (minimal unless large doses are given) ...
- BioTek Instruments
... Nuclear receptors make up a super family of signal mediating, intra-cellular receptors that are found in multiple species including insects and vertebrates such as humans. Being transcriptional regulators, they function as metabolic ligand activated transcription factors, regulating a number of func ...
... Nuclear receptors make up a super family of signal mediating, intra-cellular receptors that are found in multiple species including insects and vertebrates such as humans. Being transcriptional regulators, they function as metabolic ligand activated transcription factors, regulating a number of func ...
Allergy and Immunology Review Corner: Chapter 87 of
... local concentrations are high enough to saturate mucosal receptors. When inhaled corticosteroids are delivered with spacers/aerochambers, the oral deposition decreases by up to 90%. Because a large proportion of drug can be swallowed, it is advantageous that inhaled steroids have a low oral bioavail ...
... local concentrations are high enough to saturate mucosal receptors. When inhaled corticosteroids are delivered with spacers/aerochambers, the oral deposition decreases by up to 90%. Because a large proportion of drug can be swallowed, it is advantageous that inhaled steroids have a low oral bioavail ...
Patrick chapter 19 part 2
... has been largely replaced by use of analogs tropicamide and cyclopenatolate (vida infra). • However, atropine, and its chiral analog hyoscyamine, are utilized to treat gastrointestinal disorders • Also these antagonists can be used to treat the symptoms of an excess of acetylcholine, such as might o ...
... has been largely replaced by use of analogs tropicamide and cyclopenatolate (vida infra). • However, atropine, and its chiral analog hyoscyamine, are utilized to treat gastrointestinal disorders • Also these antagonists can be used to treat the symptoms of an excess of acetylcholine, such as might o ...
Pharmacology
... Responses that are not found in the general population, such as general toxic effects, allergies, or side effects, but due to an inherited trait that produces a diminished or enhanced response to a drug. • Differences in Enzyme Activity – Acetylation polymorphism – Butylcholinesterase alterations – ...
... Responses that are not found in the general population, such as general toxic effects, allergies, or side effects, but due to an inherited trait that produces a diminished or enhanced response to a drug. • Differences in Enzyme Activity – Acetylation polymorphism – Butylcholinesterase alterations – ...
The receptors have a long extracellular domain
... The GABA a and c receptor are members of the ligand-gated channel superfamily. By analogy to the well studied nicotinic acytocholine receptors, GABAc receptors are thought to exhibit the structure shown schematically in Fig. 2. These receptors are pentomers, i.e. five subunits constitute the funct ...
... The GABA a and c receptor are members of the ligand-gated channel superfamily. By analogy to the well studied nicotinic acytocholine receptors, GABAc receptors are thought to exhibit the structure shown schematically in Fig. 2. These receptors are pentomers, i.e. five subunits constitute the funct ...
Pharmacodynamics
... Two drugs act on different receptors or by different mechanisms, but have opposite effects on same physiological function ...
... Two drugs act on different receptors or by different mechanisms, but have opposite effects on same physiological function ...
Pharm_essays
... typical drugs. Endocrine side effects such as gynaecomastia occur due to the blockade of D2 in the tuberoinfunibular pathway of the brain. The drugs also have a range of actions on other receptors (Alpha-adrenoceptors, histamine H1 receptors, muscarinic receptors, 5HT receptors) that modifies their ...
... typical drugs. Endocrine side effects such as gynaecomastia occur due to the blockade of D2 in the tuberoinfunibular pathway of the brain. The drugs also have a range of actions on other receptors (Alpha-adrenoceptors, histamine H1 receptors, muscarinic receptors, 5HT receptors) that modifies their ...
Slide 1
... relation between drug concentration and response - This is based on receptor’s affinity to bind and it’s abundance in target cells or tissues - Drug response depends on: - Affinity of drug for receptor - Drug’s efficacy (degree to which a drug is able to induce maximal effects) ...
... relation between drug concentration and response - This is based on receptor’s affinity to bind and it’s abundance in target cells or tissues - Drug response depends on: - Affinity of drug for receptor - Drug’s efficacy (degree to which a drug is able to induce maximal effects) ...
Anti-tumor Effects of Targeted Follicle
... prostate cancer cases of 220,800 and 27,540 men died from the disease in 2015 [2]. Though currently used chemotherapeutic drugs are effective in reducing the mortality and morbidity caused by prostate cancer; but disease progression is inevitable [3-6]. One of the major problems associated with canc ...
... prostate cancer cases of 220,800 and 27,540 men died from the disease in 2015 [2]. Though currently used chemotherapeutic drugs are effective in reducing the mortality and morbidity caused by prostate cancer; but disease progression is inevitable [3-6]. One of the major problems associated with canc ...
PRODUCT MONOGRAPH CYPROTERONE Cyproterone Acetate
... Cyproterone acetate is absorbed at most dose levels tested except in high doses. Peak plasma levels are usually obtained within 1 - 4 hours of oral dosing. Because of its lipophilic character, cyproterone acetate is taken up and concentrated in the liver and fatty tissues in all animal species. Cypr ...
... Cyproterone acetate is absorbed at most dose levels tested except in high doses. Peak plasma levels are usually obtained within 1 - 4 hours of oral dosing. Because of its lipophilic character, cyproterone acetate is taken up and concentrated in the liver and fatty tissues in all animal species. Cypr ...
What happened? - Canadian Family Physician
... could achieve an erection only with the 100-mg dose (level II evidence).31 Positive results have been reported with the newer phosphodiesterase inhibitors; vardenafil was shown to be effective in promoting erections among 71.1% of men taking 20 mg and 59.7% of men taking 10 mg of the drug after bilate ...
... could achieve an erection only with the 100-mg dose (level II evidence).31 Positive results have been reported with the newer phosphodiesterase inhibitors; vardenafil was shown to be effective in promoting erections among 71.1% of men taking 20 mg and 59.7% of men taking 10 mg of the drug after bilate ...
Chapter 4 Lecture Notes Page
... Antagonists - stimulates autoreceptor- thus inhibits synthesis and release of neurotransmitter (example: apomorphine) Agonists – blocks autoreceptors – drug increases synthesis and release of nuerotransmitter (example: clonadine) Binding sites Agonist – masquerades as the neurotransmitter by binding ...
... Antagonists - stimulates autoreceptor- thus inhibits synthesis and release of neurotransmitter (example: apomorphine) Agonists – blocks autoreceptors – drug increases synthesis and release of nuerotransmitter (example: clonadine) Binding sites Agonist – masquerades as the neurotransmitter by binding ...
PPT
... metabolize it. half-life 10 minutes. During continuous infusions of esmolol, steady-state concentrations are achieved quickly, and actions of the drug are terminated rapidly when its infusion is discontinued. • Esmolol may be safer in critically ill patients who require a β -adrenoceptor antagonist. ...
... metabolize it. half-life 10 minutes. During continuous infusions of esmolol, steady-state concentrations are achieved quickly, and actions of the drug are terminated rapidly when its infusion is discontinued. • Esmolol may be safer in critically ill patients who require a β -adrenoceptor antagonist. ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.