Kinetic models
... Qualitatively, the amount of receptor activation is not necessarily directly related to the binding affinity for a drug to any particular "state" of the receptor. Therefore, the value of EC50 cannot directly be related to a molecular step (for example, binding of a drug to an inactive receptor). Sim ...
... Qualitatively, the amount of receptor activation is not necessarily directly related to the binding affinity for a drug to any particular "state" of the receptor. Therefore, the value of EC50 cannot directly be related to a molecular step (for example, binding of a drug to an inactive receptor). Sim ...
GENERAL ANESTHETICS INHALATION ANESTHETICS
... Surmountable antagonists of the specific effects of narcotics (reduces potency of agonist) o Little effect when given alone, showing that endogenous opiates are not very active under normal circumstances ...
... Surmountable antagonists of the specific effects of narcotics (reduces potency of agonist) o Little effect when given alone, showing that endogenous opiates are not very active under normal circumstances ...
The future of pharmacological treatment. Anne Lingford-Hughes Professor of Addiction Biology, Imperial College.
... Drugs of abuse increase dopamine concentration in the nucleus accumbens of the mesolimbic system Dopamine system is modulated by other ...
... Drugs of abuse increase dopamine concentration in the nucleus accumbens of the mesolimbic system Dopamine system is modulated by other ...
Practical I
... glycopyrrolate or methscopolamine and which therefore do not cross the blood-brain barrier) are recommended to prevent the peripheral side effects of physostigmine. Edrophonium (Tensilon®) is a quaternary amine widely used as a clinical test for myasthenia gravis. ...
... glycopyrrolate or methscopolamine and which therefore do not cross the blood-brain barrier) are recommended to prevent the peripheral side effects of physostigmine. Edrophonium (Tensilon®) is a quaternary amine widely used as a clinical test for myasthenia gravis. ...
The so-called „designer steroids“ Nor
... Norbolethone, Desoxymethyltestosterone (DMT) or Tetrahydrogestrinone (THG) concerning their endocrine and pharmacological properties. Besides conceiving chemical possibilities to access the modified steroids, we characterized their hormonal potential using modified industrial methods like Hershberge ...
... Norbolethone, Desoxymethyltestosterone (DMT) or Tetrahydrogestrinone (THG) concerning their endocrine and pharmacological properties. Besides conceiving chemical possibilities to access the modified steroids, we characterized their hormonal potential using modified industrial methods like Hershberge ...
Press Releases - Guy Griebel Homepage
... hygiene in depressed humans). SSR149415 reduced all of the measures of ‘depression’ in these rodent models, which are normally good predictors of antidepressant efficacy in humans. Although these results might be therapeutically useful, they do not tell us where in the brain SSR149415 acts to reduce ...
... hygiene in depressed humans). SSR149415 reduced all of the measures of ‘depression’ in these rodent models, which are normally good predictors of antidepressant efficacy in humans. Although these results might be therapeutically useful, they do not tell us where in the brain SSR149415 acts to reduce ...
DOPAMINE ANTAGONISTS: PHENOTHIAZINE/THIOXANTHENE SAR
... antisychotics are dopamine receptor antagonists with a higher affinity for D2 over D1 receptors. They also exhibit varying degrees of selectivity among the cortical dopamine tracts; nigrostriatal (movement disorders), mesolimbic (relief of hallucinations and delusions), mesocortical (relief of psych ...
... antisychotics are dopamine receptor antagonists with a higher affinity for D2 over D1 receptors. They also exhibit varying degrees of selectivity among the cortical dopamine tracts; nigrostriatal (movement disorders), mesolimbic (relief of hallucinations and delusions), mesocortical (relief of psych ...
Part 2 - OoCities
... delocalized into the cyclic amide structure and the carbonyl group of the other amide bond. The fact that our estimated values are higher than the experimental value is also due largely to the fact that there are many other factors that determine protein binding. Taking our predictors separately to ...
... delocalized into the cyclic amide structure and the carbonyl group of the other amide bond. The fact that our estimated values are higher than the experimental value is also due largely to the fact that there are many other factors that determine protein binding. Taking our predictors separately to ...
Bentley Poster 2011
... further evaluated to observe the self-assembled structures which can form and tested for its drug delivery potential. The results presented here are the first steps towards developing a novel drug delivery system with passive targeting potential through size control. ...
... further evaluated to observe the self-assembled structures which can form and tested for its drug delivery potential. The results presented here are the first steps towards developing a novel drug delivery system with passive targeting potential through size control. ...
A clinical approach to women with hirsutism
... GnRH agonist therapy acts by inhibiting LH and to a lesser extent FSH secretion, thereby decreasing ovarian function and consequently the ovarian androgen production. Although weak evidence suggests that GnRH agonist therapy is more effective than placebo in the treatment of hirsutism, it does not h ...
... GnRH agonist therapy acts by inhibiting LH and to a lesser extent FSH secretion, thereby decreasing ovarian function and consequently the ovarian androgen production. Although weak evidence suggests that GnRH agonist therapy is more effective than placebo in the treatment of hirsutism, it does not h ...
Botanicals as Therapeutics
... Staphylococcus aureus (Manohar et al., 2001). The experiments were carried out both in vitro and in vivo. The spices examined included oregano, cinnamon/ cassia, myrtle, bay leaf, lavender, and cumin. Oregano and cinnamon were found to be the most potent based on their ability to kill both Candida ...
... Staphylococcus aureus (Manohar et al., 2001). The experiments were carried out both in vitro and in vivo. The spices examined included oregano, cinnamon/ cassia, myrtle, bay leaf, lavender, and cumin. Oregano and cinnamon were found to be the most potent based on their ability to kill both Candida ...
2 receptor
... JH, a 63-year-old architect, complains of urinary symptoms to his family physician. He has hypertension and the last 8 years, he has been adequately managed with a thiazide diuretic and an angiotensin-converting enzyme inhibitor. During the same period, JH developed the signs of benign prostatic hyp ...
... JH, a 63-year-old architect, complains of urinary symptoms to his family physician. He has hypertension and the last 8 years, he has been adequately managed with a thiazide diuretic and an angiotensin-converting enzyme inhibitor. During the same period, JH developed the signs of benign prostatic hyp ...
Understanding Treatment Choices for Prostate Cancer
... of men will have some cancerous changes in their prostate glands. Most of these cancers remain latent, producing no signs of symptoms, or are so indolent, or slow-growing, that they never become a serious threat to health. A much smaller number of men will actually be treated for prostate cancer. Ab ...
... of men will have some cancerous changes in their prostate glands. Most of these cancers remain latent, producing no signs of symptoms, or are so indolent, or slow-growing, that they never become a serious threat to health. A much smaller number of men will actually be treated for prostate cancer. Ab ...
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... Ligand-gated Ion Channels • At the NMJ, N receptors Pentameric with four types of subunits, two a subunits bind ACh for ligand gating • All other nAChRs, including those at the peripheral ganglia, have 2 a’s and 3 b’s ...
... Ligand-gated Ion Channels • At the NMJ, N receptors Pentameric with four types of subunits, two a subunits bind ACh for ligand gating • All other nAChRs, including those at the peripheral ganglia, have 2 a’s and 3 b’s ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
Management of Hot Flashes in Men With Prostate Cancer
... options for localized disease are radical prostatectomy or radiation therapy. For patients who have metastatic disease or recurrence after surgery or radiation therapy, the treatment of choice is hormone deprivation, as prostate cancer growth is promoted by endogenous testosterone. Hormone deprivati ...
... options for localized disease are radical prostatectomy or radiation therapy. For patients who have metastatic disease or recurrence after surgery or radiation therapy, the treatment of choice is hormone deprivation, as prostate cancer growth is promoted by endogenous testosterone. Hormone deprivati ...
Advances in targeted therapeutic agents
... has significantly increased over the past decade due to advances in molecular and cellular biology technologies, human genetic mapping efforts and information gathered from the human genome project. The identification of gene products that appear to be involved in supporting the underlying cause of ...
... has significantly increased over the past decade due to advances in molecular and cellular biology technologies, human genetic mapping efforts and information gathered from the human genome project. The identification of gene products that appear to be involved in supporting the underlying cause of ...
Benign prostatic hyperplasia (BPH)
... monotherapy with an alpha blocker (doxazosin) or a 5-ARI (finasteride [Proscar]) versus combination therapy (doxazosin and finasteride) for BPH.28 This study randomized patients into four treatment groups: an alpha blocker (doxazosin) alone, a 5-ARI (finasteride) alone, combination therapy, and plac ...
... monotherapy with an alpha blocker (doxazosin) or a 5-ARI (finasteride [Proscar]) versus combination therapy (doxazosin and finasteride) for BPH.28 This study randomized patients into four treatment groups: an alpha blocker (doxazosin) alone, a 5-ARI (finasteride) alone, combination therapy, and plac ...
Histamine - heartha..
... methyl group (CH3) followed by a chemical oxidation. o Most of the time very little histamine is excreted unchanged because of these metabolic steps. One exception would be the case of neoplastic disease (cancer). For instance, significant histamine is excreted unchanged in the presence of these dis ...
... methyl group (CH3) followed by a chemical oxidation. o Most of the time very little histamine is excreted unchanged because of these metabolic steps. One exception would be the case of neoplastic disease (cancer). For instance, significant histamine is excreted unchanged in the presence of these dis ...
Neuraxial Opioid-Induced Pruritus: A Review
... through the release of serotonin. There are dense concentration of serotonin receptors in the dorsal part of spinal cord & the nucleus of spinal tract of the trigeminal nerve in the medulla, in which opioid receptor density is also high. These observations suggest that the 5-HT receptor may be i ...
... through the release of serotonin. There are dense concentration of serotonin receptors in the dorsal part of spinal cord & the nucleus of spinal tract of the trigeminal nerve in the medulla, in which opioid receptor density is also high. These observations suggest that the 5-HT receptor may be i ...
PROSTATE CANCER COMMUNICATION ,
... could not have been more favorable; suggesting that anything short of cure is a significant failure. This case history establishes very clearly why a more conservative approach may have been the better first choice. Unfortunately, Jon had never been told that he could live a long and prosperous life ...
... could not have been more favorable; suggesting that anything short of cure is a significant failure. This case history establishes very clearly why a more conservative approach may have been the better first choice. Unfortunately, Jon had never been told that he could live a long and prosperous life ...
MOTM SALVINORIN A MAGIC MINT
... So why has it been in the news? It has gained a lot of publicity through exposure of its use on YouTube, and politicians have reacted to this. Long before she twerked, Miley Cyrus celebrated her 18th birthday at a party, after which a video of her using a bong (allegedly smoking salvia) was widely ...
... So why has it been in the news? It has gained a lot of publicity through exposure of its use on YouTube, and politicians have reacted to this. Long before she twerked, Miley Cyrus celebrated her 18th birthday at a party, after which a video of her using a bong (allegedly smoking salvia) was widely ...
Benign Prostatic Hyperplasia (BPH)
... A more limited surgical procedure which may be an option in some cases (e.g. patients with small prostates.) In this procedure, an instrument is passed through the urethra to make cuts in the prostate instead of removing prostate tissue. These cuts reduce prostate pressure on the urethra, making uri ...
... A more limited surgical procedure which may be an option in some cases (e.g. patients with small prostates.) In this procedure, an instrument is passed through the urethra to make cuts in the prostate instead of removing prostate tissue. These cuts reduce prostate pressure on the urethra, making uri ...
Discovery and development of antiandrogens
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.