![Antiemetic drugs](http://s1.studyres.com/store/data/012712850_1-d6afd22010a3f91759f702a37f3e3d7e-300x300.png)
Antiemetic drugs
... Antiemetic mechanism • Neurokinin 1 (NK1) receptor antagonist on nucleus of tractus solitaries and Visceral afferent nerves • So it prevent both peripheral and central stimulation of the vomiting center Uses as antiemetic: • In combination with 5-HT3 blockers to treat vomiting due to cancer chemothe ...
... Antiemetic mechanism • Neurokinin 1 (NK1) receptor antagonist on nucleus of tractus solitaries and Visceral afferent nerves • So it prevent both peripheral and central stimulation of the vomiting center Uses as antiemetic: • In combination with 5-HT3 blockers to treat vomiting due to cancer chemothe ...
pps
... Assessment and management of physical and psychosocial effects of prostate cancer and treatment Fracture risk/osteoporosis - specific risk for men receiving ADT • For men determined to be high risk, prescribe weekly bisphosphonate therapy (oral alendronate at a dose of 70 mg) or annual intravenous z ...
... Assessment and management of physical and psychosocial effects of prostate cancer and treatment Fracture risk/osteoporosis - specific risk for men receiving ADT • For men determined to be high risk, prescribe weekly bisphosphonate therapy (oral alendronate at a dose of 70 mg) or annual intravenous z ...
Data Sheet
... After single s.c. injection of Lucrin Depot 30mg PDS Injection serum levels of leuprorelin rise quickly with a subsequent decrease to a plateau within a few days. Within two hours mean maximum serum levels of 100 ng/ml are measured. In the plateau phase detectable serum levels were found until up t ...
... After single s.c. injection of Lucrin Depot 30mg PDS Injection serum levels of leuprorelin rise quickly with a subsequent decrease to a plateau within a few days. Within two hours mean maximum serum levels of 100 ng/ml are measured. In the plateau phase detectable serum levels were found until up t ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... patient, favors the emergence of multidrug-resistant (MDR) and extensively drug resistant (XDR) TB. Combined treatment in patients’ co-infected with HIV may cause drug interaction and subsequent adverse effect to immune system. The available drugs are ineffective against the MDR and XDR strains of M ...
... patient, favors the emergence of multidrug-resistant (MDR) and extensively drug resistant (XDR) TB. Combined treatment in patients’ co-infected with HIV may cause drug interaction and subsequent adverse effect to immune system. The available drugs are ineffective against the MDR and XDR strains of M ...
Used Drugs to Treat Peptic Ulcer Disease
... emesis linked with chemotherapy. They have the advantage of a long duration of action. The specific antagonists of the 5-HT3 receptor ondansetron , granisetron, palonosetron and dolasetron selectively block 5HT3 receptors in the periphery (visceral vagal afferent fibers) and in the brain (chemorecep ...
... emesis linked with chemotherapy. They have the advantage of a long duration of action. The specific antagonists of the 5-HT3 receptor ondansetron , granisetron, palonosetron and dolasetron selectively block 5HT3 receptors in the periphery (visceral vagal afferent fibers) and in the brain (chemorecep ...
An overview of the anti-cancer properties of some plants used in
... surgery, radiation therapy, and chemotherapy but despite these therapeutic options, cancer remains associated with high mortality. As chemotherapy destroys the normal cells along with cancer cells, biological active components from plants are significant and important source of new drugs that are li ...
... surgery, radiation therapy, and chemotherapy but despite these therapeutic options, cancer remains associated with high mortality. As chemotherapy destroys the normal cells along with cancer cells, biological active components from plants are significant and important source of new drugs that are li ...
Anti HER2 mAbs
... Tzahar E., et al. Mol Cell Biol. 1996. Sergina NV, et al. Nature. 445:437-441. ...
... Tzahar E., et al. Mol Cell Biol. 1996. Sergina NV, et al. Nature. 445:437-441. ...
Antagonistic analogs of growth hormone-releasing
... The resulting phenotype is highly motile and possesses stem-cell-like properties, a high degree of resistance to treatments, and an increased rate of drug efflux.[49-51] Numerous studies have firmly established the regulatory role of inflammatory cytokines in cancer.[3, 37-39, 46, 47, 50, 52] Our gr ...
... The resulting phenotype is highly motile and possesses stem-cell-like properties, a high degree of resistance to treatments, and an increased rate of drug efflux.[49-51] Numerous studies have firmly established the regulatory role of inflammatory cytokines in cancer.[3, 37-39, 46, 47, 50, 52] Our gr ...
Testosterone and breast cancer prevention
... in psychological symptoms (depressive mood, irritability, anxiety, physical and mental exhaustion), somatic symptoms (hot flashes, heart discomfort, sleep problems, pain) and urogenital symptoms including sexual desire, activity, satisfaction, vaginal dryness and bladder problems (Fig. 2). There were ...
... in psychological symptoms (depressive mood, irritability, anxiety, physical and mental exhaustion), somatic symptoms (hot flashes, heart discomfort, sleep problems, pain) and urogenital symptoms including sexual desire, activity, satisfaction, vaginal dryness and bladder problems (Fig. 2). There were ...
Concentration-Effect Relationship of l
... and Perrier, 1982). The pharmacokinetic parameters used to calculate the rate of infusion required for a given steady-state concentration were derived from Terao and Shen (1983) and Vermeulen et al. (1993). A 30 min (T) loading infusion was followed by a maintenance infusion over 2 hr and 20 min, fo ...
... and Perrier, 1982). The pharmacokinetic parameters used to calculate the rate of infusion required for a given steady-state concentration were derived from Terao and Shen (1983) and Vermeulen et al. (1993). A 30 min (T) loading infusion was followed by a maintenance infusion over 2 hr and 20 min, fo ...
The Relationship Between Thiopurine
... steadily such that most trials now report a long-term survival rate of over 70%.1,2 However, current treatment protocols are complex and are associated with significant toxicity.3-6 There are therefore two major priorities in the treatment of childhood ALL; further improvement in the survival rate a ...
... steadily such that most trials now report a long-term survival rate of over 70%.1,2 However, current treatment protocols are complex and are associated with significant toxicity.3-6 There are therefore two major priorities in the treatment of childhood ALL; further improvement in the survival rate a ...
DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES OF BENZOTHIAZOLE Research Article
... spectrum of biodynamic properties having potent clinical significance [4]. Schiff bases are currently been applied for the treatment of a number of disease condition. Though extensive research work has been reported on benzothiazole with Schiff base, relatively very little is known about the substit ...
... spectrum of biodynamic properties having potent clinical significance [4]. Schiff bases are currently been applied for the treatment of a number of disease condition. Though extensive research work has been reported on benzothiazole with Schiff base, relatively very little is known about the substit ...
4a-Pharmacodynamics,ADRs (Lec.1 & 2)
... Due to the induction of drug metabolizing enzymes Called metabolic tolerance or drug disposition tolerance Warfarin (oral anticoagulant) dose needs to be increased in patient taking barbiturates or phenytoin ...
... Due to the induction of drug metabolizing enzymes Called metabolic tolerance or drug disposition tolerance Warfarin (oral anticoagulant) dose needs to be increased in patient taking barbiturates or phenytoin ...
6-作用于神经系统的药物
... receipt site, the Cl- channel open, Clinflux, then postsynaptic membrane super-polarization, to produce postsynaptic inhibition; (4)When BZ combine with BZ receptor, to promote GABA combine with GABAA receipt site, the frequency of which Cl- channel open increases, more Clinflux. ...
... receipt site, the Cl- channel open, Clinflux, then postsynaptic membrane super-polarization, to produce postsynaptic inhibition; (4)When BZ combine with BZ receptor, to promote GABA combine with GABAA receipt site, the frequency of which Cl- channel open increases, more Clinflux. ...
Prostate Cancer: Pathophysiology, Diagnosis, and
... A complete understanding of the causes of prostate cancer remains elusive[27].The primary risk factors are obesity, age and family history. Prostatecancer is very uncommon in men younger than 45, but becomes more common with advancing age. The average age at the time diagnosis is 70[28].However many ...
... A complete understanding of the causes of prostate cancer remains elusive[27].The primary risk factors are obesity, age and family history. Prostatecancer is very uncommon in men younger than 45, but becomes more common with advancing age. The average age at the time diagnosis is 70[28].However many ...
Performance Enhancement
... Insulin and IGF-1 • GH anabolic effects are regulated by Insulin-like Growth Factor-1 (IGF-1) • Complex interaction of Insulin, GH and IGF-1 to control the nutrients supplied to the tissues during fasting and feeding. • Insulin and GH have been widely available and now so is IGF-1. – Let the games ...
... Insulin and IGF-1 • GH anabolic effects are regulated by Insulin-like Growth Factor-1 (IGF-1) • Complex interaction of Insulin, GH and IGF-1 to control the nutrients supplied to the tissues during fasting and feeding. • Insulin and GH have been widely available and now so is IGF-1. – Let the games ...
PRODUCT MONOGRAPH TRELSTAR 3.75 mg Triptorelin for
... WARNINGS AND PRECAUTIONS General During the early phase of therapy, sex hormones usually rise above baseline levels because of the physiologic effect of the drug. An increase in clinical signs and symptoms of endometriosis is often observed during the initial days of therapy. These will subside with ...
... WARNINGS AND PRECAUTIONS General During the early phase of therapy, sex hormones usually rise above baseline levels because of the physiologic effect of the drug. An increase in clinical signs and symptoms of endometriosis is often observed during the initial days of therapy. These will subside with ...
PRODUCT MONOGRAPH Pr TRELSTAR® 3.75 mg
... WARNINGS AND PRECAUTIONS General During the early phase of therapy, sex hormones usually rise above baseline levels because of the physiologic effect of the drug. An increase in clinical signs and symptoms of endometriosis is often observed during the initial days of therapy. These will subside with ...
... WARNINGS AND PRECAUTIONS General During the early phase of therapy, sex hormones usually rise above baseline levels because of the physiologic effect of the drug. An increase in clinical signs and symptoms of endometriosis is often observed during the initial days of therapy. These will subside with ...
Terms and symbols - Guide to Pharmacology
... such, to avoid confusion). Furthermore, a receptor may consist of several proteins, called subunits. In some cases the large number of combinatorial possibilities for assembly of multiple subunits may require NC-IUPHAR to use an interim nomenclature based on the individual subunits (Spedding et al., ...
... such, to avoid confusion). Furthermore, a receptor may consist of several proteins, called subunits. In some cases the large number of combinatorial possibilities for assembly of multiple subunits may require NC-IUPHAR to use an interim nomenclature based on the individual subunits (Spedding et al., ...
- ISpatula
... From sesquiterpenes we will continue to our next group of the terpenoids substances. We talked about 10C "monoterpenes" , 15C "sesquiterpenes" , and now we'll talk about 20C "Diterpenes" substances. We know that the aliphatic compound is the first compound in the biosynthesis of any subclass of the ...
... From sesquiterpenes we will continue to our next group of the terpenoids substances. We talked about 10C "monoterpenes" , 15C "sesquiterpenes" , and now we'll talk about 20C "Diterpenes" substances. We know that the aliphatic compound is the first compound in the biosynthesis of any subclass of the ...
A pilot phase II study of digitoxin for
... 7600 men are diagnosed with prostate cancer. The incidence has increased the last years mainly due to increased diagnostic activity and an increased life span of the population (1). Since more than 50 years androgen ablation has been a cornerstone in the treatment. Most patients with metastatic dise ...
... 7600 men are diagnosed with prostate cancer. The incidence has increased the last years mainly due to increased diagnostic activity and an increased life span of the population (1). Since more than 50 years androgen ablation has been a cornerstone in the treatment. Most patients with metastatic dise ...
Leuprolide acetate: a drug of diverse clinical
... on overall survival, it does not seem to have a benefit for those patients with metastatic disease [4]. The dose that shows equivalence to castration (150 mg) is not approved by the FDA. Although antiandrogen therapy has gynecomastia and breast pain as its common side effects, it does offer improvem ...
... on overall survival, it does not seem to have a benefit for those patients with metastatic disease [4]. The dose that shows equivalence to castration (150 mg) is not approved by the FDA. Although antiandrogen therapy has gynecomastia and breast pain as its common side effects, it does offer improvem ...
Autonomní nervový systém
... cardiovascular: decrease of BP and CO negative chronotropic, inotropic, dromotropic effect. Decrease of rennin production, but due to inhibition of beta-vasodilatation peripheral vascular resistance can increase - increase of PVR (peripheral -receptors are not opposed) ...
... cardiovascular: decrease of BP and CO negative chronotropic, inotropic, dromotropic effect. Decrease of rennin production, but due to inhibition of beta-vasodilatation peripheral vascular resistance can increase - increase of PVR (peripheral -receptors are not opposed) ...
transrectal ultrasound and prostatic biopsy
... seen in present Urological practice. At this point, MRI does not have sufficient evidence to allow its use as an image-based biopsy system. Whether this happens in the future ...
... seen in present Urological practice. At this point, MRI does not have sufficient evidence to allow its use as an image-based biopsy system. Whether this happens in the future ...
New Treatment for Patients with Refractory Metastatic Colorectal
... treatments. Lonsurf is potentially a valuable new drug that I can offer to my patients with metastatic colorectal cancer regardless of their RAS status or resistance to previous lines of treatment. It’s great news that NICE has recommended Lonsurf - because I now have a treatment that could give my ...
... treatments. Lonsurf is potentially a valuable new drug that I can offer to my patients with metastatic colorectal cancer regardless of their RAS status or resistance to previous lines of treatment. It’s great news that NICE has recommended Lonsurf - because I now have a treatment that could give my ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.