![Pharmacology/Therapeutics II Block I Lectures](http://s1.studyres.com/store/data/016658308_1-c74df4ca29de8de1076b33acc1a9ecd8-300x300.png)
Pharmacology/Therapeutics II Block I Lectures
... Prodrugs – activated in acid environment – enter the parietal cells from the blood The prolonged duration of anti-secretory action of PPI reflects irreversible inactivation by covalent modification, of the parietal cell H+ ,K+ -ATPase, rather than a prolonged serum half-life. A single daily dose can ...
... Prodrugs – activated in acid environment – enter the parietal cells from the blood The prolonged duration of anti-secretory action of PPI reflects irreversible inactivation by covalent modification, of the parietal cell H+ ,K+ -ATPase, rather than a prolonged serum half-life. A single daily dose can ...
VIRTUAL SCREENING AND LEAD OPTIMIZATION TO IDENTIFY
... or alleviate symptoms. Drug usually act on either cellular or genetic chemicals in the body, known as targets, which are believed to be associated with disease. Scientists use a variety of techniques to identify and isolate a target and learn more about its functions and how these influence disease. ...
... or alleviate symptoms. Drug usually act on either cellular or genetic chemicals in the body, known as targets, which are believed to be associated with disease. Scientists use a variety of techniques to identify and isolate a target and learn more about its functions and how these influence disease. ...
Rosen et al. Endoglin for Targeted Cancer Treatment. CurrOncRep
... Endoglin expression is required for endothelial cell proliferation, and endoglin is upregulated in the setting of hypoxia through the induction of hypoxia-inducible factor (HIF) 1α [25, 26]. The expression of endoglin by endothelial cells is essential for the development of new vasculature, whether ...
... Endoglin expression is required for endothelial cell proliferation, and endoglin is upregulated in the setting of hypoxia through the induction of hypoxia-inducible factor (HIF) 1α [25, 26]. The expression of endoglin by endothelial cells is essential for the development of new vasculature, whether ...
Targets and the Renin Angiotensin Aldosterone System
... Bradykinin‐specific treatment may decrease ...
... Bradykinin‐specific treatment may decrease ...
PROSTATE CANCER
... ofProstate gland1,1a The prostate gland is present only in males, although females have homologous glands (having the same embryological origin) around the urethra; these are called 'Skene's glands' or 'the female prostate'. The prostate gland surrounds the proximal part of the urethra as it exits t ...
... ofProstate gland1,1a The prostate gland is present only in males, although females have homologous glands (having the same embryological origin) around the urethra; these are called 'Skene's glands' or 'the female prostate'. The prostate gland surrounds the proximal part of the urethra as it exits t ...
Slide 1
... 3) competitive antagonism by atropine 4) ACh-induced ganglionic transmission 5) Mechanism of Ach-induced vasodilation & experimental ...
... 3) competitive antagonism by atropine 4) ACh-induced ganglionic transmission 5) Mechanism of Ach-induced vasodilation & experimental ...
Cervical Cancer - MD Anderson Cancer Center
... This practice algorithm has been specifically developed for MD Anderson using a multidisciplinary approach and taking into consideration circumstances particular to MD Anderson, including the following: MD Anderson’s specific patient population; MD Anderson’s services and structure; and MD Anderson’ ...
... This practice algorithm has been specifically developed for MD Anderson using a multidisciplinary approach and taking into consideration circumstances particular to MD Anderson, including the following: MD Anderson’s specific patient population; MD Anderson’s services and structure; and MD Anderson’ ...
Prevention and Treatment of Cancer with Indole-3
... has been compared to DIM in only one published animal study to date. In this study, I-3C and DIM were each found to inhibit chemically-induced carcinogenesis of both the mammary and the forestomach.26 In each model, I3-C was more effective than DIM, although not with statistical significance. Oral I ...
... has been compared to DIM in only one published animal study to date. In this study, I-3C and DIM were each found to inhibit chemically-induced carcinogenesis of both the mammary and the forestomach.26 In each model, I3-C was more effective than DIM, although not with statistical significance. Oral I ...
Marine Invertebrate Xenobiotic-Activated Nuclear Receptors: Their
... majority of NRs the LBD cavities have well-defined shapes with restricted mobility, thereby ensuring specificity of ligand—NR LBD interactions [102,103]. In contrast, the human PXR LBD is both larger than is typical of NRs and also displays significant flexibility during ligand binding allowing it t ...
... majority of NRs the LBD cavities have well-defined shapes with restricted mobility, thereby ensuring specificity of ligand—NR LBD interactions [102,103]. In contrast, the human PXR LBD is both larger than is typical of NRs and also displays significant flexibility during ligand binding allowing it t ...
Lycopene: Redress for Prostate Cancer
... males of age 40-50 years. So, in countries of north America and Europe food contains much of the lycopene supplements. In accordance with the American journal of epidemiology 2002 studies implies that men with crushed serum lycopene levels are more divulged to prostate cancer and those with sound di ...
... males of age 40-50 years. So, in countries of north America and Europe food contains much of the lycopene supplements. In accordance with the American journal of epidemiology 2002 studies implies that men with crushed serum lycopene levels are more divulged to prostate cancer and those with sound di ...
Anti-platelet agents
... that can be administered orally, and absorption is approximately 8090% • Thienopyridines are prodrugs that must be activated in the liver ...
... that can be administered orally, and absorption is approximately 8090% • Thienopyridines are prodrugs that must be activated in the liver ...
Targeting cell signaling pathways for drug discovery
... to the human disease. This is followed in turn by identification of specific chemical- or antibodybased small molecule modulators or inhibitors of the target. Target validation is a complex and extremely difficult process [Tobert, 2003], and extremely few disease-relevant targets are amenable to dru ...
... to the human disease. This is followed in turn by identification of specific chemical- or antibodybased small molecule modulators or inhibitors of the target. Target validation is a complex and extremely difficult process [Tobert, 2003], and extremely few disease-relevant targets are amenable to dru ...
STUDY OF HALOGEN SUBSTITUENT ON DOCKING AND 3D
... of docking studies and 3D QSAR studies have shown that halogen substitution in phenyl ring at Meta position plays important role in protection from seizures. Bromo substituent was found to be more effective as compared to chloro and fluoro substituents. ...
... of docking studies and 3D QSAR studies have shown that halogen substitution in phenyl ring at Meta position plays important role in protection from seizures. Bromo substituent was found to be more effective as compared to chloro and fluoro substituents. ...
Newer Antihypertensive Drugs
... conditions, but can be provoked by the release or infusion of catecholamines. Renalase is also expressed in the heart, skeletal muscle, and liver. Kidney seems to be the major source of circulating renalase because no compensatory rises in reduced renalase levels are observed among patients with end ...
... conditions, but can be provoked by the release or infusion of catecholamines. Renalase is also expressed in the heart, skeletal muscle, and liver. Kidney seems to be the major source of circulating renalase because no compensatory rises in reduced renalase levels are observed among patients with end ...
herbal medicine for cancer patients
... components within the plant are rather low in concentration, it has become evident that there is an involvement of substances which are inactive medicinally but enhance the activity of and protect the integrity of the so-called active principles of the plant. In the case of Artemisia annua, a plant ...
... components within the plant are rather low in concentration, it has become evident that there is an involvement of substances which are inactive medicinally but enhance the activity of and protect the integrity of the so-called active principles of the plant. In the case of Artemisia annua, a plant ...
Drug Design (Physicochemical Properties in
... interaction are collected in table 2-8 :• In most cases, it is desirable that the drug leaves the receptor site when the concentration decrease in the extracellular(EC) fluid . therefore , most useful drugs are held to their receptors by ionic or weaker bonds , when relatively long lasting or irreve ...
... interaction are collected in table 2-8 :• In most cases, it is desirable that the drug leaves the receptor site when the concentration decrease in the extracellular(EC) fluid . therefore , most useful drugs are held to their receptors by ionic or weaker bonds , when relatively long lasting or irreve ...
TESTOPEL - Endo Pharmaceuticals
... Animal Data. Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their s ...
... Animal Data. Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their s ...
Structure-Based Identification of Binding Sites, Native Ligands and
... This is extremely time-consuming and as a result of the sheer scale of the task means that many important potential ligands are missed and never tested. Testing is usually limited to compounds with similar structural characteristics; therefore, new potentially structurally diverse ligands will never ...
... This is extremely time-consuming and as a result of the sheer scale of the task means that many important potential ligands are missed and never tested. Testing is usually limited to compounds with similar structural characteristics; therefore, new potentially structurally diverse ligands will never ...
The main role of vitamin D - The University of North Carolina at
... been recognized to act on other organs and in the male as well, including elements of the skin, atrial cardiomyocytes, thymus reticular cells, Leydig cells in the testis, epithelium of the epididymis, prostate, and distinct regions throughout the brain and spinal cord (9). On that basis, estradiol w ...
... been recognized to act on other organs and in the male as well, including elements of the skin, atrial cardiomyocytes, thymus reticular cells, Leydig cells in the testis, epithelium of the epididymis, prostate, and distinct regions throughout the brain and spinal cord (9). On that basis, estradiol w ...
Facing Our Children UROLOGIC CHALLENGES EDUCATION REGULAR
... the most vulnerable groups of urology patients: children. Youngsters—and their parents and caregivers—can be profoundly affected by these conditions. They can be left feeling confused, embarrassed and scared. But many of these conditions are common and there are steps you can take to help your child ...
... the most vulnerable groups of urology patients: children. Youngsters—and their parents and caregivers—can be profoundly affected by these conditions. They can be left feeling confused, embarrassed and scared. But many of these conditions are common and there are steps you can take to help your child ...
Ontario Prostate Specific Antigen (PSA) Clinical Guidelines: The
... prostatic hyperplasia (BPH), in less aggressive-appearing, low-grade tumours, as well as in rapidlygrowing tumours, or because of day-to-day variation (see Section IV). Prostate cancer differs from other types of cancer in that its clinical course can vary widely. In some men, prostate cancers can b ...
... prostatic hyperplasia (BPH), in less aggressive-appearing, low-grade tumours, as well as in rapidlygrowing tumours, or because of day-to-day variation (see Section IV). Prostate cancer differs from other types of cancer in that its clinical course can vary widely. In some men, prostate cancers can b ...
Treatment of Peptic Ulcer Disease
... The PPIs are well absorbed after oral dosing, and the simultaneous administration of antacids does not appear to affect their bioavailability. Food may delay the absorption of lansoprazole, pantoprazole, and rabeprazole,[35] but this delay does not alter the area under the plasma concentration–time ...
... The PPIs are well absorbed after oral dosing, and the simultaneous administration of antacids does not appear to affect their bioavailability. Food may delay the absorption of lansoprazole, pantoprazole, and rabeprazole,[35] but this delay does not alter the area under the plasma concentration–time ...
2. Virtual Screening of Molecular Properties and Bioactivity Score of
... bioactivity score for drug targets including nuclear receptor ligand, protease inhibitor and enzyme inhibition and thus expected to have excellent pharmacological activity in vivo. The results of this study justify their topical application in arthritic conditions but some structural modifications i ...
... bioactivity score for drug targets including nuclear receptor ligand, protease inhibitor and enzyme inhibition and thus expected to have excellent pharmacological activity in vivo. The results of this study justify their topical application in arthritic conditions but some structural modifications i ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.