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Prostate Cancer
Prostate Cancer

... • Needs to involve discussion with patient: – Prostate cancer is an important health problem – Prostate cancer screening is controversial – Prostate screening may reduced the chance of dying from prostate cancer however the evidence is mixed and the absolute benefit is small – In order to determine ...
evidence intratumoral DHT synthesis drives castration
evidence intratumoral DHT synthesis drives castration

... by loss of heterozygosity of the wild-type allele. Increased stability of 3βHSD1-N367T was associated with decreased ubiquitin-mediated degradation and higher levels of dihydrotestosterone  (DHT). The studies suggest that genetic instability in castration-resistant prostate cancer favors the more st ...
Responding to Reviews of Submitted Manuscripts
Responding to Reviews of Submitted Manuscripts

The Male Lumpectomy
The Male Lumpectomy

... 3. Radiation limits the curative treatments patients can have if they fail therapy.3 Unfortunately, radiation changes the tissue and fuses the tissue planes in the area of the prostate. Attempts at radical prostatectomy after radiation are fraught with danger to the rectum and surrounding structures ...
The Treatment Challenge of Hormone
The Treatment Challenge of Hormone

... Chemotherapeutic agents in the management of HRPC were traditionally viewed as having little or no impact on the natural history of the disease. In 1985, Eisenberger et al [8] reviewed 17 randomized clinical trials with 1,464 patients, and the overall response rate was 4.5%. In a review of 26 cytoto ...
Slide 1
Slide 1

Diabetes and beta-adrenergic blockage are risk factors for
Diabetes and beta-adrenergic blockage are risk factors for

... Prostate cancer (PCa) is the second most common cancer and third most leading cause of death of men in the western world [1]. Correct risk stratification is crucial for optimal of high-risk patients and avoiding overtreatment in low-risk patients. Risk stratification is based on histologic analysis ...
Document
Document

Prostate NICaN SACT CMG Version 2.0 June 2016 FINAL
Prostate NICaN SACT CMG Version 2.0 June 2016 FINAL

... supplies it with the discount agreed in the patient access scheme). [Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy TA377] ...
Variation in Prostate Cancer Detection Rates in a Statewide Quality
Variation in Prostate Cancer Detection Rates in a Statewide Quality

RESEARCH STATEMENT
RESEARCH STATEMENT

Treatment Options for Localized Prostate Cancer
Treatment Options for Localized Prostate Cancer

... In the United States, more than 90 percent of prostate cancers are detected by serum prostatespecific antigen testing. Most patients are found to have localized prostate cancer, and most of these patients undergo surgery or radiotherapy. However, many patients have low-risk cancer and can follow an ...
CXCR4 inhibition reduces bone metastases BY AFFECTING tumoUr
CXCR4 inhibition reduces bone metastases BY AFFECTING tumoUr

... Aims. The majority of prostate cancer (PCa) patient morbidity can be attributed to bone metastases posing a significant clinical obstacle. Therefore, a better understanding of this phenomenon is imperative and might help to develop novel therapeutic strategies.I woul like to study the expression of ...
IMRT - unicarestateplan.com
IMRT - unicarestateplan.com

... ___Individual with primary lung cancer where radiation is to be used for  curative intent  ___Percent of normal lung receiving more than 20 Gy (V20%) accounts for more than 35% of the normal lung,          defined as the total lung volume minus the planning target volume (PTV)  ___The IMRT plan will ...
PROSTATIC DISEASES About the Diagnosis Like male human
PROSTATIC DISEASES About the Diagnosis Like male human

... Prostatitis is an inflammation of the prostate gland, usually due to bacterial infection. Prostatitis has a wide range of severity, from mild discomfort to severe or even lifethreatening illness if it causes sepsis (blood-borne infection/blood poisoning). Prostatitis is more likely to happen in dogs ...
Controversies in Prostate Cancer
Controversies in Prostate Cancer

... • “Screening may only occur after shared decisionmaking based on a man’s values and preferences weighing the benefits of preventing prostate cancer mortality in 1 man for every 1,000 men screened over a decade against the known potential harms associated with screening and treatment”. • The “benefit ...
to read about our Bowel Cancer Screening Programme
to read about our Bowel Cancer Screening Programme

... Bowel cancer is the third most common cancer in Scotland after lung and breast cancer. The Scottish Bowel Screening Programme invites all men and women between the ages of 50-74 for screening every two years. Screening aims to find bowel cancer at an early stage in people with no symptoms. If bowel ...
Improving the diagnosis and treatment of high‐risk localised or
Improving the diagnosis and treatment of high‐risk localised or

... Key to the administration of radiotherapy is three-dimensional (3D) treatment planning with image guidance. Initial studies with 3D conformal radiotherapy (CRT) showed that individually shaping the treatment fields to the patient’s prostate gland can significantly reduce radiationinduced proctitis f ...
Aragon Pharmaceuticals Secures $22 Million in Series B Financing
Aragon Pharmaceuticals Secures $22 Million in Series B Financing

The Development of Sipuleucel-T  (Provenge®) for Active Cellular
The Development of Sipuleucel-T (Provenge®) for Active Cellular

External-Beam Radiotherapy in the Management of Carcinoma of
External-Beam Radiotherapy in the Management of Carcinoma of

... required to achieve maximal tumor control probability without exceeding the limits of acceptable risk. This is analogous to the classically described dose-response effect in pharmacology, including the risk for toxic side effects or irreversible complications at high treatment (irradiation) dosages. ...
Advanced Prostate Cancer - Urology Care Foundation
Advanced Prostate Cancer - Urology Care Foundation

... Radiopharmaceuticals are drugs with radioactivity. In the past, they were used to help with bone pain from metastatic cancer. Examples are Strontium-89 (Metastron®) and Samarium-153 (Quadramet®). Radium-223 (Xofigo®) is newer for men whose mCPRC has spread to their bones. It was approved because it ...
Essiac
Essiac

Advances in biomarkers for the early diagnosis of prostate cancer
Advances in biomarkers for the early diagnosis of prostate cancer

... the sarcosine level was significantly elevated in localized PCa as  compared to adjacent benign prostate specimens. When  compared to localized PCa, the sarcosine level in metastatic  specimens was even higher. When compared to a control group  with negative biopsy results, the sarcosine level was s ...
Post-treatment Follow-up of Prostate Cancer
Post-treatment Follow-up of Prostate Cancer

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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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