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CHAPTER 14 - Hormonal therapy of prostate cancer
CHAPTER 14 - Hormonal therapy of prostate cancer

... by castration alone has never been shown to prolong life in metastatic prostate cancer, combination of castration (surgical or medical with a gonadotropin-releasing hormone (GnRH) agonist) with a pure antiandrogen has been the first treatment shown to prolong life. Most importantly, when applied at ...


Cancer in Ireland 1994 to 2007 - National Cancer Registry Ireland
Cancer in Ireland 1994 to 2007 - National Cancer Registry Ireland

Pharmacological Targeting of the Integrated Protein Kinase B,
Pharmacological Targeting of the Integrated Protein Kinase B,

Special Report: Recent Developments in Prostate Cancer Genetics and Genetic Testing
Special Report: Recent Developments in Prostate Cancer Genetics and Genetic Testing

Regional challenges in cancer prevention
Regional challenges in cancer prevention

... Global burden of cancer ...
Evolving role of chemotherapy in castration
Evolving role of chemotherapy in castration

... activity in prostate cancer cell lines. In a Phase II trial, Beer et al. demonstrated that docetaxel was well tolerated in 25 patients treated with docetaxel 36 mg/m2 weekly for 6 weeks. Eleven out of 24 patients with an elevated PSA had a PSA response (defined as a reduction in serum PSA levels of ...
ESIAD_Pipeline-Pancreatic_Ahlquist_FINAL v4
ESIAD_Pipeline-Pancreatic_Ahlquist_FINAL v4

Stage I - inoncology
Stage I - inoncology

... T categories describe the extent of spread through the layers that form the wall of the colon and rectum These layers, from inner to outer, include: ...
Aqueous extract of urtica dioica makes significant inhibition on
Aqueous extract of urtica dioica makes significant inhibition on

... commonly prescribed.7 For example, it has been observed that β-sitosterol which is rich in Urtica dioica causes significant improvement in symptoms and urinary flow parameters of patients with prostate diseases.8 In fact, drugs derived from plants have a long tradition in the medical treatment of pr ...
Targeting Bone Physiology for the Treatment of Metastatic Prostate
Targeting Bone Physiology for the Treatment of Metastatic Prostate

... growth factor (PDGF)—and bone morphogenic proteins (BMPs), cytokines, and cell adhesion molecules.6,9 While bone marrow endothelial cells, hematopoietic stem cells, and other local cells such as fibroblasts participate in this dialogue, perhaps the best studied and most highly implicated interaction ...
(PSA)-Based Population Screening for Prostate Cancer
(PSA)-Based Population Screening for Prostate Cancer

... controlled trials in Europe and North America was mixed: PSA screening was associated with a reduction in prostate cancer mortality in some European countries but not in the United States. The trials are not directly comparable because of major differences in the way men were screened, diagnosed, an ...
tHE NEXt GENERAtION - Prostate Cancer Foundation of Australia
tHE NEXt GENERAtION - Prostate Cancer Foundation of Australia

... Notwithstanding that prostate cancer is primarily a disease of older men with more than 97% of diagnoses occurring in men over age 50, younger men aged 18 to 50 clearly see prostate cancer as an important male health issue alongside obesity and heart disease. Perhaps not surprisingly, younger men al ...
ovarian cancer
ovarian cancer

... Ovarian cancer refers to cancers of the ovaries. It is the fifth most common cancer in Europe for females, with around 65,600 new cases diagnosed in 2012 (4% of female cases and 2% of the total).1 Ovarian cancer causes more deaths than any other type of female reproductive cancer.2 Europe has one of ...
Recommendations to lower the risk and mortality rate of the most
Recommendations to lower the risk and mortality rate of the most

... European healthcare problem to engage closer collaboration between Member States within the healthcare sector, including patient representatives, and an agreed approach to tackling it. At present, effective treatments exist , but consistency in getting them to patients is complicated by European and ...
Advances Elusive in the Drive to Cure Cancer
Advances Elusive in the Drive to Cure Cancer

... But difficulties arise when cancer spreads, and, often, it has by the time of diagnosis. That is true for the most common cancers as well as rarer ones. With breast cancer, for example, only 20 percent with metastatic disease — cancer that has spread outside the breast, like to bones, brain, lungs ...
Save as PDF
Save as PDF

... The Prolaris test report includes both the Prolaris score and a D'Amico risk analysis, which shows how the patient's score compares to that of patients within the same D'Amico risk category (low or intermediate; the test is not intended for high-risk prostate cancer). This allows differentiation bet ...
Comparative analysis of protein-coding genes and long
Comparative analysis of protein-coding genes and long

... biotechnologies, gene expression microarrays have been used in numerous applications, including measuring the expression levels of large numbers of genes to identify novel genes associated with certain cancers such as prostate cancer. For example, Reams et al. compared the microarray datasets of pro ...
Oxidative stress in prostate cancer Lakshmipathi Khandrika , Binod Kumar , Sweaty Koul
Oxidative stress in prostate cancer Lakshmipathi Khandrika , Binod Kumar , Sweaty Koul

The Excess Burden of Cancer in Men in the UK (2009)
The Excess Burden of Cancer in Men in the UK (2009)

... Branney P. (Eds) The Gender and Access to Health Services Study: final report. London, Department of Health. Brenner H., Hoffmeister M., & Arndt U. (2007). Gender differences in colorectal cancer: implications for age at initiation of screening. British Journal of Cancer 96(5): 828–831. Cancer Resea ...
Hypermethylation of the GABRE$miR-452$miR
Hypermethylation of the GABRE$miR-452$miR

... nonmalignant and 281 prostate cancer tissue samples. GABREmiR-452miR-224 promoter methylation was determined by methylation-specific qPCR (MethyLight) in 35 nonmalignant, 293 prostate cancer [radical prostatectomy (RP) cohort 1] and 198 prostate cancer tissue samples (RP cohort 2). Diagnostic/prog ...
Colon Cancer - Needs Beyond Medicine
Colon Cancer - Needs Beyond Medicine

... and/or after surgery. Hepatic artery infusion may be used if the cancer has spread to the liver. If the metastases cannot be surgically removed, chemo may be given, then, if the tumors shrink, surgery may be tried. Chemo would then be given again after surgery. Another option may be to destroy tumor ...
1 A novel group of genes regulates susceptibility to antineoplastic
1 A novel group of genes regulates susceptibility to antineoplastic

In Vivo Imaging Of Prostate Cancer Using
In Vivo Imaging Of Prostate Cancer Using

... Prostate cancer (PCa) is the most frequently diagnosed cancer and the second most common cause of cancer deaths among men (1). Prostate specific antigen (PSA) and digital rectal examination are the first-line investigations in evaluating the risk of PCa while diagnosis is mainly based on transrectal ...
position paper - Royal Australasian College of Surgeons
position paper - Royal Australasian College of Surgeons

... positive result must then be followed up by a colonoscopy. FOBT’s only major drawback is its relatively high rate of false-positive results. This drawback notwithstanding, FOBT in the home has been chosen by both governments as the primary tool in their national screening programs. Governments in bo ...
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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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