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Chapter 2: Neuroscience and Biological Foundations
Chapter 2: Neuroscience and Biological Foundations

... motor information to and from the sense organs and skeletal muscles ...
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B6 Brain and Mind

... lot better when my brain got bigger. Notice I can now use simple tools! Mammals have complex brains with billions of neurons. The interaction between our ancestors and their environment caused neuron pathways to form in the brain. ...
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... specificity of fMRI when compared with ERPs. This in turn would assist in the interpretation of these ERP effects in clinical populations and may offer additional information useful for the diagnosis and treatment of CNS disorders. Previous ERP studies suggested that the oddball task involves multip ...
Chap 2 Outline
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... We can use case studies of human brain damage to learn about the brain’s functions, but cannot easily generalize from one case to another.  We can study the brain by using deep lesioning to destroy certain areas of the brain in laboratory animals, or by electrically stimulating those areas (ESB).  ...
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... Broca’s area lies in the left frontal lobe. If this area is damaged, one may have difficulty moving the tongue or facial muscles to produce the sounds of speech. The individual can still read and understand spoken language but has difficulty in speaking and writing (i.e. forming letters and words, d ...
Brain Anatomy “Science erases what was previously true.”
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... temporal-differences (TD), which postulates that a synaptically reinforcing substance, e.g. dopamine, is released in response to errors in reward prediction (Schultz et al., 1997). This model has been used in a wide variety of applications including complex learning tasks, like backgammon (Sutton, 1 ...
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... disorders such as Parkinson's disease. Both a computer and a brain can get "sick" - a computer can get a "virus" and there are many diseases that affect the brain. The brain has "built-in back up systems" in some cases. If one pathway in the brain is damaged, there is often another pathway that will ...
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the summary and précis of the conference

... suggesting that approximately 50% of the brain’s energy is used to drive signals along axons and across synapses. Partha Mitra showed that this cost is important to keep the brain poised near threshold. The remainder supports the maintenance of resting potentials and the vegetative function of neuro ...
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Functional magnetic resonance imaging



Functional magnetic resonance imaging or functional MRI (fMRI) is a functional neuroimaging procedure using MRI technology that measures brain activity by detecting associated changes in blood flow. This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases.The primary form of fMRI uses the blood-oxygen-level dependent (BOLD) contrast, discovered by Seiji Ogawa. This is a type of specialized brain and body scan used to map neural activity in the brain or spinal cord of humans or other animals by imaging the change in blood flow (hemodynamic response) related to energy use by brain cells. Since the early 1990s, fMRI has come to dominate brain mapping research because it does not require people to undergo shots, surgery, or to ingest substances, or be exposed to radiation, etc. Other methods of obtaining contrast are arterial spin labeling and diffusion MRI.The procedure is similar to MRI but uses the change in magnetization between oxygen-rich and oxygen-poor blood as its basic measure. This measure is frequently corrupted by noise from various sources and hence statistical procedures are used to extract the underlying signal. The resulting brain activation can be presented graphically by color-coding the strength of activation across the brain or the specific region studied. The technique can localize activity to within millimeters but, using standard techniques, no better than within a window of a few seconds.fMRI is used both in the research world, and to a lesser extent, in the clinical world. It can also be combined and complemented with other measures of brain physiology such as EEG and NIRS. Newer methods which improve both spatial and time resolution are being researched, and these largely use biomarkers other than the BOLD signal. Some companies have developed commercial products such as lie detectors based on fMRI techniques, but the research is not believed to be ripe enough for widespread commercialization.
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